Gopal Krishna Padhy

Centurion University of Technology and Management

Spathodea campanulata P. Beauv., belonging to the family Bignoniaceae, is a big erect tree with an ancient history of medicinal use in Africa. In the traditional system, it is mentioned for the treatment of malaria, diabetes, stomach ulcers, wounds, skin infections and viral diseases. The aim of the review is to make available the current informati...

Lactuca, a genus within the Asteraceae family, comprises a diverse group of herbaceous plants commonly known as lettuces. This review seeks to offer an extensive summary of Lactuca species, exploring their taxonomy, morphological diversity, nutritional content, medicinal properties, and potential agricultural and environmental applications. Lactuca...

In this study, based on the molecular docking study, the antioxidant activity of phytochemicals constituents of hydroalcoholic extract of Gyrocarpus asiaticus Willd. and Lactuca runcinata DC were evaluated. For molecular docking study, ligand generation of phytochemicals constituents of Lactuca runcinata DC and Gyrocarpus asiaticus Willd. were perf...

Benzimidazole is considered a privileged moiety for the development of molecules with therapeutic potential. Over the years several drugs viz: albendazole, pantoprazole, astemizole, telmisartan, thiabendazole, and benomyl have been developed by optimizing benzimidazole-based structures. Given the various pharmacological implications of benzimidazol...

Cleaning validation is a process used by pharmaceutical manufacturers to ensure that their equipment and facilities are thoroughly cleaned and free of any residual contaminants that could potentially compromise the quality of their products. This process is guided by regulatory guidelines set forth by FDA and European Medicines Agency (EMA) are t...

Appearance of resistance to available antibacterial and anticancer drugs became a major challenge in the recent time. Hence, finding of new antibacterial and anticancer compounds become highly essential. Pyrazolines and benzimidazoles were reported to have potent antibacterial and anticancer activity. Therefore,a hybrid tactic has been used, combin...

The present study is aimed at reviewing the phytochemistry and pharmacological activities of Gyrocarpus asiaticus Willd and Lactuca runcinata DC. The results of the current study are based on literature research on phytochemistry and pharmacological properties of Gyrocarpus asiaticus & Lactuca runcinata. These plants are valuable for antibacterial,...

The advance progression in the pharmaceuticals brought a new era in human health. These pharmaceutical preparations might serve their envisioned solitary if they're free from impurities and as long as are administered in suitable quantity. With intensifying regulatory stringency on the control of medicines, impurities and their degradation constitu...

A new HPLC stability indicating method was developed and optimized by using a statistical tool, design expert 13.0.1.0 (Stat-Ease) for simultaneous quantitation of bilastine and montelucast sodium in marketed tablet dosage form. Randomized response surface methodology with two factor central composite design was utilized for mobile phase optimizati...

Background: Aristolochia indica L. of the family Aristolochiaceae is a twining perennial herbs with an ancient history of medicinal use. In the Indian Ayurvedic system, it is mentioned for the treatment of snake venom, scorpion venom, pimple, fever and worm infection. Objective: To make accessible the current information that is existing on the tr...

Benzimidazole is an important moiety from a medicinal chemistry perspective due to its various biological activities such as antimicrobial, anti-cancer, anti-diabetic, anti-Alzheimers, and anti-inflammatory, etc. 2-acetylbenzimidazole is exploited to obtain various heterocyclic compounds of pharmacological interest. This review's main motive is to...

An easy RP-HPLC method was developed and validated considering the parameters like selectivity, linearity, precision and accuracy for the rapid assay of atorvastatin in tablet dosage form. Flow rate of 1 mL/ min was engaged on an Eclipse XDB plus column (C18) at a temperature of 40 ºC. Mobile phase was comprised of Acetonitrile: Potassium dihydroge...

A reverse phase HPLC method was successfully developed and validated for concurrent assessment of omeprazole and aspirin for bulk and pharmaceutical formulation. The method was developed employing a reversed phase C 18 column. A optimized mobile phase having a composition of acetonitrile-methanol (20:80 v/v) was used. The experiment was carried out...

Objective: The objective of the present work is to develop and validate a new UV derivative spectrophotometric method for simultaneous estimation of metoprolol succinate and ramipril in methanol: water (50:50v/v). Methods: “Zero crossing technique” was chosen for quantitative determination. The zero-crossing points (ZCP’s) were found to be 209 nm w...

An efficient synthesis of some new benzimidazole derivatives linked to various heterocyclic scaffolds was performed by multistep reaction sequences. The structures of synthesized compounds were elucidated by spectral studies (infrared, nuclear magnetic resonance [ 1 H NMR], 13 C NMR, and mass spectrometry). The compounds were evaluated for their an...

Background: Emergence of resistance to accessible anticancer drugs became a threat to human lives in the recent time. To address this issue, discovery of novel anticancer agents becomes very essential. Benzimidazoles and pyrimidines have been reported to possess potent anticancer activity. Material and Methods: A hybrid approach has been used, in...

Efficient syntheses of some new substituted pyrazoline derivatives linked to substituted benzimidazole scaffold were performed by multistep reaction sequences. All the synthesized compounds were characterized using elemental analysis and spectral studies (IR, 1D/2D NMR techniques and mass spectrometry). The synthesized compounds were screened for t...

A novel series of 2-Benzyl substituted benzimidazole acetohydrazone derivatives was synthesized by multistep reaction sequences. The synthesized compounds were characterized using IR, 1 H NMR, mass and elemental analysis. Antibacterial activities of the compounds were evaluated against selective gram positive and gram negative bacteria. Compound 7...

Efficient synthesis of some new N-Benzyl substituted benzimidazole chalcone derivatives were performed by multistep reaction sequences. The synthesized compounds were characterized using IR, 1H NMR, mass spectrometry and elemental analysis. The synthesized compounds were screened for their antibacterial activity against selective gram positive and...

A simple, accurate, specific and precise UV Spectrophotometric method has been developed for estimation of valsartan in pure and pharmaceutical formulation. The λmax of valsartan in methanol and water was found to be 248.21 nm. Methanol and water is used as diluent in equal proportion. The drug exhibited the linearity in the concentration range of...

Drugs are the most important elements in healthcare and must be manufactured to the highest quality levels. Multiple views on obtaining such quality are the current interest in the pharmaceutical industry. Process validation performs this task ensuring that the process does what it purports to do. The process validation is establishing documented e...

The medicinal plants are widely used by the traditional medical practitioners for curing various diseases. Helminthiasis is the most common infection in human affecting a large proportion of world population. Parasitic diseases may cause severe morbidities including lymphatic filariasis and onchocerciasis. Development of resistance to most of the c...

A simple, selective, linear, precise and accurate RP-HPLC method was developed and validated for rapid assay of Ritonavir in pharmaceutical dosage form. Isocratic elution at a flow rate of 1ml/min was employed on a symmetry C18 column at ambient temperature. The mo bile phase consisted of acetonitrile: methanol: buffer 50:35:15 (V/V). The UV detect...

The present study was undertaken to evaluate Anthelmintic activity of petroleum ether and alcoholic extracts of whole plant of Tephrosia purpurea against Pheretima posthuma and Ascardi galli. Various concentrations (10, 25 and 50 mg/ml) of extracts were evaluated and results were expressed in terms of time of paralysis (P) and time of death (D) for...

The aim of the present study was to evaluate the anthelmentic activity of seed oils of Ricinus communis,Brassica nigra and Madhuca indica using adult Indian earthworm Pheritima posthuma as test worm .The oils were tested at different concentrations (10mg/ml, 25mg/ml, 50mg/ml) for the determination of time of paralysis(p)and time of death(d) of the...

The present study was undertaken to evaluate the Anthelmintic activity of ethanol extracts of Zingiber officinalis (Zingiberacae), Zingiber zerumbet (Zingiberacae) and Curcuma longa on Indian earthworm, Pheretima posthuma.Various concentrations (10ug/ml, 25ug/ml, 50ug/ml) of all extracts were tested and results were expressed in terms of time of pa...

The present study was under taken to evaluate anthelmintic activity of ethanolic extract of leaves and roots of vitex negunda and leaves of moringa olifera and roots of tamarindus indica on Indian earthworm pheritima posthuma. Various concentrations (10, 25, 50 mg/ml) of extracts were tested and results were expressed in terms of time of paralysis...