Gary R Klinefelter

Senior Research Scientist
United States Environmental Pr... · Office of Research and Development, RTP, NC


We need to understand the molecular function of the sperm fertility biomarker SP22 , how various toxicants compromise SP22 expression, if this protein can serve as a diagnostic indicator of fertility in men. We need better data in both toxicology and epidemiology to determine whether semen quality is declining in men, and if so to what degree is exposure to environmental chemicals involved. New biomarkers of exposure and effect need to be identified, validiated, and used in epidemiology.

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