Publications (58) View all
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Article: The Effects of Oxcarbazepine on 4-Aminopyridine-Induced Afterpotentials on Isolated Rat Sural Nerves
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ABSTRACT: Objective: Oxcarbazepine is used for the treatment of neuropathic pain syndromes. In the present study, we have investigated the effect of oxcarbazepine on the amplitude of compound action potentials (CAP), and the depolarizing after-potentials induced by 4-aminopyridine in the rat sural nerves which plays an important role of the neuropathic pain.Material and Method: The experiments were conducted with sucrose-gap technique, which is an electrophysiological method on the isolated wistar rat sural nerves. Effects of oxcarbazepine at 0.1- 0.8 mM on the nerve conduction and 4-aminopyridine (4-ap) induced depolarizing after potentials were investigated.Results: All concentrations of oxcarbazepine exerted a significant concentration- and frequency dependent reduction in the amplitude of CAP, and prolonged the rising and the ½ falling phase of the CAP (P<0.01). The tonic blocks were measured as 0.1 mM; 14.7 ± 1.7%, 0.8 mM; 73.3±3.0%, and the phasic blocks (100Hz) were 0.1 mM; 15.9 ± 1.4%, 0,8 mM; 96.6±3.3% (n=6). 2 mM 4-ap prolonged the falling phase of CAP and produced a depolarizing after-potential. Oxcarbazepine reduced the amplitude of the depolarizing after-potential, which was more pronounced than that of the amplitude of the CAP in the presence of 4-aminopyridine.Conclusions: The findings showed that oxcarbazepine may reduce the amplitude of depolarizing afterpotentials in the rat sural nerves which contributes to sensory signaling and may play a role in neuropathic pain. We concluded that the results may be relevant to our understanding of effect of oxcarbazepine on sensory nerves and its therapeutic role on neuropathic pain.Journal of Neurological Sciences. 01/2010; -
Article: Neurofibromatosis type 1 associated with Charcot-Marie-Tooth type 1A.
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ABSTRACT: Neurofibromatosis and Charcot-Marie-Tooth are genetic disorders of the nervous system affecting the development and growth of nerve cells and demyelination of peripheral neurons, respectively. We report a 22-year-old man who presented clinical manifestations of both neurofibromatosis type 1 (NF1) and Charcot-Marie-Tooth type 1A. The simultaneous occurrence of neurofibromatosis and Charcot-Marie-Tooth disease has rarely been reported. More extensive reports and further investigations of this combination will certainly provide a better understanding of this linkage in the near future.The Journal of Dermatology 06/2009; 36(5):306-11. · 1.49 Impact Factor -
Article: Joubert syndrome associated with new MRI findings and posterior reversible encephalopathy syndrome.
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ABSTRACT: Joubert syndrome (JS) is an inherited disorder characterized by transient episodic hyperpnea, ataxia, and vermian hypoplasia. Typical imaging findings of JS include hypoplasia or aplasia of the cerebellar vermis, thick and elongated superior cerebellarpeduncles and an abnormally deep interpeduncular fossa with 'molar tooth sign'. We present a case of JS associated with deep cerebral sulci and fissures, polymicrogyria, and additional findings of posterior reversible encephalopathy syndrome associated with renal involvement.Acta neurologica Belgica 04/2009; 109(1):49-52. · 0.54 Impact Factor -
Article: Myeloneuritis due to acute organophosphate (DDVP) intoxication.
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ABSTRACT: Given the importance of agriculture and widespread use of pesticides, intoxication due to organophosphate insecticides is common in Turkey. Organophosphorus compounds may cause late-onset distal polyneuropathy occurring 2 or more weeks after the acute exposure. An 18-year-old woman and a 22-year-old man were admitted to the hospital with weakness, paresthesia, and gait disturbances at 35 and 22 days, respectively, after ingesting dimethyl-2,2-dichloro vinyl phosphate (DDVP). Neurological examination revealed weakness, vibration sense loss, bilateral dropped foot, brisk deep tendon reflexes, and bilaterally positive Babinski sign. Electroneurography demonstrated distal motor polyneuropathy with segmental demyelination associated with axonal degeneration prominent in the distal parts of both lower extremities.The International journal of neuroscience 01/2009; 119(10):1538-47. · 0.86 Impact Factor -
Article: Effects of colchicine on strength-duration properties of sensory and motor axons.
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ABSTRACT: The strength-duration time constant (SDTC) is a measure of axonal excitability and it can provide information about Na(+) channel function. In this study, we sought to examine the changes in the SDTCs of motor and sensory fibers of the median nerve in patients taking colchicine, which affects axoplasmic flow and may result in axonal neuropathy. The SDTCs of motor and sensory fibers of 29 patients who had been taking colchicine were measured following stimulation of the right median nerve at the wrist. The results were compared with ten healthy age-matched subjects. No significant differences were found between the groups. The lack of any effect on the SDTC by colchicine might have been due to the fact that axonal degeneration caused by colchicine affects the Na(+)-K(+) ATP pump or that it affects internodal channels other than nodal channels.Neurological Research 10/2008; 31(3):300-3. · 1.52 Impact Factor
