Eduard F. Stange

• 402Impact points

• 72Publications

• 14Followers

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Publications

• Effects of SLC10A2 variant rs9514089 on gallstone risk and serum cholesterol levels- meta-analysis of three independent cohorts.

  Authors: Anke Tonjes, Henning Wittenburg, Jan Halbritter, Olga Renner, Simone Harsch, Eduard F Stange, Frank Lammert, Michael Stumvoll, Peter Kovacs

  BMC medical genetics. 12(1):149.

• Intestinal bacterial translocation in cirrhotic rats is related to compromised paneth cell antimicrobial host defence.

  Authors: Zora Teltschik, Reiner Wiest, Julia Beisner, Sabine Nuding, Claudia Hofmann, Juergen Schoelmerich, Charles L Bevins, Eduard F Stange, Jan Wehkamp

  Hepatology (Baltimore, Md.).

• Waking the wimp: Redox-modulation activates human beta-defensin 1.

  Authors: Bjoern O Schroeder, Eduard F Stange, Jan Wehkamp

  Gut microbes. 2(4).

• Efficacy of azathioprine versus mesalazine in postoperative Crohn's disease-The Authors' response.

  Authors: Walter Reinisch, Eduard F Stange

  Gut.

• Reduction of disulphide bonds unmasks potent antimicrobial activity of human β-defensin 1.

  Authors: Bjoern O Schroeder, Zhihong Wu, Sabine Nuding, Sandra Groscurth, Moritz Marcinowski, Julia Beisner, Johannes Buchner, Martin Schaller, Eduard F Stange, Jan Wehkamp

  Nature. 469(7330):419-23.

• Authors' reply.

  Authors: Daniel E Stange, Bernhard Radlwimmer

  Gut.

• Paneth's disease.

  Authors: Jan Wehkamp, Eduard F Stange

  Journal of Crohn's & colitis. 4(5):523-31.

• Innate antimicrobial immunity in inflammatory bowel diseases.

  Authors: Julia Beisner, Eduard F Stange, Jan Wehkamp

  Expert review of clinical immunology. 6(5):809-18.

• Azathioprine versus mesalazine for prevention of postoperative clinical recurrence in patients with Crohn's disease with endoscopic recurrence: efficacy and safety results of a randomised, double-blind, double-dummy, multicentre trial.

  Authors: Walter Reinisch, Sieglinde Angelberger, Wolfgang Petritsch, Olga Shonova, Milan Lukas, Simon Bar-Meir, Alexander Teml, Elke Schaeffeler, Matthias Schwab, Karin Dilger, Roland Greinwald, Ralph Mueller, Eduard F Stange, Klaus R Herrlinger

  Gut. 59(6):752-9.

• Peroxisome proliferator-activated receptor gamma activation is required for maintenance of innate antimicrobial immunity in the colon.

  Authors: Laurent Peyrin-Biroulet, Julia Beisner, Guoxing Wang, Sabine Nuding, Sajit Thottathil Oommen, Denise Kelly, Erika Parmentier-Decrucq, Rodrigue Dessein, Emilie Merour, Philipe Chavatte, Teddy Grandjean, Aude Bressenot, Pierre Desreumaux, Jean-Frédéric Colombel, Béatrice Desvergne, Eduard F Stange, Jan Wehkamp, Mathias Chamaillard

  Proceedings of the National Academy of Sciences of the United States of America.

• Paneth cell function - Implications in pediatric Crohn disease.

  Authors: Julia Beisner, Eduard F Stange, Jan Wehkamp

  Gut microbes. 2(1):47-51.

• Antimicrobial peptides in gastrointestinal inflammation.

  Authors: Simon Jäger, Eduard F Stange, Jan Wehkamp

  International journal of inflammation. 2010:910283.

• Innate antimicrobial host defense in small intestinal Crohn's disease.

  Authors: Maureen J Koslowski, Julia Beisner, Eduard F Stange, Jan Wehkamp

  International journal of medical microbiology : IJMM.

• Genetic variants of Wnt transcription factor TCF-4 (TCF7L2) putative promoter region are associated with small intestinal Crohn's disease.

  Authors: Maureen J Koslowski, Irmgard Kübler, Mathias Chamaillard, Elke Schaeffeler, Walter Reinisch, Guoxing Wang, Julia Beisner, Alexander Teml, Laurent Peyrin-Biroulet, Stefan Winter, Klaus R Herrlinger, Paul Rutgeerts, Séverine Vermeire, Rachel Cooney, Klaus Fellermann, Derek Jewell, Charles L Bevins, Matthias Schwab, Eduard F Stange, Jan Wehkamp

  PLoS ONE. 4(2):e4496.

• Antibacterial activity of human defensins on anaerobic intestinal bacterial species: a major role of HBD-3.

  Authors: Sabine Nuding, Lutz T Zabel, Corinne Enders, Edith Porter, Klaus Fellermann, Jan Wehkamp, Holger A G Mueller, Eduard F Stange

  Microbes and infection / Institut Pasteur.

• Antimicrobial host defense in the upper gastrointestinal tract.

  Authors: Yoshio Hosaka, Maureen Koslowski, Sabine Nuding, Guoxing Wang, Miriam Schlee, Christian Schäfer, Katunori Saigenji, Eduard F Stange, Jan Wehkamp

  European journal of gastroenterology & hepatology. 20(12):1151-8.

• A Variant of the SLC10A2 Gene Encoding the Apical Sodium-Dependent Bile Acid Transporter Is a Risk Factor for Gallstone Disease.

  Authors: Olga Renner, Simone Harsch, Elke Schaeffeler, Stefan Winter, Matthias Schwab, Marcin Krawczyk, Jonas Rosendahl, Henning Wittenburg, Frank Lammert, Eduard F Stange

  PloS one. 4(10):e7321.

• Diminished Expression of Apical Sodium-Dependent Bile Acid Transporter in Gallstone Disease Is Independent of Ileal Inflammation.

  Authors: Arthur Holzer, Simone Harsch, Olga Renner, André Strohmeyer, Silke Schimmel, Jan Wehkamp, Peter Fritz, Eduard F Stange

  Digestion. 78(1):52-59.

• Is there a role for defensins in IBD?

  Authors: Jan Wehkamp, Eduard F Stange

  Inflammatory bowel diseases. 14(S2):S85-S87.

• The European consensus on ulcerative colitis: new horizons?

  Authors: Eduard F Stange, Simon P L Travis

  Gut. 57(8):1029-31.

• Reduced ileal expression of organic solute transporter alpha and beta (OSTalpha -OSTbeta ) in non-obese gallstone disease.

  Authors: Olga Renner, Simone Harsch, André Strohmeyer, Silke Schimmel, Eduard F Stange

  Journal of lipid research.

• [Inflammatory bowel diseases--new therapeutic options]

  Authors: Klaus Herrlinger, Eduard F Stange

  Medizinische Klinik (Munich, Germany : 1983). 103(2):90-101; quiz 102-3.

• How effective is natalizumab induction therapy in patients with Crohn's disease?

  Authors: Klaus Fellermann, Eduard F Stange

  Nature clinical practice. Gastroenterology & hepatology. 5(2):78-9.

• Host-microbe interaction: mechanisms of defensin deficiency in Crohn's disease.

  Authors: Guoxing Wang, Eduard F Stange, Jan Wehkamp

  Expert review of anti-infective therapy. 5(6):1049-57.

• The Paneth cell alpha-defensin deficiency of ileal Crohn's disease is linked to Wnt/Tcf-4.

  Authors: Jan Wehkamp, Guoxing Wang, Irmgard Kübler, Sabine Nuding, Alex Gregorieff, Anke Schnabel, Robert J Kays, Klaus Fellermann, Oliver Burk, Matthias Schwab, Hans Clevers, Charles L Bevins, Eduard F Stange

  Journal of immunology (Baltimore, Md. : 1950). 179(5):3109-18.

• Reduced mucosal antimicrobial activity in Crohn's disease of the colon.

  Authors: Sabine Nuding, Klaus Fellermann, Jan Wehkamp, Eduard F Stange

  Gut. 56(9):1240-7.

• Defensins and other antimicrobial peptides in inflammatory bowel disease.

  Authors: Jan Wehkamp, Michael Schmid, Eduard F Stange

  Current opinion in gastroenterology. 23(4):370-8.

• Induction of human beta-defensin 2 by the probiotic Escherichia coli Nissle 1917 is mediated through flagellin.

  Authors: Miriam Schlee, Jan Wehkamp, Artur Altenhoefer, Tobias A Oelschlaeger, Eduard F Stange, Klaus Fellermann

  Infection and immunity. 75(5):2399-407.

• Attenuated induction of epithelial and leukocyte serine antiproteases elafin and secretory leukocyte protease inhibitor in Crohn's disease.

  Authors: Michael Schmid, Klaus Fellermann, Peter Fritz, Oliver Wiedow, Eduard F Stange, Jan Wehkamp

  Journal of leukocyte biology. 81(4):907-15.

• Defensins and cathelicidins in gastrointestinal infections.

  Authors: Jan Wehkamp, Jürgen Schauber, Eduard F Stange

  Current opinion in gastroenterology. 23(1):32-8.

• Paneth cells and the innate immune response.

  Authors: Jan Wehkamp, Eduard F Stange

  Current opinion in gastroenterology. 22(6):644-50.

• A chromosome 8 gene-cluster polymorphism with low human beta-defensin 2 gene copy number predisposes to Crohn disease of the colon.

  Authors: Klaus Fellermann, Daniel E Stange, Elke Schaeffeler, Hartmut Schmalzl, Jan Wehkamp, Charles L Bevins, Walter Reinisch, Alexander Teml, Matthias Schwab, Peter Lichter, Bernhard Radlwimmer, Eduard F Stange

  American journal of human genetics. 79(3):439-48.

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• A new look at Crohn's disease: breakdown of the mucosal antibacterial defense.

  Authors: Jan Wehkamp, Eduard F Stange

  Annals of the New York Academy of Sciences. 1072:321-31.

• Extraintestinal manifestations and complications in inflammatory bowel diseases.

  Authors: Katja S Rothfuss, Eduard F Stange, Klaus R Herrlinger

  World journal of gastroenterology : WJG. 12(30):4819-31.

• Heterogeneous expression of human cathelicidin hCAP18/LL-37 in inflammatory bowel diseases.

  Authors: Jürgen Schauber, Daniel Rieger, Frank Weiler, Jan Wehkamp, Matthias Eck, Klaus Fellermann, Wolfgang Scheppach, Richard L Gallo, Eduard F Stange

  European journal of gastroenterology & hepatology. 18(6):615-21.

• A flow cytometric assay to monitor antimicrobial activity of defensins and cationic tissue extracts.

  Authors: Sabine Nuding, Klaus Fellermann, Jan Wehkamp, Holger A G Mueller, Eduard F Stange

  Journal of microbiological methods. 65(2):335-45.

• Randomized, double blind controlled trial of subcutaneous recombinant human interleukin-11 versus prednisolone in active Crohn's disease.

  Authors: Klaus R Herrlinger, Thomas Witthoeft, Andreas Raedler, Bernd Bokemeyer, Thomas Krummenerl, Jorg-Dieter Schulzke, Norbert Boerner, Bruno Kueppers, Joerg Emmrich, Axel Mescheder, Ulrich Schwertschlag, Mark Shapiro, Eduard F Stange

  The American journal of gastroenterology. 101(4):793-7.

• High-resolution genomic profiling reveals association of chromosomal aberrations on 1q and 16p with histologic and genetic subgroups of invasive breast cancer.

  Authors: Daniel E Stange, Bernhard Radlwimmer, Falk Schubert, Frank Traub, Andreas Pich, Grischa Toedt, Frank Mendrzyk, Ulrich Lehmann, Roland Eils, Hans Kreipe, Peter Lichter

  Clinical cancer research : an official journal of the American Association for Cancer Research. 12(2):345-52.

• NOD2/CARD15 mediates induction of the antimicrobial peptide human beta-defensin-2.

  Authors: Eske Voss, Jan Wehkamp, Kai Wehkamp, Eduard F Stange, Jens M Schröder, Jürgen Harder

  The Journal of biological chemistry. 281(4):2005-11.

• Reduced Paneth cell alpha-defensins in ileal Crohn's disease.

  Authors: Jan Wehkamp, Nita H Salzman, Edith Porter, Sabine Nuding, Michael Weichenthal, Robert E. Petras, Bo Shen, Elke Schaeffeler, Matthias Schwab, Rose Linzmeier, Ryan W Feathers, Hiutung Chu, Heriberto Lima, Klaus Fellermann, Tomas Ganz, Eduard F Stange, Charles L Bevins

  Proceedings of the National Academy of Sciences of the United States of America. 102(50):18129-34.

• Apical sodium bile acid transporter and ileal lipid binding protein in gallstone carriers.

  Authors: Ina Bergheim, Simone Harsch, Oliver Mueller, Silke Schimmel, Peter Fritz, Eduard F Stange

  Journal of lipid research. 47(1):42-50.

• Genomic and protein expression profiling identifies CDK6 as novel independent prognostic marker in medulloblastoma.

  Authors: Frank Mendrzyk, Bernhard Radlwimmer, Stefan Joos, Felix Kokocinski, Axel Benner, Daniel E Stange, Kai Neben, Heike Fiegler, Nigel P Carter, Guido Reifenberger, Andrey Korshunov, Peter Lichter

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 23(34):8853-62.

• Mechanisms of disease: defensins in gastrointestinal diseases.

  Authors: Jan Wehkamp, Klaus Fellermann, Klaus R Herrlinger, Charles L Bevins, Eduard F Stange

  Nature clinical practice. Gastroenterology & hepatology. 2(9):406-15.

• Detection of chromosomal imbalances in retinoblastoma by matrix-based comparative genomic hybridization.

  Authors: Boris Zielinski, Sandrine Gratias, Grischa Toedt, Frank Mendrzyk, Daniel E Stange, Bernhard Radlwimmer, Dietmar R Lohmann, Peter Lichter

  Genes, chromosomes & cancer. 43(3):294-301.

• NOD2 mutation and mice: no Crohn's disease but many lessons to learn.

  Authors: Jan Wehkamp, Eduard F Stange

  Trends in molecular medicine. 11(7):307-9.

• The case against using 5-aminosalicyclates in Crohn's disease: con.

  Authors: Eduard F Stange

  Inflammatory bowel diseases. 11(6):613-5.

• Defensin deficiency, intestinal microbes, and the clinical phenotypes of Crohn's disease.

  Authors: Jan Wehkamp, Michael Schmid, Klaus Fellermann, Eduard F Stange

  Journal of leukocyte biology. 77(4):460-5.

• Mesenteric pulsatility index analysis predicts response to azathioprine in patients with Crohn's disease.

  Authors: Nils Homann, Ute Klarmann, Klaus Fellermann, Andreas Brüning, Rolf Klingenberg-Noftz, Thomas Witthöft, Eduard F Stange, Diether Ludwig

  Inflammatory bowel diseases. 11(2):126-32.

• Human defensins in Crohn's disease.

  Authors: Jan Wehkamp, Klaus Fellermann, Eduard F Stange

  Chemical immunology and allergy. 86:42-54.

• Autoantibodies against the bactericidal/permeability-increasing protein from inflammatory bowel disease patients can impair the antibiotic activity of bactericidal/permeability-increasing protein.

  Authors: Susanne Schinke, Klaus Fellermann, Karen Herlyn, Philipp H Reichel, Rilana Fundke, Eduard F Stange, Wolfgang L Gross, Hendrik Schultz

  Inflammatory bowel diseases. 10(6):763-70.