Article: Fluorogenic sensing of CH3CO2− and H2PO4− by Ditopic receptor through conformational Change.Nisar Ahmed, Vangaru Suresh, Bahareh Shirinfar, Inacrist Geronimo, Amita Bist, In-Chul Hwang, Kwang S. Kim[show abstract] [hide abstract]
ABSTRACT: Cyclo-bis-(urea-3,6-dichlorocarbazole) (1) forms a 1 : 2 complex with CH3CO2 − and H2PO4 − through hydrogen bonding with the two urea moieties, resulting in fluorescence enhancement via a combined photoinduced electron transfer (PET) and energy transfer mechanism. The binding mechanism involves a conformational change of the two urea receptors to a trans orientation after binding of the first anion, which facilitates the second interaction.Organic & Biomolecular Chemistry 01/2012; 10:2094-2100. · 3.70 Impact Factor
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ABSTRACT: Design and Synthesis of a new imidazolium based fluorescent cyclophane 1, we observed the highly selective fluorescence quenching effect with iodide compare to other anions, which examined using fluorescence, 1H NMR and theoretical calculations and the selectivity mentioned in thermodynamic quantities using the fluorescence titrations.Chemistry - An Asian Journal 01/2012; · 4.50 Impact Factor
Article: A highly selective fluorescent chemosensor for guanosine-50-triphosphate via excimer formation in aqueous solution of physiological pH[show abstract] [hide abstract]
ABSTRACT: A new water-soluble and fluorescent imidazolium-anthracene cyclophane 1 effectively recognizes and differentiates the biologically important GTP and ATP in 100% aqueous solution of physiological pH 7.4. Fluorescence, 1H-NMR spectra and ab initio calculations demonstrate that excimer formation and fluorescence enhancement occur upon GTP and ATP binding, respectively, through (C–H)+� � �A� hydrogen bond interactions.Chemical Communications 01/2012; 48:2662–2664. · 6.17 Impact Factor
Article: First Asymmetric Total Synthesis of (R,E)-1-[4-(3-Hydroxyprop-1-enyl)phenoxyl]-3-methylbutane-2,3-diol[show abstract] [hide abstract]
ABSTRACT: A new anti-inflammatory active phenylpropenoid, (R,E)-1-[4-(3-hydroxyprop-1- enyl) phenoxyl]-3-methylbutane-2,3-diol, isolated from the stem wood of Zanthoxylum integrifoliolum, has been synthesized for the first time using commercially available 4-hydroxy benzaldehyde. The key step involves the Sharpless asymmetric dihydroxylation of olefin.Synthetic Communications 04/2011; 41(7):993-998. · 1.06 Impact Factor
Karuturi Rajesh, Vangaru Suresh, Jondoss Jon Paul Selvam, Dokuburra Chanti Babu, Yenamandra Venkateswarlu[show abstract] [hide abstract]
ABSTRACT: A simple and highly efficient stereoselective total synthesis of (11b)-11-methoxycurvularin (5), a polyketide natural product, was achieved. The synthesis commenced with a Cu-mediated regioselective opening of (2S)-2-methyloxirane (6) and comprised a Keck asymmetric allylation and intramolecular Friedel – Crafts acylation as key stepsHelvetica Chimica Acta 01/2010; 93:147-152. · 1.48 Impact Factor
Expertise in design and execution of multi-step synthesis of bioactive target molecules.
Design and synthesis of “Novel Chemical Entities” (NCEs) by innovative strategies with efficient way.
Skilled in designing the total synthesis of complicated molecules using retrosynthetic approach.
Development of novel synthetic methodologies as tools in multistep organic synthesis.
Experience in purification of products in milligrams scale.
Capable of collaborative and independent research.