Topics (39) View all

Skills (75)

Research experience

  • Mar 2012–
    present
    Research: Consultant: Risk based process design for large scale manufacturing of male injectable contraceptive.
    IIT Kharagpur
    India · Kharagpur
  • Jan 2010–
    Dec 2011
    Research: Researchable Issues of male injectable contraceptive RISUG
    IIT Kharagpur
    India · Kharagpur
  • Jan 2010–
    Mar 2011
    Research: Technology Trainer
    RISUG Technology Transfer to USA based Medical Foundation
  • Mar 2009–
    Jun 2010
    Research: Visiting Faculty
    J.P School of Business, Meerut · J.P School of Business, Meerut
  • Jan 2009–
    Dec 2010
    Research: IIT Kharagpur
    IIT Kharagpur · Department of Medical Science and Technology
    India · Kharagpur
  • Jan 2008
    Research: Technology Trainer
    Icubedg Ideas Pvt Ltd and Science and Technology Entrepreneurship(STEP) IIT Kharagpur · Icubedg Ideas Pvt Ltd and Science and Technology Entrepreneurship(STEP) IIT Kharagpur
    RISUG Development and Clinical trial
  • Jun 2006–
    present
    Research: Senior Research Scientist
    Indian Institute of Technology, Kharagpur, National Centre For Technology in Family Welfare · School Of Medical Science and Technology · Indian Institute of Technology, Kharagpur, National Centre For Technology in Family Welfare
    Kharagpur
  • Aug 2005–
    Jun 2006
    Research: Research Scientist Drug Discovery and Process design(Transcervical)
    Marksans Pharma Ltd.(Glenmark Laboratories) · New Drug Reserch & Development
    Pharmaceutical
  • Mar 2005
    Research: JPA
    IIT Kharagpur · ,RISUG Production ,Irradiation Quality control and innovative strategy for their assurance ,RISUG Pilot Plant · Indian Institute of Technology Kharagpur

Education

  • Jun 2012–
    Jul 2012
    Post Doctoral Program[EuroMA Summer School]
    Global Operation Management · EurOMA European Institute for Advanced Studies in Management Hungary
    Hungary · Budapest
  • Sep 2006–
    Jan 2011
    Ph.D
    Quality Mangement in Contraceptive Development /R&D · G. B. Technical University Lucknow at I.I.T. Kharagpur,India
  • Aug 2006–
    Dec 2008
    Pre-Ph.D
    Production and Operation Research · V. Institute of Engineering and Technology Gaziabad
  • Apr 2003–
    Jun 2005
    M.S(Total Quality Management)
    Sikkim Manipal University Gangtok,India
  • Sep 1998–
    Jan 2003
    B.Sc(Hon)Chemistry and M.Sc Che
    L.N.M University Darbhanga, India

Awards & achievements

  • Jul 2012
    Scholarship: WABT Fellowship
  • Oct 2011
    Grant: Parsemus Travel Grant to USA
  • May 2004
    Award: Environmental Protection Award

Questions and Answers (1) View all

Publications (6) View all

  • Article: An approach to noninvasive delivery, biodistribution, and fertility control potential evaluation of the Cuproferrogel iron oxide-copper-styrene maleic anhydride-dimethyl sulphoxide in the female.
    Rakhi Jha, Pradeep K Jha, Suresh V S Rana, Sujoy K Guha
    [show abstract] [hide abstract]
    ABSTRACT: Under guidance of an external pulsed magnetic field the Cuproferrogel iron oxide-copper-styrene maleic anhydride-dimethyl sulphoxide delivered into the rat/rabbit oviduct resulted in oocytes with granulated cytoplasm, zona enlargement, membrane disintegration, and finally loss of viability in 72 hours. Also, the percentage biodistribution of magnetic and electrically conductive particles observed under safe level advocates the use of Cuproferrogel as a potential female fertility control molecule.
    Fertility and sterility 12/2010; 94(7):2850-3. · 3.97 Impact Factor
  • Source
    Article: Effect of γ-dose rate and total dose interrelation on the polymeric hydrogel: A novel injectable male contraceptive
    Pradeep K. Jha, Rakhi Jha, B.L. Gupta, Sujoy K. Guha
    [show abstract] [hide abstract]
    ABSTRACT: Functional necessity to use a particular range of dose rate and total dose of γ-initiated polymerization to manufacture a novel polymeric hydrogel RISUG® (reversible inhibition of sperm under guidance) made of styrene maleic anhydride (SMA) dissolved in dimethyl sulphoxide (DMSO), for its broad biomedical application explores new dimension of research. The present work involves 16 irradiated samples. They were tested by fourier transform infrared spectroscopy, matrix assisted laser desorption/ionization–TOF, field emission scanning electron microscopy, high resolution transmission electron microscopy, etc. to see the interrelation effect of gamma dose rates (8.25, 17.29, 20.01 and 25.00 Gy/min) and four sets of doses (1.8, 2.0, 2.2 and 2.4 kGy) on the molecular weight, molecular weight distribution and porosity analysis of the biopolymeric drug RISUG®. The results of randomized experiment indicated that a range of 18–24 Gy/min γ-dose rate and 2.0–2.4 kGy γ-total doses is suitable for the desirable in vivo performance of the contraceptive copolymer.
    Radiation Physics and Chemistry. 01/2010; 79:663-671.
  • Article: Entropy in Good Manufacturing System: Tool for quality assurance
    Pradeep K. Jha, Rakhi Jha, Rajul datt, Sujoy K. Guha
    [show abstract] [hide abstract]
    ABSTRACT: It has been customary to implement Good Manufacturing Practices (GMP) in pharmaceutical organizations as a systematic and comprehensive quality approach and sometimes by regulatory enforcement. In this scenario, determination of the obvious entropy/disorder arising during the implementation has not been taken care of yet. Therefore, this paper gives the basis for applying query and visual perception of GMP system driven visualization approach, particularly the Laplace equation, to the determination of disorder and deviation pattern inside the GMP system applied in the organization. In this study, a three-dimensional mesh approached with raw and intermediate input handled under GMP parameter is considered to produce high quality products with minimum entropy (variation distribution) by adding the analogy wise different GMP parameters and process variables with Gauss Seidel iteration and thus producing visual picture of the entire system. The approximation involved in applying the equations to the GMP compliant aseptic region was analyzed. Using numerical technique and computer program, the Gauss Seidel iteration equations have been solved with appropriate GMP parameter and process variable. The result indicates that deviations vary over the GMP compliant system and that the process entropy affects the totality of disorderness. Experiments with model of GMP compliant reproductive medicine laboratory confirm that the new method provides optimal manufacturing maintaining GMP and high product quality through the visual representation of the entire system and activity to bring into notice the deviations.
    European Journal of Operational Research 01/2011; 211:658-665. · 1.82 Impact Factor
  • Source
    Article: Smart RISUG: a potential new contraceptive and its magnetic field-mediated sperm interaction.
    Rakhi K Jha, Pradeep K Jha, Sujoy K Guha
    [show abstract] [hide abstract]
    ABSTRACT: The rationale and technique underlying a novel concept of noninvasive fertility control by a new Cuproferrogel contraceptive drug, iron oxide-copper-styrene maleic anhydride-dimethyl sulphoxide (Fe3O4-Cu-SMA-DMSO) composite named 'Smart RISUG' (smart reversible inhibition of sperm under guidance) in presence of pulsed magnetic field (PMF; 1 mT to 800 mT) is explained. It was synthesized by dispersing iron oxide particles and copper particles into SMA-DMSO (male contraceptive RISUG) and characterized for particle distribution, particle size measurement and transmittance peaks, etc. Interaction of the RISUG particles as well as Smart RISUG particles with Albino rat sperm cell was studied in presence as well as absence of PMF. To find an explanation to increased reaching of the Smart RISUG drug into sperm under influence of magnetic field, the transport properties were characterized by high resolution transmission electron microscopy and atomic force microscopy. Smart RISUG could be mobilized into sperm cell membrane at the PMF, 760 mT in about 50 seconds. Adoption of novel drug Smart RISUG involving new technique may open the pathway for non surgical control of drug distribution, detection and restoration of the normal fertility after removal of the contraceptive from the male/female reproductive tube in presence of electromagnetic field.
    International Journal of Nanomedicine 02/2009; 4:55-64. · 3.13 Impact Factor
  • Article: Spermicidal Action of Styrene Maleic Anhydride Polyelectrolyte in Combination with Magnetic and Electrically Conductive Particles
    Jha Rakhi.K, Jha Pradeep.K, Rana Suresh.V.S, Guha Sujoy.K
    [show abstract] [hide abstract]
    ABSTRACT: The aim of this study is to evaluate impact of a new polymeric contraceptive SMA-Fe<sub>3</sub>O<sub>4</sub>-Cu-DMSO called Smart RISUG (acronym for Smart Reversible Inhibition of Sperm under Guidance), a colloidal suspension of styrene maleic anhydride co-polymer (SMA), nano-micro iron oxide (Fe<sub>3</sub>O<sub>4</sub>) and copper powder (Cu) (one milligram) dissolved in dimethylsulphoxide (DMSO) (1:30); on Albino rat`s sperm solution (one milliliter). Experiments to assess the morphology and viability of control as well as treated sperm cells were performed by using microscopic techniques like High Resolution Transmission Electron Microscopy (HRTEM), Field Emission Scanning Electron Microscopy (FESEM), Atomic Force Microscopy (AFM), Scanning Electron Microscopy (SEM)-X ray microanalysis, phase contrast microscopy and Fluorescent Activated Cell Sorting (FACS). Treated cells indicate uniform adhesion of Smart RISUG particles to the sperm cell membrane, topological alteration, decrease in the cell count, reduced cell motility and viability, increased sperm abnormality and complete cell inactivation in about 72 h. This study suggests use of smart RISUG as a potential non-invasively reversible male/female contraceptive in future.
    International Journal of Pharmacology. 01/2009;

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