Dr. Kaneez Fatima Ansari

Publications

• 3.27

  Impact points

  Synthesis, physicochemical properties and antimicrobial activity of some new benzimidazole derivatives.

  K F Ansari, C Lal

  European journal of medicinal chemistry. 06/2009;

  Some derivatives of benzimidazole were synthesized by nucleophilic substitution of 2-substituted-1H-benzimidazole. The resulting ethyl (2-substituted-1H-benzimidazol-1-yl) acetate on treatment with hydrazine hydrate yielded 2-(2-substituted-1H-benzimidazol-1-yl) acetohydrazide, which on further reac... [more] Some derivatives of benzimidazole were synthesized by nucleophilic substitution of 2-substituted-1H-benzimidazole. The resulting ethyl (2-substituted-1H-benzimidazol-1-yl) acetate on treatment with hydrazine hydrate yielded 2-(2-substituted-1H-benzimidazol-1-yl) acetohydrazide, which on further reaction with one equivalent of different aliphatic or aromatic carboxylic acids in the presence of phosphoryl chloride afforded the corresponding target compounds, 2-substituted-1-[{(5-substituted alkyl/aryl)-1,3,4-oxadiazol-2-yl} methyl]-1H-benzimidazole. The structures of the synthesized compounds were evaluated by spectral and elemental methods of analyses. All the synthesized compounds were screened for their antimicrobial activities. All of the derivatives showed good activity towards Gram-positive bacteria and negligible activity towards Gram-negative bacteria. Some of the synthesized compounds showed moderate activity against tested fungi.

• Synthesis, characterization and antimicrobial properties of some new benzimidazole derivatives

  K. F. Ansari, C. Lal

  National seminar on recent advances in chemical science, Assam, India; 03/2009

• Synthesis and biological properties of some new benzimidazole derivatives

  K. F. Ansari, C. Lal

  96th Indian Science Congress, Shillong, India; 01/2009

• Synthesis, characterization and biological properties of some new benzimidazole derivatives

  K. F. Ansari, C. Lal

  2nd International Symposium of Organic Chemistry (ORGANIC 2008), Sofia, Bulgaria; 12/2008
• 3.27

  Impact points

  Synthesis and evaluation of some new benzimidazole derivatives as potential antimicrobial agents.

  K F Ansari, C Lal

  European journal of medicinal chemistry. 02/2008;

  The efficient synthesis of novel azetidin-2-ones 6 has been established. Thus, condensation of 5-[(2-methyl-1H-benzimidazol-1-yl)methyl]-1,3,4-thiadiazol-2-amine 4 with various aromatic aldehydes afforded 5-[(2-methyl-1H-benzimidazol-1-yl)methyl]-N-[(substituted) phenylmethylidene]-1,3,4-thiadiazol-... [more] The efficient synthesis of novel azetidin-2-ones 6 has been established. Thus, condensation of 5-[(2-methyl-1H-benzimidazol-1-yl)methyl]-1,3,4-thiadiazol-2-amine 4 with various aromatic aldehydes afforded 5-[(2-methyl-1H-benzimidazol-1-yl)methyl]-N-[(substituted) phenylmethylidene]-1,3,4-thiadiazol-2-amine 5 which on cycloaddition with chloroacetyl chloride in the presence of triethylamine catalyst yielded 3-chloro-1-{5-[(2-methyl-1H-benzimidazol-1-yl)methyl]-1,3,4-thiadiazol-2-yl}-4-(substituted) phenylazetidin-2-one 6. Structures of the synthesized compounds have been elucidated on the basis of their elemental analyses and spectral data. All the synthesized compounds were screened for their antimicrobial activity.

• Synthesis of some new 2-phenyl-1H-benzimidazole derivatives as potential antibacterial agents

  K. F. Ansari, C. Lal

  Emerging trends in chemical sciences, Kanpur, India; 11/2007