Dr. Faizan Haider Khan

PhD

University of Lucknow · Department of Zoology

Nothing special.. but have dream to establish my own research institute.

Research skills

Technical

techniques used in Molecular as well as biochemical sciences
IT

Bioinformatics
Statistical

SPSS 12

Research interests

Interests

Human Genetics

Research experience

Nov 2006

Research: Faizan Haider

University of Lucknow · Department of Zoology · University of Lucknow

Sudhir et al. · Lucknow

Molecular Genetics

Other

Scientific Memberships

STOX, India... ISHG, MARC,

Publications

3.25

Impact points

Y Chromosome microdeletion and altered sperm quality in human males with high concentration of seminal hexachlorocyclohexane (HCH).

Faizan Haider Khan, Panneer Ganesan, Sudhir Kumar

Chemosphere. 08/2010; 80(9):972-7.

Recent studies have shown Y chromosome microdeletions associated with male infertility. The factors responsible for Y chromosome microdeletions in spermatozoa remain unresolved. However, the environmental pollutants are known to damage DNA in differentiating and maturing germ cells in the male repro... [more] Recent studies have shown Y chromosome microdeletions associated with male infertility. The factors responsible for Y chromosome microdeletions in spermatozoa remain unresolved. However, the environmental pollutants are known to damage DNA in differentiating and maturing germ cells in the male reproductive tract. Therefore, the aim of this study was to investigate the effects of seminal hexachlorocyclohexane (HCH) and its isomers, an environmental pollutant, in 50 fertile and 50 infertile males in relation to semen quality and the incidence of Y chromosome microdeletion in azoospermic factor (AZF) region. As compared to control, an increased HCH level and significantly decreased semen quality were observed in the infertile males. A positive significant association was found between sperm count with alpha-HCH and beta-HCH in the infertile males. A negative significant association was observed between sperm counts with gamma-HCH in asthenospermia patients and with beta-HCH and total HCH in oligo-asthenospermic patients. Out of 100 males studied, we found 10 patients with Yq deletion in AZFa and AZFc regions. Subdivision of infertile group revealed a deletion incidence of 61.5% in azoospermic patients, 11.1% in oligospermic patients and 16.6% in oligo-asthenospermic patients. The presence of Yq deletion in azoospermic patients with a significant mean difference of beta-HCH and total HCH in relation to reduced semen quality seem to corroborate with the mutagenic activity of HCH. The results of this study indicated the susceptibility of male germ line to mutagenic potential of HCH which is an acknowledged risk factor leading to spermatogenic failure.

Download