Dora Han

Publications (86) View all

• Article: Incidence and clinical features of Clostridium difficile infection in Korea: a nationwide study.

  Y S Kim, D S Han, Y H Kim, W H Kim, J S Kim, H S Kim, Y S Park, H J Song, S J Shin, S K Yang, B D Ye, C S Eun, K M Lee, S H Lee, B I Jang, S A Jung, J H Cheon, C H Choi, K C Huh
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  ABSTRACT: The incidence and severity of Clostridium difficile infections (CDI) have increased in Western countries. However, there are limited data regarding the epidemiology of CDI in Eastern countries. This nationwide study was conducted in 17 hospitals to determine temporal trends in CDI incidence (from 2004 to 2008) in South Korea. The total incidence of CDI in Korea was 1·7 cases/1000 adult admissions in 2004, and 2·7/1000 cases in 2008 (P=0·028). When analysing the clinical features of 1367 CDI patients diagnosed in 2008, oral metronidazole was effective as a first-line treatment for CDI (61·9%). Relapse rate was 8·9% and complicated CDI was only observed in 3·6%. The incidence of CDI increased significantly in Korea from 2004 to 2008. Although the clinical features were milder than in Western countries, the increasing burden of CDI needs ongoing surveillance systems.
  Epidemiology and Infection 04/2012; · 2.84 Impact Factor
• Article: Translationally controlled tumour protein is associated with podocyte hypertrophy in a mouse model of type 1 diabetes.

  D K Kim, B Y Nam, J J Li, J T Park, S H Lee, D H Kim, J Y Kim, H Y Kang, S H Han, T H Yoo, D S Han, S W Kang
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  ABSTRACT: Translationally controlled tumour protein (TCTP) is thought to be involved in cell growth by regulating mTOR complex 1 (mTORC1) signalling. As diabetes characteristically induces podocyte hypertrophy and mTORC1 has been implicated in this process, TCTP may have a role in the pathogenesis of diabetes-induced podocyte hypertrophy. We investigated the effects and molecular mechanisms of TCTP in diabetic mice and in high glucose-stimulated cultured podocytes. To characterise the role of TCTP, we conducted lentivirus-mediated gene silencing of TCTP both in vivo and in vitro. Glomerular production of TCTP was significantly higher in streptozotocin induced-diabetic DBA/2J mice than in control animals. Double-immunofluorescence staining for TCTP and synaptopodin revealed that podocyte was the principal cell responsible for this increase. TCTP knockdown attenuated the activation of mTORC1 downstream effectors and the overproduction of cyclin-dependent kinase inhibitors (CKIs) in diabetic glomeruli, along with a reduction in proteinuria and a decrease in the sizes of podocytes as well as glomeruli. In addition, knockdown of TCTP in db/db mice prevented the development of diabetic nephropathy, as indicated by the amelioration of proteinuria, mesangial expansion, podocytopenia and glomerulosclerosis. In accordance with the in vivo data, TCTP inhibition abrogated high glucose-induced hypertrophy in cultured podocytes, which was accompanied by the downregulation of mTORC1 effectors and CKIs. These findings suggest that TCTP might play an important role in the process of podocyte hypertrophy under diabetic conditions via the regulation of mTORC1 activity and the induction of cell-cycle arrest.
  Diabetologia 04/2012; 55(4):1205-17. · 6.81 Impact Factor
• Article: Erratum: comparison of guaiac-based and quantitative immunochemical fecal occult blood testing in a population at average risk undergoing colorectal cancer screening.

  D I Park, S Ryu, Y-H Kim, S H Lee, C K Lee, C S Eun, D S Han
  The American Journal of Gastroenterology 02/2012; 107(2):331-2. · 7.28 Impact Factor
• Article: Criteria for decision making after endoscopic resection of well-differentiated rectal carcinoids with regard to potential lymphatic spread.

  C H Park, J H Cheon, J O Kim, J E Shin, B I Jang, S J Shin, Y T Jeen, S H Lee, J S Ji, D S Han, S A Jung, D I Park, I H Baek, S H Kim, D K Chang
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  ABSTRACT: Rectal carcinoids are low-grade malignancies that are usually treated by endoscopic resection. However, on pathologic examination, resection margins that are positive for carcinoid cells are frequently found. Patient outcomes were reviewed after endoscopic resection of rectal carcinoids and the clinical significance of possible residual disease, as defined by pathologic and endoscopic examination, was evaluated. The medical records and endoscopic findings of 347 patients presenting with rectal carcinoids to 14 university hospitals in Korea between January 1999 and June 2007 were retrospectively analyzed. A total of 304 patients were treated with endoscopic resection, and 43 patents were treated with surgery. In the endoscopic resection group, the complete resection rate was 88.2% based on endoscopic appearance (CR-E) and 60.2% based on pathologic evaluation (CR-P). The agreement between CR-E and CR-P was low (κ=0.192). No residual tumors were found in 77 of 85 patients (90.6%) who were CR-E but not CR-P and who had endoscopic biopsy taken at 24-month follow-up. The receiver-operating characteristic curve identified an optimal cut-off value of 10.5 mm, at which the sensitivity and the specificity for metastasis were 100% and 89%, respectively. The risk factors for metastasis by multivariate analysis were tumor size, increased mitotic rate, and lymphovascular invasion. Endoscopic resection is a safe and effective modality for treating well-differentiated rectal carcinoids smaller than 10 mm in diameter. Discrepancies were observed between CR-E and CR-P. The risk factors for metastasis were tumor size, increased mitotic rate, and lymphovascular invasion.
  Endoscopy 07/2011; 43(9):790-5. · 5.21 Impact Factor
• Article: Gastric emphysema after endoscopic submucosal dissection.

  Y S Hyun, D S Han, H L Lee, J H Bae, C S Eun
  Endoscopy 03/2011; 43 Suppl 2 UCTN:E83-4. · 5.21 Impact Factor