Dario Sacchini

Publications (25) View all

• Source

  Available from: Antonio G. Spagnolo

  Article: Patient-reported outcomes (PROs): the significance of using humanistic measures in clinical trial and clinical practice.

  P Refolo, R Minacori, V Mele, D Sacchini, A G Spagnolo
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  ABSTRACT: Patient-reported outcome (PRO) is an "umbrella term" that covers a whole range of potential types of measurement but it is used specifically to refer to all measures quantifying the state of health through the evaluation of outcomes reported by the patient himself/herself. PROs are increasingly seen as complementary to biomedical measures and they are being incorporated more frequently into clinical trials and clinical practice. After considering the cultural background of PROs - that is the well known patient-centered model of medicine -, their historical profile (since 1914, the year of the first outcome measure) and typologies, the paper aims at debating their methodological complexity and implementation into practice. Some clinical trials and therapeutic managements utilizing patient-centered measures will be also analyzed.
  European review for medical and pharmacological sciences 10/2012; 16(10):1319-1323. · 1.04 Impact Factor
• Source

  Available from: Antonio G. Spagnolo

  Article: Male fertility and reduction in semen parameters: a single tertiary-care center experience.

  D Milardi, G Grande, D Sacchini, A L Astorri, G Pompa, A Giampietro, L De Marinis, A Pontecorvi, A G Spagnolo, R Marana
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  ABSTRACT: Background. Infertility is both a clinical and a public problem, affecting the life of the couple, the healthcare services, and social environment. Standard semen analysis is the surrogate measure of male fertility in clinical practice. Objective. To provide information about the relationship between semen parameters and spontaneous conception. Methods. We evaluated retrospectively 453 pregnancies that occurred among 2935 infertile couples evaluated at an infertility clinic of a tertiary-care university hospital, between 2004 and 2009. Results. Normal semen analysis was present only in 158 patients; 295 subfertile patients showed alterations in at least one seminal parameter. A reduction in all seminal parameters was observed in 41 patients. Etiological causes of male infertility were identified in 314 patients. Conclusion. Our data highlights the possibility of a spontaneous conception with semen parameters below WHO reference values. Therefore, we support the importance of defining reference values on a population of fertile men. Finally, we analyzed the related ethical issues.
  International Journal of Endocrinology 01/2012; 2012:649149. · 1.87 Impact Factor
• Article: Diagnosis.

  V Tambone, D Sacchini
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  ABSTRACT: The paper deals with the term Medical Diagnosis (D). It is the process of identifying a disease by its signs, symptoms and results of various diagnostic (laboratory or imaging) procedures. D. is part of clinical reasoning. It includes the following phases: 1. observation (anamnesis, medical examination); 2. problem determination; 3. hypotheses generation; 4. hypothesis control (through laboratory and imaging tests); 5. working D.; 6. therapeutic/caring decisions; 7. final D., 8. follow-up. In order to choose correctly a diagnostic test (DT), it is necessary to answer the following questions: 1. Is an evidence about the accuracy of a DT valid? 2. Does the valid evidence show that this test can accurately distinguish patients who do and do not have a specific disorder? 3. How applying a valid, accurate diagnostic test to a specific patient?
  La Clinica terapeutica 01/2010; 161(3):273-5. · 0.27 Impact Factor
• Article: Ethics committees.

  D Sacchini, M Pennacchini
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  ABSTRACT: Ethics committees (ECs) are a relevant body for dealing with ethical issues in healthcare. They born in order to resolve dilemmatic situations. Contemporary ECs are independent standing committees with multidisciplinary representation, including medicine, nursing, social work, law, pastoral care, healthcare administration, and other different expertises. The functions of ECs are various: estimating clinical trials; analyzing ethically relevant clinical cases; drafting hospital/organizational guidelines, and to carry out education activity. The composition and kind of skills requested in an EC could change according to national laws. About international ethical standards in clinical experimentation, the World Medical Association's Declaration of Helsinki is the reference according to which examining clinical trials by ECs.
  La Clinica terapeutica 01/2010; 161(3):281-3. · 0.27 Impact Factor
• Article: [Prevention of the maternal-fetal CMC infection: ethical and deontologic aspects].

  V Tambone, D Sacchini
  La Clinica terapeutica 11/2004; 155(10):471-5. · 0.27 Impact Factor