Daniel F Hanley

Publications (195) View all

• Article: Research and Technology in Neurocritical Care

  C. A. C. Wijman, S. M. Smirnakis, P. Vespa, K. Szigeti, W. C. Ziai, M. M. Ning, J. Rosand, D. F. Hanley, R. Geocadin, C. Hall, P. D. Le Roux, J. I. Suarez, O. O. Zaidat, For the First Neurocritical Care Research Conference Investigators
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  ABSTRACT: The daily practice of neurointensivists focuses on the recognition of subtle changes in the neurological examination, interactions between the brain and systemic derangements, and brain physiology. Common alterations such as fever, hyperglycemia, and hypotension have different consequences in patients with brain insults compared with patients of general medical illness. Various technologies have become available or are currently being developed. The session on “research and technology” of the first neurocritical care research conference held in Houston in September of 2009 was devoted to the discussion of the current status, and the research role of state-of-the art technologies in neurocritical patients including multi-modality neuromonitoring, biomarkers, neuroimaging, and “omics” research (proteomix, genomics, and metabolomics). We have summarized the topics discussed in this session. We have provided a brief overview of the current status of these technologies, and put forward recommendations for future research applications in the field of neurocritical care. KeywordsNeurocritical care–Neuromonitoring–Genomics–Neuroimaging–Biomarkers
  Neurocritical Care 04/2012; 16(1):42-54. · 2.47 Impact Factor
• Article: Research and technology in neurocritical care.

  C A C Wijman, S M Smirnakis, P Vespa, K Szigeti, W C Ziai, M M Ning, J Rosand, D F Hanley, R Geocadin, C Hall, P D Le Roux, J I Suarez, O O Zaidat
  [show abstract] [hide abstract]
  ABSTRACT: The daily practice of neurointensivists focuses on the recognition of subtle changes in the neurological examination, interactions between the brain and systemic derangements, and brain physiology. Common alterations such as fever, hyperglycemia, and hypotension have different consequences in patients with brain insults compared with patients of general medical illness. Various technologies have become available or are currently being developed. The session on "research and technology" of the first neurocritical care research conference held in Houston in September of 2009 was devoted to the discussion of the current status, and the research role of state-of-the art technologies in neurocritical patients including multi-modality neuromonitoring, biomarkers, neuroimaging, and "omics" research (proteomix, genomics, and metabolomics). We have summarized the topics discussed in this session. We have provided a brief overview of the current status of these technologies, and put forward recommendations for future research applications in the field of neurocritical care.
  Neurocritical Care 07/2011; 16(1):42-54. · 2.47 Impact Factor
• Article: Noncompliance in antiplatelet trials: the AGATE trial perspective.

  V L Serebruany, D F Hanley, D Atar, J J Ferguson
  Stroke 07/2004; 35(6):e143. · 5.73 Impact Factor
• Conference Proceeding: Approaching brain injury after cardiac arrest: from bench to bedside

  R.G. Geocadin, Shanbao Tong, A. Bezerianos, S. Smith, T. Iwamoto, N.V. Thakor, D.F. Hanley
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  ABSTRACT: The neurological injury after resuscitation from cardiac arrest (CA) is a major cause of morbidity and mortality. The unavailability of primary brain directed measures of injury and effective therapy worsens the problem. We have embarked on better understanding the process of injury and recovery by developing an animal model in our laboratory. Using this model, we have discovered that the use of quantitative EEG (Q-EEG) analysis will allow us to titrate the brain injury, monitor the recovery process, study the electrophysiological and biochemical mechanisms of injury and recovery and detect the neuroprotective effect afforded by a drug that prevents neuronal death after injury. With ideas derived from the laboratory research, we have designed a study to test the applicability of QEEG analysis in human subjects resuscitated from cardiac arrest. Our preliminary analysis shows that our measure is able to track the neurological changes of these patients. With this very promising start of this QEEG based measure, we can utilize this technology to develop more rational and effective therapeutic strategies that will improve the neurological outcome in this patient population.
  Neural Engineering, 2003. Conference Proceedings. First International IEEE EMBS Conference on; 04/2003
• Source

  Available from: N.v. Thakor

  Conference Proceeding: Detection of brain herniation with spectral coherence analysis of somatosensory evoked potentials

  O. Gerovichev, H.M. Naeini, D.L. Sherman, F. Al Hatib, S. Venkatesha, R. Geocadin, D.F. Hanley, N.V. Thakor
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  ABSTRACT: Brain herniation was induced in a rat model by expansion of a balloon in the epidural space. Somatosensory evoked potentials (SEPs) from median nerve stimulation were recorded on the cranium and analyzed with spectral coherence algorithm. Post-experimental MRI evaluation of the brains was correlated to coherence analysis results.
  Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint; 11/2002