Research experience
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Jan 2012
Research: Catholic University of Korea
Catholic University of Korea · Division of BiotechnologySouth Korea · Seoul -
Jan 2011–
Dec 2012Research: Seoul National University
Seoul National University · School of Chemical and Biological EngineeringSouth Korea · Seoul
Publications (6) View all
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Article: Chemical Design of Biocompatible Iron Oxide Nanoparticles for Medical Applications.
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ABSTRACT: Iron oxide nanoparticles are one of the most versatile and safe nanomaterials used in medicine. Recent progress in nanochemistry enables fine control of the size, crystallinity, uniformity, and surface properties of iron oxide nanoparticles. In this review, the synthesis of chemically designed biocompatible iron oxide nanoparticles with improved quality and reduced toxicity is discussed for use in diverse biomedical applications.Small 12/2012; · 8.35 Impact Factor -
Article: Theranostic Probe Based on Lanthanide-Doped Nanoparticles for Simultaneous In Vivo Dual-Modal Imaging and Photodynamic Therapy.
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ABSTRACT: Dual-modal in vivo tumor imaging and photodynamic therapy using hexagonal NaYF(4) :Yb,Er/NaGdF(4) core-shell upconverting nanoparticles combined with a photosensitizer, chlorin e6, is reported. Tumors can be clearly observed not only in the upconversion luminescence image but also in the magnetic resonance image. In vivo photodynamic therapy by systemic administration is demonstrated under 980 nm irradiation.Advanced Materials 08/2012; · 13.88 Impact Factor -
Article: Hyaluronic acid-conjugated graphene oxide/photosensitizer nanohybrids for cancer targeted photodynamic therapy
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ABSTRACT: Hyaluronic acid (HA)–graphene oxide (GO) conjugates, with a high loading of photosensitizers (PS; Ce6), were developed as a cancer cell targeted and photoactivity switchable nanoplatform for photodynamic therapy (PDT). HA–GO conjugates with size below 100 nm were first prepared by the chemical conjugation between ADH-modified HA and fractionated GO sheets with size relevant for drug delivery. Before evaluating the drug delivery efficacies, their chemical structure, morphology, and biocompatibility were characterized by 1H NMR, UV, TGA, AFM, DLS and MTT assays. The physical adsorption of Ce6 onto HA–GO nanocarriers was mainly due to the π–π stacking as well as hydrophobic interactions. It was demonstrated by CLSM and FACS that the cellular internalization of the HA–GO/Ce6 nanohybrids was much more effective when compared with free Ce6, which was also found to be significantly influenced by the co-treatment with an excess amount of HA polymers, illustrating their active targeting to HA receptors overexpressed on cancer cells. The photoactivity of Ce6 adsorbed on HA–GO nanocarriers was mostly quenched in aqueous solution to ensure biocompatibility, but was quickly recovered after the release of Ce6 from HA–GO nanocarriers upon cellular uptake. As a result, the PDT efficiency of the HA–GO/Ce6 nanohybrids was remarkably improved 10 times more than that of free Ce6, as well demonstrated in both MTT and LIVE/DEAD assays.Journal of Materials Chemistry 01/2013; · 5.97 Impact Factor -
Article: Photodynamic efficacy of photosensitizers under an attenuated light dose via lipid nano-carrier-mediated nuclear targeting.
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ABSTRACT: Photodynamic therapy (PDT) has emerged as a treatment for certain malignant-like skin, head and neck, gastrointestinal, and gynecological cancers. The broader acceptance of PDT treatment for large or deep-seated tumors is still hindered, at least in part, by the low photodynamic efficiency of photosensitizers (PS) in the deep-seated tumor environment where the light energy fluency rate is severely attenuated after propagation via skin and/or tissue barriers. In this report, efficient nuclear-targeted intracellular delivery of PS is achieved using an easily fabricated yet entirely biocompatible and inexpensive polysaccharide-functionalized nanoscale lipid carrier, which triggers the intracellular release of photosensitizers inside cancer cells and targets cell nuclear to achieve a significantly enhanced photocytotoxicity. Cancer cells are killed efficiently even under an extremely low light fluency of 1 mW/cm(2) attenuated via an interval meat layer with a thickness of 3 mm. Therefore, this nuclei-targeting system may contribute to the development of a new generation of PS carriers that fight against deep-seated tumors and that exhibit excellent photodynamic efficiency under faint light irradiation.Biomaterials 05/2012; 33(21):5478-86. · 7.40 Impact Factor -
Article: Multiple-interaction ligands inspired by mussel adhesive protein: synthesis of highly stable and biocompatible nanoparticles.
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ABSTRACT: All bound up: A poly(l-3,4-dihydroxyphenylalanine)-based ligand converts hydrophobic nanoparticles into hydrophilic and biocompatible species through several binding modes. Nanoparticles functionalized with this ligand (see picture) are highly stable in various aqueous solutions. A successful in vivo MRI application using functionalized Fe3O4 nanoparticles confirmed their suitability for various biomedical applications.Angewandte Chemie International Edition 09/2011; 50(48):11360-5. · 13.45 Impact Factor
