Christoph Kleinschnitz

• 368Impact points

• 77Publications

• 316Followers

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Publications

• Focal cerebral ischemia.

  Authors: Stefan Braeuninger, Christoph Kleinschnitz, Bernhard Nieswandt, Guido Stoll

  Methods in molecular biology (Clifton, N.J.). 788:29-42.

• von Willebrand Factor: An Emerging Target in Stroke Therapy.

  Authors: Simon F De Meyer, Guido Stoll, Denisa D Wagner, Christoph Kleinschnitz

  Stroke; a journal of cerebral circulation.

• Megakaryocyte-specific RhoA deficiency causes macrothrombocytopenia and defective platelet activation in hemostasis and thrombosis.

  Authors: Irina Pleines, Ina Hagedorn, Shuchi Gupta, Frauke May, Lidija Chakarova, Jolanda van Hengel, Stefan Offermanns, Georg Krohne, Christoph Kleinschnitz, Cord Brakebusch, Bernhard Nieswandt

  Blood.

• Blood coagulation factor XII-a neglected player in stroke pathophysiology.

  Authors: Mirko Pham, Guido Stoll, Bernhard Nieswandt, Martin Bendszus, Christoph Kleinschnitz

  Journal of molecular medicine (Berlin, Germany).

• [Acute ischemic stroke : New approaches to antithrombotic treatment.]

  Authors: P Kraft, B Nieswandt, G Stoll, C Kleinschnitz

  Der Nervenarzt.

• α(2)-Adrenoceptors do not mediate neuroprotection in acute ischemic stroke in mice.

  Authors: Marc Brede, Stefan Braeuninger, Friederike Langhauser, Lutz Hein, Norbert Roewer, Guido Stoll, Christoph Kleinschnitz

  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

• Ischaemic stroke: a thrombo-inflammatory disease ?

  Authors: Bernhard Nieswandt, Christoph Kleinschnitz, Guido Stoll

  The Journal of physiology.

• [Pregabalin and gabapentin in multiple sclerosis : Clinical experiences and therapeutic implications.]

  Authors: S Bittner, K Höhn, K Göbel, C Kleinschnitz, H Wiendl, S G Meuth

  Der Nervenarzt.

• Report on the 2nd scientific meeting of the Verein zur Foerderung des Wissenschaftlichen Nachwuchses in der Neurologie" (NEUROWIND e.V.) held in Motzen, Germany, Oct. 29'th - Oct. 31'st, 2010.

  Authors: Tim Magnus, Ralf A Linker, Sven G Meuth, Christoph Kleinschnitz, Thomas Korn

  Experimental & translational stroke medicine. 3(1):3.

• Glucocorticoid Insensitivity at the Hypoxic Blood-Brain Barrier Can Be Reversed by Inhibition of the Proteasome.

  Authors: Christoph Kleinschnitz, Kinga Blecharz, Timo Kahles, Tobias Schwarz, Peter Kraft, Kerstin Göbel, Sven G Meuth, Malgorzata Burek, Thomas Thum, Guido Stoll, Carola Förster

  Stroke; a journal of cerebral circulation.

• Expression of K2P5.1 potassium channels on CD4+ T lymphocytes correlates with disease activity in rheumatoid arthritis patients.

  Authors: Stefan Bittner, Nicole Bobak, Martin Feuchtenberger, Alexander M Herrmann, Kerstin Gobel, Raimund W Kinne, Anker J Hansen, Thomas Budde, Christoph Kleinschnitz, Oliver Frey, Hans-Peter Tony, Heinz Wiendl, Sven G Meuth

  Arthritis research & therapy. 13(1):R21.

• Blockade of the kinin receptor B1 protects from autoimmune CNS disease by reducing leukocyte trafficking.

  Authors: Kerstin Göbel, Susann Pankratz, Tilman Schneider-Hohendorf, Stefan Bittner, Michael K Schuhmann, Harald F Langer, Guido Stoll, Heinz Wiendl, Christoph Kleinschnitz, Sven G Meuth

  Journal of autoimmunity.

• Sustained reperfusion after blockade of glycoprotein-receptor-Ib in focal cerebral ischemia: an MRI study at 17.6 Tesla.

  Authors: Mirko Pham, Xavier Helluy, Christoph Kleinschnitz, Peter Kraft, Andreas J Bartsch, Peter Jakob, Bernhard Nieswandt, Martin Bendszus, Guido Stoll

  PloS one. 6(4):e18386.

• In vivo imaging of stepwise vessel occlusion in cerebral photothrombosis of mice by f MRI.

  Authors: Gesa Weise, Thomas C Basse-Lüsebrink, Christoph Kleinschnitz, Thomas Kampf, Peter M Jakob, Guido Stoll

  PloS one. 6(12):e28143.

• Therapeutic approaches to multiple sclerosis: an update on failed, interrupted, or inconclusive trials of neuroprotective and alternative treatment strategies.

  Authors: Sven G Meuth, Stefan Bittner, Jochen C Ulzheimer, Christoph Kleinschnitz, Bernd C Kieseier, Heinz Wiendl

  BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy. 24(5):317-30.

• Combating innate inflammation: a new paradigm for acute treatment of stroke?

  Authors: Guido Stoll, Christoph Kleinschnitz, Bernhard Nieswandt

  Annals of the New York Academy of Sciences. 1207:149-54.

• Glatiramer Acetate Attenuates Pro-Inflammatory T Cell Responses but Does Not Directly Protect Neurons from Inflammatory Cell Death.

  Authors: Alexander M Herrmann, Kerstin Göbel, Ole J Simon, Nico Melzer, Michael K Schuhmann, Max-Philipp Stenner, Andreas Weishaupt, Christoph Kleinschnitz, Stefan Bittner, Patrick Meuth, Olaf Stuve, Thomas Budde, Bernd C Kieseier, Heinz Wiendl, Sven G Meuth

  The American journal of pathology.

• Therapeutic approaches to multiple sclerosis: an update on failed, interrupted, or inconclusive trials of immunomodulatory treatment strategies.

  Authors: Jochen C Ulzheimer, Sven G Meuth, Stefan Bittner, Christoph Kleinschnitz, Bernd C Kieseier, Heinz Wiendl

  BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy. 24(4):249-74.

• The role of glycoprotein Ibalpha and von Willebrand factor interaction in stroke development.

  Authors: G Stoll, C Kleinschnitz, B Nieswandt

  Hämostaseologie. 30(3):136-8.

• Binding of von Willebrand Factor to Collagen and Glycoprotein Ib{alpha}, But Not to Glycoprotein IIb/IIIa, Contributes to Ischemic Stroke in Mice.

  Authors: Simon F De Meyer, Tobias Schwarz, Hans Deckmyn, Cécile V Denis, Bernhard Nieswandt, Guido Stoll, Karen Vanhoorelbeke, Christoph Kleinschnitz

  Arteriosclerosis, thrombosis, and vascular biology.

• Two pore domain potassium channels in cerebral ischemia: a focus on K2P9.1 (TASK3, KCNK9).

  Authors: Petra Ehling, Stefan Bittner, Nicole Bobak, Tobias Schwarz, Heinz Wiendl, Thomas Budde, Christoph Kleinschnitz, Sven G Meuth

  Experimental & translational stroke medicine. 2(1):14.

• Report on the 1'st scientific meeting of the Verein zur Foerderung des Wissenschaftlichen Nachwuchses in der Neurologie" (NEUROWIND e.V.) held in Mittenwalde/Motzen, Germany, Oct. 30'th - Nov. 1'st, 2009.

  Authors: Tim Magnus, Ralf Linker, Sven G Meuth, Christoph Kleinschnitz, Thomas Korn

  Experimental & translational stroke medicine. 2(1):7.

• Inhibition of bradykinin receptor B1 protects mice from focal brain injury by reducing blood-brain barrier leakage and inflammation.

  Authors: Furat Raslan, Tobias Schwarz, Sven G Meuth, Madeleine Austinat, Michael Bader, Thomas Renné, Klaus Roosen, Guido Stoll, Anna-Leena Sirén, Christoph Kleinschnitz

  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

• Early detrimental T cell effects in experimental cerebral ischemia are neither related to adaptive immunity nor thrombus formation.

  Authors: Christoph Kleinschnitz, Nicholas Schwab, Peter Kraft, Ina Hagedorn, Angela Dreykluft, Tobias Schwarz, Madeleine Austinat, Bernhard Nieswandt, Heinz Wiendl, Guido Stoll

  Blood.

• Outcome of experimental stroke in C57Bl/6 and Sv/129 mice assessed by multimodal ultra-high field MRI.

  Authors: Mirko Pham, Xavier Helluy, Stefan Braeuninger, Peter Jakob, Guido Stoll, Christoph Kleinschnitz, Martin Bendszus

  Experimental & translational stroke medicine. 2(1):6.

• Factor XIIa Inhibitor Recombinant Human Albumin Infestin-4 Abolishes Occlusive Arterial Thrombus Formation Without Affecting Bleeding.

  Authors: Ina Hagedorn, Stefan Schmidbauer, Irina Pleines, Christoph Kleinschnitz, Ulrich Kronthaler, Guido Stoll, Gerhard Dickneite, Bernhard Nieswandt

  Circulation.

• Multifocal Motor Neuropathy: Update on Clinical Characteristics, Pathophysiological Concepts and Therapeutic Options.

  Authors: Sven G Meuth, Christoph Kleinschnitz

  European neurology. 63(4):193-204.

• Deficiency of the negative immune regulator B7-H1 enhances inflammation and neuropathic pain after chronic constriction injury of mouse sciatic nerve.

  Authors: Nurcan Uçeyler, Kerstin Göbel, Sven G Meuth, Sonja Ortler, Guido Stoll, Claudia Sommer, Heinz Wiendl, Christoph Kleinschnitz

  Experimental neurology.

• Interleukin-18 does not influence infarct volume or functional outcome in the early stage after transient focal brain ischemia in mice.

  Authors: Stefan Braeuninger, Christoph Kleinschnitz, Guido Stoll

  Experimental & translational stroke medicine. 2:1.

• COU254, a specific 3-carboxamide-coumarin inhibitor of coagulation factor XII, does not protect mice from acute ischemic stroke.

  Authors: Peter Kraft, Tobias Schwarz, Lionel Pochet, Guido Stoll, Christoph Kleinschnitz

  Experimental & translational stroke medicine. 2(1):5.

• Thrombin-Activatable Fibrinolysis Inhibitor (TAFI) Deficient Mice Are Susceptible to Intracerebral Thrombosis and Ischemic Stroke.

  Authors: Peter Kraft, Tobias Schwarz, Joost C M Meijers, Guido Stoll, Christoph Kleinschnitz

  PloS one. 5(7):e11658.

• Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration.

  Authors: Christoph Kleinschnitz, Henrike Grund, Kirstin Wingler, Melanie E Armitage, Emma Jones, Manish Mittal, David Barit, Tobias Schwarz, Christian Geis, Peter Kraft [......] Anja Schrewe, Lore Becker, Valérie Gailus-Durner, Helmut Fuchs, Thomas Klopstock, Martin Hrabé de Angelis, Karin Jandeleit-Dahm, Ajay M Shah, Norbert Weissmann, Harald H H W Schmidt

  PLoS biology. 8(9).

• Deficiency of vasodilator-stimulated phosphoprotein (VASP) increases blood-brain-barrier damage and edema formation after ischemic stroke in mice.

  Authors: Peter Kraft, Peter Michael Benz, Madeleine Austinat, Marc Elmar Brede, Kai Schuh, Ulrich Walter, Guido Stoll, Christoph Kleinschnitz

  PloS one. 5(12):e15106.

• Impaired alpha(IIb)beta(3) integrin activation and shear-dependent thrombus formation in mice lacking phospholipase D1.

  Authors: Margitta Elvers, David Stegner, Ina Hagedorn, Christoph Kleinschnitz, Attila Braun, Marijke E J Kuijpers, Michael Boesl, Qin Chen, Johan W M Heemskerk, Guido Stoll, Michael A Frohman, Bernhard Nieswandt

  Science signaling. 3(103):ra1.

• Stromal Interaction Molecules 1 and 2 Are Key Regulators of Autoreactive T Cell Activation in Murine Autoimmune Central Nervous System Inflammation.

  Authors: Michael K Schuhmann, David Stegner, Alejandro Berna-Erro, Stefan Bittner, Attila Braun, Christoph Kleinschnitz, Guido Stoll, Heinz Wiendl, Sven G Meuth, Bernhard Nieswandt

  Journal of immunology (Baltimore, Md. : 1950).

• Enhanced cortical reperfusion protects coagulation factor XII-deficient mice from ischemic stroke as revealed by high-field MRI.

  Authors: M Pham, C Kleinschnitz, X Helluy, A J Bartsch, M Austinat, V C Behr, T Renné, B Nieswandt, G Stoll, M Bendszus

  NeuroImage.

• Rodent models of focal cerebral ischemia: procedural pitfalls and translational problems.

  Authors: Stefan Braeuninger, Christoph Kleinschnitz

  Experimental & translational stroke medicine. 1:8.

• Deficiency of von Willebrand factor protects mice from ischemic stroke.

  Authors: Christoph Kleinschnitz, Simon F De Meyer, Tobias Schwarz, Madeleine Austinat, Karen Vanhoorelbeke, Bernhard Nieswandt, Hans Deckmyn, Guido Stoll

  Blood.

• Recent clinical trials and future therapies.

  Authors: Sven G Meuth, Christoph Kleinschnitz, Heinz Wiendl

  Journal of neurology. 255 Suppl 6:93-6.

• STIM2 regulates capacitive Ca2+ entry in neurons and plays a key role in hypoxic neuronal cell death.

  Authors: Alejandro Berna-Erro, Attila Braun, Robert Kraft, Christoph Kleinschnitz, Michael K Schuhmann, David Stegner, Thomas Wultsch, Jens Eilers, Sven G Meuth, Guido Stoll, Bernhard Nieswandt

  Science signaling. 2(93):ra67.

• Blockade of Bradykinin Receptor B1 but Not Bradykinin Receptor B2 Provides Protection From Cerebral Infarction and Brain Edema.

  Authors: Madeleine Austinat, Stefan Braeuninger, João B Pesquero, Marc Brede, Michael Bader, Guido Stoll, Thomas Renné, Christoph Kleinschnitz

  Stroke; a journal of cerebral circulation.

• [Multiple sclerosis - a channelopathy? : Targeting ion channels and transporters in inflammatory neurodegeneration.]

  Authors: S G Meuth, N Melzer, C Kleinschnitz, T Budde, H Wiendl

  Der Nervenarzt.

• Orai1 (CRACM1) is the platelet SOC channel and essential for pathological thrombus formation.

  Authors: Attila Braun, David Varga-Szabo, Christoph Kleinschnitz, Irina Pleines, Markus Bender, Madeleine Austinat, Michael Bosl, Guido Stoll, Bernhard Nieswandt

  Blood.

• The Trials and Errors in MS Therapy.

  Authors: Christoph Kleinschnitz, Sven G Meuth, Prof Heinz Wiendl

  International MS journal / MS Forum. 15(3):79-90.

• The neuroprotective impact of the leak potassium channel TASK1 on stroke development in mice.

  Authors: Sven G Meuth, Christoph Kleinschnitz, Tilman Broicher, Madeleine Austinat, Stefan Bräuninger, Stefan Bittner, Stephan Fischer, Douglas A Bayliss, Thomas Budde, Guido Stoll, Heinz Wiendl

  Neurobiology of disease.

• Transient widespread blood-brain barrier alterations after cerebral photothrombosis as revealed by gadofluorine M-enhanced magnetic resonance imaging.

  Authors: Guido Stoll, Christoph Kleinschnitz, Sven G Meuth, Stefan Braeuninger, Chi Wang Ip, Carsten Wessig, Ingo Nölte, Martin Bendszus

  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

• Molecular mechanisms of thrombus formation in ischemic stroke: novel insights and targets for treatment.

  Authors: Guido Stoll, Christoph Kleinschnitz, Bernhard Nieswandt

  Blood.

• The calcium sensor STIM1 is an essential mediator of arterial thrombosis and ischemic brain infarction.

  Authors: David Varga-Szabo, Attila Braun, Christoph Kleinschnitz, Markus Bender, Irina Pleines, Mirko Pham, Thomas Renné, Guido Stoll, Bernhard Nieswandt

  The Journal of experimental medicine. 205(7):1583-91.

• Deficiency of bradykinin receptor B2 is not detrimental in experimental stroke.

  Authors: Christoph Kleinschnitz, Madeleine Austinat, Michael Bader, Thomas Renné, Guido Stoll

  Hypertension. 51(5):e41; author reply e42-3.

• Origin of CD11b+ macrophage-like cells in the CNS of PLP-overexpressing mice: Low influx of haematogenous macrophages and unchanged blood-brain-barrier in the optic nerve.

  Authors: Chi Wang Ip, Bianca Kohl, Christoph Kleinschnitz, Bernhard Reuss, Klaus-Armin Nave, Antje Kroner, Rudolf Martini

  Molecular and cellular neurosciences.