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I am Associate prof at the Dermatology Dept of Aarhus University Hospital. I have since 2005 studied the regulation of MSK1 and RSK1 activation by Dimethylfumarate in keratinocytes stimulated with pro-inflammatory cytokines IL-1 beta and MIF.
Dimethylfumarate inhibits MSK1 and RSK1 activation through the ERK induced signaling pathway but supports p-c-Jun S63 and p-p53 S15 expression through the JNK signaling pathway leading to inhibition of keratinocyte proliferation in vitro and in psoriasis.

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