Publications (33) View all
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Article: Evaluation of autologous plasma skin test in patients with chronic idiopathic urticaria.
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ABSTRACT: The pathophysiological mechanism of chronic urticaria is still poorly understood and its aetiology is considered to have an autoreactive basis. Autologous serum skin tests (ASSTs) and autologous plasma skin tests (APSTs) comprise the simplest ways for diagnosing autoreactive urticaria (with autoantibodies, histamine-releasing factor and coagulation factors, especially thrombin) in a clinical setting. However, there are still some questions about the specificity of these tests. To evaluate the role of autoreactivity in the pathogenesis of chronic urticaria by means of measuring plasma prothrombin fragments 1 + 2, which are used as markers of thrombin, and to compare the APST with the ASST. Forty-two patients (19 men and 23 women; mean age 35·7 years, range 28-76) and 35 healthy volunteers (19 men and 16 women; mean age 30·3 years, range 20-80) were included in the study. APST, negative (ASST, sodium citrate, saline) and positive (histamine) control tests were performed in the patient and control groups. The levels of plasma prothrombin fragments 1 + 2 were also assessed. When the APST was evaluated without negative controls, it was positive in 67% of patients. However, the APST was positive in 0% when it was evaluated with negative controls. Levels of prothrombin fragments 1 + 2 were found to be elevated in patients with chronic idiopathic urticaria. We suggest that as negative control tests were not performed along with the APST in previous studies, the APST showed a high rate of positivity. Thus, the use of APST for evaluating autoreactivity in clinical practice is not superior to the use of ASST and further studies should be conducted.British Journal of Dermatology 09/2011; 165(6):1205-9. · 3.67 Impact Factor -
Article: Treatment of candidal intertrigo with a topical combination of isoconazole nitrate and diflucortolone valerate.
Mycoses 09/2008; 51 Suppl 4:42-3. · 2.25 Impact Factor -
Article: Inflammation and hypercoagulable state in adult psoriatic men.
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ABSTRACT: Hyperhomocysteinaemia is a well-known risk factor for cardiovascular disease and plays a role in atherothrombosis. Psoriasis is a common chronic and recurrent inflammatory skin disease associated with increased thrombosis. The aim of this study was to examine serum homocysteine levels and their relationships with inflammatory and atherothrombotic markers in psoriasis. Twenty patients with mild or moderate psoriasis and 20 age-matched healthy men were included in this study. Patients with acquired hyperhomocysteinaemia were excluded from both groups. The inflammation markers, mean platelet volume, C-reactive protein and ceruloplasmin levels, were significantly increased in the study group compared with the control group. In the study group there was decreased antithrombin III and total homocysteine levels, for haemostatic parameters. Folic acid levels, cardiovascular risk factors, endothelial inflammation markers and blood coagulation factors demonstrated significant correlations. Folic acid levels correlated inversely with homocysteine and positively with fibrinogen levels. In conclusion, increased homocysteine concentration and inflammation markers may play a role in the atherothrombotic state in psoriasis.Acta Dermato Venereologica 02/2008; 88(4):337-40. · 3.18 Impact Factor -
Article: Oral etoposide-induced leucocytoclastic vasculitis in a patient with lung carcinoma.
Journal of the European Academy of Dermatology and Venereology 11/2007; 21(9):1297-8. · 2.98 Impact Factor -
Article: Atopic dermatitis and house dust mite control measures.
British Journal of Dermatology 08/2002; 147(1):191; author reply 191-2. · 3.67 Impact Factor
