Bernadette Rogé

Publications (25) View all

• Article: Blame and forgiveness judgements among children, adolescents and adults with autism.

  Bernadette Rogé, Etienne Mullet
  [show abstract] [hide abstract]
  ABSTRACT: We compared the capacity of children, adolescents and adults with and without autism to use (a) intent and severity of consequences information for attributing blame to an offender, and (b) intent and apologies information for inferring willingness to forgive. Participants were presented with two sets of six scenarios obtained by combination of intent and severity (or apology) information, and instructed to indicate appropriate levels of blame (or willingness to forgive). In the blame condition, persons with autism were able to consistently use intent information but not to the same degree as their comparison counterparts. In the forgiveness condition, intent was not taken into account for judging by persons with autism, irrespective of their age.
  Autism 06/2011; 15(6):702-12. · 2.27 Impact Factor
• Source

  Available from: Bernadette Rogé

  Article: Oxytocin may be useful to increase trust in others and decrease disruptive behaviours in patients with Prader-Willi syndrome: a randomised placebo-controlled trial in 24 patients.

  Maïthe Tauber, Carine Mantoulan, Pierre Copet, Joseba Jauregui, Genevieve Demeer, Gwenaëlle Diene, Bernadette Rogé, Virginie Laurier, Virginie Ehlinger, Catherine Arnaud, Catherine Molinas, Denise Thuilleaux
  [show abstract] [hide abstract]
  ABSTRACT: Prader-Willi syndrome (PWS) is a complex neurodevelopmental genetic disorder with hypothalamic dysfunction, early morbid obesity with hyperphagia, and specific psychiatric phenotypes including cognitive and behavioural problems, particularly disruptive behaviours and frequent temper outbursts that preclude socialization. A deficit in oxytocin (OT)-producing neurons of the hypothalamic paraventricular nucleus has been reported in these patients. In a double-blind, randomised, placebo-controlled study, 24 adult patients with PWS received a single intranasal administration of 24 IU of OT or placebo and were tested 45 min later on social skills. Behaviours were carefully monitored and scored using an in-house grid as follows: over the two days before drug administration, on the half-day following administration, and over the subsequent two days. All patients were in a dedicated PWS centre with more than ten years of experience. Patients are regularly admitted to this controlled environment. Patients with PWS who received a single intranasal administration of OT displayed significantly increased trust in others (P = 0.02) and decreased sadness tendencies (P = 0.02) with less disruptive behaviour (P = 0.03) in the two days following administration than did patients who received placebo. In the half-day following administration, we observed a trend towards less conflict with others (p = 0.07) in the OT group compared with the placebo group. Scores in tests assessing social skills were not significantly different between the two groups. This study needs to be reproduced and adapted. It nevertheless opens new perspectives for patients with PWS and perhaps other syndromes with behavioural disturbances and obesity. ClinicalTrials.gov: NCT01038570.
  Orphanet Journal of Rare Diseases 06/2011; 6:47. · 5.83 Impact Factor
• Article: Early processing of emotional faces in children with autism: An event-related potential study.

  Magali Batty, Emilie Meaux, Kerstin Wittemeyer, Bernadette Rogé, Margot J Taylor
  [show abstract] [hide abstract]
  ABSTRACT: Social deficits are one of the most striking manifestations of autism spectrum disorders (ASDs). Among these social deficits, the recognition and understanding of emotional facial expressions has been widely reported to be affected in ASDs. We investigated emotional face processing in children with and without autism using event-related potentials (ERPs). High-functioning children with autism (n=15, mean age=10.5±3.3 years) completed an implicit emotional task while visual ERPs were recorded. Two groups of typically developing children (chronological age-matched and verbal equivalent age-matched [both ns=15, mean age=7.7±3.8 years]) also participated in this study. The early ERP responses to faces (P1 and N170) were delayed, and the P1 was smaller in children with autism than in typically developing children of the same chronological age, revealing that the first stages of emotional face processing are affected in autism. However, when matched by verbal equivalent age, only P1 amplitude remained affected in autism. Our results suggest that the emotional and facial processing difficulties in autism could start from atypicalities in visual perceptual processes involving rapid feedback to primary visual areas and subsequent holistic processing.
  Journal of Experimental Child Psychology 03/2011; 109(4):430-44. · 3.12 Impact Factor
• Article: PET scan perfusion imaging in the Prader-Willi syndrome: new insights into the psychiatric and social disturbances.

  Carine Mantoulan, Pierre Payoux, Gwenaëlle Diene, Mélanie Glattard, Bernadette Rogé, Catherine Molinas, Annick Sevely, Monica Zilbovicius, Pierre Celsis, Maïthé Tauber
  [show abstract] [hide abstract]
  ABSTRACT: The Prader-Willi syndrome (PWS), a rare multisystem genetic disease, leads to severe disabilities, such as morbid obesity, endocrine dysfunctions, psychiatric disorders, and social disturbances. We explored the whole brain of patients with PWS to detect abnormalities that might explain the behavioral and social disturbances, as well as the psychiatric disorders of these patients. Nine patients with PWS (six males, three females; mean age 16.4 years) underwent a positron emission tomography (PET) scan with H(2)(15)O as a tracer to measure regional cerebral blood flow (rCBF). The images were compared with those acquired from nine controls (six males, three females; mean age 21.2 years). A morphologic magnetic resonance imaging (MRI) was also performed in PWS patients, and their cognitive and behavioral skills were assessed with Wechsler Intelligence Scale for Children III and the Child Behavior Check List (CBCL). The MRI images showed no evident anatomic abnormalities, whereas PET scans revealed hypoperfused brain regions in PWS patients compared with controls, particularly in the anterior cingulum and superior temporal regions. We observed a significant relationship (P<0.05) between rCBF in the hypoperfused regions and CBCL scores. The functional consequences of these perfusion abnormalities in specific brain regions might explain the behavioral and social problems observed in these individuals.
  Journal of cerebral blood flow and metabolism: official journal of the International Society of Cerebral Blood Flow and Metabolism 01/2011; 31(1):275-82. · 5.46 Impact Factor
• Source

  Available from: Michèle Guidetti

  Article: Recognition of emotional and nonemotional facial expressions: a comparison between Williams syndrome and autism.

  Agnès Lacroix, Michèle Guidetti, Bernadette Rogé, Judy Reilly
  [show abstract] [hide abstract]
  ABSTRACT: The aim of our study was to compare two neurodevelopmental disorders (Williams syndrome and autism) in terms of the ability to recognize emotional and nonemotional facial expressions. The comparison of these two disorders is particularly relevant to the investigation of face processing and should contribute to a better understanding of social behaviour and social cognition. Twelve participants with WS (from 6;1 to 15 years) and twelve participants with autism (from 4;9 to 8 years) were matched on verbal mental age. Their performances were compared with those of twelve typically developing controls matched on verbal mental age (from 3;1 to 9;2). A set of five tasks assessing different dimensions of emotional and nonemotional facial recognition were administered. Results indicated that recognition of emotional facial expressions is more impaired in Williams syndrome than in autism. Our study comparing Williams syndrome and autism over a small age range highlighted two distinct profiles which call into question the relationships between social behaviour/cognition and emotion perception.
  Research in developmental disabilities 04/2009; 30(5):976-85. · 4.41 Impact Factor