Banno Kouji

Publications (51) View all

• Article: Uterus transplantation in nonhuman primates.

  Iori Kisu, Kouji Banno, Makoto Mihara, Daisuke Aoki
  Fertility and sterility 05/2013; · 3.97 Impact Factor
• Article: Current status of uterus transplantation in primates and issues for clinical application.

  Iori Kisu, Kouji Banno, Makoto Mihara, Nobuhiko Suganuma, Daisuke Aoki
  [show abstract] [hide abstract]
  ABSTRACT: OBJECTIVE: To clarify the current status of uterus transplantation (UT) and the medical, ethical, and social problems surrounding UT. DESIGN: Systematic review. SETTING: Not applicable. PATIENT(S): Mainly nonhuman primates and humans. INTERVENTION(S): Not applicable. MAIN OUTCOME MEASURE(S): A systematic search of Pubmed with the terms "uterus/uterine transplantation" was performed for English-language articles to review the current status of UT and issues associated with its clinical application, with a focus on nonhuman primate and human studies on UT. RESULT(S): The first UT procedure in humans was conducted for a patient with absolute uterine infertility in Saudi Arabia in 2000. The transplanted uterus was removed after 99 days owing to prolapse and necrosis. That attempt led to a greater focus on basic UT experiments in animal models, including nonhuman primates. The subsequent accumulation of basic data has led to performance of UT in humans by groups in Turkey and Sweden. However, there has yet to be a pregnancy or delivery after allo-UT in primates. Moreover, there are many medical, ethical, and social problems that require examination before clinical application. CONCLUSION(S): Clinical application of UT has just begun, but more basic data are needed and medical, ethical, and social problems require thorough discussion before clinical application.
  Fertility and sterility 04/2013; · 3.97 Impact Factor
• Article: Uterine Transplantation: Towards Clinical Application.

  Iori Kisu, Kouji Banno, Makoto Mihara, Nobuhiko Suganuma, Daisuke Aoki
  Gynecologic and Obstetric Investigation 03/2013; · 1.28 Impact Factor
• Article: Experience of Risk-reducing Salpingo-oophorectomy for a BRCA1 Mutation Carrier and Establishment of a System Performing a Preventive Surgery for Hereditary Breast and Ovarian Cancer Syndrome in Japan: Our Challenges for the Future.

  Akira Hirasawa, Kenta Masuda, Tomoko Akahane, Tomohiko Tsuruta, Kouji Banno, Kazuya Makita, Nobuyuki Susumu, Hiromitsu Jinno, Yuko Kitagawa, Kokichi Sugano, Kenjiro Kosaki, Daisuke Aoki
  [show abstract] [hide abstract]
  ABSTRACT: BACKGROUND: Risk-reducing salpingo-oophorectomy is currently regarded as the most certain primary method for preventing ovarian cancer among BRCA1/2 mutation carriers with hereditary breast and ovarian cancer syndrome. However, risk-reducing salpingo-oophorectomy has rarely been performed in Japan. METHODS: We developed the first system in Japan for performing risk-reducing salpingo-oophorectomy for BRCA1/2 mutation carriers at our university hospital in 2008. RESULTS: The indication for risk-reducing salpingo-oophorectomy for patients with hereditary breast/ovarian cancer syndrome is currently limited in Japan. This situation may be because of the limited number of genetic counseling units, the limited number of facilities that can perform BRCA1/2 genetic testing and the fact that prophylactic surgery is not covered by health insurance in Japan. CONCLUSIONS: Recent treatment guidelines for breast cancer in Japan recommended risk-reducing salpingo-oophorectomy for BRCA1/2 mutation carriers. Risk-reducing salpingo-oophorectomy should be performed in the framework of the standard therapeutic modality for BRCA1/2 mutation carriers in the near future.
  Japanese Journal of Clinical Oncology 03/2013; · 1.78 Impact Factor
• Article: MicroRNAs in endometrial cancer.

  Kouji Banno, Megumi Yanokura, Iori Kisu, Wataru Yamagami, Nobuyuki Susumu, Daisuke Aoki
  [show abstract] [hide abstract]
  ABSTRACT: MicroRNAs (miRNAs) are small non-coding ribonucleic acids (RNAs) of approximately 22 bp that induce RNA interference with a complementary messenger RNA (mRNA) and act in silencing of mRNA. miRNAs are strongly associated with cancer development and those involved in carcinogenesis are classified into oncogenic miRNAs and tumor suppressor miRNAs (tumor suppressor miRs). Specific miRNAs are expressed in various tissues and changes in regulation of gene expression are thought to cause carcinogenesis. Thus, tissue-specific miRNAs may be biomarkers for cancer diagnosis and prognosis. Approaches to application of miRNAs as cancer therapy are also ongoing, based on the involvement of miRNAs in carcinogenesis. In endometrial cancer, miRNAs are associated with regulation of gene expression, epigenetic dysfunction and carcinogenesis. Thus, miRNAs are likely to have key roles in diagnosis, prognostic prediction, and therapy in endometrial cancer.
  International Journal of Clinical Oncology 02/2013; · 1.41 Impact Factor