Article: Migraine prophylaxis by anodal transcranial direct current stimulation, a randomized, placebo-controlled trial.Paradee Auvichayapat, Taweesak Janyacharoen, Alexander Rotenberg, Somsak Tiamkao, Thawatchai Krisanaprakornkit, Supat Sinawat, Wiyada Punjaruk, Bandit Thinkhamrop, Narong Auvichayapat[show abstract] [hide abstract]
ABSTRACT: Migraine is a common headache syndrome in adult populations. Prophylaxis is necessary to improve the quality of life but some patients with migraine have contraindication or suffer from side effects of medication, and therefore, establishing non-medical, neuromodulatory approaches is necessary. Past evidence had shown that consecutive motor cortex (M1) stimulation with anodal transcranial direct current stimulation (tDCS) was effective to relieve central pain. To determine whether 20 consecutive days of the left M1 can be an effective prophylactic treatment for migraine. Forty-two episodic migraine patients who had never received any prophylactic treatment, failed prophylactic treatment, or discontinued treatment due to adverse events were recruited in the present study. Patients were randomized to receive either active tDCS or sham tDCS 1mA, 20 m for 20 consecutive days and followed up for 12 weeks. Differences between and within groups were determined using repeated measures ANOVA. The level of significance was set at p < 0.05. Thirty-seven patients participated in the final analyses (active: n = 20, sham: n = 17). Between-groups comparison of attack frequency, pain intensity, and abortive medications used were performed at 4, 8, and 12 weeks after treatment. The results showed statistically significant reduction in attack frequency and abortive medications at week 4 and 8 after treatment. The pain intensity was statistically significant reduced at week 4, 8, and 12. All patients tolerated the tDCS well without any serious adverse events. The present study suggests that anodal M1 tDCS may be a safe and useful clinical tool in migraine prophylaxis. The mechanism of action of anodal tDCS on neuromodulation in migraine patients needs further investigation.Journal of the Medical Association of Thailand = Chotmaihet thangphaet 08/2012; 95(8):1003-12.
Article: Elevated plasma IL-6 associates with increased risk of advanced fibrosis and cholangiocarcinoma in individuals infected by Opisthorchis viverrini.Banchob Sripa, Bandit Thinkhamrop, Eimorn Mairiang, Thewarach Laha, Sasithorn Kaewkes, Paiboon Sithithaworn, Maria Victoria Periago, Vajarabhongsa Bhudhisawasdi, Ponlapat Yonglitthipagon, Jason Mulvenna, Paul J Brindley, Alex Loukas, Jeffrey M Bethony[show abstract] [hide abstract]
ABSTRACT: Opisthorchis viverrini is considered among the most important of the food-borne trematodes due to its strong association with advanced periductal fibrosis and bile duct cancer (cholangiocarcinoma). We investigated the relationship between plasma levels of Interleukin (IL)-6 and the risk of developing advanced fibrosis and bile duct cancer from chronic Opisthorchis infection. We show that IL-6 circulates in plasma at concentrations 58 times higher in individuals with advanced fibrosis than age, sex, and nearest-neighbor matched controls and 221 times higher in individuals with bile duct cancer than controls. We also observed a dose-response relationship between increasing levels of plasma IL-6 and increasing risk of advanced fibrosis and bile duct cancer; for example, in age and sex adjusted analyses, individuals with the highest quartiles of plasma IL-6 had a 19 times greater risk of developing advanced periductal fibrosis and a 150 times greater risk of developing of bile duct cancer than individuals with no detectable level of plasma IL-6. Finally, we show that a single plasma IL-6 measurement has excellent positive predictive value for the detection of both advanced bile duct fibrosis and bile duct cancer in regions with high O. viverrini transmission. These data support our hypothesis that common mechanisms drive bile duct fibrosis and bile duct tumorogenesis from chronic O. viverrini infection. Our study also adds a unique aspect to the literature on circulating levels of IL-6 as an immune marker of hepatobiliary pathology by showing that high levels of circulating IL-6 in plasma are not related to infection with O. viverrini, but to the development of the advanced and often lethal pathologies resulting from chronic O. viverrini infection.PLoS Neglected Tropical Diseases 05/2012; 6(5):e1654. · 4.69 Impact Factor
Article: Thai Clinical Trials Registry.[show abstract] [hide abstract]
ABSTRACT: The Thai Clinical Trials Registry (TCTR) was established in 2009 by a group of university academics. The Thailand Center of Excellence for Life Sciences has supported the registry financially, while the basic infrastructure including the administration, staff and computer servers has been provided by the Clinical Research Collaboration Network and the Medical Research Foundation. In December 2010, the Ministry of Public Health of Thailand endorsed the registry. In addition to the major purposes of reducing publication bias, promoting research transparency, and reducing redundancy in clinical research, TCTR aims to create a collective database of the clinical researches in Thailand, in order to help construct a pool database for local researchers.Journal of Evidence-Based Medicine 08/2011; 4(3):182-184.
Article: Ultrasonography assessment of hepatobiliary abnormalities in 3359 subjects with Opisthorchis viverrini infection in endemic areas of Thailand.Eimorn Mairiang, Thewarach Laha, Jeffrey M Bethony, Bandit Thinkhamrop, Sasithorn Kaewkes, Paiboon Sithithaworn, Smarn Tesana, Alex Loukas, Paul J Brindley, Banchob Sripa[show abstract] [hide abstract]
ABSTRACT: A cross sectional study on hepatobiliary abnormalities in opisthorchiasis was performed in 8936 males and females aged from 20 to 60 years from 90 villages of Khon Kaen province, Northeast Thailand. All were stool-examined for Opisthorchis viverrini infection by standard quantitative formalin/ethyl acetate concentration technique. Of these, 3359 participants with stool egg positive underwent ultrasonography of the upper abdomen. The hepatobiliary abnormalities detected by ultrasound are described here. This study found a significantly higher frequency of advanced periductal fibrosis in persons with chronic opisthorchiasis (23.6%), particularly in males. Risks of the fibrosis included intensity of infection, and age younger than 30 years. Height of left lobe of the liver, cross-section of the gallbladder dimensions post fatty meal, sludge, and, interestingly, intrahepatic duct stones were significantly associated with the advanced periductal fibrosis. Eleven suspected cholangiocarcinoma (CCA) cases were observed. This study emphasizes the current status of high O. viverrini infection rate and the existence of hepatobiliary abnormalities including suspected CCA in opisthorchiasis endemic areas of Thailand.Parasitology International 07/2011; 61(1):208-11. · 2.13 Impact Factor
Article: Association Between Infant Feeding Practices and First Meaningful Words at First Year of Life : A Prospective Cohort Study of Thai Children.[show abstract] [hide abstract]
ABSTRACT: Feeding practices show many benefits for child and cognitive development. The objective was to investigate the association between infant feeding practices and the first meaningful words of Thai children. The participants enrolled in this longitudinal study were 4245 children born between July 2000 and June 2002. They resided in 3 rural and 2 urban areas of Thailand and were followed from birth to childhood. The outcome was time from birth to expression of first meaningful words. Outcome and feeding information were gathered using a diary method, with parents and caregivers recording daily development. Nonstatistically significant corresponding reduction in time to expression of first meaningful words was found among children who were breastfed, and this increased with duration of breastfeeding. Breastfeeding may reduce the time taken for expression of first meaningful words by about 2% (hazard ratio = 0.98; 95% confidence interval = 0.94 to 1.01). No association between infant feeding practices and the expression of first meaningful words was found.Asia-Pacific Journal of Public Health 01/2011; · 1.06 Impact Factor