Avvarisanjeeva Kumar

Publications (7) View all

• Source

  Available from: Kattamanchi Gnananath

  Article: STIMULATION OF IMMUNE SYSTEM FUNCTION BY POLYSACCHARIDES OF MANILKARA HEXANDRA (ROXB.) BARK

  P Gomathi, A Sanjeev Kumar, R Prameela, K Kishorekumar, K Gnananath
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  ABSTRACT: The main aim of the present investigation was to evaluate the stimulating effect of polysaccharides from Manilkara hexandra bark on immune system. Firstly crude polysaccharides were extracted from Manilkara hexandra bark using standard procedure and the acute toxicity study was performed according to OECD guidelines. Polysaccharides at dose level of 250 and 500 mg/kg were administered seven days to the experimental animals orally and Septilin syrup was used as standard. At the end of seven days, blood was collected from retro orbital plexes and the immunomodulatory property was assessed using four methods, viz Humoral immune response, Cellular immune response, White blood cell count and Phagocytic index. The results were found that the polysaccharides from Manilkara hexandra bark significantly stimulating the immune system function. This activity may be due to the stimulation of macrophage function which is a known action of botanical polysaccharides.
  International Journal of phramacy and pharmaceutical sciences. 03/2012; 4(3-ISSN- 0975-1491):430-432.
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  Available from: Avvarisanjeeva Kumar

  Article: ANTI DIABETIC ACTIVITY OF ETHANOLIC EXTRACT OF Cynodon dactylon ROOT STALKS IN STREPTOZOTOCIN INDUCED DIABETIC RATS

  Avvari Sanjeeva, Kumar, Kattamanchi Gnananath, Doni Kiran, Anugu Madhukar Reddy, Raju Ch
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  ABSTRACT: Herbal medicines are products from medicinal plants and these are considered as safe since they are natural products. Herbal medicine is the oldest form of health care to mankind. There are as many as 700 species of medicinal plants used in herbal formulations available in India. Herbal medicines are alternative medicines used throughout the world and in the past herbs are often the original sources of most drugs. Today we are witnessing an increase in herbal remedy use throughout the western world raining the question as to how safe are these preparations. The British Herbal Medicine Association (BHMA) has been founded in 1964 and it engaged the legislation in productive discussion about the controls of herbal medicines. The present study was undertaken to evaluate the anti diabetic activity of ethanolic extract of Cynodon dactylon root stalks in Streptozotocin induced Diabetic Rats as this type of scientific documentation was not filed so far. The whole plant was collected and shade dried, root stalks were separated and grinded to get the root stalk powder. The extraction was carried using soxhlation procedure with petroleum ether and ethanol. This extract was subjected to preliminary Phytochemical screening using standard procedure. The anti diabetic activity of ethanolic extract of Cynodon dactylon root stalks was evaluated in streptozotocin induced diabetic rats using Tolbutamide as standard. The phyto chemical investigation shows the presence of alkaloids, carbohydrates, phytosterols, glycosides, saponins, phenolic compounds, Flavonoids and tri terpenoids. The anti diabetic activity of ethanolic extract of Cynodon dactylon root stalks was comparable with the standard drug. Our results showed a good anti diabetic activity of the extract against the treated model.
  International Journal of Advances in Pharmaceutical Research. 07/2011; 2(8):418-422.
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  Available from: Avvarisanjeeva Kumar

  Article: A COMPREHENSIVE REVIEW ON MARINE ALGAE AND THEIR MULTIDISCIPLINARY ACTIVITIES

  Avvari Sanjeeva, Kumar, S Nagarjuna, N Venkata Kullai Setty, Ch Raju, M Kashinath
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  ABSTRACT: The ocean, which is called the 'mother of origin of life', also the source of structurally unique natural products that are mainly accumulated in living organisms. Several of these compounds show pharmacological activities and are helpful for the invention and discovery of bioactive compounds, primarily for deadly diseases like cancer, Acquired immuno-deficiency syndrome (AIDS), arthritis, etc., while other compounds have been developed as analgesic or for treatment of inflammation, etc. Recent findings have demonstrated that indigenous marine algae exist in the ocean and are widely distributed in different marine eco systems. There is tremendous diversity and novelty among the marine algae present in marine environment. These marine algae produce different type of new secondary metabolites. Many of these metabolites possess biological activities and have potential to be developed as therapeutic agents. In the present paper various research reports on marine algae like, anti bacterial, immunomodulatory, antiviral, antimicrobial, anticancer, hemagglutinin, alkaline phosphatase, food supplement, gastro protective, hyalurudinase, natural preservative, anticoagulant, and antioxidant activities were discussed.
  International Journal of Advances in Pharmacy and Biological Sciences. 07/2011; 1(2):44-50.
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  Available from: Avvarisanjeeva Kumar

  Article: ANTI ULCER EFFECT OF ALANGIUM SALVIFOLIUM ETHANOLIC LEAF EXTRACT ON GASTRIC LESION INDUCED BY ETHANOL IN RATS

  Sreekanth .P, Sudhakara .K Gouse Basha .G, Murali .K, Sanjeeva Kumar .A
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  ABSTRACT: Herbalism is a traditional medicinal or folk medicine practice based on the use of plants and plant extracts. Alangium salvifolium, belongs to the family of Alanginaceae. Based on the ethno pharmacological literatures, the plant Alangium salvifolium has been selected to prove its anti ulcer property on experimental animal models. The phytoconstituents present in the plant were extracted by using different solvents of increasing polarity like n-hexane, chloroform, ethyl acetate, acetone, ethanol and water. The phytoconstituents were identified by various chemical tests which showed the presence of various phytoconstituents. The ethanolic extract of leaves of Alangium salvifolium was selected for the pharmacological screening and evaluated using mice for its toxicity. The LD50 was calculated by using Karber's method. The ED50 Key words: value was found to be 150 mg/kg body weight. By performing anti ulcer activity on male Wistar rats and screened pharmacologically for the anti ulcer activity. From our findings it can be concluded that the ethanolic extract of Alangium salvifolium has a significant anti ulcer activity at 400mg/kg and 800mg/kg dose. The results were comparable with that of standard and control groups. Herbalism, Ethanol induced ulcers, Anti ulcer activity, Alangium salvifolium.
  Asian Journal of Pharmaceutical and Clinical Research 09/2011; 4(2):112-114.
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  Available from: Avvarisanjeeva Kumar

  Article: Proximate Analysis and Comparative in vitro Anti microbial and Anthelminthic Activities of Different Parts of Tribulus terrestris Linn

  Sanjeeva Kumar, Rama Rao, Madhusudana Rao, Venkata Kullai
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  ABSTRACT: The medicinal properties of several herbal plants have been documented in ancient Indian literature and the preparations have been found to be effective in the treatment of diseases. Tribulus terrestris belongs to zygophyllaceae family, has long been a constituent in tonics in Indian Ayurveda practice, where it is known by its Sanskrit name, "gokshura." It's also used as an aphrodisiac in Ayurveda. Tribulus terrestris is one of the important herbs being used by human beings of long period and is available abundantly throughout India. However there was no scientific data available on the anti microbial and anthelminthic properties of different parts of Tribulus terrestris. Hence it is worthwhile to carry out preliminary phytochemical screening, proximate analysis which include moisture content, total ash and acid insoluble ash, and in vitro screening and comparison of anti microbial and anthelminthic activities of leaves, fruit and roots of Tribulus terrestris. Among all the three extracts, Tribulus terrestris fruit extract (FETR) was exerting significant and much better anti microbial and anthelmintic activities and the results obtained were comparable with those of standard.
  International Journal of Pharmaceutical Research and Development. 12/2011; 3(8):37-44.