Atsushi Tanemura

Publications (43) View all

• Article: Guidelines for the diagnosis and treatment of vitiligo in Japan.

  Naoki Oiso, Tamio Suzuki, Mari Wataya-Kaneda, Atsushi Tanemura, Miki Tanioka, Tomoko Fujimoto, Kazuyoshi Fukai, Tamihiro Kawakami, Katsuhiko Tsukamoto, Yuji Yamaguchi, Shigetoshi Sano, Yoshihiko Mitsuhashi, Chikako Nishigori, Akimichi Morita, Hidemi Nakagawa, Masako Mizoguchi, Ichiro Katayama
  [show abstract] [hide abstract]
  ABSTRACT: Vitiligo is an acquired pigment disorder in which depigmented macules result from the loss of melanocytes from the involved regions of skin and hair. The color dissimilarity on the cosmetically sensitive regions frequently induces quality of life impairment and high willingness to pay for treatment in patients with vitiligo. The Vitiligo Japanese Task Force was organized to overcome this situation and to cooperate with the Vitiligo Global Issues Consensus Conference. This guideline for the diagnosis and treatment of vitiligo in Japan is proposed to improve the circumstances of Japanese individuals with vitiligo. Its contents include information regarding the diagnosis, pathogenesis, evaluation of disease severity and effectiveness of treatment, and evidence-based recommendations for the treatment of vitiligo. The therapeutic algorithm based on the proposed recommendation is designed to cure and improve the affected lesions and quality of life of individuals with vitiligo.
  The Journal of Dermatology 02/2013; · 1.49 Impact Factor
• Article: Toxic epidermal necrolysis complicated by sepsis, haemophagocytic syndrome, and severe liver dysfunction associated with elevated interleukin-10 production.

  Toshifumi Yamaoka, Hiroaki Azukizawa, Atsushi Tanemura, Hiroyuki Murota, Tomoya Hirose, Koichi Hayakawa, Takeshi Shimazu, Naoki Wada, Eiichi Morii, Ichiro Katayama
  European journal of dermatology : EJD. 11/2012;
• Article: Positive link between STAT3 activation and Th17 cell infiltration to the lesional skin in vitiligo vulgaris.

  Atsushi Tanemura, Yorihisa Kotobuki, Saori Itoi, Tomoya Takata, Shigetoshi Sano, Ichiro Katayama
  Journal of dermatological science 06/2012; 67(3):207-9. · 3.71 Impact Factor
• Article: An extremely rare case of Merkel cell carcinoma metastasized to the duodenum.

  Atsushi Tanemura, Mayuko Nakano, Tetsuya Iwasaki, Akinori Yokomi, Noriko Arase, Mari Wataya-Kaneda, Masanori Miyazaki, Takayuki Yakushijin, Tetsuro Takehara, Ichiro Katayama
  European journal of dermatology : EJD. 05/2012; 22(4):568-70.
• Article: Periostin, a matricellular protein, accelerates cutaneous wound repair by activating dermal fibroblasts.

  Kanako Ontsuka, Yorihisa Kotobuki, Hiroshi Shiraishi, Satoshi Serada, Shoichiro Ohta, Atsushi Tanemura, Lingli Yang, Minoru Fujimoto, Kazuhiko Arima, Shoichi Suzuki, Hiroyuki Murota, Shuji Toda, Akira Kudo, Simon J Conway, Yutaka Narisawa, Ichiro Katayama, Kenji Izuhara, Tetsuji Naka
  [show abstract] [hide abstract]
  ABSTRACT: Cutaneous wound repair is a highly ordered and well-coordinated process involving various cell lineages and many molecular effectors. Cell-matrix interactions through integrin molecules provide key signals important for wound repair. Periostin is a matricellular protein that may provide signals important during tissue development and remodelling by interacting with several integrin molecules, via the phosphatidylinositol 3-kinase/Akt and MAP kinase pathways. In this study, we examined the role of periostin in the process of cutaneous wound repair using periostin-deficient mice and by analysing the effects of periostin on dermal fibroblasts. We first determined the expression profile and localization of periostin in a well-characterized wound repair model mice. Periostin was robustly deposited in the granulation tissues beneath the extended epidermal wound edges and at the dermal-epidermal junctions in wounded mice. Moreover, periostin-deficient mice exhibited delayed in vivo wound repair, which could be improved by direct administration of exogenous periostin. In vitro analyses revealed that loss of periostin impaired proliferation and migration of dermal fibroblasts, but exogenous supplementation or enforced periostin expression enhanced their proliferation. Combined, these results demonstrate that periostin accelerates the process of cutaneous wound repair by activating fibroblasts.
  Experimental Dermatology 05/2012; 21(5):331-6. · 3.54 Impact Factor