Topics (5)

Research experience

    • Jan 2011
      Research: Tehran University of Medical Sciences
      Tehran University of Medical Sciences
      Tehrān · Iran
  • Jun 2009–
    Jun 2011
    Research: Cabergoline versus Albumin in prevention of OHSS
    Royan · Department of Endocrinology and Female Infertility · Royan
    Ensieh Shahrokh Tehraninejad MD, Maryam Hafezi MD, Arezoo Arabipoor MSc, Elham Azimi nekoo MD, Akram Bahmanabadi BSc, Mohammad Chehrazi MSc · Tehran
    Albumin, Cabergoline, IVF Outcome, Ovarian Hyperstimulation Syndrome

Other

  • Languages
    Persian, English

Publications (4) View all

  • Article: Comparison of cabergoline and intravenous albumin in the prevention of ovarian hyperstimulation syndrome: a randomized clinical trial.
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    ABSTRACT: To compare the efficacy of cabergoline (Cb2) and intravenous human albumin (HA) in the prevention of ovarian hyperstimulation syndrome. In this randomized controlled trial study, 138 women who were at high risk for developing OHSS were randomly allocated into two groups. In Group one, 20 gr of HA 20% was infused over 1 h. Group two received 0.5 mg per day of Cb2 orally for 7 days, starting on oocyte pickup day. All patients were visited seven and 14 days after oocyte retrieval to determine early clinical or ultrasound evidence of OHSS. Moderate OHSS was observed in 33 versus 14 cases in the HA and Cb2 groups, respectively, which was significantly different. The number of severe OHSS cases in the HA group was significantly higher than in the Cb2 group (P < 0.001). Prophylactic oral low dose cabergoline was more effective and less costly than intravenous human albumin in the prevention of OHSS in high-risk patients.
    Journal of Assisted Reproduction and Genetics 03/2012; 29(3):259-64. · 1.84 Impact Factor
  • Article: A possible role for familial thrombophilia in women with polycystic ovarian syndrome.
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    ABSTRACT: The aim of this study is to evaluate familial thrombophilia factors in infertile patients with polycystic ovarian syndrome (PCOS). This analytic study was performed on 123 infertile women with PCOS as the case group, and 73 infertile women with male factor as the control group, who were under treatment. Blood samples were taken on the third day of the menstrual cycle for evaluation of protein S, protein C, antithrombin III, APC-resistance, homocysteine levels and additional metabolic and endocrine parameters for both groups. Comparisons between groups were performed by the t-test, and Fisher exact test. p<0.05 was accepted as statistically significant. Although the mean value of protein S and protein C in the case group was lower than the control group, there was no significance difference (p=0.752 and p=0.602, respectively). The mean of antithrombin III, activated protein C resistance (APC-R) and homocysteine levels in the two groups were not significant (p=0.756, p=0.603 and p=0.157, respectively). We were unable to determine a positive relationship between PCOS and thrombophilia. The existence of a possible trend towards high prevalence of thrombophilia in women with PCOS needs further research.
    Gynecological Endocrinology 02/2011; 27(2):80-5. · 1.58 Impact Factor
  • Source
    Article: A Successful Induction of Lactation in Surrogate Pregnancy with Metoclopramide and Review of Lactation Induction
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    ABSTRACT: In surrogate pregnancies genetic parents have little opportunity for early bonding with their infants, either prenatally (in utero) or during the immediate postnatal period. Procedures commonly used to induce lactation include both pharmacologic and nonpharmacologic methods, often in combination. Studies reporting induced lactation are sparse, due to the rarity of augmented lactation. Here we report a case of lactation induction following a surrogate pregnancy. Other methods that can be used to augment lactation are described below. We used metoclopramide in this case due to the success rates reported in previous studies and case reports. Additionally, it is a well tolerated and safe agent.
  • Article: Obstetric and neonatal outcomes of twin pregnancies conceived by assisted reproductive technology compared with twin pregnancies conceived spontaneously: a prospective follow-up study.
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    ABSTRACT: OBJECTIVE: To compare the obstetric and neonatal outcomes of twin pregnancies conceived by assisted reproduction technology (ART) with spontaneously conceived (SC) twin pregnancies. STUDY DESIGN: A prospective cohort study compared all dichorionic twin pregnancies in nulliparous women following fresh in vitro fertilization/intra-cytoplasmic sperm injection (ICSI) or ICSI cycles at Royan Institute (n=320) with SC dichorionic twin pregnancies in nulliparous women at Arash Women's hospital (n=170) from January 2008 to October 2010. These pregnancies were followed-up until hospital discharge following delivery. Obstetric and neonatal outcomes of SC and ART twin pregnancies were compared. RESULTS: Multivariate analysis, adjusted for maternal age and body mass index, revealed that the obstetric outcomes were similar in both groups. However, the risks of very preterm birth [odds ratio (OR) 5.2, 95% confidence interval (CI) 2.1-12.9], extremely low birth weight (OR 2.2, 95% CI 1.0-3.9), admission to a neonatal intensive care unit (OR 2.0, 95% CI 1.2-3.2) and perinatal mortality (OR 2.3, 95% CI 1.2-4.0) were higher in the ART group. CONCLUSIONS: The maternal outcomes of ART dichorionic twins were comparable with those of SC twins. However, despite the same obstetric management, the rates of very preterm birth, extremely low birth weight, admission to a neonatal intensive care unit and perinatal mortality were significantly higher in the ART group.
    European journal of obstetrics, gynecology, and reproductive biology 08/2012; · 1.97 Impact Factor

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