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  • Article: Femtosecond laser versus mechanical microkeratomes for flap creation in laser in situ keratomileusis and effect of postoperative measurement interval on estimated femtosecond flap thickness.
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    ABSTRACT: To prospectively compare laser in situ keratomileusis (LASIK) flaps created with a femtosecond laser or a mechanical microkeratome and analyze the effect of the postoperative measurement interval on estimated femtosecond flap thickness using ultrasound (US) pachymetry. Department of Ophthalmology, University Hospital of Coimbra, and Coimbra Surgical Centre, Coimbra, Portugal. Flaps were created with a Hansatome Zero Compression microkeratome (Group 1), Zyoptix XP keratome (Group 2), or IntraLase 60 kHz femtosecond laser (Groups 3 and 4). Flap thickness was determined by intraoperative US pachymetry immediately after flap creation in Groups 1, 2, and 3. In Group 4, pachymetry was performed 20 minutes after the laser treatment. The main outcome measures were flap thickness and deviation from the target value. Eighty patients had LASIK for myopia or myopic astigmatism. The mean flap thickness was 149.1 microm +/- 24.9 (SD) in Group 1, 124.7 +/- 23.8 microm in Group 2, 143.1 +/- 18.4 microm in Group 3, and 115.5 +/- 12.5 microm in Group 4. The difference in flap thickness between Group 3 and Group 4 was statistically significant (P<.01). The flap thickness deviation from the target value was 22.8 microm in Group 1, 19.0 microm in Group 2, 26.1 microm in Group 3, and 10.4 microm in Group 4. Results indicate that the time of measurement after femtosecond affects the estimated flap thickness. Waiting 20 minutes after laser treatment permitted easier separation and may eliminate the effect of variable corneal dehydration on flap measurement by subtraction pachymetry.
    Journal of cataract and refractive surgery 05/2009; 35(5):833-8. · 2.75 Impact Factor
  • Article: Bilateral nanophthalmos and pigmentary retinal dystrophy--an unusual syndrome.
    Helena Proença, A Castanheira-Dinis, M Monteiro-Grillo
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    ABSTRACT: To report the clinical picture of the rare association of nanophthalmos and pigmentary retinal dystrophy and its cataract surgery outcome. We report a case of a 60-year-old female who presented with bilateral slowly progressive visual loss. The patient presented with bilateral light perception visual acuity, exotropia, brunescent cataract hindering fundus examination and hypodontia. Ultrasonography revealed bilateral nanophthalmos. A visual-evoked potential was also performed preoperatively. Cataract surgery with +40D IOL implantation was uneventful. Postoperative fundus examination revealed pigmentary retinal dystrophy, confirmed by electrophysiologic tests. Glycosaminoglycan urinary excretion was normal. Congenital bilateral nanophthalmos may rarely be associated with pigmentary retinal dystrophy. We suggest thorough preoperative evaluation in nanophthalmic eyes for the exclusion of significant features concerning visual prognosis.
    Albrecht von Graæes Archiv für Ophthalmologie 10/2006; 244(9):1203-5. · 2.17 Impact Factor
  • Article: Visual function in neurofibromatosis.
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    ABSTRACT: To evaluate the visual function in patients with neurofibromatosis (NF) and to study the etiology and incidence of visual dysfunction associated with NF. A total of 75 patient with diagnostic criteria for NF were evaluated. Neuro-ophthalmological examination as well as electrophysiological and imaging studies were performed. Special attention was given to the presence of visual dysfunction and to its correlation with the ophthalmic changes that were found. Ocular findings were present in 42 (56%) patients. Visual dysfunction was identified in only 11 (14.7%) patients. Visual acuity decrease was the most prevalent change, being present in eight (72.7%) of patients with visual dysfunction. Nystagmus, strabismus, visual field defects, and color vision defects were also detected. Therapy is also reviewed. The prognosis of the 11 patients with visual dysfunction was unfavorable, and is discussed. The prevalence of NF and ophthalmological findings related to it make the problem of visual dysfunction in NF a serious one, deserving of the attention of all ophthalmologists. Clinical examination, associated with complementary diagnostic techniques (mainly imaging studies), allows NF's identification, definition, and therapy. The high prevalence of asymptomatic ocular findings in NF (73.8%) highlights the role of imaging techniques in its evaluation.
    Journal of Neuro-Ophthalmology 01/1997; 16(4):234-40. · 1.45 Impact Factor
  • Article: Congenital optic disc deformities. A clinical approach.
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    ABSTRACT: Different kinds of optic disc deformities are considered in this paper. These optic disc deformities include the tilted disc, the morning glory syndrome, the optic pit and the typical coloboma. All of these optic nerve deformities are probably typical and atypical optic disc colobomas. A clinical approach of these typical and atypical colobomas included different tests: angiography, electrophysiology and psychophysics. The genetic characteristics of these colobomas are considered.
    Ophthalmic paediatrics and genetics 03/1985; 5(1-2):67-70.
  • Article: Electrophysiological studies before and after argon-laser photocoagulation in diabetic retinopathy.
    J François, A De Rouck, E Cambie, A Castanheira-Dinis
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    ABSTRACT: 50 eyes with diabetic retinopathy were studied before and after treatment with argon-laser coagulation. After treatment, decreases of the L/D ratios of the EOGs and of the amplitudes of all ERG components were found. The scotopic b waves were more involved than the photopic b waves. The peak times were hardly modified. The dark-adaptation curves were not modified. Interesting was the fact that in the pretreatment findings the EOGs were involved before the ERGs. The decreases of the L/D ratios started when avascular and ischemic zones were seen on fluorescein angiography.
    Ophthalmologica 02/1977; 176(3):133-44. · 1.42 Impact Factor

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