Anthony Melvin Crasto Dr.
Glenmark scientist helping millions with websites, million hits on google
Research skills
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TechnicalTo carry out research and development activity in the field of Organic Chemistry, to make profit for the organization, motivate, guide & lead a team of scientists, conduct literature search, identify and execute new/novel routes for the synthesis, scale up from grams to kilo levels in lab., conduct pilot trials and assist in production upto ton levels. Carry out impurity profiles and assist in dossier writing. All the above being done keeping in mind the regulatory, Safety, environmental issues. To keep in mind IPR issues and draft patents, Commercial aspects taken care are the time schedules, quality parameters and cost factors. All this with a view of non infringement and confidentiality. Simultaneously develop business acumen and convert to profits.file DMFS in US and EU, file patents and contribute to intellectual property
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ITOTHER COURSES, 1. Part time Certificate course in Basic Computer Programming from Students Computer land – Mulund Bombay (First Class, 2. Part time Certificate course in General Electronics from Bombay Inst. Of Tech. – Mulund – Bombay., 3. Postgraduate Diploma Course in Industrial and Analytical Chemistry from Ruia College – Matunga (1986-1987 – Grade A, Course included, Electroanalytical Technology, Microbiology, Spectroscopy, Separation Technology, Statistics, packing, Air-water analysis, Management, 4. Diploma Course in Business Management from Prin-L.N.Welingkar Inst. Of Management, Research & Development, Matunga Bombay (Aug. 1989 – 1990 – Grade A, Courses included, Marketing Research and Advertising, Marketing Management, Personnel Management, Office Management and Administration, Managerial Economics, Financial and Cost Accounting, industrial law, Principles and Practice of Management, Organizational Behavior, Stores Management and Inventory Control
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OtherEXPERIENCE: (academic 1987-1991, 4years) (Industry 1991-CURRENT, 19+, years) total=23+ yrs, 1 Currently working as Principal Scientist, Process research(Bulk Actives) with GLENMARK PHARMACEUTICALS LTD research centre, API division at Mahape, Navi Mumbai, India job involves research and development work on APIs from lab to commercial production, support for DMF filing, in the process develop novel non infringing routes and file patents, dec05-present, 2 Worked as Sr Manager R&D with Innovassynth technologies Limited, Khopoli, India (formerly IOC ltd) and led a team of 20 chemists for the custom synthesis business in the area of drugs, organic intermediates, Specialty Chemicals, flavours and fragrances, nutraceuticals and mettalocenes. (25 projects) This included rapid development, scale up and commercialization as per the needs of the foreign clients with a time frame.(may03-dec05----2 yrs 7 months, 3 Worked as a Manager (R&D) at RPG Life Sciences Ltd ( formerly Searle India ltd). Thane Belapur. INDIA The job involved all aspects of synthesis and commercialization from research lab to production, including third party activities. (Oct. 1997- may2003, 5 years 6 months, 4 Worked as an Executive, process development at German multinational Hoechst Marion Roussel Ltd, NOW SANOFI-AVENTIS)Mulund, Mumbai, India in the QA dept, GMP section (Feb.1997 – oct. 1997, 8 months, 5 Worked as an Executive, QA/GMP at a German multinational Hoechst Marion Roussel Ltd, Mulund, India in the Process Development Team. (Jan1993 - Jan1997, 4 years, 6 Carried out Synthetic Research work as a Management trainee (R&D) at an American multinational Searle India ltd, Research and development centre, Thane, India (Now RPG Life Sciences Ltd) (May 1991 to Dec. 1992, 1 year 7 months, 7 Worked as Indian Organic chemicals research fellow at UDCT Matunga, for PhD programme(organic chemistry) on the topic “ Synthesis of novel pyrethroids analogues”. Simultaneously did project work for IOC.(1987-1991
Research interests
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InterestsSynthesis, Process Development, Natural Product Chemistry, Spectrometry, Drugs, Process, GMP, Polymorphism, API, Reaction Mechanisms, Process Research, Custom Synthesis, Synthesis Of Medicinal Compounds, Polymorphs, Reactions, Matunga, Intellectual Property Management, Reagents, Business Management, Analytical, Chromatography, Computers, Patents, scaleup, DMF filing, RPG Life Sciences (5.7yrs), HOECHST MARION ROUSSEL/sanofi aventis (GMP dept, HOECHST MARION ROUSSEL (Process Devl. dept, SEARLE INDIA Ltd (1.7 yrs), Indian Organic Chemicals Research Fellow, UDCT, IMPURITIES, SEPERATIONS, GLENMARK-GENERICS LTD, MUMBAI INDIA BASED, INNOVASSYNTH TECH LTD, High Performance Liquid Chromatography (HPLC)
Research experience
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Jan 1987
Research: DR A.M. CRASTO
MUMBAIEXPERIENCE: (academic 1987-1991, 4years) (Industry 1991-CURRENT, 20+ years) total=24+ yrs
Education
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Jan 1987–
Apr 1991Mumbai university dept. of chem. technology
Ph.D Organic chem.India · Matunga, Mumbai -
Jun 1984–
Aug 1986MUMBAI UNIVERSITY
MSc Organic chemistryIndia · Mumbai
Other
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Other Interestscreating organic chemistry websites, free and advertisement free, million hits already
Publications
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Method for preparation of 2, 3-diaryl-5-substituted pyridines and their intermediates
Ref. No: PCT Int. Appl. (2011), WO 2011158250 A1 20111222
Year: 01/2012
Method for preparation of 2, 3-diaryl-5-substituted pyridines and their intermediates
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Method for preparation of dronedarone via palladium-catalyzed hydrogenation and methanesulfonylation
Ref. No: PCT Int. Appl. (2012), WO 2012007959 A1 20120119
Year: 01/2012
Method for preparation of dronedarone via palladium-catalyzed hydrogenation and methanesulfonylation
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ANTHONY CRASTO PHARMACEUTICALS SITE
GOOGLE. 01/2011;
https://sites.google.com/site/anthonycrastoorganicchemistry/
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ANTHONY CRASTO ORGANIC CHEMISTRY, COPY PASTE LINK ON BROWSER
GOOGLE, https://sites.google.com/site/anthonycrastoorganicchemistry/. 01/2011;
https://sites.google.com/site/anthonycrastoorganicchemistry/
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Title:AMORPHOUS BAZEDOXIFENE ACETATE AND PREPARATION THEREOF
Ref. No: US 20100310870
Year: 01/2010
The present invention relates to amorphous form of bazedoxifene acetate and a process for the preparation thereof.
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A PROCESS FOR THE PREPARATION OF ATOVAQUONE CRYSTALLINE
Ref. No: 1742/MUM/2007 A
Year: 01/2009
The present invention provides a process for the preparation of Atovaquone in a pure polymorphic form characterized by an X-ray powder diffraction pattern with peaks at about 7.0, 9.7, 14.2, 14.8, 17.0, 19.2, 20.4, 22.1, 22.7, 26.9 and 28.7�0.2 degrees 2 theta comprising: a) providing a solution of ... [more] The present invention provides a process for the preparation of Atovaquone in a pure polymorphic form characterized by an X-ray powder diffraction pattern with peaks at about 7.0, 9.7, 14.2, 14.8, 17.0, 19.2, 20.4, 22.1, 22.7, 26.9 and 28.7�0.2 degrees 2 theta comprising: a) providing a solution of atovaquone in aprotic polar solvent b) adding a suitable antisolvent to precipitate atovauone c) isolating the resultant solid. No. of Pages : 23 No. of Claims : 10
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IMPROVED PROCESS FOR THE PREPARATION OF TADALAFIL
Ref. No: 1135/MUM/2006 - Published: 2008-07-18 - GLENMARK PHARMACEUTICALS LIMITED
Year: 07/2008
IMPROVED PROCESS FOR THE PREPARATION OF TADALAFIL,A process for the preparation of (6R,12aR)-2,3,6,7,12,12a-hexahydro-2methyl-6-(3,4-methylenedioxyphenyl)pyrazino1’,2’;1,6pyrido3,4-bindole-1,4-dion of Formula I: the process comprising cyclizing a ...... [more] IMPROVED PROCESS FOR THE PREPARATION OF TADALAFIL,A process for the preparation of (6R,12aR)-2,3,6,7,12,12a-hexahydro-2methyl-6-(3,4-methylenedioxyphenyl)pyrazino1’,2’;1,6pyrido3,4-bindole-1,4-dion of Formula I: the process comprising cyclizing a ...
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Amorphous eprosartan mesylate and process for the preparation thereof
Ref. No: United States Patent Application 20080014263
Year: 01/2007
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A PROCESS OF PREPARATION OF METHANAMINE-N-[4(3,4-DICHLOROPHENY)-3,4-DIHYDRO-1(2H)-NAPHTHALENYLIDENE
Ref. No: Application No.243/BOM/1999 A
Year: 01/1999
A process for the preparation of methanamine-N-[4(3,4-dichlorophenyl)]-3,4-dihydro-1(2H)-naphthalenylidene, a critical intermediate in the synthesis of cis-(1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1- naphthylamine hydrochloride generally knwon as sertraline hydrochloride which is a... [more] A process for the preparation of methanamine-N-[4(3,4-dichlorophenyl)]-3,4-dihydro-1(2H)-naphthalenylidene, a critical intermediate in the synthesis of cis-(1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1- naphthylamine hydrochloride generally knwon as sertraline hydrochloride which is an anti-depressant and anorectic agent. Tetralone is condensed with methylamine in the presence of an aliphatic alcohol at 30-60ºC.
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Heterocyclic Analogues of Pyrethroids
Thirteenth International Congress of Heterocyclic Chemistry, held at Corvallis, Oregon (U.S.A.) Abstract No. GE-11-129; 01/1991
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Synthesis of Novel & Chloromethyl esters via Regiospecific ring opening reactions of aryl glycidyl ethers with acid chlorides and the synthesis of alpha- morpholino methyl and alpha- cyano methyl esters
Paper presented at the 3rd Research Scholars Meeting, Indian Chemical Society, Feb. 1991., TIRUPATI, INDIA; 01/1988
Following (2291)
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Najma Sultana
University of Karachi -
Joke Hadermann
University of Antwerpen -
N.Priyadharshini Natarajan
Indira Gandhi Centre for Atomic Research -
Nutan Chauhan
Birla Institute of Technology, Mesra