Andrzej Kuźmiński

Eosinophilic gastroenteritis (EGE) is a relatively rare disease, but it should be considered whenever a patient presents with unexplained gastrointestinal symptoms that cannot be explained by parasitic infection or other gastrointestinal diseases characterized by eosinophilic infiltration. A high coexistence of EGE and allergic diseases has been do...

Treatment of eosinophilic gastroenteritis (EGE) is mainly empirical and is based on the assessment of symptom severity and the experience of clinicians. Patients with mild disease can be treated symptomatically, while patients with more severe symptoms or malabsorption symptoms require more aggressive therapy. So far, several therapeutic options ha...

Food protein induced enterocolitis syndrome (FPIES) belongs to a group of IgE-independent food allergies. It is the domain of paediatric patients, but it can also occur in adults. In this disease there is a life-threatening risk resulting from the possibility of a severe course of the disease and the development of hypovolemic shock. The disease wa...

Background An allergy to kiwi is rare in Poland. Most (65–72%) of the patients who are allergic to kiwi report symptoms of an oral allergy syndrome (OAS); however, systemic manifestations (18–28%) have also been reported. Case report A 27-year-old male patient, previously not suffering from chronic diseases, exercised in the gym. He began with iso...

From a botanical point of view, a nut is a kind of dry, closed, unbroken, single-seeded fruit, which has a ligneous pericarp made up of several fruiting bodies surrounded by one free semen. The term “allergy to tree nuts” includes allergies to almonds, Brazil nuts, cashew nuts, hazelnuts, chestnuts, macadamia nuts, pecan nuts, pistachios and walnut...

Background Levels of specific IgE (sIgE) against allergen components can be assessed using multiplex assays or with highly sensitive, quantitative methods. The aim of this study was to compare the sensitivity and specificity of different immunological methods for diagnosis of shrimp allergy. Methods Twenty patients with positive skin prick tests f...

Eosinophilic esophagitis (EoE) belongs to a broad group of allergic gastrointestinal diseases. More narrowly, it is classified as an eosinophilic gastrointestinal disease and is its most common representative. Until recently, this disease was extremely rare, but the last 3 decades have seen a rapid increase in its prevalence to such an extent that...

Diagnosis of food allergy is often very difficult. Patients report numerous symptoms that are sometimes difficult to associate with a specific kind of food. Despite the development of immunological diagnostic methods, most importantly the increasing availability of component resolved diagnosis, in vivo tests, in particular oral challenge tests, are...

Clinical symptoms of food allergy may affect not only the digestive tract, but also the respiratory system, skin, or cardiovascular system. They may manifest themselves as gastrointestinal problems, asthma attacks, hives, or anaphylactic shock. Allergic reactions of the gastrointestinal tract may be IgE-independent (oral anaphylaxis syndrome, acute...

Background Component resolved allergen diagnosis allows for a precise evaluation of the sensitization profiles of patients sensitized to felines and canines. An accurate interpretation of these results allows better insight into the evolution of a given patients sensitizations, and allows for a more precise evaluation of their prognoses. Methods70...

Lymphocytes Th17 and other types of immune system cells produce IL17. By induction of cytokines and chemokines, the IL17 cytokine is involved in mechanisms of allergic reaction with participation of neutrophil granulocytes. It affects activation, recruitment, and migration of neutrophils to the tissues, regulating inflammatory reaction intensity. E...

Vipera berus bites lead to a variety of clinical manifestations. Local swelling, coagulopathy, nephrotoxicity, cardiac effects and myotoxicity are known to be associated with envenoming by a viper bite. Although a variety of clinical manifestations have been reported in viper bite cases, anaphylactic reactions and liver injury events have not been...

The prevalence of food allergies and other allergic reactions is increasing worldwide, particularly in highly-urbanized populations. Cell adhesion molecules are expressed in response to various pro-inflammatory cytokines. The expression of intercellular adhesion molecule 1 - ICAM-1 (CD54), ICAM-1 (CD106), P-selectin (CD62P), and E-selectin (CD62E)...

During the migration to the site of inflammation, allergic inflammatory cells must overcome several structures that constitute an impregnable barrier under normal conditions. One such structure is the extracellular matrix responsible for closely filling the intercellular space of tissues. The loosening of this tight structure by the activity of spe...

Introduction: Neutrophilic granulocytes (neutrophils) are the most important cells of the non-specific immune response. These cells have the capability of chemotaxis and phagocytosis and also participate in inflammatory processes. Stimulated neutrophils or reactive oxygen species (ROS) and elastase, important mediators of the inflammatory process r...

Introduction: The purpose of this paper is to present the level of protease-antiprotease balance disorder with patients hospitalised for acute COPD depending on the stage of the condition in relation to smokers and non-smokers. Materials and Methods: The research was carried out on 61 patients with COPD. They consisted of 27 women and 34 men; 32 sm...

5-aminosalicylates are extensively prescribed for the treatment of ulcerative colitis but have a wide range of described adverse effects. Preparation of 5-aminosalicylates can also induce acute pancreatitis. The article is a description of a 18-year-old woman case, being treated with oral mesalazine for ulcerative colitis, developed upper abdominal...

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are variants of the same process. In SJS, epidermal detachment involves less than 10% of the total body skin area; the SJS-TEN overlap is said to represent an epidermal detachment between 10 and 30%; TEN is associated with a detachment greater than 30%. SJS-TEN is an acute, potenti...

Introduction. The concentration of eosinophil cationic protein (ECP) in the serum can reflect the intensity of the inflammation in bronchial tree, however its clinical value as a marker of asthma is controversial. Recent studies suggest that also disturbances of the protease-antiprotease balance may play a role in the pathogenesis of asthma. Aim of...