Skills (31)
Education
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Aug 2008–
Aug 2010Biju Patnaik University of Technology
M.Pharm in PharmacologyIndia · Berhampur, Orissa
Other
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LanguagesBengali, English, Hindi, Oriya.
Publications (9) View all
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Dataset: EVALUATION OF ANTI-DIARRHOEAL ACTIVITY OF ETHANOLIC LEAF EXTRACT OF SCOPARIA DULCIS LINN ON WISTER ALBINO RATS
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ABSTRACT: The objective of the study was to find out the ethanolic extract of the leaves of Scoparia dulcis Linn for antidiarrhoeal effects on Wister albino rats. The extract was evaluated for castor oil-induced diarrhoea and intestinal transit in rats by charcoal meal. S. dulcis Linn. Significantly (p<0.05) and dose-dependently reduced frequency of stooling in castor oil-induced diarrhoea and intestinal motility in rats. The oral LD 50 values obtained were greater than 2000mg/ kg in Wister albino mice. These findings suggest that the ethanolic extract of the leaves of S. dulcis Linn may contain some biologically active ingredients that are useful for the treatment of diarrhoea in Indian herbal traditional medicine. -
Article: "In Vitro and In Vivo Evaluation of Polyherbal Formulation against Russell’s Viper and Cobra Venom and Screening of Bioactive Components by Docking Studies," Evidence-Based Complementary and Alternative Medicine"
Evidence-based Complementary and Alternative Medicine 01/2013; · 4.77 Impact Factor -
Article: Protective Role of Methanolic And Aqueous Extracts of Cucurbita moschata Linn. Fruits In Inflammation and Drug Induced Gastric Ulcer In Wister Rats.
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ABSTRACT: To validate the science behind the traditional use of Cucurbita moschata Linn. fruits in Indian system of traditional medicine to treat inflammation and gastric ulcer, present study was designed to explore the protective effect of methanolic and aqueous extracts of Cucurbita moschata fruits against inflammation and drug induced gastric ulcer. Both the extracts exhibits dose dependent (200mg/kg and 400mg/kg) protection against acute inflammation (Carrageenan induced inflammation) and chronic inflammation (cotton pellet granuloma) in experimental animals, these extracts also shows significant activity against hard liquor and drug (Aspirin) induced gastric ulcers in albino rats. To support activity and to find the mechanism of action free radical scavenging activity of the extracts has also been studied. The test extracts shows free radical scavenging activity with IC50 value of 39.85 μg for methanolic extract and 12.30 μg for aqueous extract. Moreover both the test extracts has not shown any abnormality and mortality up to 2000mg/kg p.o. in experimented animals, when evaluated for acute toxicity study. The results of the present investigation suggest that Cucurbita moschata Linn. fruits having anti-inflammatory and antiulcer activity, and this could be the next generation safe and effective anti-inflammatory drug which helps in protection against drug induced ulcers.International Journal of PharmTech Research 12/2012; -
Conference Proceeding: Effect of hexane extract of Zingiber zerumbet (Zingiberaceae) rhizomes on acute inflammation: a rich source of novel free radical scavenger
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ABSTRACT: Zingiber zerumbet (L.) Sm. commonly known as Singkha, Namna and Haijung in Manipuri, is a useful Zingiberaceae plant. Zerumbone, a sesquiterpene compound of phytomedical interest was quantified from hexane extract of Z. zerumbet (HXZZ) rhizomes by HPLC method. Antioxidant activity of the extract was determined by reducing power and superoxide anion radical scavenging methods. Antiinflammatory activity was determined by COX inhibition assay (in vitro), and carrageenan induced inflammation (in vivo) in rats. HPLC data shows the presence of 466.59 µg of zerumbone/ml of the extract. In in-vitro antioxidant assay, EC50 value of reducing power and IC50 value of superoxide anion scavenging activity was found to be 152.05 µg and 844.02 µg respectively. In carrageenan induced inflammation model HXZZ shows a significant (p<0.001) inhibition in paw edema as compared to control, and in in-vitro assay, HXZZ inhibited both the COX enzymes, but COX-II inhibition was higher as compared to COX-I. The anti-inflammatory action of HXZZ was further substantiated by hemodynamic assay of rat paw fluid. The present study shows that Z. zerumbet can be a source of lead antiinflammatory drug candidate in future.6 th International Zingiberaceae Symposium 2012, Kerala, India; 09/2012 -
Article: Antihyperglycemic effect of Aqueous and Ethanol extract of Aerial part of Osbeckia nepalensis Hook in Alloxan induced Diabetic rats
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ABSTRACT: Aqueous and ethanolic extract of Osbeckia nepalensis Hook was evaluated for the antihyperglycemic activity in alloxan induced diabetic rats. Hyperglycemic was confirmed to Albino rats (150- 200 g) by treated with alloxan upto 320.6 ± 3.59 at 1 hr, 445.6 ± 4.23 at 5 days from non treated rats of 316 ± 3.56± mg/ dL. A significant hypoglycemic activity of aqueous and ethanolic extract was confirmed in alloxan induced diabetic rats (P<0.001). The serum glucose level of alloxan induced diabetic rats reduced upto 312.2 ± 3.65 and 232 ± 3.05 mg/dL at 1 hr and 120 hrs from 359±3.8 mg/ dL in aqueous extract and 320.6 ± 3.59, 445.6 ±4.24 mg /dL at 1 hr and 120 hrs. after treatment from 330 ± 3.64 mg/ dL before treatment in ethanolic extract of the test herbal. The aqueous and ethanolic extract of Osbeckia nepalensis enhance the checking of reduction in weight in comparision to normal and diabetic control animals. Further in the present work, phytochemicals of antioxidant (IC50 23 μg/ml ); saponin (20.0 ± 0.89 mg/g); flavonoid (38.28 mg/g) and minerals of K, (6.02 ± 0.51); N(22.1± 0.94); P(0.53±0.14) and Co (N.D) have screened out from the methanolic extract of Osbeckia nepalensis suggesting a unique supportive to the health care ingredients. The extracts both in aqueous and ethanolic substantiates for pharmaceutical formulation upto 4000 mg/kg oral toxicity.International Journal of PharmTech Research 01/2012; 4(1):233-244.
