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  • Article: Improving active contour methods for tracking endothelial cells by the removal of low-confidence edge segments.
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    ABSTRACT: Previously we developed an active contour method for segmenting and tracking cells in phase-contrast microscopy images. Our method is capable of fine-grained segmentation on noisy image sequences. In this paper, we improve the active contour segmentation model to provide better accuracy, by selectively identifying areas of the contour with low confidence and removing them. The method is applied to HMEC-1 cells (human microvascular endothelial cells). The segmentation provided by the method is quantitavely compared with manually-drawn contours, showing close fit and capability to 'lock' on to cell boundaries for hundreds of frames.
    Conference proceedings: ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 08/2012; 2012:5368-71.
  • Source
    Article: Letter to the Editor
    AIChE Journal 01/2012; 58(12):3930-3930. · 2.26 Impact Factor
  • Article: 3-D Modeling of nitric oxide emission and vasodilation induced by CA3 hippocampal neurons.
    Alireza Nejati, Charles P Unsworth
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    ABSTRACT: The modeling of the spread, diffusion, and decay of chemicals in the brain is a complex problem that is made difficult by the fact that the structures that produce chemicals (synapses etc.) may be very small in comparison to their radii of chemical influence. In this article, we concentrate on modeling a simple instance of this problem; that of a proficiently diffusing molecule that may cause changes in smooth muscle contractions over relatively large areas. An optimized diffusion system was developed to study the diffusion of neuronal nitric oxide. Our diffusion system allows us to model the spread of nitric oxide from all areas of neurons, including the soma and dendritic processes. In addition, our system allows us to model tiny diffusing structures without sacrificing large-scale granularity. To study the effect of NO-producing neurons on vasodilation, we simulate systems of 1 and 2 neurons. We show that it is possible for nitric oxide emitted from neurons to be involved in regulating blood flow.
    Conference proceedings: ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 08/2011; 2011:708-11.

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