Skills (3)
Other
-
LanguagesEnglish, Indonesia, Deutsch
-
Scientific MembershipsMalaysian Society of Parasitology and Tropical Medicine
-
Other InterestsParasitology, Ecology, Entomology, Biodiversity
Publications (2) View all
-
Dataset: The Detection of Point Mutation in Voltage Gated Sodium Channel Gene using Polymerase Chain Reaction in Resistant Synthetic Pyrethroid Aedes aegypti in Palembang
-
Dataset: DETEKSI MUTASI GEN VOLTAGE GATED SODIUM CHANNEL Aedes aegypti SEBAGAI PENANDA RESISTENSI INSEKTISIDA SINTETIK PIRETROID
[show abstract] [hide abstract]
ABSTRACT: Aedes aegypti is the vector of various pathogens, including, yellow fever virus, and dengue virus. More than 100 countries had experienced 500.000 dengue hemorrhagic fever cases (DHF) occur annually throughout the world with an average of 24,000 deaths cases. Until now, drug or vaccine yet to be discovered and vector control is an alternative way to break the chains of disease. The use of insecticides have managed to lower the case but unfortunately there have been some outbreak events, is alleged due to the insectisida resistance. Insecticides resistance can be detected in two ways, through the detection of changes in detoxification enzymes and of gene mutations in voltage gated sodium channel. Detection of enzymes means that the amount of enzymes that detoxify are found elevate in the biochemical essays. The enzyme elevation will make the amount of insecticide is reduced and not capable of killing capability. Detection using an enzyme shown to be effective way but that there are also resistance that not accompanied with the enzyme elevation, alleging that related with mutation. The second insecticide detection is in gene mutations in voltage gated sodium channel gene (VGSC) which can detect changes in the insecticide target cells. The first target cell mutation is reported on the Musca domestica flies, where the flies enzymatic is not elevated but it has been resistant to the insecticide spraying. In Aedes aegypti, the point mutation genes related to insecticides resistance are found in seven point mutations, one of them will be described in this literature review.
