Agnieszka Kordek
Research interests
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InterestsPediatric, Neonatal Intensive Care Units, Neonatal Resuscitation, Neonatal medicine, Neonatal Hyperbilirubinemia, Neonatal Sepsis, Neonatal Screening, Neonatal, Neonatal Diseases Abnormalities Congenital, Neonatology
Publications
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1.59Impact points
Possible counter effect in newborns of 1936A>G (I646V) polymorphism in the AKAP10 gene encoding A-kinase-anchoring protein 10.
Journal of perinatology : official journal of the California Perinatal Association. 06/2011; 32(3):230-4.
Objective:Cyclic adenosine monophosphate/protein kinase A (PKA) is important in embryonic development. The human AKAP10 gene is polymorphic: 1936A>G results in changes to a PKA-binding domain and increased targeting to mitochondria. Previous studies found G1936 as 'deleterious' in adults,... [more] Objective:Cyclic adenosine monophosphate/protein kinase A (PKA) is important in embryonic development. The human AKAP10 gene is polymorphic: 1936A>G results in changes to a PKA-binding domain and increased targeting to mitochondria. Previous studies found G1936 as 'deleterious' in adults, and this study investigates whether this holds true in preterm birth.Study Design:Study group consisted of 80 preterm newborns (PTNs) born before the 38th gestation week. Control group consisted of 123 full-term healthy newborns born after the 37th gestation week with uncomplicated pregnancies. Genomic DNA was extracted from umbilical blood and AKAP10 genotypes were identified by PCR/restriction enzyme.Result:Significant differences in frequencies of 1936A>G genotypes/alleles between both groups were found. PTNs had increased frequency (55%) of AA homozygotes (odds ratio, AA versus AG+GG: 2.63 (95% confidence interval: 1.33 to 5.20), P=0.006) after adjustments: mothers with previous PTNs, smoking, first pregnancy, first delivery and Cesarean section.Conclusion:Results suggest G1936 is preventative factor against preterm birth, in contrast with previously asserted negative effects in adults.
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The role of hemoglobin variant replacement in retinopathy of prematurity.
Indian journal of pediatrics. 06/2011; 78(12):1498-502.
To conduct tests of relationships between different factors that could influence the course of retinopathy of prematurity (ROP) and ROP, particularly the role of hemoglobin variant replacement in adult blood transfusions. A retrospective, observational study of 83 infants born between 23 and 34 wks ... [more] To conduct tests of relationships between different factors that could influence the course of retinopathy of prematurity (ROP) and ROP, particularly the role of hemoglobin variant replacement in adult blood transfusions. A retrospective, observational study of 83 infants born between 23 and 34 wks gestation was conducted. The infants without ROP, with 1 and 2 stage of ROP and with ≥ 3 stage of ROP received Q 28 (12-134); 51 (14-149); 156 (38-244) ml/kg of transfused blood, respectively, and the factor Qt was 1,545 (560-10,045); 3,093 (614-13,419); 11,907 (1,288-20,638) (ml/kg)·day, respectively. For the same groups MCV(35) (mean cell volume at the arbitrary time of the 35(th) wk post-conception) was 92.3 (82.9-110.5); 91.0 (79.3-101.4); 87.1 (80.2-94.8) fl, respectively, and factor P(MCV)/t was 99.5 (89.2-108.8); 96.3 (84.6-106.3); 90.7 (85.3-96.5) fl, respectively. There is high influence on the stage of ROP of the amount of transfused blood and MCV, both with or without the time factor. The statistical differences between P(MCV)/t were more significant than the differences between MCV(35), for different stages of ROP. The influence of the time factor on the statistical differences of MCV but not on the amount of transfused adult blood suggests that HbF - HbA replacement may play a role in ROP development.
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1.74Impact points
Does prenatal antibiotic therapy compromise the diagnosis of early-onset infection and management of the neonate?
Journal of perinatal medicine. 05/2011; 39(3):337-42.
To assess the impact of prenatal antibiotic treatment on procalcitonin (PCT) and C-reactive protein (CRP) concentrations in cord blood, and on the rate of positive neonatal blood cultures. Neonates with early-onset infection (Group A; n=46) were compared with healthy controls (Group B; n=240). We ev... [more] To assess the impact of prenatal antibiotic treatment on procalcitonin (PCT) and C-reactive protein (CRP) concentrations in cord blood, and on the rate of positive neonatal blood cultures. Neonates with early-onset infection (Group A; n=46) were compared with healthy controls (Group B; n=240). We evaluated the relationship between prenatal antibiotic therapy and early-onset infection, and for interactions with antibiotic therapy in the neonate immediately after birth. In the Group A antibiotics were administered significantly more often prenatally and more often to neonates just after birth. The percentage of negative blood cultures in infected neonates was higher when antibiotic treatment was instituted prenatally. Differences in cord blood PCT and CRP concentrations were significant between both groups and were independent of prenatal antibiotic treatment. Streptococcus agalactiae was the most frequent species. Almost one-third of neonates present with early-onset infection in spite of prenatal antibiotic therapy. Cord blood PCT and CRP measurements may be helpful in the diagnosis of infection also in cases when antibiotic therapy was started prenatally. Prenatal antibiotic administration reduced the number of positive blood cultures in neonates with early-onset infection and was associated with a greater rate of antibiotic treatment after birth in neonates without infection.
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Molecular Studies of an Impetigo Bullosa Epidemic in Full-Term Infants.
Neonatology. 04/2009; 96(1):61-68.
Background: Carriers ofStaphylococcus aureus strains can be the source of epidemic infection for patients. Objectives: A molecular epidemiological analysis of an impetigo bullosa outbreak in a neonatal ward was performed in order to determine a potential source of the infection and possible routes o... [more] Background: Carriers ofStaphylococcus aureus strains can be the source of epidemic infection for patients. Objectives: A molecular epidemiological analysis of an impetigo bullosa outbreak in a neonatal ward was performed in order to determine a potential source of the infection and possible routes of subsequent spreading of the epidemic strain. Methods: The genetic relatedness of S. aureus strains isolated from 6 neonates with epidermal lesions and from 21 staff members was verified by the pulsed field gel electrophoresis (PFGE) method. Additionally, detection of eta and etb genes of S. aureus strains using PCR was performed. Results: None of the infected newborns' mothers was a carrier. Seven strains, 6 isolated from the newborns and 1 taken from a midwife, showed the same restriction pattern, i.e. type A. In the other 20 health care workers colonized with S. aureus, 3 genetic types could be distinguished, i.e. B (2), C (7) and D (2), as well as 9 strains with unique PFGE patterns. The eta gene detected in 7 strains belonged to the genetic type A; there was no etb gene in any of the 27 S. aureus isolates. Conclusions: The presence of the same genetic type A of S. aureus in the infected newborns is a factor which indicates that the impetigo bullosa was a hospital infection. A probable source of the infection was a midwife who was colonized with the same S. aureus type. She was present at the birth of the first infected newborn. Today, molecular methods are essential for prompt recognition of an epidemic and implementation of appropriate infection control strategies.
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1.89Impact points
Early detection of an early onset infection in the neonate based on measurements of procalcitonin and C-reactive protein concentrations in cord blood.
Clinical chemistry and laboratory medicine : CCLM / FESCC. 07/2008;
Abstract Background: The aim of this study was to test the diagnostic model of combining procalcitonin (PCT) and C-reactive protein (CRP) levels in the cord blood and routinely used biochemical parameters and clinical data in the prediction of early onset neonatal infection. Methods: PCT and CRP con... [more] Abstract Background: The aim of this study was to test the diagnostic model of combining procalcitonin (PCT) and C-reactive protein (CRP) levels in the cord blood and routinely used biochemical parameters and clinical data in the prediction of early onset neonatal infection. Methods: PCT and CRP concentrations were measured in cord blood of neonates with infection (group A, n=46) and compared with uninfected neonates (group B, n=240). Inclusion criteria for group A were based on obstetric history, clinical data and results of laboratory tests. Logistic regression was applied. The receiver operating characteristic (ROC) curves were constructed for PCT, CRP and the diagnostic model. Results: There was a highly significant (p<0.000001) difference in PCT and CRP concentrations between both groups. The cut-off point for PCT in cord blood was 1.22 ng/mL [sensitivity % (SE%) 80.43, specificity % (SP%) 71.67, positive predictive value % (PPV%) 35.24, negative predictive value % (NPV%) 95.03], and 1.0 mg/L for CRP (SE% 73.91, SP% 77.92, PPV% 39.08, NPV% 93.97). In total, seven variables were included in the model (concentrations of PCT and CRP in cord blood, tocolysis, nutritional status of the newborn, Apgar score, neutrophil ratio and red blood cell count in neonatal venous blood), which proved to offer the highest sensitivity (91.3%; 95% CI: 83-99) and specificity (90%; 95% CI: 86-94) for the detection of early onset neonatal infection. The likelihood ratio for the model was high at 9.13, with PPV% 63.64 (95% CI: 52-75), NPV% 98.18 (95% CI: 96-100) and calculated area under the curve at 0.973. Conclusions: The diagnostic model based on seven clinical and laboratory parameters, using the concentration of PCT and CRP measurements in the cord blood, could be a useful tool for the prediction of early onset neonatal infection. Clin Chem Lab Med 2008;46.
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1.44Impact points
Maternal serum proinflammatory cytokines in preterm labor with intact membranes: neonatal outcome and histological associations.
European cytokine network. 06/2007; 18(2):102-7.
Our aim was to compare maternal serum concentrations of interleukin(IL)-1alpha IL-1beta, IL-6 and IL-8 in pregnancies complicated by preterm labor (PTL), with the levels in healthy controls at comparable gestational age, and to determine if these assays have any value in the prediction of early-onse... [more] Our aim was to compare maternal serum concentrations of interleukin(IL)-1alpha IL-1beta, IL-6 and IL-8 in pregnancies complicated by preterm labor (PTL), with the levels in healthy controls at comparable gestational age, and to determine if these assays have any value in the prediction of early-onset neonatal infection or histological chorioamnionitis. The study population consisted of 65 women with new-onset PTL, and 31 healthy controls. Maternal serum concentrations of IL-6 (8.40 versus 3.30 pg/mL; p = 0.002) and IL-1beta (2.20 versus 0.50 pg/mL; p = 0.003) were significantly higher in patients with PTL as compared to healthy pregnant women. The IL-1beta concentration (13.60 versus 1.20 pg/mL; p = 0.02) was significantly higher in the serum of mothers whose babies developed early-onset infections, than in mothers of newborns that were healthy. However, its predictive value, and the value of the other cytokines studied, was poor. In addition, IL-1beta levels (28.79 versus 5.19 pg/mL; p = 0.001) were significantly higher in patients with histological chorionamnionitis, than in those without the condition,. The cut-off value of >or= 14 pg/mL predicted inflammatory changes with a sensitivity of 80%, specificity of 86%, PPV of 80% and NPV of 86%. IL-1beta seems to be of moderate value in the prediction of histological chorioamnionitis.
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1.63Impact points
Value of vaginal fluid proinflammatory cytokines for the prediction of early-onset neonatal infection in preterm premature rupture of the membranes.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. 06/2007; 27(5):393-8.
The usefulness of vaginal fluid proinflammatory cytokine assays in the prediction of neonatal congenital infection was evaluated. Sixty-two women between 24 and 34 weeks of pregnancy, complicated by premature rupture of the membranes, were divided into those who delivered newborns with (n = 21) and ... [more] The usefulness of vaginal fluid proinflammatory cytokine assays in the prediction of neonatal congenital infection was evaluated. Sixty-two women between 24 and 34 weeks of pregnancy, complicated by premature rupture of the membranes, were divided into those who delivered newborns with (n = 21) and without (n = 41) signs of infection. Concentrations of all studied cytokines were higher in women who delivered babies with infection. The cutoff values of interleukin-1alpha (IL-1alpha) and IL-1beta > or = 400, IL-6 > or = 2000, and IL-8 > or = 2100 pg/mL predicted infection with a sensitivity of 57%, 57%, 33%, and 76%, a specificity of 73%, 73%, 93%, and 59%, a positive predictive value of 52%, 52%, 70%, and 48%, and a negative predictive value of 77%, 77%, 73%, and 83%, respectively. Receiver operating characteristic (ROC) curve analysis revealed that the predictive performance of the four studied cytokines was comparable. In conclusion, vaginal fluid cytokines after premature rupture of the membranes have moderately predictive value of whether or not a neonate will develop early sepsis.
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Clinical and microbiological characteristics of hospital infections in the neonatal intensive care unit.
Advances in medical sciences. 02/2007; 52 Suppl 1:30-3.
Neonates hospitalized in intensive care units, are exposed to a higher risk of infectious complications. The research involved 52 neonates hospitalized in the Neonatal Intensive Care Unit (NICU), Chair and Clinic of Obstetrics and Perinatology over a span of one year. The incidence of hospital infec... [more] Neonates hospitalized in intensive care units, are exposed to a higher risk of infectious complications. The research involved 52 neonates hospitalized in the Neonatal Intensive Care Unit (NICU), Chair and Clinic of Obstetrics and Perinatology over a span of one year. The incidence of hospital infections as well as etiological factors were analyzed. Clinically manifested hospital infections were diagnosed in 38.5% of babies with very low or extremely low birth weight, in boys twice as often as in girls. Generalised invasive infections prevailed; in most cases they were caused by Gram-negative rods, mainly Klebsiella spp.
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Clinical forms of infections in neonates hospitalized in clinic of obstetrics and perinatology within the space of one year.
Advances in medical sciences. 02/2007; 52 Suppl 1:23-5.
Because of their specificity, infections in neonatal units form one of the main clinical problems. Our research involved all neonates (1019) hospitalized in Clinic of Obstetrics and Perinatology within the space of one year. Clinically manifested infections were diagnosed in the total number of 47 (... [more] Because of their specificity, infections in neonatal units form one of the main clinical problems. Our research involved all neonates (1019) hospitalized in Clinic of Obstetrics and Perinatology within the space of one year. Clinically manifested infections were diagnosed in the total number of 47 (4.6%) newborns, including 23 (2.4%) neonates from the neonatal unit (NU) and 24 (46.2%)--from the Neonatal Intensive Care Unit (NICU). In both units, the most commonly observed were general infections (59.6%) and pneumonias (21.3%); cerebrospinal meningitis and necrotic enteritis were diagnosed in a few cases. Urinary system infections were only found in neonates hospitalized in the NU (30.5%). The course of infection was mild in most cases.
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Neonatal Infection Diagnosis Using Constructive Induction in Data Mining.
Rough Sets, Fuzzy Sets, Data Mining and Granular Computing, 11th International Conference, RSFDGrC 2007, Toronto, Canada, May 14-16, 2007, Proceedings; 01/2007
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2.45Impact points
Reliability of semiquantitative determination of procalcitonin serum concentrations in neonates.
Diagnostic microbiology and infectious disease. 10/2006; 56(1):31-4.
We studied the diagnostic usefulness of semiquantitative determination of procalcitonin (PCT) concentrations in neonatal serum by reference to a quantitative method. We compared 302 results of PCT measurements in 151 samples of venous blood collected during the 1st 7 days of life. The semiquantitati... [more] We studied the diagnostic usefulness of semiquantitative determination of procalcitonin (PCT) concentrations in neonatal serum by reference to a quantitative method. We compared 302 results of PCT measurements in 151 samples of venous blood collected during the 1st 7 days of life. The semiquantitative BRAHMS PCT-Q test and the quantitative immunoluminometric LUMItest were compared with Cohen's kappa as a measure of concordance. Concordance was revealed for 28.4% of samples, whereas 11.9% showed total disagreement. Concordance between both methods reached 88% when results from the next (lower or higher) category were included. The weighted kappa value was 0.235, indicative of satisfactory agreement between both methods. The semiquantitative BRAHMS PCT-Q test reveals satisfactory concordance with the quantitative method when results in the next category are included to account for readout error. The semiquantitative test is rapid, easy to use, and helpful as a supportive test when the quantitative assay is not available.
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1.74Impact points
Maternal venous procalcitonin levels do not correlate with umbilical cord blood and venous blood concentrations in the neonate.
Journal of perinatal medicine. 02/2006; 34(6):462-5.
BACKGROUND: To compare procalcitonin (PCT) concentrations between maternal blood and levels in umbilical cord or venous blood of neonates who were born with or without infection. METHODS: Forty-six women with singleton pregnancies, complicated by premature rupture of membranes, preterm delivery and/... [more] BACKGROUND: To compare procalcitonin (PCT) concentrations between maternal blood and levels in umbilical cord or venous blood of neonates who were born with or without infection. METHODS: Forty-six women with singleton pregnancies, complicated by premature rupture of membranes, preterm delivery and/or chorioamnionitis, were enrolled in this study. The study group comprised 15 patients and their infected newborns. The control group consisted of 31 women and their healthy newborns. We compared PCT concentrations between maternal, umbilical cord and neonatal serum, in both study and control groups. Additionally, PCT levels were compared between the corresponding compartments. RESULTS: PCT concentrations in the umbilical cord and venous blood in infected newborns, but not in non-infected neonates, were significantly higher than maternal serum PCT levels. PCT concentrations of mothers who delivered infected newborns were comparable to those in the controls. However, PCT concentrations in the umbilical cord and in the venous blood of the infected newborns were higher than in healthy newborns. CONCLUSION: Measurement of maternal PCT concentration during labor does not contribute to early prediction of infection in the neonate. However, umbilical cord PCT concentrations, as well as its neonatal venous levels on the second day of life, seem to be related to intrauterine infection, and may be a useful tool in the diagnosis of early neonatal infection.
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[Pneumocystis pneumonia in newborns: a challenge in contemporary intensive care]
Annales Academiae Medicae Stetinensis. 02/2006; 52(2):65-70; discussion 70.
Pneumocystis jiroveci (P. jiroveci) is the etiological agent of pneumocystis pneumonia (PCP) in immunodeficient patients. The increased interest of clinicians in this particular pathogen during the past decade was prompted by rising numbers of patients with immunosuppression caused by AIDS, chemothe... [more] Pneumocystis jiroveci (P. jiroveci) is the etiological agent of pneumocystis pneumonia (PCP) in immunodeficient patients. The increased interest of clinicians in this particular pathogen during the past decade was prompted by rising numbers of patients with immunosuppression caused by AIDS, chemotherapy, or organ transplantation. Premature, seriously ill infants at intensive care units constitute a potential risk group for infection with P. jiroveci. Recent advances in medical sciences, owing mainly to developments in molecular biology, permitted the verification of the taxonomic position of pathogens and contributed to a better understanding of new aspects of pathophysiology and pathogenesis of PCP. It has been demonstrated that the genus Pneumocystis represents a heterogeneous group of opportunistic fungi exhibiting narrow host specificity. Pneumocystis jiroveci is the species which is specific for humans. The present paper outlines the clinical symptoms of PCP in infants, currently used diagnostic methods, and treatment procedures in PCP.
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[The detachment of retina as possible complication after BCG vaccination during HOP--description of case]
Klinika oczna. 02/2006; 108(10-12):446-9.
PURPOSE: The authors described the rare case of the progression of changes in the retina of child in course of retinopathy of prematurity. It happened after finished laser-treatment and full regression of changes of the retina. It seems that BCG vaccination done in 3-th month of life could reactivat... [more] PURPOSE: The authors described the rare case of the progression of changes in the retina of child in course of retinopathy of prematurity. It happened after finished laser-treatment and full regression of changes of the retina. It seems that BCG vaccination done in 3-th month of life could reactivate the disease of the retina which caused total retina detachment of both eyes. MATERIAL AND METHODS: The ophthalmologic examination included: indirect ophthalmoscopy using Fisson ophthalmoscope, slit-lamp examination and USG B-mode examination, using USG Echo Scan 3300 Oculus with the head 10 MHz--performed during all control visits. RESULTS: The regular ophthalmologic examination enabled estimation of the dynamic of changes in the retina and correctness of treatment. In author's opinion, the secondary retina detachment in 3-th month of life could be associated with reaction post BCG vaccination. CONCLUSIONS: Probably secondary inflammation after BCG vaccination could be the reason of reactivation of earlier treated with good results ROP Possible vision complications should incline to take special ophthalmologic care of premature infants from high risk group (very low mass of the body or fetal immaturity). Decision of changing time of BCG vaccination in such group should be made by attending physician.
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[Impact of delivery type on EGF and IGF-1 concentration in umbilical blood of newborns and their mothers' milk]
Ginekologia polska. 12/2004; 75(11):821-4.
Peptide growth factors, including EGF and IGF-1, play a substantial role in child's growth and maturation processes. Growth factors found in mother's milk can modify development of the newborn and the infant, especially in the area of alimentary tract differentiation and maturation. OBJECTIV... [more] Peptide growth factors, including EGF and IGF-1, play a substantial role in child's growth and maturation processes. Growth factors found in mother's milk can modify development of the newborn and the infant, especially in the area of alimentary tract differentiation and maturation. OBJECTIVES: Study was undertaken to evaluate impact of the delivery type on EGF and IGF-1 concentration in the umbilical blood of newborns and their mothers' milk. MATERIAL AND METHODS: Sixty eight newborns and their mothers were examined. EGF and IGF-1 concentration was measured in serum of venous umbilical blood as well as in the mothers' milk collected on the first day of lactation. To measure EGF and IGF-1 concentration radioimmunoassay method (RIA) was applied. RESULTS: No correlation was found between the concentration of the two growth factors in umbilical blood and the delivery type. Neither significant difference was found between EGF concentration in the milk of the mothers who had spontaneous labour and the factor concentration in the milk of the mothers who had a caesarean section. Contrary to EGF, IGF-1 concentration in the milk of the mothers who had a caesarean section was lower than in the milk of the mothers who had a spontaneous delivery. However, significant differences were observed only in a group of mothers of newborns born at term. CONCLUSIONS: Caesarean section may disturb mechanisms of IGF-1 synthesis and release to mother's milk in the initial stage of lactation.
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[Supplementary education of physicians working in education on the Polish Territory (up to 1939)]
Archiwum historii i filozofii medycyny / Polskii Towarzystwo Historii Medycyny i Farmacji. 02/2004; 67(1):79-83.
With the progress in social medicine and hygiene, it became necessary to create a school of medicine. It was in 1900 when this subject was discussed for the first time in Poland, firstly on the Convention of Polish Medicinal Doctors and Naturalists and then on a conference organized by the Warsaw So... [more] With the progress in social medicine and hygiene, it became necessary to create a school of medicine. It was in 1900 when this subject was discussed for the first time in Poland, firstly on the Convention of Polish Medicinal Doctors and Naturalists and then on a conference organized by the Warsaw Society of Hygiene. During those meetings a set of rules was created. In 1907 Wernicki, M.D. gave a few lectures, but this was left without any important continuation. In 1907 at another conference of the Warsaw Society of hygiene, Matylda Biehler, M.D. introduced a project of supplemental course of school fo hygiene for doctors.First course took place after publication of report by S. Kopczyński which showed how horrible the health care in schools was. Lectures were given by professionals, participants had to pay only a symbolic fee. In 1929 there existed an opinion that in all institutions there should be paediatricians who take care of children under 14.In the thirties many medicine schools and organizations organized a lot of supplementary courses. After that we did not find any mentions about latest courses.
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[Nosocomial infections in a neonatology department, 1995-2002]
Ginekologia polska. 11/2003; 74(10):1256-61.
Nosocomial infections in newborns department are common due to number of invasive diagnostic and therapeutic procedures, prolonged hospitalization and development antibiotic resistance culture. Sepsis achieved 1 to 8 newborn infants for 1000 live births. This is still unresolved very important medic... [more] Nosocomial infections in newborns department are common due to number of invasive diagnostic and therapeutic procedures, prolonged hospitalization and development antibiotic resistance culture. Sepsis achieved 1 to 8 newborn infants for 1000 live births. This is still unresolved very important medical, organization, ethical and medical problem. The aim of this study was the estimation on the number, etiology and clinical form of nosocomial infection in Neonatology Department as well as the way of spread. We analyzed nosocomial infection in 8770 newborn infants in Neonatology Department with Intensive Therapy Chair and Clinic Obstetric and Perinatology Pomeranian University of Medicine from 1995 to 2002. For this retrospective study we used data from Commission for Nosocomial Infection. In analyzed period total percentage of newborn infants with nosocomial infection was under 1%, but in NICU was over 11%. Inborn vertical infection was 26.8% and horizontal strictly nosocomial infection was diagnosed in 73.2%. Etiology was mainly due to Gram negative bacterial infection. Clinically sepsis, pneumonia and meningitis was diagnosed. Clinical manifestation and laboratory tests like CRP, PCT, blood count, leukocyte index and microbiological culture was used for diagnosis. The most often positive bacterial culture was obtained from cock, washstand, bath and medical staff. Nosocomial infections in neonatology department are significant medical problem which need continuous monitoring, systemic prevention and in case of infection early intervention.
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[Immaturity or hypotrophy? The cord blood leptin levels in preterm and small-for-gestational age neonates]
Ginekologia polska. 06/2003; 74(5):356-61.
OBJECTIVES: To assess cord blood leptin levels in preterm and small-for-gestational age neonates and determine whether fetal leptin levels correlate with selected clinical parameters associated with prematurity and undernutrition at birth. DESIGN: Study of preterm newborns (p-AGA; n = 31) and small-... [more] OBJECTIVES: To assess cord blood leptin levels in preterm and small-for-gestational age neonates and determine whether fetal leptin levels correlate with selected clinical parameters associated with prematurity and undernutrition at birth. DESIGN: Study of preterm newborns (p-AGA; n = 31) and small-for-gestational age (t-SGA; n = 23) cases in a population of neonates born in Szczecin between September 2001 and June 2002. METHODS: Fetal cord blood was sampled after delivery. Leptin levels were measured by RIA. Anthropometric data (birth weight, birth length, head and chest circumferences, body mass index, Ponderal index) were also recorded. RESULTS: Cord blood leptin levels did not differ significantly between p-AGA and t-SGA neonates with similar birthweight. Among the two groups of newborns the correlations between fetal leptin and anthropometric data were only observed in p-AGAs, but not in t-SGA group. CONCLUSIONS: We suggest that cord blood leptin level depends on body mass rather than maturity of newborn. It is also hypothesized that leptin level in SGA neonates is determined by other than anthropometric parameters used in this study.
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1.59Impact points
Umbilical cord blood serum procalcitonin concentration in the diagnosis of early neonatal infection.
Journal of perinatology : official journal of the California Perinatal Association. 03/2003; 23(2):148-53.
OBJECTIVE: To evaluate serum procalcitonin concentration in umbilical cord blood for diagnosis of intrauterine bacterial infection. MATERIALS AND METHODS: A prospective study was conducted between 2000 and 2001. Serum procalcitonin concentrations were evaluated in 187 umbilical cord blood samples. F... [more] OBJECTIVE: To evaluate serum procalcitonin concentration in umbilical cord blood for diagnosis of intrauterine bacterial infection. MATERIALS AND METHODS: A prospective study was conducted between 2000 and 2001. Serum procalcitonin concentrations were evaluated in 187 umbilical cord blood samples. Five groups have been defined: controls A (n=37), full-term noninfected B1 (n=80) and infected neonates B2 (n=8), preterm noninfected C1 (n=38) and infected C2 (n=24) newborns. An immunoluminometric assay was used to determine procalcitonin concentration. The Mann-Whitney U-test and Spearman's correlation ratio were applied. The sensitivity and specificity, the positive and negative predictive values, and the area under receiver operating characteristic curves were calculated. RESULTS: A statistically higher serum procalcitonin concentration was found in the preterm infected group (p<0.005; C2 vs A and C1). CONCLUSION: Serum procalcitonin concentration in umbilical cord blood may be a useful parameter in the diagnosis of early neonatal infection.
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[The forms of postgraduate education of physicians in Poland in years (1918-1939)]
Archiwum historii i filozofii medycyny / Polskii Towarzystwo Historii Medycyny i Farmacji. 02/2003; 66(1):19-37.
Postgraduate studies of the Polish physicians between World Wars was not obligatory, except the doctors, who occupied positions in Health Services Administration. They were trained in The State School of Hygiene, in which were performed systematically courses regarding social diseases (tuberculosis,... [more] Postgraduate studies of the Polish physicians between World Wars was not obligatory, except the doctors, who occupied positions in Health Services Administration. They were trained in The State School of Hygiene, in which were performed systematically courses regarding social diseases (tuberculosis, trachoma), organization of health protection. This studies were founded by Department of Health in Ministry of Public Care. The other forms of training were courses of several weeks, regarding general practice or particularly specializations, organized by medical departments of Universities. The aim of this education was completion of the theoretical academic knowledge wish practical skills. The trainings were also organized by medical associations, departments, institutes, hospital wards and other public societies. The postgraduate studies were continued during the domain and foreign medical meetings, by reading medical journals and publications and by practicing in hospital wards.Until the II World War the postgraduate training was not obligatory and the idea of the state institution coordinating this area was not realized.
Following (3)
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Andrzej Torbe
Pomeranian Medical University in Szczecin -
Beata Pawlus
HOLY FAMILY HOSPITAL , OBSTERICS AND GYNECOLOGY HOSPITAL in Warsaw -
Jacek Rudnicki
Pomeranian Medical University in Szczecin -
Beata Łoniewska
Pomorski Uniwersytet Medyczny
Topics (6)
