Décio de Natale Caly, Acklei Viana, Abrão Rapoport, Rogério Aparecido Dedivitis, Otávio Alberto Curioni, Cláudio Roberto Cernea, Lenine Garcia Brandão[show abstract] [hide abstract]
ABSTRACT: Immunohistochemistry (IHC) has been employed in the differential diagnosis of tumors. OBJECTIVE: To assess the use of IHC in cases of head and neck tumor. METHOD: This is a retrospective study of the cases included in the Cancer Registry of the institution. RESULTS: IHC was used in 76 (11%) of 704 pathology tests. Most cases were carcinomas (85.80%), and 83.66% of them were squamous cell carcinomas. All tests were done with diagnostic purposes. The most frequently used antibodies were 34BE12 (37.18%), AE1/AE3 (35.9%), 35BH11 (28.21%), CD45 (25.64%), CD20 (24.36%), CD30 (24.36%), CK7 (23.08%) and CD3 (23.08%). CONCLUSIONS: IHC was used in 10.67% of the head and neck tumor cases submitted to pathology testing, mostly for carcinoma (5.26%). In the determination of squamous cell carcinoma, IHC accounted for 18.42% of all tumors.Brazilian journal of otorhinolaryngology 02/2013; 79(1):75-81.
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ABSTRACT: OBJECTIVE: To study the treatment of fractures of the mandibular condyle and discuss conservative versus surgical therapy. METHODS: We examined the medical records of 892 bucofacial traumas, from which we selected only those who had: reports of condylar fractures, isolated or associated with other facial bones, identification data, dental care history and treatment applied for the condylar fracture. Data were analyzed using descriptive statistics, and the conservative and surgical therapies were compared. RESULTS: Condyle fractures were present in 124 cases. Males represented 72.0% of the sample, the age group most affected being the one between 21 and 30 years. Conservative treatment was used in 61.0% of patients. CONCLUSION: Surgical treatment was predominantly used in patients over ten years old, victims of traffic accidents and falls, followed by assaults, firearms and sporting accidents.Revista do Colégio Brasileiro de Cirurgiões 10/2012; 39(5):373-376.
Débora Modelli Vianna, Otávio Alberto Curioni, Luciano José de Lemos França, Diógenes Lopes de Paiva, Bernardo Fontel Pompeu, Rogério Aparecido Dedivitis, Abrão Rapoport[show abstract] [hide abstract]
ABSTRACT: Thyroid cancer is the most common endocrine cancer, accounting for about 1% of all cancers. Sarcomas, lymphomas and metastases to the thyroid gland are rare and only with a handful of descriptions in the literature. To describe rare histological types of thyroid cancer found in a reference center. Medical chart review from admitted patients diagnosed with thyroid cancer in the period from 1977 to 2010. Demographic, diagnostic, therapeutic and histopathological information were collected. 3,018 records of patients admitted with thyroid disease were reviewed. Among the cases diagnosed with rare tumors there was a predominance of: anaplastic carcinoma: 22 cases (0.7%), followed by 11 cases of medullary carcinoma (0.36%); 2 cases of sarcoma (0.07%), 2 cases of lymphoma (0.07%) and one case of metastatic carcinoid tumor (0.03%). There were more females diagnosed (57%) as well as Caucasians (84%). The most frequent clinical presentation was a palpable thyroid nodule. All patients with lymphoma, sarcoma and anaplastic carcinoma died. Sarcomas, lymphomas and thyroid metastases are uncommon and tend to worse outcomes.Brazilian journal of otorhinolaryngology 08/2012; 78(4):48-51.
Article: The density of metastatic lymph node as prognostic factor in squamous cell carcinoma of the tongue and floor of the mouth.Ali Amar, Abrão Rapoport, Otávio Alberto Curioni, Rogério Aparecido Dedivitis, Cláudio Roberto Cernea, Lenine Garcia Brandão[show abstract] [hide abstract]
ABSTRACT: The presence of metastatic lymph nodes is a relevant prognostic factor in oral cancer. This paper aims to assess metastatic lymph node density (pN+) in patients with tongue and floor-of-mouth squamous cell carcinoma (SCC) and the association of this parameter with disease-free survival (DFS). A group of 182 patients seen between 1985 and 2007 was included, 169 of which were males. Five were on stage I, 35 on stage II, 56 on stage III, and 85 on stage IV. Median values were considered in lymph node density assessment, and the Kaplan-Meier curve was used to evaluate DFS; survival differences within the group were elicited through the log-rank test. An average 3.2 metastatic lymph nodes were excised from the patients in the group. Density ranged from 0.009 to 0.4, with a mean value of 0.09. Five-year DFS rates were of 44% and 28% for the groups with lymph node densities below and above the median respectively (p = 0.006). Two-year local/regional control was achieved for 71% and 49% for the patients below and above the median density respectively (p = 0.01). In terms of pN staging, local/regional control was achieved in 70% and 54% of pN1 and pN2 patients respectively, albeit without statistical significance (0.20%). Lymph node density may be used as a prognostic indicator for tongue and floor-of-mouth SCC.Brazilian journal of otorhinolaryngology 06/2012; 78(3):86-90.
Luciano José de Lemos França, Otávio Alberto Curioni, Diógenes Lopes Paiva, Débora Modelli Vianna, Rogério Aparecido Dedivitis, Abrão Rapoport[show abstract] [hide abstract]
ABSTRACT: Dental lesions represent about 1% of oral cavity tumors being ameloblastoma the most common one. It is a tumor of epithelial origin that mainly affects the jaw, and less commonly the maxilla. Its clinical presentation is that of an asymptomatic slow-growing tumor. Despite being a benign tumor, it has an invasive behavior with a high rate of recurrence if not treated properly. To describe the cases of ameloblastoma in a reference department. Retrospective analysis of 40 cases. The variables analyzed were: age, gender, ethnicity, tumor location, type of treatment, complications and recurrence. The most affected gender was male - 21 cases (52.5%); with a predominance of Caucasians - 24 cases (60%). The mean age was 35.45 years; the most common location was in the jaw - 37 cases (92.5%). Facial asymmetry was the most frequent complaint. Of the 40 cases, 33 were submitted to surgery. Of those submitted to surgery, 24 (72.72%) underwent segmental resection, with recurrence in 4 (12.12%) cases. Ameloblastoma may relapse when treatment is not performed with broad surgical resection of the lesion with wide safety margins.Brazilian journal of otorhinolaryngology 06/2012; 78(3):38-41.