Dr. Asif Ahmed, their are many ways to deliver miRNAs into human .none is being approved yet to apply. In general, the delivery of miRNA into the human body depends on the targeted cells / organ, amount of miRNA needed to function effectively, the duration and the repetitive treatment needed to be effective, specifity and other targets of this miRNA that can cause serious side effects , ext. . for example, to target the lung , you can use nasal aerosol spray, or one can use synthetic tissue marker labeled micro-vesicles containing specific concentration of miRNA to be up taken by the cells , also you can introduce oligonucleotides directly or in a vector containing tissue specific marker which will target specific cell type in the organ.
in addition, you can purified cells from the patient, treat them with miRNA in-vitro and re-introduce them back to the patient again after treatment to be monitored.
hope I answered your question :)
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