Due to higher rate of cell differentiation, there is irratic and uncontrolled growth where the oxygen supply is lower. Hence the tumor cells undergo anearobic respiration resulting into formation of lactic acid. This event changes the pH profile of tumor cells (acidic i.e., lower pH) when compared to the normal cells. Moreover, the temperature also rises due to continuous cell growth and differentiation to liberate energy.
Dear all, as clinician -ignorant of molecular issues- I have a naive question to ask. O2 tension in capillaries is quite low in many tissues: at enterocyte in colon (I read) it is 4%, and in cartilage 0,1%, far lower than the 1% I read for tumor (which ones?). Hence, it is low O2 by definition. I have difficultis finding NORMAL/usual concentration in non-tumoral tissues. Moreover, I read that stem cells proliferate preferably in low O2 tension, and that cartilage growth requires high glucose. Malignancy in cartilage is not frequent, in my experience (I'm not a specialist). Antonio.firstname.lastname@example.org
Dear all, your discussion has been very interesting. Can somebody refer me to suitable literature on what type of cancer tissues show increased temperature and to what extent? Also if there is any source of temperature of different cancer types.
Tehran University of Medical Sciences
Robert Michael Davidson
Independent Physician and Medical Researcher
Syed Mohsin Waheed
Graphic Era University
Ospan A. Mynbaev
Moscow Institute of Physics and Technology
All India Institute of Medical Sciences
Ahed Jumah Alkhatib
Jordan University of Science and Technology
South Asian University
Sphaera Pharma, IMT Manesar, Gurgaon, India
Shashank Prakash Katiyar
Indian Institute of Technology Delhi
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