What is the most famous gene whose transcript levels are regulated by ERK?
I want to know whether or not the gene of my interest is sensitive to PD98059 (MEK/ERK inhibitor) and I have this distinct feeling that it is not. Even if the gene was indeed insensitive to PD98059, I still have to check other genes regulated by ERK to see if my PD98059 was really working. I know the most credible way to do this is to do the Western blot analysis of phospho-ERK, but the easiest way is RT-PCR and I heard c-Fos is regulated by ERK. Can someone please tell me other genes regulated by ERK?