Question

How to ensure BLAST sequences are homologues?

I am currently learning homology modelling. I have finished sequence alignment with BLAST and many of the sequences produce significant alignment, how could I know if they are homologues?
Jul 30, 2012

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  • Amit Singh · PREMAS Biotech
    Hello Zhang, BLAST is based on algorithm which fetches out homologues sequences, so you dont neeed to cross validate those sequences. Alternatively you can try phylogentic tree to analyze your sequences.
    Sep 22, 2012
  • Yujuan Zhang · 19840625
    But i think BLAST only give the results of sequence identity, not the results of sequece homology. Because the value does not reflect an evolutionary relationship.
    Sep 24, 2012

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