Question
Can anyone recommend where to find reliable information about biomaterials usable for bone regeneration?
Biomaterials
All Answers (27)
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The literature is full of calcium phosphate composites, BMP's, electroosteo-elongation, and delivery vehicles. What info are you looking for? The real questions always ends up how you define "useable". -
Design of biomimetic habitats for tissue engineering with P-15, a synthetic peptide analogue of collagen.
Bhatnagar RS, Qian JJ, Wedrychowska A, Sadeghi M, Wu YM, Smith N.
Tissue Eng. 1999 Feb;5(1):53-65.
Biomimetic collagen scaffolds for human bone cell growth and differentiation.
Yang XB, Bhatnagar RS, Li S, Oreffo RO.
Tissue Eng. 2004 Jul-Aug;10(7-8):1148-59., and look up the literature using the search term "P-15". P-15 based-bone grafts have been in people since 1999.
P-15 is a force transducing ligand for alpha 2 beta 1 integrin. P-15 scaffolds mediate bi-directional flow of biomechanical force signals and allow tissue regeneration to conform to host architecture by processing force signals, and promote vectorial synthesis and organization of bone matrix as well as oriented secretion of morphogens. Good luck. -
Seems like a slightly generic question. Are you inquiring about just the scaffold for bone TE, or more? There is a lot of research on porous synthetic biomaterials, I am currently using PU. -
Ceramics ae also being used with manufacture normally based on some form of scaffold that is usedto buildthe structure that is then destroyed duringthe cintering phase, leaving you pores/ tubes etc of a known size. MAterials used are titanium dioxide and tantulum - both materials now commercialised.
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we`re using beta-tri-calcium phosphat material in our approaches, as bulk material as well as granulate. also we`re planning to use polylactites.
just search for beta-TCP. you`ll find a lot.
greets,
alex -
You can use Cnt/Ha/biorreabsorble polimers. -
Polymers
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I suppose you need to define exactly that you mean by usable for bone regeneration. What's the end point you're after? What application do you have in mind? There have been a number of biomaterials shown to regenerate bone, both in vitro and in vivo, but nothing that has answered every issue involved in tissue regeneration, hence why you'll be inundated with answers, but possibly nothing that suits your need. Sorry to complicate matters. Hope you find what you're after. David
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Hydroxyapatite/polymer nanocomposites
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P-15
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It depends of what you wanna do. It is a generical question and i suggest you to look for a good review. You have natural or synthetic materials (with biocompatible, biodegradable or biomimetic proprieties) and they can be processed in a wide range of scaffold forms. You should have attention to your cells and choose a material with a surface suitable for them. -
This is not my area but literature suggests that PEEK which has already been used for orthopaedic and dental implants, and approved by FDA offers various advantages: it is biocompatible and its mechanical properties are very close to bone’s values and it consider to be very reliable implantable biomaterial with great confidence , so search more
Good luck -
Its depands of which are you want to use. For example if you want to use you teeth problems slove Before placing dental implants, alveolar bone regeneration is often required due to bone defects caused by periodontitis, traumatism or even a simple tooth extraction. Bone augmentation surgical procedures have very much evolved thanks to a better understanding of biological processes and to the introduction of biomaterials.
The overall objective of this thesis is to bring a contribution to the understanding of the biological concept of alveolar bone regeneration, and in particular sinus lift and socket preservation procedures. The influence of biomaterials on bone regeneration has been emphasized through preclinical and clinical studies.
Good luck. -
may be a look to homepage of Osteopore international (http://www.osteopore.com.sg/index.htm) is helpful. They offer a polycaprolactone material with outstanding characteristics....bioresorbable, slow degradation, perfect mineralization etc. Available in different sizes and shapes. FDA approved for cranio fascial surgery.
Regards
Jochen -
What is your application? Spine? Long Bone: Maxilo facial. There are many described mineralized bone matrices that have been validated. We currently use a novel biomimetic mineralized collagen matrix. Collagen slurries with the proper cocktail of growth factors and cells has been used within a shell.
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In addition to tissue engineerig journals you can find very usefull review articles in chemical reviews. -
As Anabela already posted, I would suggest to look for a good review. There are plenty of Biomaterials for Bone Reg. and which to choose depends on the application you have in mind. Below some reviews that coudl be useful:
Bone regeneration: current concepts and future directions (2011)
Rozalia Dimitriou1,2†, Elena Jones3†, Dennis McGonagle3† and Peter V Giannoudis1,2*† http://www.biomedcentral.com/1741-7015/9/66
Bone grafting, orthopaedic biomaterials, and the clinical need for bone engineering. (2010)
Brydone AS, Meek D, Maclaine S.
PMID: 21287823
Bone tissue substitutes and replacements. (2011)
Theler JM.
PMID: 21677587
Enjoy ! -
You can refer to the following:
http://www.researchgate.net/profile/Kim-Cheng_Tan/publications/?ch=reg&cp=re50_x_p2 -
check the new HTA Report, although the detailed report is in German, it has a very compact summary un english and a very good literature review and references.
http://www.dimdi.de/dynamic/de/linkgalerie/hta-bericht-281.elnk
enjoy ! -
A review from 2005, in Portuguese, covering glasses and glass-ceramics for bone regeneration or other biomedical applications is available as the first chapter of my Ph.D. Thesis:
C. M. G. A. Queiroz, Ph.D Thesis in Science and Engineering of Materials, Universidade de Aveiro – Departamento de Engenharia Cerâmica e do Vidro, Aveiro, 2005 (xxviii + 270 pp.)
https://www.researchgate.net/publication/231157960_Cristalizao_de_Biomateriais_Vitrocermicos_e_Mineralizao_em_Meio_Fisiolgico_Simulado -
Tanner reference is a must ! A very good starting point for Bone Reg.
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Google Scholar: Larry L. Hench.... he is my mentor and the inventor of Bioglass, this will give you a really good start. Also look up Dr. Molly Stevens, Dr. Julian Jones, and Prof. Dame Julia Polak. Larry also has a book titled "Bioceramics" which focuses mainly on this topic, and is about to release a 2nd ed. as well as you can look up The History of Bioglass. It is a very interesting material as is the story of how it was discovered back in 1969 here at the University of Florida. If you would like any specific papers or have any specific questions please let me know, I would be happy to help you out and to find the best direction for the research you are doing. Also, (as a quick plug for Larry, Dr. Jones, and myself) There are a number of really good chapters in our new book "New Materials and Technologies for Healthcare". (http://www.worldscientific.com/worldscibooks/10.1142/p713).
Let me know what you are specifically looking for.... -
Hi...Take a look at this review: "Biomaterials for bone tissue engineering"... you can easily find several ceramic, polymeric and composite materials...Best of lucks!!!
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Hydroxyapatite. Biomaterials Science. Ratner&Hoffman. Academic Press.
Popular Answers
Bone regeneration: current concepts and future directions (2011)
Rozalia Dimitriou1,2†, Elena Jones3†, Dennis McGonagle3† and Peter V Giannoudis1,2*† http://www.biomedcentral.com/1741-7015/9/66
Bone grafting, orthopaedic biomaterials, and the clinical need for bone engineering. (2010)
Brydone AS, Meek D, Maclaine S.
PMID: 21287823
Bone tissue substitutes and replacements. (2011)
Theler JM.
PMID: 21677587
Enjoy !