Question

Can anyone suggest a relationship between BCL-2 and calcium in relation to pancreatic cancer?

As I know BCL-2 is responsible for programmed cell death, and i believe the relationship between BCL-2 and calcium may have a relationship in inhibiting the cancer cells as I know the lower level of BCL-2 will increase the rate of apoptosis.
Jun 16, 2012

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  • Daniel Clark · University of Otago
    As a starting point you could have a look on PubMed ( http://www.ncbi.nlm.nih.gov/pubmed/15607561 )
    "Disparate forms of MK 886-induced programmed death in BCL-2 (+) blood and BCL-2 (-) solid cancer cells and a putative "nuclear" Ca2+ channel: "soil" trumps "seed"? " Anderson et.al., 2005
    Jun 18, 2012
  • Aishwarya Ravisankar · Sri Ramachandra Medical College & Research Institute
    Thanks all for the help.. It was useful for my research work
    Jun 19, 2012
  • Gavin Mcstay · Columbia University
    BCL-2 proteins regulate ER calcium stores. There are several papers from Craig Thompson's group describing this and also Clark Distelhorst. Use the terms "Thompson CB BCL-2 calcium" or Distelhorst C BCL-2 calcium" and you will find the references in PubMed.
    Jun 19, 2012
  • رافت ابراهيم · استشارى ادوية
    Http://tpx.sagepub.com/content/35/4/495.full
    Jun 21, 2012
  • Maria Baou · University of Essex
    Very good papers suggested by Gavin. You may also find interesting: http://www.ncbi.nlm.nih.gov/pubmed/16388593 and http://www.ncbi.nlm.nih.gov/pubmed/15245329 showing that Bcl-2 interacts and inhibits SERCA
    and also Proc Natl Acad Sci U S A. 2000 May 23;97(11):5723-8.
    Nov 21, 2012

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