Journal of Applied Physiology (J APPL PHYSIOL )

Publisher: American Physiological Society (1887- ), American Physical Society


The Journal of Applied Physiology publishes original papers that deal with diverse areas of research in applied physiology, especially those emphasizing adaptive and integrative mechanisms. Adaptive physiology includes 1) inherent adaptations such as those related to development, aging, and pathophysiological conditions and 2) adaptations to the external environment such as those occurring with exercise, microgravity, hypoxia, hypo- and hyperbaria, and hypo- and hyperthermic conditions. Integrative physiology includes 1) horizontal integration across organ systems and 2) vertical integration from molecule to cell to organ. In all areas of applied physiology, the use of cutting-edge techniques including molecular and cellular biology is strongly encouraged.

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  • Website
    Journal of Applied Physiology website
  • Other titles
    Journal of applied physiology (Bethesda, Md.: 1985), Journal of applied physiology
  • ISSN
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  • Material type
    Periodical, Internet resource
  • Document type
    Journal / Magazine / Newspaper, Internet Resource

Publisher details

American Physical Society

  • Pre-print
    • Author cannot archive a pre-print version
  • Restrictions
    • Journal of Neurophysiology only (until February 2011)
  • Post-print
    • Author cannot archive a post-print version
  • Conditions
    • NIH funded authors, may archive papers in PubMed Central after 12 months
    • Wellcome Trust authors may use Paid Option to archive in PubMed Central
    • Authors are requested to notify publisher of funding source at time of submission and to modify copyright statement to indicate time of release in PubMed
    • Journal of Neurophysiology only - pre-print only before submission
    • Journal of Neurophysiology only - pre-print on preprint server or non peer reviewed websites
    • Journal of Neurophysiology only - pre-print must not be revised
    • Publisher's version/PDF cannot be used
  • Classification
    ​ white

Publications in this journal

  • Journal of Applied Physiology 09/2014;
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    ABSTRACT: To investigate the kinetics of cell-free DNA (cfDNA) due to exercise, we established a direct real-time PCR for the quantification of cfDNA from unpurified capillary plasma by amplification of a 90 bp and a 222 bp multi-locus L1PA2 sequence. 26 male athletes performed an incremental treadmill test. For cfDNA measurement capillary samples were collected serially from the fingertip pre, during and several times post exercise. Venous blood was drawn before and immediately after exercise to compare capillary and venous cfDNA values. To elucidate the strongest association of cfDNA accumulations with either cardiorespiratory or metabolic function during exercise, capillary cfDNA values were correlated with standard measures like heart rate, oxygen consumption or lactate concentrations. The venous cfDNA concentrations were significantly higher compared to the capillary plasma, but in both fractions cfDNA increased 9.8-fold and the values correlated significantly (r=0.796). During incremental treadmill running the capillary cfDNA concentrations increased nearly parallel to the lactate values. The values correlated best with heart rate and energy expenditure, followed by oxygen consumption, Borg values and lactate levels (0.710≤r≥0.808). With this article we present a sensitive procedure for the direct quantification of cfDNA in unpurified capillary plasma instead of purified venous plasma. Further studies should investigate the differences between capillary and venous cfDNA that might mirror different physiological mechanisms. Enhanced cardiorespiratory function during exercise might lead to the accumulation of cfDNA via the release of stress hormones that already increase at intensities below the anaerobic threshold. Furthermore, cfDNA might be released by neutrophil extracellular traps (NETs).
    Journal of Applied Physiology 05/2014;
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    ABSTRACT: Inspiratory resistance (RINSP) and reactance (XINSP) were measured for 7min at 5 Hz in 10 mild asymptomatic asthmatics and 9 healthy subjects to assess the effects of airway smooth muscle (ASM) activation by methacholine (MCh) and unloading by chest wall strapping (CWS) on the variability of lung function and the effects of deep inspiration (DI). Subjects were studied at control conditions, after MCh, with CWS, and after MCh with CWS. In all experimental conditions XINSP was significantly more negative in asthmatic than healthy subjects, suggesting greater inhomogeneity in the former. However, the variability of both RINSP and XINSP was increased by either ASM activation or CWS, without significant difference between groups. DI significantly reversed MCh-induced changes in RINSP in both asthmatic and healthy subjects but XINSP in the former only. This effect was impaired by CWS more in the asthmatic than healthy subjects. The velocity of RINSP and XINSP recovery after deep inspiration was faster in asthmatic than healthy subjects. In conclusion, these results support the opinion that the short-term variability of respiratory impedance is related to ASM tone or operating length, rather than the disease. Nevertheless, asthmatic ASM differs from the healthy one for an increased velocity of shortening and a reduced sensitivity to mechanical stress when strain is reduced.
    Journal of Applied Physiology 06/2013;
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    ABSTRACT: Dear Editor: Mündel et al. (1) reported an interesting study, which is done to investigate the mechanisms of action of nasal high flow oxygen (HNF) in spontaneously breathing healthy subjects, during wakefulness and sleep. It is widely believed that the application of high flow of heated and humidified oxygen to the nasopharynx forms a continuous positive airway pressure (CPAP), which can relieve respiratory distress (2). To investigate this theory the authors took a multi step approach first by measuring ventilation characteristics of 10 subjects at the awake state with 3 different flows (15, 30 and 45 L/min respectively) in a cross over fashion. Then the measurements were repeated while the subjects were sleeping. In this study, ventilation was monitored non-invasively by respiratory inductance plethysmographyIn another part of this study an artificial nose model was used to measure the effect of two different sizes of nasal high flow cannulas on flow characteristics and pressure/flow relationships during inspiration and expiration. One interesting finding is that, during wakefulness the tidal volume increased and respiratory rate decreased significantly with increasing flows. The decrease in respiratory rate was mainly due to an increase in expiratory time. This may be an indicator of increased expiratory resistance due to high flows in the opposite direction of expiratory flow. During sleep the measurements generated different results, in this setting increasing flow rates were associated with a decrease in minute ventilation due to a decrease in tidal volume with unchanged respiratory rate. In this study the authors did not measure the PaCO2 levels, perhaps HNF decreased minute ventilation by the washout of dead space of upper airways. This had been showed in a very recent study by Braunlich et al. in healthy subjects and pulmonary fibrosis patients (3). With the nasal cavity model, HNF increased expiratory resistance causing a slight positive pressure in the nasal cavity during expiration, but it decreased resistance during inspiration. The nasal prongs of the system contributed to the increased expiratory resistance by narrowing the nasal orifices (1).The findings of this study support the hypothesis that, HNF works by increasing expiratory pressure. But it was found to be different form the application of CPAP in nose model. The nose model can be criticized as it does not take the state of mouth (open or closed) in to account. Application of nasal CPAP in a normal subject would behave differently, especially if the mouth is open (2). There may be other mechanisms acting on the respiratory system during HNF, which may explain the findings during sleep, as the authors stated, the wash out of pharyngeal dead space with high flow, the lowering of metabolic needs to heat and humidify the inspiratory gases with heated humidified flow may play a role in sleeping subjects. Although there are several mechanisms proposed for the mechanism of favorable actions of HNF, the main action seems to be the increased airway pressures especially during expiration. In this way it works similar to the nasal CPAP, but the latter forms higher pressures in the upper airways as shown by Braunlich et al. study (3). 1 Mündel T, Feng S, Tatkov S, et al. Mechanisms of nasal high flow on ventilation during wakefulness and sleep. J Appl Physiol 114:1058-1065, 2013 2 Groves N, Tobin A. High flow nasal oxygen generates positive airway pressure in adult volunteers. Aust Crit Care 20:126-131, 2007 3 Bräunlich J, Beyer D, Mai D, et al. Effects of Nasal High Flow on Ventilation in Volunteers, COPD and Idiopathic Pulmonary Fibrosis Patients. Respiration 85:319-325, 2013
    Journal of Applied Physiology 05/2013; 05/2013.
  • Journal of Applied Physiology 01/2013;
  • Journal of Applied Physiology 12/2012;
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    ABSTRACT: In this paper we report the results of an experiment to investigate the emergence of ocular vestibular evoked myogenic potentials (OVEMPs) during the linear vestibular ocular reflex (LVOR) evoked by whole-body vibration (WBV). OVEMP and electrooculogram (EOG) montages were employed to record periocular potentials (POPs) from six subjects during WBV in the nasooccipital (NO) axis over a range of frequencies from 0.5 to 64 Hz with approximately constant peak head acceleration of 1.0 ms(-2) (i.e., 0.1 g). Measurements were made in two context conditions: a fixation context to examine the effect of gaze eccentricity (0 vs. 20°), and a visual context, where a target was either head-fixed or earth-fixed. The principal results are that from 0.5 to 2 Hz POP magnitude in the earth-fixed condition is related to head displacement, so with constant acceleration at all frequencies it reduces with increasing frequency, but at frequencies greater than 2 Hz both POP magnitude and POP gain, defined as the ratio of POP magnitude at 20 and 0°, increase with increasing frequency. By exhibiting this high-pass characteristic, a property shared with the LVOR, the results are consistent with the hypothesis that the OVEMP, as commonly employed in the clinical setting, is a high-frequency manifestation of the LVOR. However, we also observed low-frequency acceleration following POPs in head-fixed conditions, consistent with a low-frequency OVEMP, and found evidence of a high-frequency visual context effect, which is also consistent with the OVEMP being a manifestation of the LVOR.
    Journal of Applied Physiology 01/2012; 113(10):1613-1623.
  • Journal of Applied Physiology 10/2009; 107(3):1002.
  • Journal of Applied Physiology 10/2009; 107(3):999; discussion 997-8, 998.
  • Source
    Journal of Applied Physiology 10/2009; 107(3):994-7.
  • Source
    Journal of Applied Physiology 10/2009; 107(3):1003.

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