Journal of Applied Physiology (J APPL PHYSIOL )
The Journal of Applied Physiology publishes original papers that deal with diverse areas of research in applied physiology, especially those emphasizing adaptive and integrative mechanisms. Adaptive physiology includes 1) inherent adaptations such as those related to development, aging, and pathophysiological conditions and 2) adaptations to the external environment such as those occurring with exercise, microgravity, hypoxia, hypo- and hyperbaria, and hypo- and hyperthermic conditions. Integrative physiology includes 1) horizontal integration across organ systems and 2) vertical integration from molecule to cell to organ. In all areas of applied physiology, the use of cutting-edge techniques including molecular and cellular biology is strongly encouraged.
- Impact factor3.48Show impact factor historyHide impact factor history
- 5-year impact4.16
- Cited half-life0.00
- Immediacy index0.52
- Article influence1.24
- WebsiteJournal of Applied Physiology website
- Other titlesJournal of applied physiology (Bethesda, Md.: 1985), Journal of applied physiology
- Material typePeriodical, Internet resource
- Document typeJournal / Magazine / Newspaper, Internet Resource
- Author cannot archive a pre-print version
- Journal of Neurophysiology only (until February 2011)
- Author cannot archive a post-print version
- NIH funded authors, may archive papers in PubMed Central after 12 months
- Wellcome Trust authors may use Paid Option to archive in PubMed Central
- Authors are requested to notify publisher of funding source at time of submission and to modify copyright statement to indicate time of release in PubMed
- Journal of Neurophysiology only - pre-print only before submission
- Journal of Neurophysiology only - pre-print on preprint server or non peer reviewed websites
- Journal of Neurophysiology only - pre-print must not be revised
- Publisher's version/PDF cannot be used
- Classification white
Publications in this journal
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ABSTRACT: Abstract We experimentally altered the timing of respiratory motoneuron activity as a means to modulate and better understand otherwise hidden human central neural and hemodynamic oscillatory mechanisms. We recorded the electrocardiogram, finger photoplethysmographic arterial pressure, tidal carbon dioxide concentrations, and muscle sympathetic nerve activity in 13 healthy supine young men who gradually increased or decreased their breathing frequencies between 0.05 and 0.25 Hz over 9-min periods. We analyzed results with traditional time- and frequency-domain methods, and also with time-frequency methods (wavelet transform, wavelet phase coherence, and directional coupling). We determined statistical significance and identified frequency boundaries by comparing measurements with randomly generated surrogates. Our results support several major conclusions. First, respiration causally modulates both sympathetic (weakly) and vagal motoneuron (strongly) oscillations over a wide frequency range-one that extends well below the frequency of actual breaths. Second, breathing frequency broadly modulates vagal baroreflex gain, with peak gains registered in the low frequency range. Third, breathing frequency does not influence median levels of sympathetic or vagal activity over time. Fourth, phase relations between arterial pressure and sympathetic and vagal motoneurons are unaffected by breathing, and are therefore likely secondary to intrinsic responsiveness of these motoneurons to other synaptic inputs. Finally, breathing frequency does not affect phase coherence between diastolic pressure and muscle sympathetic oscillations, but it augments phase coherence between systolic pressure and R-R interval oscillations over a limited portion of the usual breathing frequency range. These results refine understanding of autonomic oscillatory processes and those physiological mechanisms known as the human respiratory gate.Journal of Applied Physiology 12/2013; 115:1806-1821.
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ABSTRACT: Inspiratory resistance (RINSP) and reactance (XINSP) were measured for 7min at 5 Hz in 10 mild asymptomatic asthmatics and 9 healthy subjects to assess the effects of airway smooth muscle (ASM) activation by methacholine (MCh) and unloading by chest wall strapping (CWS) on the variability of lung function and the effects of deep inspiration (DI). Subjects were studied at control conditions, after MCh, with CWS, and after MCh with CWS. In all experimental conditions XINSP was significantly more negative in asthmatic than healthy subjects, suggesting greater inhomogeneity in the former. However, the variability of both RINSP and XINSP was increased by either ASM activation or CWS, without significant difference between groups. DI significantly reversed MCh-induced changes in RINSP in both asthmatic and healthy subjects but XINSP in the former only. This effect was impaired by CWS more in the asthmatic than healthy subjects. The velocity of RINSP and XINSP recovery after deep inspiration was faster in asthmatic than healthy subjects. In conclusion, these results support the opinion that the short-term variability of respiratory impedance is related to ASM tone or operating length, rather than the disease. Nevertheless, asthmatic ASM differs from the healthy one for an increased velocity of shortening and a reduced sensitivity to mechanical stress when strain is reduced.Journal of Applied Physiology 06/2013;
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ABSTRACT: Dear Editor: Mündel et al. (1) reported an interesting study, which is done to investigate the mechanisms of action of nasal high flow oxygen (HNF) in spontaneously breathing healthy subjects, during wakefulness and sleep. It is widely believed that the application of high flow of heated and humidified oxygen to the nasopharynx forms a continuous positive airway pressure (CPAP), which can relieve respiratory distress (2). To investigate this theory the authors took a multi step approach first by measuring ventilation characteristics of 10 subjects at the awake state with 3 different flows (15, 30 and 45 L/min respectively) in a cross over fashion. Then the measurements were repeated while the subjects were sleeping. In this study, ventilation was monitored non-invasively by respiratory inductance plethysmographyIn another part of this study an artificial nose model was used to measure the effect of two different sizes of nasal high flow cannulas on flow characteristics and pressure/flow relationships during inspiration and expiration. One interesting finding is that, during wakefulness the tidal volume increased and respiratory rate decreased significantly with increasing flows. The decrease in respiratory rate was mainly due to an increase in expiratory time. This may be an indicator of increased expiratory resistance due to high flows in the opposite direction of expiratory flow. During sleep the measurements generated different results, in this setting increasing flow rates were associated with a decrease in minute ventilation due to a decrease in tidal volume with unchanged respiratory rate. In this study the authors did not measure the PaCO2 levels, perhaps HNF decreased minute ventilation by the washout of dead space of upper airways. This had been showed in a very recent study by Braunlich et al. in healthy subjects and pulmonary fibrosis patients (3). With the nasal cavity model, HNF increased expiratory resistance causing a slight positive pressure in the nasal cavity during expiration, but it decreased resistance during inspiration. The nasal prongs of the system contributed to the increased expiratory resistance by narrowing the nasal orifices (1).The findings of this study support the hypothesis that, HNF works by increasing expiratory pressure. But it was found to be different form the application of CPAP in nose model. The nose model can be criticized as it does not take the state of mouth (open or closed) in to account. Application of nasal CPAP in a normal subject would behave differently, especially if the mouth is open (2). There may be other mechanisms acting on the respiratory system during HNF, which may explain the findings during sleep, as the authors stated, the wash out of pharyngeal dead space with high flow, the lowering of metabolic needs to heat and humidify the inspiratory gases with heated humidified flow may play a role in sleeping subjects. Although there are several mechanisms proposed for the mechanism of favorable actions of HNF, the main action seems to be the increased airway pressures especially during expiration. In this way it works similar to the nasal CPAP, but the latter forms higher pressures in the upper airways as shown by Braunlich et al. study (3). 1 Mündel T, Feng S, Tatkov S, et al. Mechanisms of nasal high flow on ventilation during wakefulness and sleep. J Appl Physiol 114:1058-1065, 2013 2 Groves N, Tobin A. High flow nasal oxygen generates positive airway pressure in adult volunteers. Aust Crit Care 20:126-131, 2007 3 Bräunlich J, Beyer D, Mai D, et al. Effects of Nasal High Flow on Ventilation in Volunteers, COPD and Idiopathic Pulmonary Fibrosis Patients. Respiration 85:319-325, 2013Journal of Applied Physiology 05/2013; 05/2013.
- Journal of Applied Physiology 01/2013;
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ABSTRACT: Three species of macroalgae, Ceramium virgatum (Rhodophyta), Ulva intestinalis, and Cladophora vagabunda (Chlorophyta), harvested from the Romanian Black Sea coast, were studied as sources of valuable compounds that could be used as additives and biopreservatives. Volatile compounds including hexanal (11.2 %), octane (9.8 %), nonanal (7.0 %), octanal (6.7 %), 2,5,5-trimethyl-2-hexene (4.7 %), 3-hexen-2-one (4 %), and o-cymene (3.6 %) were identified as the major components in the biomass extract of C. vagabunda. In C. virgatum, the major volatile components were 3-hexen-2-one (27.9 %), acetone (12.4 %), hexanal (3.4 %), and o-cymene (2.7 %). The major volatile compounds of U. intestinalis were hexanal (14.6 %), trichloromethane (7.3 %), nonanal (5.6 %), 3-hexen-2-one (5.3 %), and octanal (3.1 %). Some of these compounds have industrial applications as additives in the food, pharmaceutical, or cosmetics industries. The U. intestinalis extract had a greater content of mono- and polyunsaturated fatty acids around 46.0 % as compared with 42.0 % for C. vagabunda and 31.9 % for C. virgatum. The most abundant fatty acids were palmitic acid (C16:0), arachidonic acid (C20:4n-6), and oleic acid (C18:1ω-9cis). The antimicrobial effect of fatty acid extracts was tested against four pathogenic bacteria. The minimum inhibitory concentrations of C. vagabunda, C. virgatum, and U. intestinalis fatty acids extracts were 1.8, 3.8, and 3.8 mg mL−1, respectively, for all bacterial strains. This study can help the efforts of finding new, value-added uses for natural marine resources.Journal of Applied Physiology 01/2013;
- Journal of Applied Physiology 12/2012;
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ABSTRACT: In this paper we report the results of an experiment to investigate the emergence of ocular vestibular evoked myogenic potentials (OVEMPs) during the linear vestibular ocular reflex (LVOR) evoked by whole-body vibration (WBV). OVEMP and electrooculogram (EOG) montages were employed to record periocular potentials (POPs) from six subjects during WBV in the nasooccipital (NO) axis over a range of frequencies from 0.5 to 64 Hz with approximately constant peak head acceleration of 1.0 ms(-2) (i.e., 0.1 g). Measurements were made in two context conditions: a fixation context to examine the effect of gaze eccentricity (0 vs. 20°), and a visual context, where a target was either head-fixed or earth-fixed. The principal results are that from 0.5 to 2 Hz POP magnitude in the earth-fixed condition is related to head displacement, so with constant acceleration at all frequencies it reduces with increasing frequency, but at frequencies greater than 2 Hz both POP magnitude and POP gain, defined as the ratio of POP magnitude at 20 and 0°, increase with increasing frequency. By exhibiting this high-pass characteristic, a property shared with the LVOR, the results are consistent with the hypothesis that the OVEMP, as commonly employed in the clinical setting, is a high-frequency manifestation of the LVOR. However, we also observed low-frequency acceleration following POPs in head-fixed conditions, consistent with a low-frequency OVEMP, and found evidence of a high-frequency visual context effect, which is also consistent with the OVEMP being a manifestation of the LVOR.Journal of Applied Physiology 01/2012; 113(10):1613-1623.
- Journal of Applied Physiology 10/2009; 107(3):1002.
- Journal of Applied Physiology 10/2009; 107(3):1003.
- Journal of Applied Physiology 10/2009; 107(3):994-7.
Article: It's too early for the shunt debate.Journal of Applied Physiology 10/2009; 107(3):999; discussion 997-8, 998.
- Journal of Applied Physiology 09/2009; 107(3):1000; discussion 997-8, 998.
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.
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