Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment Journal Impact Factor & Information

Publisher: Taylor & Francis

Journal description

Current impact factor: 1.80

Impact Factor Rankings

2015 Impact Factor Available summer 2016
2014 Impact Factor 1.802
2013 Impact Factor 2.341
2012 Impact Factor 2.22
2011 Impact Factor 1.765
2010 Impact Factor 2.23

Impact factor over time

Impact factor

Additional details

5-year impact 2.20
Cited half-life 7.40
Immediacy index 0.31
Eigenfactor 0.01
Article influence 0.52
ISSN 1944-0057

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Publications in this journal

  • Abdur Razzak · Sharifah Bee Abd Hamid · Eaqub Ali
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    ABSTRACT: Food forgery has posed considerable risk to public health, religious rituals, personal budget and wildlife. Pig, dog, cat, rat and monkey meat are restricted in most religions, but their sporadic adulteration are rampant. Market controllers need a low-cost, but reliable technique to track and trace suspected species in the food chain. Considering the need, here we documented a Lab-on-a-chip-based multiplex polymerase chain reaction (PCR) assay for the authentication of five non-halal meat-species in foods. Using species-specific primers, 172, 163, 141, 129 and 108-bp sites of mitochondrial ND5, ATPase 6, and cytochrome b genes were amplified to detect cat, dog, pig, monkey and rat species under complex matrices. Species-specificity was authenticated against 20 different species with potential to be used in food. The targets were stable under extreme sterilisation (121°C at 45psi for 2.5 h) which severely degrades DNA. The assay was optimised under the backgrounds of various commercial meat products and validated for the analysis of meatballs, burgers and frankfurters, which are popular fast food items across the globe. The assay was tested to detect 0.1% suspected meats under commercial backgrounds of marketed foods. Instead of simplex PCR which detects only one species at a time, such a multiplex platform can reduce cost by at least five-folds by detecting five different species in a single assay platform.
    Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment 10/2015; DOI:10.1080/19440049.2015.1087060
  • Frederic D Müller · Christin Hackethal · Roman Schmidt · Oliver Kappenstein · Karla Pfaff · Andreas Luch
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    ABSTRACT: The release of elemental ions from eight coffee machines and eleven electric kettles into food simulants was investigated. Three different types of coffee machines were tested: portafilter espresso machines, pod machines and capsule machines. All machines were tested subsequently on 3 days before and on 3 days after decalcification. Decalcification of the machines was performed with agents according to procedures as specified in the respective manufacturer's manuals. The electric kettles showed only a low release of the elements analysed. For the coffee machines decreasing concentrations of elements were found from the first to the last sample taken in the course of 1 day. Metal release on consecutive days showed a decreasing trend as well. After decalcification a large increase in the amounts of elements released was encountered. In addition, the different machine types investigated clearly differed in their extent of element release. By far the highest leaching, both quantitatively and qualitatively, was found for the portafilter machines. With these products releases of Pb, Ni, Mn, Cr and Zn were in the range and beyond the release limits as proposed by the Council of Europe. Therefore a careful rinsing routine, especially after decalcification, is recommended for these machines. The comparably lower extent of release of one particular portafilter machine demonstrates that metal release at levels above the threshold that triggers health concerns are technically avoidable.
    Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment 10/2015; DOI:10.1080/19440049.2015.1086929
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    ABSTRACT: A dietary survey of 3431 residents was conducted by 24-hour dietary recall method in Shanghai quarterly from September 2013 to September 2014. A total of 400 food samples were tested for aluminium concentration, including wheat flour and puffed products from 2011 to 2013. Probabilistic analysis was used to estimate the dietary exposure to aluminium from wheat and puffed products. The mean of dietary aluminium exposure for children (2-6 years old), juveniles (7-17 years old), adults (18-65 years old) and seniors (over 65 years old) were 1.88, 0.94, 0.44 and 0.42 mg kg(-1) body weight (bw) week(-1) respectively, with a population average of 0.51 mg kg(-1) bw week(-1). The proportions of those who had aluminium exposure from wheat and puffed products lower than the provisional tolerable weekly intake (PTWI) were 77%, 90%, 97%, and 97% respectively from children to seniors. We estimated that the proportions of people at risk would decrease by 13%, 6%, 2% and 2% respectively under the new China National Standards-GB 2760-2014 National Food Safety Standards for-Standards (GB 2760-2014) for using food additives. The results indicated that aluminium from wheat flour and puffed products is unlikely to cause adverse health effects in the general population in Shanghai, however, children were at a higher risk of excess aluminium exposure. Significant improvements in reducing the dietary exposure to aluminium are expected in the population, especially for children after the implementation of GB 2760-2014.
    Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment 09/2015; DOI:10.1080/19440049.2015.1099078
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    ABSTRACT: The purpose of this study was to identify the pufferfish species and detect the tetrodotoxin (TTX) in roasted fish fillet samples which were collected in Beijing, Qingdao and Xiamen of China. Cytochrome c oxidase I (COI) gene was used as target gene for identification of the pufferfish species in samples. Enzyme-linked immunosorbent assay (ELISA) were used to screen the TTX levels in samples which had been detected as containing pufferfish by DNA barcode. 125 samples were identified by DNA barcodes, 32(26%) samples contained pufferfish composition and among them 26 (81%) were the highly toxic species named Lagocephalus lunaris. All 32 samples containing the pufferfish composition were positive for TTX with the levels ranging from 100 ng/g to 63,800 ng/g. Most of the 32 samples contained the highly toxic species Lagocephalus lunari. Based on the results, we suggest that the monitoring of roasted fish fillet should be strengthened and the processing procedures should be standardised to minimise TTX poisoning caused by pufferfish.
    Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment 09/2015; DOI:10.1080/19440049.2015.1087056
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    ABSTRACT: Lichenysin which is produced by 53 different Bacillus licheniformis strains has been structurally examined with a qualitative liquid chromatography - tandem mass spectrometry (LC-MS/MS) method using quadrupole - time of flight mass spectrometry. The same lichenysin isoforms are produced from all strains, indicating that the growth conditions have a stronger influence on the lipopeptide production than the genotype. A rapid method for the quantification of lichenysin from bacterial cell cultures with LC-MS/MS after a simple methanol extraction has been refined. For the first time, commercially available lichenysin has been used as calibrant, making quantification more accurate. The trueness for C15-lichenysin has been improved to 94% using matrix-matched calibration with lichenysin compared to 30% using solvent calibration with surfactin. The quantitative method was fully validated based on Commission Decision 2002/657/EC. The LOD of the method was below 1 µg g(-1) and the repeatability ranged from 10% to 16%.
    Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment 09/2015; DOI:10.1080/19440049.2015.1096967
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    ABSTRACT: Physiologically based pharmacokinetic (PBPK) models are powerful tools to predict tissue distribution and depletion of veterinary drugs in food animals. However, most models only simulate the pharmacokinetics of the parent drug, without considering their metabolites. In this study, a PBPK model was developed to simultaneously describe the depletion in pigs of the food animal antimicrobial agent cyadox (CYA), and its marker residue 1,4-bisdesoxycyadox (BDCYA). The CYA and BDCYA sub-models included blood, liver, kidney, gastrointestinal tract, muscle, fat and other organ compartments. Extent of plasma-protein binding, renal clearance and tissue-plasma partition coefficients of BDCYA were measured experimentally. The model was calibrated with the reported pharmacokinetic and residue depletion data from pigs dosed by oral gavage with CYA for five consecutive days, and then extrapolated to exposure in feed for two months. The model was validated with 14 consecutive day feed administration data. This PBPK model accurately simulated CYA and BDCYA in four edible tissues at 24-120 h after both oral exposure and 2-month feed administration. There was only slight overestimation of CYA in muscle and BDCYA in kidney at earlier time points (6-12 h) when dosed in feed. Monte Carlo analysis revealed an excellent agreement between the estimated concentration distributions and observed data. The present model could be used for tissue residue monitoring of CYA and BDCYA in food animals, and provides a foundation for developing PBPK models to predict residue depletion of both parent drugs and their metabolites in food animals.
    Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment 09/2015; DOI:10.1080/19440049.2015.1100330
  • Natalia Campillo · María Jesús Iniesta · Pilar Viñas · Manuel Hernández-Córdoba
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    ABSTRACT: Seven strobilurin fungicides were pre-concentrated from soya-based drinks using dispersive liquid-liquid microextraction (DLLME) with a prior protein precipitation step in acid medium. The enriched phase was analysed by liquid chromatography (LC) with dual detection, using diode array detection (DAD) and electrospray-ion trap tandem mass spectrometry (ESI-IT-MS/MS). After selecting 1-undecanol and methanol as the extractant and disperser solvents, respectively, for DLLME, the Taguchi experimental method, an orthogonal array design, was applied to select the optimal solvent volumes and salt concentration in the aqueous phase. The matrix effect was evaluated and quantification was carried out using external aqueous calibration for DAD and matrix-matched calibration method for MS/MS. Detection limits in the 4-130 and 0.8-4.5 ng g(-1) ranges were obtained for DAD and MS/MS, respectively. The DLLME-LC-DAD-MS method was applied to the analysis of ten different samples, none of which was found to contain residues of the studied fungicides.
    Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment 09/2015; DOI:10.1080/19440049.2015.1096966
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    ABSTRACT: For the treatment of rabbit dysentery and bacterial enteritis, veterinary practitioners often adopt veterinary medicinal products authorised for other food producing species, but in some cases non-authorised drugs frequently used in the past, such as carbadox and olaquindox, might be illegally adopted. To verify the carbadox and olaquindox distribution and persistence in rabbit tissues, two independent in vivo studies were carried out. In the first study 24 healthy rabbits received water medicated with carbadox at 100 mg L(-1) over a period 28 days, whereas in the second one 24 healthy rabbits were administered water containing olaquindox at 100 mg L(-1). In each study rabbits were randomly assigned to four groups to be sacrificed respectively at 0; 5; 10; 20 days from treatment withdrawal, for depletion studies. A control group of 6 animals was adopted for control and as a reservoir of blank tissues. Muscle and liver samples collected from each treated animal were stored at -20°C pending the analysis. Sensitive and robust liquid chromatography-tandem mass spectrometry analytical methods were set up for the parent compounds and their main metabolites quinoxaline-2-carboxylic acid, desoxycarbadox and 3-methylquinoxaline-2-carboxylic acid to verify their residual. Data collected demonstrate that the combination of liver as target matrix, quinoxaline-2-carboxylic acid and 3-methylquinoxaline-2-carboxylic acid as marker residue and enzymatic digestion is strategic to evidence carbadox and/or olaquindox illegal treatments in rabbits, even 20 days after treatment withdrawal at concentration levels higher than 0.5 µg kg(-1). This findings suggests that liver should be proposed as target matrix for official control in national monitoring plan.
    Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment 09/2015; DOI:10.1080/19440049.2015.1086822
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    ABSTRACT: The use of sulphur dioxide in the treatment of foodstuffs presents some problems as it could lead to pseudo-allergies for some people. The aim of this research work was to study the addition of different preservative mixtures and their influence on the concentration of volatile compounds and sensorial quality in wine. To do so, vinifications were carried out using Garnacha must to which lysozyme, dimethyl dicarbonate and mixtures of these with SO2 were added in different doses (25 and 50 mg L(-1)). The results were compared with a control sample to which only SO2 had been added (50 mg L(-1)). In general, mixtures of SO2 with lysozyme and dimethyl dicarbonate favoured the formation of volatile compounds in the wines. Wines obtained from the mixtures of lysozyme and dimethyl dicarbonate with 25 mg L(-1) of SO2 had better sensorial quality than the wines obtained with 50 mg L(-1) as the only preservative used.
    Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment 09/2015; DOI:10.1080/19440049.2015.1094831
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    ABSTRACT: An ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) multi-mycotoxin analytical method has been developed to simultaneously identify and quantify 20 mycotoxins in grass silages, inclusive of mycotoxins that are currently regulated in EU feeds. Extraction of mycotoxins from dried grass silages was performed using of a modified QuEChERS extraction employing an acidified aqueous extraction (0.1N HCl) with no further clean-up. Following chromatographic separation, analytes were detected using a fast polarity switching MS/MS method that allowed both positive and negative ions to be analysed from a single injection, thus reducing time and cost of analysis. The limits of detection and quantification ranged between 3 µg/kg DM (aflatoxin B1, beauvericin and enniatin A and A1) to 200 µg/kg DM (deoxynivalenol) and 10 µg/kg DM (aflatoxin B1, beauvericin and enniatin A1) to 500 µg/kg DM (deoxynivalenol), respectively. Inter-assay accuracy and precision ranged between 90-107% and 3.9-15.0% CV, respectively. The accuracy of the method was assessed through application to a range of incurred samples in an inter-laboratory study.
    Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment 09/2015; DOI:10.1080/19440049.2015.1094830
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    ABSTRACT: Liquorice is an herbal medicine produced mainly in China and Iran. This plant is suspected to contain ochratoxin A (OTA), a secondary metabolite produced by fungi. Although liquorice is not included in the daily dietary of humans, the high levels of OTA reported in this product has concerned consumers. Registration of a standard method for measuring the amount of this mycotoxin in liquorice derived products is an important challenge and requires introduction of a reliable, simple, fast performance and reproducible technique. This review examines studies which have been carried out concerning the occurrence of OTA in liquorice products. Recent information regarding contaminated liquorice, regulatory framework and methods to degrade OTA in liquorice are discussed.
    Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment 09/2015; DOI:10.1080/19440049.2015.1094708
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    ABSTRACT: Food composite samples from the Canadian total diet study which was conducted each year from 2008-2012 rotating between different cities were analysed for bisphenol A (BPA). The overall levels of BPA in the composite food samples from each of the five years from 2008-2012 were similar in general with averages (range) of 7.7 ng/g (0.20-106 ng/g), 7.8 ng/g (0.26-110 ng/g), 6.9 ng/g (0.20-84 ng/g), 7.7 ng/g (0.20-105 ng/g), and 9.0 ng/g (0.15-90 ng/g) for 2008, 2009, 2010, 2011, and 2012, respectively. Levels of BPA in most of the non-canned food composite samples were low and no particular trends were observed. In contrast, the trend of BPA levels in canned food composite samples over the five years (2008-2012) varies. BPA levels in most of the canned food composite samples from 2008-2012 were consistent in general (e.g., canned luncheon meat: 10-18 ng/g, canned baked beans: 18-25 ng/g). While BPA levels over the five years were found to decrease for some canned food composite samples (e.g., canned fish: 109 ng/g in 2009 vs. 51 ng/g in 2012), they were also found to increase for some other canned food composite samples (e.g., canned meat soups: 90-104 ng/g in 2011-2012 vs. 29 ng/g in 2008). Thus, recent changes in can coating for food packaging to BPA-free alternatives may have not been fully reflected in all canned food products over the period from 2008-2012. Continued monitoring is necessary to more fully assess the potential impact on dietary exposure by the use of BPA alternatives in food contact materials.
    Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment 09/2015; DOI:10.1080/19440049.2015.1088663
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    ABSTRACT: A fast and easy-to-use confirmatory liquid-chromatography tandem mass-spectrometry (LC-MS/MS) based-method was developed for the analysis of the pesticide sodium monofluoroacetate (MFA, also called "1080") in infant formula and related dairy products. Extraction of the compound encompassed sample reconstitution and liquid-liquid extraction under acidic conditions. Time-consuming solid phase extraction steps for clean-up and enrichment and tedious derivatization were thus avoided. Resulting sample extracts were analysed by electrospray ionisation (ESI) in negative mode. Quantification was performed by the isotopic dilution approach using (13)C-labelled MFA as internal standard. The procedure was validated according to the European document SANCO/12571/2013 and performance parameters such as linearity (r(2) > 0.99), precision (RSD(r) ≤ 9%, RSD(iR) ≤ 11%) and recovery (96-117%) fulfilled its requirements. Limit of quantifications (LOQ) was 1 µg kg(-1) for infant formula and related dairy products except for whey proteins powders with a LOQ of 5 µg kg(-1). Method ruggedness was further assessed in another laboratory devoted to routine testing for quality control.
    Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment 09/2015; DOI:10.1080/19440049.2015.1087057
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    ABSTRACT: The volatile composition of 21 herb honeys (HHs) of seven different botanical origins was characterised for the first time. Ultrasound solvent extraction (USE) and headspace solid-phase microextraction (HS-SPME) followed by GC-FID/MS were successfully applied as complementary methods for monitoring the volatile plant flavours added by the bees. HHs showed significant compositional variability related to the botanical origin and compounds that could serve as traceability biomarkers were identified. The most important compounds with high abundance were (E - extract; H - headspace): caffeine (up to 68.7%, E) and trans-linalool oxide (up to 26.0%, H) in coffee HH, α-terpineol (up to 8.2%, E; 27.1%, H) and bornyl acetate (up to 3.1, E; 11.9%, H) in pine HH, thymol (up to 3.1%, E; 55.4%, H) in thyme HH. Hawthorn HH was characterised by the presence of herniarin (up to 13.4%, E) and lemon HH contained limonene (up to 1.6%, E; 33.2%, H). Other HHs (nettle and aloe) contained lower amounts of volatiles and their profiles were not specific. In all the HHs, methyl syringate was found and it was most abundant in thyme HH (up to 17.4%, E). The volatile fraction of HHs showed some substantial similarities and differences with the composition of herbs from which they derive. It confirms the selective bee-mediated transfer of phytochemicals, including known flavour-active volatiles into the final product, but also biotransformation of several compounds. Additionally, several similarities to the corresponding natural honeys were observed, but in general HHs exhibited less rich volatile profiles.
    Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment 09/2015; DOI:10.1080/19440049.2015.1086496
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    ABSTRACT: Myricitrin, a flavonol rhamnoside of myricetin extracted from the Chinese bayberry (Myrica rubra SIEBOLD) plant, has been used in Japan since 1992 as a flavour modifier in snack foods, dairy products, and beverages. It is affirmed as "generally recognised as safe" (GRAS) by the U.S. Flavour and Extract Manufacturer Association and is considered safe by the Joint FAO/WHO Expert Committee on Food Additives (JECFA) at current estimated dietary exposures. In anticipation of expanded marketing, 97% pure myricitrin was fed to male and female Sprague-Dawley rats at dietary concentrations of 0.5%, 1.5%, and 5.0% in a 90-day toxicity study. There was increased food consumption and decreased body weight gain in males exposed to 5% myricitrin. Blood values were within laboratory reference ranges except for mean increases in basophils in low- and high-dose males and serum phosphorus in high dose males. In the absence of abnormal clinical or histopathological changes, these changes are not considered adverse. Based on the 90-day rat toxicity study, the no-observed-adverse-effect-level is 2926 mg/kg/day in males and 3197 mg/kg/day in females. Gavage administration of myricitrin resulted in blood levels of myricitrin within one hour after single oral doses of 250, 500, or 1000 mg/kg body weight, indicating direct absorption of the glycosylated form of this flavonoid. Blood levels of myricetin, a metabolite of myricitrin, were not present in rats dosed orally with 1.6 mg/kg myricetin, but were present only at 12 or 24 hours in 1of 5, 3 of 5, and 4 of 5 rats dosed with 250, 500, and 1000 mg myricitrin/kg body weight, respectively, possibly a result of hepatic conversion of myricitrin to myricetin and enterohepatic recirculation of the resulting myricetin. The current studies further support prior safety assessments of myricitrin as a food flavouring.
    Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment 09/2015; DOI:10.1080/19440049.2015.1084653
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    ABSTRACT: The objectives of the present study were to assess heavy metal cadmium (Cd) and lead (Pb), and organochlorine pesticide concentrations in tissues of red deer (Cervus elaphus) and wild boar (Sus scrofa) from 9 hunting areas and to evaluate related risk factors for the host animal. Over a period of 2 years, a total of 1055 and 210 masseters, 424 and 201 livers, 642 and 152 kidneys were collected from wild boar and red deer respectively, and concentrations of Cd, Pb and organochlorine pesticides were determined. Comparing the two species, Cd concentration in the kidney (3.72 mg/kg), liver (0.67 mg/kg) and muscle (0.02 mg/kg) of wild boar was found to be significantly higher than in the organs of red deer (1.02 mg/kg in the kidneys, 0.07 mg/kg in the liver and 0.006 mg/kg in muscle). Mean Pb concentrations were found to be similar in both animals, with 0.39 mg/kg, 0.52 mg/kg and 2.60 mg/kg detected in the wild boar kidney, liver and muscle respectively and 0.24 mg/kg, 0.21 mg/kg and 2.04 mg/kg in the respective organs of the red deer. No difference in concentrations were found based on age class, location of tissue sample or contaminant in the case of wild boar. By contrast, a significantly lower Cd concentration was found in the kidney of the young red deer. The search for organochlorine pesticides in both red deer and wild boar produced negative results with values below the limits of detection. Due to the high levels of renal Cd and muscle Pb detected in wild boar and red deer, further research needs to be carried out in an effort to identify the source of contamination and preserve the health of animals and humans.
    Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment 09/2015; DOI:10.1080/19440049.2015.1087058
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    ABSTRACT: Imazalil is one of the most widespread fungicides used for the post-harvest treatment of citrus species. The separate use of peel during food preparation and processing may hitherto concentrate most of imazalil into food products where specific maximum residue limits hardly exist for this fungicide. In order to monitor comprehensively the path of imazalil, our study covered the monitoring of the efficiency of several washing treatments, the comparison of operative and related sample preparation methods for the lemon samples, the validation of a sample preparation technique for a fatty cake matrix, the preparation of a model cake sample made separately either with imazalil containing lemon peel or with imazalil spiking, the monitoring of imazalil degradation into α-(2,4-dichlorophenyl)-1H-imidazole-1-ethanol because of the baking process, and finally the mass balance of imazalil throughout the washing experiments and the baking process. Quantification of imazalil was carried out with an LC-ESI-MS/MS set-up, while LC-QTOF was used for the monitoring of imazalil degradation. Concerning the washing, none of the addressed five washing protocols could remove more than 30% of imazalil from the surface of the lemon samples. The study revealed a significant difference between the extraction efficiency of imazalil by the EN 15662:2008 and AOAC 2007.1 methods with the advantage of the former. The use of the model cake sample helped to validate a modified version of the EN 15662:2008 method that included a freeze-out step to efficiently recover imazalil (>90%) from the fatty cake matrix. The degradation of imazalil during the baking process was significantly higher when this analyte was spiked into the cake matrix than in the case of preparing the cake with imazalil-containing lemon peel (52% vs. 22%). This observation calls the attention to the careful evaluation of pesticide stability data that are based on solution spiking experiments.
    Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment 09/2015; DOI:10.1080/19440049.2015.1086824