ACS Nano

Publisher: American Chemical Society, American Chemical Society

Journal description

Current impact factor: 12.03

Impact Factor Rankings

2015 Impact Factor Available summer 2015
2013 / 2014 Impact Factor 12.033
2012 Impact Factor 12.062
2011 Impact Factor 10.774
2010 Impact Factor 9.855
2009 Impact Factor 7.493
2008 Impact Factor 5.472

Impact factor over time

Impact factor

Additional details

5-year impact 12.52
Cited half-life 2.40
Immediacy index 1.94
Eigenfactor 0.20
Article influence 4.01
Other titles ACS nano (Online), ACS nano, American Chemical Society nano
ISSN 1936-086X
OCLC 85374429
Material type Document, Periodical, Internet resource
Document type Internet Resource, Computer File, Journal / Magazine / Newspaper

Publisher details

American Chemical Society

  • Pre-print
    • Author cannot archive a pre-print version
  • Restrictions
    • Must obtain written permission from Editor
    • Must not violate ACS ethical Guidelines
  • Post-print
    • Author cannot archive a post-print version
  • Restrictions
    • If mandated by funding agency or employer/ institution
    • If mandated to deposit before 12 months, must obtain waiver from Institution/Funding agency or use AuthorChoice
    • 12 months embargo
  • Conditions
    • On author's personal website, pre-print servers, institutional website, institutional repositories or subject repositories
    • Non-Commercial
    • Must be accompanied by set statement (see policy)
    • Must link to publisher version
    • Publisher's version/PDF cannot be used
    • If mandated sooner than 12 months, must obtain waiver from Editors or use AuthorChoice
    • Reviewed on 07/08/2014
  • Classification
    ​ white

Publications in this journal

  • Brian C Evans, Kyle M Hocking, Kameron V Kilchrist, Eric S Wise, Colleen M Brophy, Craig L Duvall
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    ABSTRACT: A platform technology has been developed and tested for delivery of intracellular-acting peptides through electrostatically complexed nanoparticles, or nano-polyplexes, formulated from an anionic, endosomolytic polymer and cationic therapeutic peptides. This delivery platform has been initially tested and optimized for delivery of two unique vasoactive peptides, a phosphomimetic of heat shock protein 20 and an inhibitor of MAPKAP Kinase II, to prevent pathological vasoconstriction (i.e., vasospasm) in human vascular tissue. These peptides inhibit vasoconstriction and promote vasorelaxation by modulating actin dynamics in vascular smooth muscle cells. Our data indicate that formulating these peptides into nano-polyplexes significantly enhances peptide uptake and retention, facilitates cytosolic delivery through a pH-dependent endosomal escape mechanism, and enhances peptide bioactivity in vitro as demonstrated by their ability to inhibit F-actin stress fiber formation. In comparison to treatment with the free peptides, which were endowed with cell penetrating sequences, the nano-polyplexes significantly increased vasorelaxation, inhibited vasoconstriction, and decreased F-actin formation in human saphenous vein ex vivo. These formulations have significant potential for treatment of conditions such as cerebral vasospasm following subarachnoid hemorrhage. Furthermore, because many therapeutic peptides include cationic cell-penetrating segments, this simple and modular platform technology may have broad applicability as a cost-effective approach for enhancing the efficacy of cytosolically-active peptides.
    ACS Nano 05/2015; DOI:10.1021/acsnano.5b00491
  • Masahiro Fujiwara, Tatsuki Imura
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    ABSTRACT: Water purification and desalination to produce end-use water are important agendas in 21st century, because the global water shortage is becoming increasingly serious. Those processes using light energy, especially solar energy, without the consumption of fossil fuels are desired for creating sustainable society. For these earth-friendly water treatments, nanoporous materials and membranes are expected to provide new technologies. We have reported before that the repetitive photo isomerization of azobenzene groups between the trans and cis isomers induced by the simultaneous irradiation of UV and visible lights accelerates the molecular movement of nearby molecules in nanoporous materials. After further studies, we recently found that the permeation of water through azobenzene modified anodized alumina membranes as a photo responsive nanoporous membrane was achieved by the simultaneous irradiation of UV and visible lights, while no water penetration occurred under no light, only single UV or visible light. The photo induced permeation of water was promoted by the vaporization of water with the repetitive photo isomerization of azobenzene. This membrane permeation achieved the purification of water solutions, because dye molecules and a protein dissolved in aqueous solutions were not involved in the photo induced penetrated water. When 3.5 % of sodium chloride solution as model seawater was employed for this membrane separation, the salt content of the permeated water was less than 0.01 % to accomplish the complete desalination of seawater.
    ACS Nano 05/2015; DOI:10.1021/nn505970n
  • Wei Rao, Hai Wang, Jianfeng Han, Shuting Zhao, Jenna Dumbleton, Pranay Agarwal, Wujie Zhang, Gang Zhao, Jianhua Yu, Debra L Zynger, Xiongbin Lu, Xiaoming He
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    ABSTRACT: Tumor reinitiating cancer stem-like cells are responsible for cancer recurrence associated with conventional chemotherapy. We developed a doxorubicin-encapsulated polymeric nanoparticle surface-decorated with chitosan that can specifically target the CD44 receptors of these cells. This nanoparticle system was engineered to release the doxorubicin in acidic environments, which occurs when the nanoparticles are localized in the acidic tumor microenvironment and when they are internalized and localized in the cellular endosomes/lysosomes. This nanoparticle design strategy increases the cytotoxicity of the doxorubicin by six times in comparison to the use of free doxorubicin for eliminating CD44+ cancer stem-like cells residing in 3D mammary tumor spheroids (i.e., mammospheres). We further show these nanoparticles reduced the size of tumors in an orthotopic xenograft tumor model with no evident systemic toxicity. The development of nanoparticle system to target cancer stem-like cells with low systemic toxicity provides a new treatment arsenal for improving the survival of cancer patients.
    ACS Nano 05/2015; DOI:10.1021/nn506928p
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    ABSTRACT: Heterogeneity of cell populations can confound population-averaged measurements and obscure important findings or foster inaccurate conclusions. The ability to generate a homogeneous cell population, at least with respect to a chosen trait, could significantly aid basic biological research and development of high-throughput assays. Accordingly, we developed a high-resolution, image-based patterning strategy to produce arrays of single-cell patterns derived from the morphology or adhesion site arrangement of user-chosen cells of interest (COIs). Cells cultured on both cell-derived patterns displayed a cellular architecture defined by their morphology, adhesive state, cytoskeletal organization, and nuclear properties that quantitatively recapitulated the COIs that defined the patterns. Furthermore, slight modifications to pattern design allowed for suppression of specific actin stress fibers and direct modulation of adhesion site dynamics. This approach to patterning provides a strategy to produce a more homogeneous cell population, decouple the influences of cytoskeletal structure, adhesion dynamics, and intracellular tension on mechanotransduction-mediated processes, and a platform for high-throughput cellular assays.
    ACS Nano 05/2015; DOI:10.1021/acsnano.5b01366
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    ABSTRACT: Surface reactions of 2,5-diethynyl-1,4-bis(phenylethynyl)benzene on Ag(111), Ag(110), and Ag(100) were systematically explored and scrutinized by scanning tunneling microscopy, molecular mechanics simulations, and density functional theory calculations. On Ag(111), Glaser coupling reaction became dominant, yielding one-dimensional molecular wires formed by covalent bonds. On Ag(110) and Ag(100), however, the terminal alkynes reacted with surface metal atoms, leading to one-dimensional organometallic nanostructures. Detailed experimental and theoretical analyses revealed that such a lattice dependence of the terminal alkyne reaction at surfaces originated from the matching degree between the periodicities of the produced molecular wires and the substrate lattice structures.
    ACS Nano 05/2015; DOI:10.1021/acsnano.5b01803
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    ABSTRACT: Developing a simple and efficient method to organize nanoscale building blocks into ordered superstructures, understanding the mechanism for self-assembly and revealing the essential collective properties are crucial steps toward the practical use of nanostructures in nanotechnology-based applications. In this study, we showed that the high-yield formation of ZnO nanoparticle chains with micrometer length can be readily achieved by the variation of solvents from methanol to water. Spectroscopic studies confirmed the solvent effect on the surface properties of ZnO nanoparticles, which were found to be critical for the formation of anisotropic assemblies. Quantum mechanical calculations and all atom molecular dynamic simulations indicated the contribution of hydrogen bonding for stabilizing the structure in water. Dissipative particle dynamics further revealed the importance of solvent-nanoparticle interactions for promoting one-dimensional self-assembly. The branching of chains was found upon aging, resulting in the size increase of the ensembles and network formation. Steady-state and time-resolved luminescent spectroscopes, which probed the variation of defect-related emission, revealed stronger Forster resonance energy transfer (FRET) between nanoparticles when the chain networks were formed. The high efficiency of FRET quenching can be ascribed to the presence of multiple energy transfer channels, as well as the short internanoparticle distances and the dipole alignment.
    ACS Nano 05/2015; DOI:10.1021/acsnano.5b00344
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    ABSTRACT: Grains and grain boundaries (GBs) in graphene are vital for the control of its properties; however, engineering or controlling them by growth remains a great challenge. Here we discover that the dynamic formation of GBs within chemical vapor deposited polygonal graphene flakes is described by a geometric rule. A GB is formed to be symmetrically tilted and a continuous straight line, and the key parameters including end point, direction of GB line, and misorientation angles between adjacent graphene grains can be determined solely by the geometries of the polygonal graphene flakes. We also show the growth control over the length of straight graphene GB lines and demonstrate the capability of parallel fabrication of field-effect transistor devices across predicted GBs in a straightforward manner. This work constitutes a significant step forward in engineering grains and GBs in graphene.
    ACS Nano 05/2015; DOI:10.1021/acsnano.5b01827
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    ABSTRACT: Self-assembly, as one kind of general phenomenon, has often been reported in solution chemistry. However, in gas-solid phase, it seldom has been disclosed. The MoN nanochex exhibits unique geometrical shape. Its body-segment is composed of textured single crystal MoN nanowires, while its edges parallel to [ ] direction is attached by nanowires whose crystal orientation is different from that of the body segment. In this paper, the structure of the MoN nanochex is studied, and accordingly a possible growth mechanism is proposed. We expect to extend this method to designed synthesis of many other functional materials, such as nitrides, carbides, and borides, and thereby to significantly tailor their resulting properties. Meanwhile, as one promising electrode material for Li-ion batteries (LIBs), MoN nanochex on Ti foil has been applied in the electrochemical energy storage, and stably delivered a specific capacity of 720 mAh/g with a remarkable coulombic efficiency up to 98.5%, implying an achieved synergic effect derived from both mesoporous structure and the direct contact with the conducting substrate.
    ACS Nano 05/2015; DOI:10.1021/acsnano.5b02415
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    ABSTRACT: To predict potential medical value or toxicity of nanoparticles (NPs), it is necessary to understand the chemical transformation during intracellular processes of NPs. However, it is a grand challenge to capture a high-resolution image of metallic NPs in a single cell and the chemical information of intracellular NPs. Here, by integrating synchrotron radiation-beam transmission X-ray microscopy (SR-TXM) and SR-X-ray absorption near edge structure (SR-XANES) spectrometry, we successfully capture the 3D distribution of silver NPs (AgNPs) inside a single human monocyte (THP-1), associated with the chemical transformation of silver. The results reveal that the cytotoxicity of AgNPs is largely due to the chemical transformation of particulate silver from elemental silver (Ag0)n, to Ag+ ions and Ag-O-, then Ag-S- species. These results provide direct evidence in the long-lasting debate on whether the nanoscale or the ionic form dominates the cytotoxicity of silver nanoparticles. Further, the present approach provides an integrated strategy capable of exploring the chemical origins of cytotoxicity of metallic nanoparticles.
    ACS Nano 05/2015; DOI:10.1021/acsnano.5b02483
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    ABSTRACT: A charge transfer plasmon (CTP) appears when an optical-frequency conductive pathway between two metallic nanoparticles is established, enabling the transfer of charge between nanoparticles when the plasmon is excited. Here we investigate the properties of the CTP in a nanowire-bridged dimer geometry. Varying the junction geometry controls its conductance, which modifies the resonance energies and scattering intensities of the CTP while also altering the other plasmon modes of the nanostructure. Reducing the junction conductance shifts this resonance to substantially lower energies in the near- and mid-infrared regions of the spectrum. The CTP offers both a high-information probe of optical frequency conductances in nanoscale junctions and a new, unique approach to controllably engineering tunable plasmon modes at infrared wavelengths.
    ACS Nano 05/2015; DOI:10.1021/acsnano.5b02087
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    ABSTRACT: Preventing reactive gas species such as oxygen or water is important to ensure the stability and durability of organic electronics. Although inorganic materials have been predominantly employed as the protective layers, their poor mechanical property has hindered the practical application to flexible electronics. The densely-packed hexagonal lattice of carbon atoms in graphene doesn't allow the transmission of small gas molecules. In addition, its outstanding mechanical flexibility and optical transmittance are expected to be useful to overcome the current mechanical limit of the inorganic materials. In this paper, we reported, for the first time, the measurement of the water vapor transmission rate (WVTR) through the 6-layer 10x10 cm(2) large-area graphene films synthesized by chemical vapor deposition (CVD) (~0.48 g/m(2)∙day). We also showed that the graphene-passivated organic field-effect transistors exhibited excellent environmental stability as well as a prolonged life time even after 500 bending cycles with strain of 2.3 %. We expect that our results would be a good reference for the excellent gas barrier properties of large-area graphene films, but further optimization is needed to fully utilize the intrinsic gas-impermeable capability of graphene films.
    ACS Nano 05/2015; DOI:10.1021/acsnano.5b01161
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    ABSTRACT: A doping-free transistor made of ambipolar α-phase molybdenum ditelluride (α-MoTe2) is proposed in which the transistor polarity (p-type and n-type) is electrostatically controlled by dual top gates. The voltage signal in one of the gates determines the transistor polarity, while the other gate modulates the drain current. We demonstrate the transistor operation experimentally, with electrostatically controlled polarity of both p- and n-type in a single transistor.
    ACS Nano 05/2015; DOI:10.1021/acsnano.5b00736
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    ABSTRACT: Semiconducting transition metal dichalcogenides (TMDCs) have attracted a lot of attention recently, because of their interesting electronic, optical, and mechanical properties. Among large numbers of TMDCs, monolayer of tungsten diselenides (WSe2) is of particular interest since it possesses a direct band gap and tunable charge transport behaviors, which make it suitable for a variety of electronic and optoelectronic applications. Direct synthesis of large domains of monolayer WSe2 and their growth mechanism studies are important steps toward applications of WSe2. Here, we report systematical studies on ambient pressure chemical vapor deposition (CVD) growth of monolayer and few layer WSe2 flakes directly on silica substrates. The WSe2 flakes were characterized using optical microscopy, atomic force microscopy, Raman spectroscopy, and photoluminescence spectroscopy. We investigated how growth parameters, with emphases on growth temperatures and durations, affect the sizes, layer numbers, and shapes of as-grown WSe2 flakes. We also demonstrated that transport properties of CVD-grown monolayer WSe2, similar to mechanically-exfoliated samples, can be tuned into either p-type or ambipolar electrical behavior, depending on the types of metal contacts. These results deepen our understandings on the vapor phase growth mechanism of WSe2, and may benefit the uses of these CVD-grown monolayer materials in electronic and optoelectronics.
    ACS Nano 05/2015; DOI:10.1021/acsnano.5b01301
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    ABSTRACT: anoporous carbon and nanoporous cobalt oxide (Co3O4) materials have been selectively prepared from single metal-organic-framework (MOF) (zeolitic imidazolate framework, ZIF-67) by optimising the annealing conditions. The resulting ZIF-derived carbon possesses highly graphitic walls and a high specific surface area of 350 m2∙g-1, while the resulting ZIF-derived nanoporous Co3O4 possesses a high specific surface area of 148 m2∙g-1 with very less carbon content (1.4 %). When nanoporous carbon and nanoporous Co3O4 were tested as electrode materials for supercapacitor application, they showed high capacitance values (250 F∙g-1 and 508 F∙g-1, respectively, at a scan rate of 5 mV∙s-1). To further demonstrate the advantages of our ZIF-derived nanoporous materials, symmetric (SSCs) and asymmetric supercapacitors (ASCs) were also fabricated using nanoporous carbon and nanoporous Co3O4 electrodes. Improved capacitance performance was successfully realized for the ASC (Co3O4//carbon), better than those of the SSCs based on nanoporous carbon and nanoporous Co3O4 materials (i.e., carbon//carbon, Co3O4//Co3O4). The thus-developed ASC with an optimal mass loading can be operated within a wide potential window of 0.0-1.6 V, which leads to achieve a high specific energy of 36 W∙h∙kg-1. More interestingly, this ASC also exhibits excellent rate capability (with the highest specific power of 8000 W∙kg-1 at specific energy of 15 W∙h∙kg-1) combined with long-term stability up to 2000 cycles.
    ACS Nano 05/2015; DOI:10.1021/acsnano.5b01790
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    ABSTRACT: The nanoparticle on mirror (NPoM) construct is ideal for the strong coupling of localized plasmons because of its simple fabrication and the nm-scale gaps it offers. Both of these are much harder to control in nanoparticle dimers. Even so, realizing controllable gap sizes in a NPoM remains difficult and continuous tunability is limited. Here, we use reactive metals as the mirror so that the spacing layer of resulting metal oxide can be easily and controllably created with specific thicknesses resulting in continuous tuning of the plasmonic coupling. Using Al as a case study, we contrast different approaches for oxidation including electrochemical oxidation, thermal annealing, oxygen plasma treatments, and photo-oxidation by laser irradiation. The thickness of the oxidation layer is calibrated with depth-mode X-ray photoemission spectroscopy (XPS). These all consistently show increasing thickness of the oxidation layer blue-shifts the plasmonic resonance peak while the transverse mode remains constant, as well matched by simulations. Our approach provides a facile and reproducible method for scalable, local and controllable fabrication of NPoMs with tailored plasmonic coupling, suited for many applications of sensing, photochemistry, photoemission and photovoltaics.
    ACS Nano 05/2015; DOI:10.1021/acsnano.5b01283
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    ABSTRACT: A rapid and simple approach is presented to address the most critical issues of surface-enhanced Raman scattering (SERS)-based immunoassay such as removal/avoiding nonspecific adsorption and reducing assay time. The approach demonstrated involves rationally designed fluorophore integrated gold/silver nanoshells as SERS nanotags and utilizes alternative current electrohydrodynamic (ac-EHD) - induced nanoscaled surface shear forces to enhance the capture kinetics. The assay performance was validated in comparison with hydrodynamic flow and conventional immunoassay based devices. These nanoscaled physical forces acting within nanometer distances from the surface enabled rapid (40 min), sensitive (10 fg/mL) and highly specific detection of human epidermal growth factor receptor 2 (HER2) in breast cancer patient samples. We believe this approach presents potential for the development of rapid and sensitive SERS immunoassays for routine clinical diagnosis.
    ACS Nano 05/2015; DOI:10.1021/acsnano.5b01929
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    ABSTRACT: Heteroatom-doped graphene materials have been intensely studied as active electrodes in energy storage devices. Here, we demonstrate that boron-doped porous graphene can be prepared in ambient air using a facile laser induction process from boric acid containing polyimide sheets. At the same time, active electrodes can be patterned for flexible microsupercapacitors. As a result of boron doping, the highest areal capacitance of as-prepared devices reaches 16.5 mF/cm^2, three times higher than non-doped devices, with concomitant energy density increases of 5 to 10 times at various power densities. The superb cyclability and mechanical flexibility of the device is well-maintained, showing great potential for future microelectronics made from this boron-doped laser induced graphene material.
    ACS Nano 05/2015; DOI:10.1021/acsnano.5b00436
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    ABSTRACT: Strain can tune desirable electronic behavior in graphene, but there has been limited progress in controlling strain in graphene devices. In this paper, we study the mechanical response of graphene on substrates patterned with arrays of mesoscale pyramids. Using atomic force microscopy, we demonstrate that the morphology of graphene can be controlled from conformal to suspended depending on the arrangement of pyramids and the aspect ratio of the array. Non-uniform strains in graphene suspended across pyramids are revealed by Raman spectroscopy and supported by atomistic modeling, which also indicates strong pseudomagnetic fields in the graphene. Our results suggest that incorporating mesoscale pyramids in graphene devices is a viable route to achieving strain-engineering of graphene.
    ACS Nano 05/2015; DOI:10.1021/acsnano.5b00335
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    ABSTRACT: The recognition of atomically distinct surface features by adsorbed biomolecules is central to the formation of surface-templated peptide or protein nanostructures. On mineral surfaces such as calcite, biomolecular recognition of, and self-assembly on, distinct atomic kinks and steps could additionally orchestrate changes to the overall shape and symmetry of a bulk crystal. In this work we show through in situ atomic force microscopy (AFM) experiments that an acidic 20 kD cement protein from the barnacle Megabalanus rosa (MRCP20) binds specifically to step edge atoms on {101̅4} calcite surfaces, remains bound and further assembles over time to form one-dimensional nanofibrils. Protein nanofibrils are continuous and organized at the nanoscale, exhibiting striations with a period of ca. 45 nm. These fibrils, templated by surface steps of a preferred geometry, in turn selectively dissolve underlying calcite features displaying the same atomic arrangement. To demonstrate this, we expose protein solution to bare and fibril-associated rhombohedral etch pits to reveal that nanofibrils accelerate only the movement of fibril-forming steps when compared to undecorated steps exposed to the same solution conditions. Calcite mineralized in the presence of MRCP20 results in asymmetric crystals defined by frustrated faces with shared mirror-symmetry, suggesting a similar step-selective behavior by MRCP20 in crystal growth. As shown here, selective surface interactions with step edge atoms lead to a cooperative regime of calcite modification, where templated long-range protein nanostructures shape crystals.
    ACS Nano 05/2015; DOI:10.1021/acsnano.5b01870