The Anatomical Record Advances in Integrative Anatomy and Evolutionary Biology (ANAT REC )

Publisher: American Association of Anatomists, John Wiley and Sons


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    Anatomical record (Hoboken, N.J.: 2007), The anatomical record (Hoboken, N.J.: 2007)
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John Wiley and Sons

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Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: Several missense mutations in the Z‐band protein, myotilin, have been implicated in human muscle diseases such as myofibrillar myopathy, spheroid body myopathy, and distal myopathy. Recently, we have reported the cloning of chicken myotilin cDNA. In this study, we have investigated the expression of myotilin in cross‐striated muscles from developing chicken by qRT‐PCR and in situ hybridizations. In situ hybridization of embryonic stages shows myotilin gene expression in heart, somites, neural tissue, eyes and otocysts. RT‐PCR and qRT‐PCR data, together with in situ hybridization results point to a biphasic transcriptional pattern for MYOT gene during early heart development with maximum expression level in the adult. In skeletal muscle, the expression level starts decreasing after embryonic day 20 and declines in the adult skeletal muscles. Western blot assays of myotilin in adult skeletal muscle reveal a decrease in myotilin protein compared with levels in embryonic skeletal muscle. Our results suggest that MYOT gene may undergo transcriptional activation and repression that varies between tissues in developing chicken. We believe this is the first report of the developmental regulation on myotilin expression in non‐mammalian species. Anat Rec, 297:1596–1603, 2014. © 2014 Wiley Periodicals, Inc.
    The Anatomical Record Advances in Integrative Anatomy and Evolutionary Biology 09/2014; 297(9).
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    ABSTRACT: The Y‐Box‐Binding Protein‐1 (YB‐1) is known to regulate the processes of transcription, translation, cellular response to drug treatment and viral infection as well as DNA repair among others. As gastric cancer is a common cancer with a high incidence in countries in Asia, we evaluated the association of YB‐1 with the malignant potential of gastric cancer cells in vitro. YB‐1 mRNA expression levels were first determined by real‐time RT‐PCR in two adherent gastric cancer cell lines (viz., MKN7 and NUGC3 gastric cancer cells) and a normal GES‐1 gastric epithelial cell line. Poorly differentiated NUGC3 gastric cancer cells were found to have the highest YB‐1 gene expression among the adherent cells. YB‐1 gene expression was also observed to be higher in non‐adherent SNU5 gastric cancer cells compared to more aggressive SNU16 cells. Silencing of the YB‐1 gene by siRNA in NUGC3 cells was associated with a significant reduction of the YB‐1 protein by more than 55% as verified by Western blot analysis. Down‐regulation of YB‐1 protein expression was further demonstrated qualitatively by immunocytochemistry and immunofluorescence staining. Silencing of the YB‐1 gene induced significant inhibition of cell migration in NUGC3 cells by 60% but did not influence cell invasion. Although epithelial‐mesenchymal‐transition (EMT) is known to be associated with the migratory phenotype in cancer cells, there was no change in the expression of EMT genes when YB‐1 expression was modulated. YB‐1 appears to have an integral role in cancer cell migration, a process which is important for gastric cancer metastasis. Anat Rec, 296:891–898, 2013. © 2013 Wiley Periodicals, Inc.
    The Anatomical Record Advances in Integrative Anatomy and Evolutionary Biology 06/2013; 296(6).
  • Article: Highlights
    The Anatomical Record Advances in Integrative Anatomy and Evolutionary Biology 01/2013; 296(4).
  • The Anatomical Record Advances in Integrative Anatomy and Evolutionary Biology 01/2012; 295(11).
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    ABSTRACT: Some coxsackievirus B serotypes are potentially diabetogenic. Previous studies revealed that the virulence and the tissue damage varied with the genetics of the virus strain as well as with the genetics of the mice. A single amino acid variation can alter virulence and tropism in both murine and in vitro models. However, the genetic determinants of this phenomenon have not been determined. In this study, infections with a laboratory strain of coxsackievirus B4 resulted in a diabetes-like syndrome in ICR mice, characterized by chronic pancreatic inflammation together with dysregulation in glucose metabolism, loss of pancreatic acinar tissue and persistent infection in islets. To characterize the genetic determinants involved in the mouse pancreas adaptation, the laboratory strain of coxsackievirus B4 was cloned for molecular characterization. Comparing the whole genome sequence of this virus strain with the other coxsackievirus B4 strains revealed some differences. Altogether 15 nucleotides were changed, resulting in 10 amino acid substitutions, which might be responsible for the pathogenic phenotype of this strain in mice.
    The Anatomical Record Advances in Integrative Anatomy and Evolutionary Biology 06/2008; 291(5):601-9.
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    ABSTRACT: The equine cheek tooth battery is part of a very dynamic system. The aim of this study was to investigate whether the curvature and position of the teeth are also involved in such dynamical processes. The alveolar crest was labelled with a radiodense marker (48 cadaver heads, 15 skulls) and laterolateral radiographs were taken. Then a geometrical method was elaborated to determine a cheek tooth's curvature and its position by means of specific angles. This method respects the remarkable changes of the equine dentition throughout life by considering two items: (1) the alveolar crest was taken as a constant landmark, (2) the central axis of the curved dental crown was determined by calculation of a linear regression equation. This equation considered several geometrically determined points on the curved dental crown which had been marked in the radiographs. Our study yielded the following results: Mandibular cheek teeth became more curved with age, but their positions (represented by the so-called mesio-occlusal angle between tooth and alveolar crest) did not change significantly. In maxillary cheek teeth, however, the mesio-occlusal angle became larger with age (indication of change of dental position), while their curvature did not change. Even though changes of the dental position were not always statistically significant, they are discussed as being biologically/functionally relevant. The mandibular anticlinal tooth, i.e. the tooth positioned at a mesio-occlusal angle of about 90 degrees , was not in contact with the maxillary anticlinal tooth. Interestingly, the maxillary anticlinal tooth is known to cause most clinical dental problems.
    The Anatomical Record Advances in Integrative Anatomy and Evolutionary Biology 06/2008; 291(5):565-70.