Experimental and clinical cardiology (Exp Clin Cardiol )

Publisher: International Academy of Cardiovascular Sciences, Pulsus


Experimental and Clinical Cardiology, an international English language journal, will consider for publication original articles, short communications, letters to the editor, editorials and mini-reviews. Emphasis is given to all aspects of the cardiovascular system from basic science to clinical cardiology. Submissions will be assessed primarily on their scientific validity and merit, not on their grammatical quality. Manuscripts are received with the understanding that they are submitted solely to Experimental and Clinical Cardiology, and that none of the material contained in the manuscript has been published previously or is under consideration for publication elsewhere, excluding abstracts. The publisher reserves copyright in any medium on all published material, and material may not be reproduced without the written permission of the publisher. Statements and opinions are the responsibility of the authors.

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  • Website
    Experimental and Clinical Cardiology website
  • Other titles
    Experimental and clinical cardiology (Online), Cardiology
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  • Material type
    Document, Periodical, Internet resource
  • Document type
    Internet Resource, Computer File, Journal / Magazine / Newspaper

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  • Pre-print
    • Author cannot archive a pre-print version
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    • Author cannot archive a post-print version
  • Conditions
    • All articles are available from PubMed Central 12 months after publication
    • Papers funded by CIHR are made open access 6 months after publication
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    ​ white

Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: To optimally improve health status after a myocardial infarction it is essential for patients to understand the seriousness of the disease and improve their self-management. Aims: To describe patients’ perceptions of preventive care, after experiencing a first episode of an acute myocardial infarction in a central hospital in Portugal and to analyze the intent to change behaviors and real changes six months after myocardial infarction. Methods: Longitudinal descriptive study; 106 patients aged between 35 and 64 years, who had cardiovascular risk factors and a first experience of myocardial infarction were selected. Data was collected in two structured interviews. Results: Of the patients, 18% had never, by their own accord, chosen to use preventive care services. During hospitalization, 43% described preventive care as a negative perception. Patients showed intent to change their habits but after discharge, they had difficulties in self-management of disease, maintaining monitoring or changing their cardiovascular risk factors such as physical activity (41%), blood pressure (37%), and eating habits (24%). Conclusions: There were considerable discrepancies between the intention and action in behavioral changes in patients after a myocardial infarction. Regarding the patients’ perceptions, there is a need to improve their involvement in the management of disease.
    Experimental and clinical cardiology 08/2014; 20(8).
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    ABSTRACT: Elevated levels of aldosterone are associated with deleterious effects on the cardiovascular system, which contributes to the development of endothelial dysfunction, fibrosis and inflammation hypertrophy, heart failure, sympathetic activation, stroke and renal dysfunction. Furthermore, it has been shown that treatment with mineralocorticoid receptor antagonists reduce the progressive damage that occurs in aldosterone target organs of patients with hypertension or heart failure, both in humans and in dogs; however, the expression of such receptors has only been demonstrated in human cardiac tissues, rabbit and rat, not so in the dog. To determine the expression of aldosterone receptors in cardiac tissues of healthy dogs, we employ the technique of immunohistochemistry for positive labeling with specific antibody in the hearts of two clinically healthy beagle dogs. Immunohistochemical assays performed, showed for first time, unpublished results of positive immunoreactivity to aldosterone receptors in dogs. This study concludes that the presence of aldosterone receptors in the heart of healthy dogs, given the existing cardio-renal axis similar to human and allows us to propose new research to test their possible alterations and pharmacological manipulation in the treatment of myocardial fibrosis reversibility using antagonists of these receptors.
    Experimental and clinical cardiology 08/2014;
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    ABSTRACT: Coronary heart disease (CHD) is the single largest killer out of all diseases in Europe and in the US. Pathologic cardiac ischemia in CHD triggers a succession of events leading to massive destruction and loss of cardiac tissues. Thus, replacement of the damaged cardiac tissues by newly regenerated myocardium would be a therapeutic ideal for pathology modifying treatment of CHD. The aim of this study was to evaluate the ability of an active fraction isolated from Chinese herb Rosa laevigata Michx (aFRLM) in therapeutic cardiomyogenesis through promoting substantial regeneration of cardiac tissues in a myocardial infarction (MI) animal model. Our results demonstrated that oral administration of aFRLM to MI animals could significantly improve cardiac functional performance and induce myocardial regeneration replacing the necrosed cardiac tissues in a sub-clinical MI animal model. The property of the aFRLM appears to be entirely novel and may provide a potential therapeutic alternative for MI treatment.
    Experimental and clinical cardiology 08/2014;
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    ABSTRACT: Aims: to assess the diagnostic value of plasma D-dimer level assay for prediction of thrombus formation in left atrial appendage( LAA) in patients with moderate or severe mitral stenosis Methods and results: We enrolled 218 patients with isolated rheumatic mitral stenosis who were candidates for commissurotomy. Trans-esophageal echocardiography and D-dimer plasma level measurement was done in all patients. Forty five percent of the patients were in sinus rhythm. Patient with a thrombus in LAA had higher levels of D-dimer than those with without thrombus (median of 691.50 and inter-quartile range of 370.5-1839.5 vs. median of 347μg/dl and inter-quartile range: 216-642, p: 0.002). Receiver operating curve analysis yielded an optimal D-dimer cut-off level of 2100 μg/dl for detection of thrombus. This cut-off level has been associated with a specificity of 95% and a negative predictive value of 88% for the presence of thrombus in LAA. Conclusion: In rheumatic mitral stenosis, D-dimer level assay has a high specificity and negative predictive value for evaluation of clot formation in LAA. This remarkable diagnostic yield may have clinical implications. Keywords: D-dimer, thrombus, mitral stenosis
    Experimental and clinical cardiology 07/2014; 20(7):1808-1818/2014.
  • Experimental and clinical cardiology 06/2014; 20(5):3447-3451.
  • Experimental and clinical cardiology 01/2014; 20(1):2491-2508.
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    ABSTRACT: Background Brassica rapa (BR) or turnip has been in use of mankind both as a food crop and an important medicinal plant. Ischemic and cardiovascular diseases are treated with BR by traditional healers in Pakistan and India, although the scientific basis of its pharmacological actions is poorly understood. Method and results In the present study, we screened BR against human platelet aggregation induced by two different aggregating agents and further delineated their underlying signal transduction pathways. Furthermore, BR was screened for the presence of calcium channel blocking potential. For this purpose, crude extract of BR was prepared and then fractionated into aqueous, chloroform and ethyl acetate fractions. Our results show that BR blocks calcium channel opening as indicated by its effects on KCl-induced contraction in guinea pig ileum and this activity is distributed into various fraction of BR except ethyl acetate fraction which did not show any significant calcium channel blocking activity. Conclusion Platelet aggregation induced by arachidonic acid (AA), platelet activating factor (PAF) and agonists of protein kinase C (PKC) and inositol triphosphate (IP3) was inhibited by various fractions of BR with different potencies, suggesting that phytocompounds responsible for these effects are differentially concentrated in various fractions. These multiple mechanisms may be responsible for the observed pharmacological actions of BR in cardiovascular diseases.
    Experimental and clinical cardiology 01/2014; 20(7):764-783.
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    ABSTRACT: Background: The aim of this study was to perform a meta-analysis comparing by gender the cardiovascular outcomes related to statin therapy in primary prevention including recent large trials. Methods: A systematic search of medical literatures was performed to identify randomized placebo and standardcare-controlled endpoint trials of statins with sex-specific outcome data, which were reported from 1994 to April 2012. Summary estimates of relative risks (RRs) of the therapy were calculated by using a random-effects model for women and men without CVD. Results: Total eight studies with 59,744 participants were included (22,490 women, 37,254 men). Although statin treatment reduced the risk of total mortality (RR 0.70; 95% confidence interval [CI], 0.53 to 0.93), the risks of major coronary events (RR 0.62; 95% CI 0.37 to 1.04) and cerebrovascular events (RR 0.69; 95% CI 0.45 to 1.03) were not reduced by statin treatment in women without CVD. Although major adverse events and total cancer were not increased in both male and female patients taking statin, the stratified analysis by gender revealed higher risk of development of diabetes mellitus (DM) in female patients (RR 1.50; 95% CI 1.11 to 2.01). Conclusions: Statin treatment was less beneficial in women without CVD with regard to lowering adverse clinical outcomes when compared to men.
    Experimental and clinical cardiology 01/2014; 20(1):1222-1247.
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    ABSTRACT: Electrocardiography, technique, which is the essential tool in the diagnosis of heart disease, as well as other organs, is used by doctors for over 100 years. It is used to measure electrical activity of the heart as a function of time and it presents it in digital or analogue form. The measurement is usually recorded from the body surface of the patient, which makes the standard electrocardiogram completely devoid of pain. Whilst the standard 12 lead ECG is the basic clinical method of heart diagnosis it has its drawbacks. Measuring all 12 leads is often difficult and impractical, most of all it restricts patient movement. In 1988, Gordon Dower developed a system of quasi-orthogonal lead called EASI, which uses only 5 electrodes in order to register standard 12 lead ECG signals. The main goal of this work is to develop a model using machine learning algorithms which transforms electrocardiographic signals (ECG) performed by EASI into a standard 12-channel ECG. EASI was proven to have high correlation with standard 12 lead ECG, it is easier an d faster to use because of smaller number of electrodes. Most of all it increases mobility of patients.
    Experimental and clinical cardiology 01/2014; 20(8):3663-3667.