Arabian Journal of Chemistry

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Impact factor 2.68

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    Impact factor
  • 5-year impact
    0.00
  • Cited half-life
    2.00
  • Immediacy index
    0.34
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    0.00
  • Article influence
    0.00
  • ISSN
    1878-5352

Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: This study investigates the effect of reactor design parameters on cadmium removal from industrial wastewater discharged by the Tunisian Chemical Group (TCG) to improve as much as possible efficiency and cost of electrocoagulation (EC) process. Based on an examination of the design parameters one by one, the best cadmium removal was achieved for an inter-electrode distance (die) of 0.5 cm, monopolar connection mode, stirring speed of 300 rev min-1, surface-area-to-volume ratio (S/V) of 13.6 m-1, and an initial temperature of 50 C°. These operating conditions allowed to achieve efficient removal in a relatively short operating time with the lowest energy consumption and cost possible. The present study proved that the parameters that have an effect on the operating cost are the electrode configuration, inter-electrode distance and S/V ratio. The energy consumption, the pH evolution, and the treatment cost were studied. The investigation of the effect of all the selected optimum EC design parameters together on the removal of cadmium from the TCG wastewater proved that the treatment was highly efficient; 100 % of cadmium removal was reached in 5 min, with a very low power consumption (1.6 kWh m-3) and very low cost (0.116 TND m-3). Moreover, EC was found to be capable of removing cadmium as well as other pollutants at the same time from the case-study industrial wastewater. The investigation carried out in this work explores and proposes a very cost-effective treatment method to remove heavy metals from industrial wastewater if compared to results reported about cost of this treatment process through other widely used technologies such as coagulation (4.36 Tunisian National Dinar (TND) m-3) and precipitation (9,96 TND m-3) employed in previous studies.
    Arabian Journal of Chemistry 12/2015; ARABJC 1523.
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    ABSTRACT: Zeolite Y in sodium form (NaY) was synthesized using silica source from rice husk. The as-synthesized samples were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), X-ray fluorescence (XRF), BET. As results, we verify that NaY zeolite obtained from the two-step route, presents a good degree of crystallinity and then can be suitable for using in various applications.
    Arabian Journal of Chemistry 01/2015; 27.
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    ABSTRACT: Two new macrocyclic Schiff bases (II) and (III) containing nitrogen–oxygen donor atoms were designed and synthesized by reaction between diethylene triamine or 2,2′-(ethylenedioxy) bis (ethylamine) and the intermediate compound: 1,7-bis (6-methoxy-2-formylphenyl)-1,7-dioxaheptane (I). Identification of these macrocyclic Schiff bases: 1,15,18,21,35,38-hexaaza-7,9; 27,29-dibenzo-[3,4;12,13;23,24;32,33-tetra-(6′-methoxy phenyl)]-5,11, 25,31-tetraoxacyclotetracontan-1,14,21,34-tetraene. (II) 1,15,24,38-Tetra aza-7,9; 30,32-dibenzo-[3,4;12,13;26,27;35,36-tetra-(6′-methoxy phenyl)]-5,11,18,21,28,34,41,44-octaoxacyclo-hexatetracontan-1,14,24,37-tetraene. (III) was determined by (LC–MS), (IR), (1H NMR) spectroscopy, and microanalysis (C,H,N). The liquid–liquid extraction of metal picrates, such as Ag+, Cu2+ and Ni2+ from aqueous phase to organic phase was carried out using the novel ligands. The effect of chloroform and dichloromethane as organic solvents over the metal picrate extractions was investigated at 25±0.1°C by using atomic absorption spectrometer. The composition of the extracted Ag+ complex was (1:2) (L:M) and Cu2+ complex was (1:1) (L:M) for ligand (III).
    Arabian Journal of Chemistry 01/2015;
  • Ali Darehkordi, Somayeh Ghazi
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    ABSTRACT: Dihydropyrimidinone derivatives were prepared by tri-component reaction of ethyl aceto acetate, aldehydes and thiourea in the presence of modified montmorinollite nanostructure as a catalyst and used as key intermediates for the synthesis of ethyl-5-(aryl)-2-(2-alkokxy-2-oxoethylidene)-7-methyl-3-oxo-3,5-dihydro-2H-thiazolo[3,2-a]pyri midine-6-carboxylate derivatives with use of diethyl and dimethyl acetylene dicarboxylate by two methods: a) in methanol as a solvent under ultrasonic irradiation at ambient temperature b) in methanol as a solvent at ambient temperature (conventional magnetic stirring). Ultrasound-assisted synthesis provides excellent yields in short reaction times (15–25 min) at room temperature.
    Arabian Journal of Chemistry 01/2015; 38.
  • Anjali Sidhu, Sharu Kukreja
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    ABSTRACT: Lead hybridization concept was used to design and synthesize twenty novel hybrid compounds by combining fungicidal leads viz. 6-flouro-1,3-benzothiazol-2-amine and 1,2,4-triazoles in a single molecule, with the aim of discovery of high potential novel fungicides. Antifungal evaluation of synthesized 6-flourobenzothiazol-2-yl-1,2,4-triazoles against various phytopathogenic fungi revealed synergistic effect of combination of leads with one another in all the test compounds. Some of the synthesized compounds showed excellent fungitoxicity comparable with the standard fungicides used. In silico toxicity of all the compounds was equivalent to the standard fungicides used. Docking studies and Lipinski filtration were performed in order to present the rationale of Structure activity relation. Compounds 2, 8, 15 and 18 were screened to act as leads for further modification and use.
    Arabian Journal of Chemistry 01/2015; 47.
  • M. Saeed Arayne, Najma Sultana, Hina Shehnaz, Saf-ur-Rehman Mandukhail, Anwarul Hassan Gilani, Amir Haider
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    ABSTRACT: In the present study the 2-methylpropanamide and benzamide derivatives of carboxyterfenadine, have been synthesized by nucleophilic substitution at carboxylic acid moiety (C-33) of tertiary carbon C-19 substituted with benzene ring. The proficient and high yielding series was carried out in two steps by continuous monitoring with TLC. The carboxylic group was utilized in the formation of 2-methylpropanamide and benzamide derivatives of carboxyterfenadine. The derivatives were characterized by spectroscopic techniques including mass. The starting material (2-[4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)piperidino]butyl]phenyl]-2-methylpropanoic acid) itself is H1 receptor antagonist. Hence, all these compounds A-E were biologically evaluated for antihistaminic and anticholinergic activity, using isolated guinea pig ileum tissues.
    Arabian Journal of Chemistry 01/2015; 50.
  • S.B. Sonone, S.P. Kokane, P.J. Shirote, N.S. Naikawade
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    ABSTRACT: Chitosan derivative was successively synthesized by initial preparation of acylthiourea reagent using ammonium thiocyanate and making it to react with at primary amino groups of chitosan and then reduced to yield thiolated chitosan. Due to the formation of disulfide bonds with mFucus glycoproteins, mucoadhesiveness is augmented. The thiol groups were then quantified using Ellman’s reagent. The derivatives inherit good swelling property in neutral and alkaline media. The different derivatives containing thiol groups were formulated into tablets using reference drug for evaluation. The thiolated chitosan display in situ gelling features due to the pH-dependent (alkaline pH) formation of inter-molecular disulfide bonds which makes the application of thiolated chitosan on intestinal mucosa and can guarantee prolonged controlled release of embedded therapeutic ingredients.
    Arabian Journal of Chemistry 01/2015; 6.
  • F. Shiri, S.M. Bakhshayesh, Jahan B. Ghasemi
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    ABSTRACT: Microtubules are tube-shaped, filamentous and cytoskeletal proteins that are essential in all eukaryotic cells. Microtubule is an attractive and promising target for anticancer agents. In this study, three-dimensional quantitative structure activity relationships (3D-QSAR) including comparative molecular field analysis, CoMFA, and comparative molecular similarity indices analysis, CoMSIA, were performed on a set of 45 (E)-N-Aryl-2-ethene-sulfonamide analogues as microtubule–targeted anti-prostate cancer agents. Automated grid potential analysis, AutoGPA module in Molecular Operating Environment 2009.10 (MOE) as a new 3D-QSAR approach with the pharmacophore-based alignment was carried out on the same dataset. AutoGPA-based 3D-QSAR model yielded better prediction parameters than CoMFA and CoMSIA. Based on the contour maps generated from the models, some key features were identified in (E)-N-Aryl-2-arylethene-sulfonamide analogues that were responsible for the anti-cancer activity. Virtual screening was performed based on pharmacophore modeling and molecular docking to identify the new inhibitors from ZINC database Seven top ranked compounds were found based on Gold score fitness function. In silico ADMET studies were performed on compounds retrieved from virtual screening in compliance with the standard ranges.
    Arabian Journal of Chemistry 01/2015; 22.
  • Sheela Joshi, Anju Shukla, Rahul Singh Jhala
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    ABSTRACT: Biologically active compounds with heteroaromatic ring system of Cefotaxime sodium have been synthesized via aminomethylation reaction. The aminomethylation of Cefotaxime sodium with various biologically potent sulphonamides / secondary amines was carried out and then characterized by elemental analysis and spectral studies – IR, 1H-NMR, 13C-NMR, Powder X-ray diffraction and Scanning Electron Microscopy. The compounds were screened for their antibacterial activity against various pathogenic bacteria at varying concentrations. The antibacterial activity of Cefotaxime sodium derivatives was compare with parent sulphonamides. The toxicity of synthesized Cefotaxime sodium derivatives was ascertained by LD50 test.
    Arabian Journal of Chemistry 01/2015; 21.
  • Vikramjeet Singh, Kuldeep Singh, Amita Nand, Huanqin Dai, Jianguo Wang, Lixin Zhang, Alejandro Merino, Jingsong Zhu
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    ABSTRACT: In order to increase the scope and utility of small molecule microarray (SMMs) we have combined SMMs and SPRi to screen small molecule antagonists against protein targets. Several small molecules, including immunosuppressive drugs (rapamycin and FK506) and reported inhibitors (FOBISIN and Blapsin) of 14-3-3ζ proteins have been used to validate this technology. Furthermore, a small library of isatin derivatives have been synthesized and screened on developed platform against 14-3-3ζ protein. Three molecules, derived from the endogenous intermediate isatin termed, FZIB-35, FZIB-36 and FZIB-38 were identified as novel inhibitors which shows significant interaction with 14-3-3ζ. A mutation in the binding groove of 14-3-3ζ, (K49E), almost abolishes the binding of these compounds to 14-3-3ζ protein. To exclude the probability of false positives, two more purified proteins (PtpA and BirA) were also tested. Furthermore, in order to confirm the binding pocket specificity, competition assay against R18 peptide was also carried out on presented platform. We show that SMMs in combination with SPRi is a powerful method to identify lead compounds in high throughput manner without the need to develop an activity based assay.
    Arabian Journal of Chemistry 01/2015; 16.
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    ABSTRACT: Emerging pollutants, as antibiotics or dyes, in aquatic ecosystems are a crucial concern and numerous techniques have been developed for their removal. Efficiency, cost effectiveness, and biodegradability reveal biomass sorption as one of the most appealing methods. This study aims to evaluate the effectiveness of grape stalk as a sorbent for ofloxacin (a fluoroquinolone antibiotic) and chrysoidine (an azo-dye). The kinetic and the thermodynamic aspects of the sorption were studied. A pseudo first-order kinetic behaviour is shown by both substances, though the kinetic constants of ofloxacin are almost double than those of chrysoidine. The sorption isotherms, which strictly follow the Langmuir model, show remarkable differences as a function of pH and of biomass size. The trend of Langmuir parameters, Qmax and K, as a function of pH and size, is discussed, and different binding mechanisms are proposed. Kinetic and thermodynamic parameters prefigure grape stalk as a potential biomass for scavenging toxic substances from wastewater.
    Arabian Journal of Chemistry 01/2015; 256.
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    ABSTRACT: A new series of pyrazole, isoxazole, benzoxazepine, benzothiazepine and benzodiazepine derivatives were prepared by the multi-component cyclo-condensation reaction of 1-phenyl-3-(2-(tosyloxy)phenyl)propane-1,3-dione, N, N-dimethylformamide dimethyl acetal and hydrazine or hydroxylamine hydrochloride or 2-aminothiophenol or 2-aminophenol or benzene-1,2-diamine using μwave technique in aqueous media. All the synthesized compounds were evaluated for their anti-bacterial and antifungal activities. Some of the selected compounds were also screened for their anti-inflammatory activity.
    Arabian Journal of Chemistry 01/2015; 46.
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    ABSTRACT: In this study the electrochemical behavior of ascorbic acid (AA) and uric acid (UA) at the surface of glassy carbon electrodes (GCEs) modified by multi-walled carbon nanotubes (MWCNTs) functionalized with Fe3+ complex was investigated. The voltammetric studies using the modified electrode showed two well-resolved anodic peaks for AA and UA with a potential difference of ∼0.4 V, revealing the possibility of the simultaneous electrochemical detection of these compounds. First, the electrochemical behavior of ferric/ferrous at Fe3+complex/MWNTs/nafion (FeCMN) modified electrode was studied. The results showed an adsorption-controlled reaction at the modified electrode. Then, the behavior of ascorbic acid and uric acid at the modified electrode was investigated. The optimum analytical conditions were sought. Linear calibration plots were obtained over the range of 4.0 to 600 μmol l-1and 0.3 to 490 μmol l-1with detection limits (3σ) of 2.57 μmol l-1and 0.137 μmol l-1 for AA and UA, respectively.
    Arabian Journal of Chemistry 01/2015; 344.
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    ABSTRACT: Titanium dioxide nanoparticles were successfully prepared by electrochemical method. The tetra propyl ammonium bromide salt was used as stabilizing agent in an organic medium viz. tetra hydro furan (THF) and acetonitrile (ACN) in 4:1 ratio by optimizing current density. The parameters such as current density, solvent polarity, distance between electrodes and concentration of stabilizers were used to control the size of nanoparticles. The synthesized titanium dioxide nanoparticles were characterized by using UV-Visible spectroscopy, X-ray diffraction, scanning electron microscopy (SEM), energy dispersive spectrophotometer (EDS) and transmission electron microscopy (TEM) analysis techniques. TEM analysis proved a nearly tetragonal structure with size of 25-30nm which was in agreement with the result calculated from the XRD analysis. EDS analysis revealed the presence of Ti and O element. The nanoparticles were screened for their in vitro antibacterial activity against human pathogens like gram negative Escherichia coli (E.coli), and gram positive Staphylococcus aureus strains and which proved excellent results.
    Arabian Journal of Chemistry 01/2015; 6.
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    ABSTRACT: This article describes a gas chromatography-mass spectrometry (GC-MS) method for the determination of flurbiprofen in pharmaceutical preparations. The method is based on the derivatization of flurbiprofen with N-methyl-N-(trimethylsilyl)trifluoroacetamide (MSTFA). For GC-MS, electron ionization mode (EI = 70 eV) and selected ion monitoring (SIM) mode were used for quantitative analysis (m/z 180 for flurbiprofen). Calibration curve was linear between the concentration range of 0.25-5.0 μg/mL. Intra- and inter-day precision values for flurbiprofen were less than 3.64, and accuracy (relative error) was better than 2.67%. The mean recovery of flurbiprofen was 99.4% for pharmaceutical preparations. The limits of detection and quantification of flurbiprofen were 0.05 and 0.15 μg/mL, respectively. No interference was found from tablet excipients at the selected assay conditions. Also, the method was applied for the quality control of five commercial flurbiprofen dosage forms to quantify the drug and to chech the formulation content uniformity.
    Arabian Journal of Chemistry 01/2015; 59.
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    ABSTRACT: The corrosion inhibition performances of three corrosion inhibitors on mild steel in acidic medium, namely 1,3-thiazole (TA), 2-amine-1,3-thiazole (2-ATA), and 4-amine-1,3-thiazole (4-ATA), were theoretically evaluated using quantum chemistry calculations and molecular dynamics simulations both in gas phase and aqueous phase. The frontier orbital energy, global activity, and Fukui indices were studied. Adsorption energy of corrosion inhibitors on iron surface was calculated. Furthermore, a prediction of iron crystal morphology was performed, and the surface energies were obtained. The results indicate that Fe(110) surface possesses the lowest surface energy. 4-ATA shows the highest reaction activity among the three molecules. The binding energies of the corrosion inhibitor molecules and iron surface follow the order 4-ATA > 2-ATA > TA.
    Arabian Journal of Chemistry 01/2015; 4.
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    Arabian Journal of Chemistry 01/2015; 72.