Arabian Journal of Chemistry

Description

  • Impact factor
    2.27
  • 5-year impact
    0.00
  • Cited half-life
    2.00
  • Immediacy index
    0.34
  • Eigenfactor
    0.00
  • Article influence
    0.00
  • ISSN
    1878-5352

Publications in this journal

  • Arabian Journal of Chemistry 01/2015;
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    ABSTRACT: Accepted for publication on 29.10.2014
    Arabian Journal of Chemistry 01/2015;
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    ABSTRACT: One of the alternative methods to identify and study the matrix effect is by determination of “relative” matrix effect. In this experiment % coefficient of variance of standard line slopes are calculated. First, six standard lines are prepared from single plasma lot. In another experiment standard line slopes are compared from six different lots of plasma. All these standard curves are prepared by using three different types of IS (Internal standard). From all these experiments it is observed that using SIL-IS (Stable isotope labeled-Internal standard) is one of the best approach in methods having matrix effects. Alternatively, analog IS is a cost effective approach. After comparing a large number of calibration curve slopes, it can be recommended that during every bioanalytical method validation, where the sample size is > 50, scientist should perform the “relative” matrix effect experiment by standard line slope method. In selected cases, the precision of standard line slopes in six different lots of a biofluid was compared with precision values determined six times in a single lot. The results of these studies indicated that the variability of standard line slopes in different lots of a biofluid [precision of standard line slopes expressed as coefficient of variation, CV (%)] may serve as a good indicator of a relative matrix effect and, it is suggested, this precision value should not exceed 5% for the method to be considered reliable and free from the relative matrix effect liability.
    Arabian Journal of Chemistry 11/2014;
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    ABSTRACT: Rhodamine B (RB) is a toxic dye used extensively in textile industry, which must be remediated before its drainage to environment. In the present study, supported gold nanoparticles on commercially available titania and zincite were successfully prepared and then their activity on the photodegradation of RB under UV A light irradiation were evaluated. The synthesized photocatalysts were characterized by ICP, BET, XRD, TEM and EDX. Kinetic results showed that Au/TiO2 was an inferior photocatalyst to Au/ZnO. This observation could be attributed to the strong reflection of UV irradiation by gold nanoparticles over TiO2 support.
    Arabian Journal of Chemistry 11/2014;
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    ABSTRACT: Compounds like Octylpalmamide (OTP), Octylsteramide (OTS), Octylcaprylamide (OTC), Octylbenzamide (OTB) and one complex compound Dicyclohexylaminebenzotriazole (DCHAB) were synthesized and characterized by Fourier Transform infrared spectroscopy (FT-IR). These synthesized compounds were drawn as volatile corrosion inhibitor (VCI) in H2S gas environment on mild steel (MS) at 323 K. Surface morphology and elemental analysis have been examined by Scanning Electron Microscopy (SEM) and Energy Dispersive X-Ray Spectroscopy (EDX) respectively. Various studies like Weight loss, Potentio dynamic polarization and electrochemical impedance spectroscopy (EIS) were used for evaluating corrosion rate, inhibitor behavior and change in charge transfer resistance (Rct) value, respectively. All the above experiments proved that DCHAB was the most efficacious corrosion inhibitor. Adsorption behavior of the inhibitor was evaluated and it obeys Langmuir adsorption isotherm.
    Arabian Journal of Chemistry 11/2014;
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    ABSTRACT: A novel microwave hydrothermal method was developed to prepare highly dispersed W/Al2O3 catalysts, in which WO3 was deposited on alumina via precipitation between tungstate and nitric acid under microwave hydrothermal environment and oxalic acid was used as an additive. Moreover, the role of oxalic acid was investigated by varying its amount and addition method. It is found that the catalysts show higher WO3 dispersion and weaker W-Al interaction than that prepared by conventional impregnation method. The hydrothermal period can be extremely reduced to a few minutes, and highly dispersed WO3 can be achieved even without oxalic acid. When oxalic acid was added after the formation of H2WO4, it mainly acts as a modifier for reacting with the hydroxyl groups on alumina and has little effect on WO3 dispersion. When oxalic acid was divided into two parts, one for pretreating alumina and the remains for preventing the aggregation of H2WO4, it may effectively act as both dispersant and modifier, leading to further increased WO3 dispersion and weakened W-Al interaction. The catalysts prepared by the microwave hydrothermal method show superior dibenzothiophene hydrodesulfurization activity. This method provides rapidity, convenience and cost effectiveness for preparing active hydrotreating catalysts.
    Arabian Journal of Chemistry 11/2014;
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    ABSTRACT: A simple, sensitive, specific, precise and accurate stability indicating reverse phase liquid chromatographic method was developed for simultaneous determination of moxifloxacin hydrochloride and dexamethasone in bulk drugs and pharmaceutical formulations. The developed chromatographic method was optimized for the separations of moxifloxacin hydrochloride, dexamethasone and stress-induced degradation products by use of BDS Hypersil C8 column (250 X 4.6 mm, 5 μm) as stationary phase with mobile phase consisting of a mixture of phosphate buffer (20 mM) containing 0.1% (v/v) triethylamine, at pH 2.8 (adjusted with dilute phosphoric acid) and methanol (38.5:61.5 v/v) at a flow rate of 1.5 mL min-1. Chromatographic separations of analytical peaks and degradation products were achieved within 10 minutes. Detection of the analytes and degradation products was performed at 254 nm using diode array detector. Method validation was performed in accordance with ICH guidelines. Linearity of the method was established over the concentration ranges of 50-350 μg mL-1 for moxifloxacin hydrochloride and 10-70 μg mL-1 for dexamethasone (correlation coefficients greater than 0.999). The method was resulted in good separation of both the analytes and degradation products with acceptable tailing and resolution with peak purity index ⩾ 0.9999 which indicated complete separation of analytes peaks from the degradation products. The method can therefore be considered as stability-indicating and can be used successfully for simultaneous determination of moxifloxacin hydrochloride and dexamethasone in pharmaceutical formulations and stability studies.
    Arabian Journal of Chemistry 11/2014;
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    ABSTRACT: This review article describes the survey of literature regarding the variety of synthetic methods of 1,3,4-thiadiazoline and related compounds in the last seven years (2004–2010). The aim of the review is to find out different methods for the synthesis of thiadiazolines. These heterocyclics are majorly obtained from the cyclization reactions of thiosemicarbazone under the various conditions. From the literature studies it was found that major importance was given to their pharmaceutical significance i.e., regarding their biological activity against different fungal and bacterial strains.
    Arabian Journal of Chemistry 11/2014;
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    ABSTRACT: Stability constants of the ternary palladium(II) complexes of triamine 2,2́:6́,2́́-terpyridine (terpy) and some amino acids, peptides, DNA constituents or thiols were determined at 25 °C and at constant 0.1 mol dm-3 ionic strength, adjusted using NaNO3. The coordination sites are pH-dependent. The results show the formation of binuclear species, 210. The speciation diagrams of the various complex species were evaluated as a function of pH. Good correlations were found between the stability constants of the complexes and basicity of ligands.
    Arabian Journal of Chemistry 11/2014;
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    ABSTRACT: The copolymer carbazole–phenol formaldehyde doped with 4 (4-hydroxy-phenyl azo)-benzene sulfonic acid (PABS), 2,5-dimethyl benzene sulfonic acid (PXSA) and 4-hydroxy-m-benzene disulfonic acid (PDSA) were prepared. These compounds are identified by FT-IR spectroscopy.The conductivity of copolymer carbazole–phenol formaldehyde doped with 4 (4-hydroxy-phenyl azo)-benzene sulfonic acid (PABS), 2,5-dimethyl benzene sulfonic acid (PXSA) and 4-hydroxy-m-benzene disulfonic acid (PDSA) was studied as a function of weight of the dopant compounds; an increase of conductance of the copolymer by doping with PABS is noted; the conductance became equal to 0.000595ohm−1 for 0.1g higher conductance for the copolymer when it is doping with PABS.
    Arabian Journal of Chemistry 11/2014;
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    ABSTRACT: The cysteine protease, falcipain-2 is an important drug target in human malaria parasite Plasmodium falciparum. A new series of 2-(4-(substituted benzoyl)-1,4-diazepan-1-yl)-N-phenylacetamide derivatives 5(a-t) were designed as per pharmacophoric requirements of falcipain-2 inhibitors using ligand-based approach. The target compounds were synthesized from the key intermediate, 2-(1, 4-Diazepan-1-yl)-N-phenylacetamide, by coupling it with appropriate carboxylic acids using carbodiimide chemistry. Structural features of target compounds were characterized by spectral data (1H NMR, and mass) and elemental analyses. The purity of the final compounds was confirmed by HPLC. The compounds were tested for their in vitro falcipain-2 inhibitor activity on recombinant falcipain-2 enzyme. Five compounds 5b, 5g, 5h, 5j, 5k showed good inhibitory activity (>60%), against falcipain-2 at 10 μM concentration, and fifteen compounds showed weak to moderate inhibitor activity. Compound 5g, is the most potent compound from this series showed 72% of inhibition at 10 μM concentrations.
    Arabian Journal of Chemistry 11/2014;
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    ABSTRACT: This paper describes the synthesis of a new series of 1,3,5-trisubstituted-1,2,4-triazoles by 1,3-dipolar cycloaddition reaction of C-phenyl-aminocarbonyl-N-arylnitrilimines with guanidine derivatives. The structures of the newly synthesized compounds were elucidated by spectral methods (IR, 1H NMR, 13C NMR and MS spectroscopy) and elemental analysis. The microbial features of the synthesized compounds were studied using well-established methods from the literature.
    Arabian Journal of Chemistry 11/2014; 7(5).
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    ABSTRACT: Alumina gels AN6 and AN7 were prepared by precipitation with NaOH from hydrated aluminum sulfate at pH 6 and 7, respectively. A third alumina gel AA7 was similarly prepared, but by precipitation with 30% ammonia. Pure cadmia C8 and C9 were precipitated from cadmium sulfate at pH 8 and 9 using NaOH. Five mechanically mixed gels ACM (1:0.25), ACM (1:0.5), ACM (1:1), ACM (0.5:1) and ACM (0.25:1) were prepared by thoroughly mixing the appropriate molar ratios of AN7 and C8. Also, five coprecipitated gels ACC (1:0.25), ACC (1:0.5), ACC (1:1), ACC (0.5:1) and ACC (0.25:1) were coprecipitated by dropping simultaneously the appropriate volumes of 1M aluminum sulfate, 1M cadmium sulfate and 3M NaOH. Calcination products at 400, 500, 600, 800 and 1000°C were obtained from each preparation.TG–DTA patterns of uncalcined samples were analyzed and the XRD of all 1000°C-products and some selected samples calcined at 400–800°C were investigated. The thermal behaviors of pure and mixed gels depend on the precipitating agent, pH of precipitation, chemical composition and method of preparation. Generally, calcination at temperatures below 800°C gave poorly crystalline phases. Well crystalline phases are obtained at 800 and 1000°C. For pure alumina γ-Al2O3 was shown as 400°C-calcination product that transforms into the δ form around 900°C and later to θ-Al2O3 as a major phase and α-Al2O3 as a minor phase at 1000°C. CdO was shown by 500°C-calcined cadmia gel that showed color changes with rise of calcination temperature. The most stable black cadmium oxide phase (Monteponite) is obtained upon calcination at 1000°C. Thousand degree celsius- calcined mixed oxides showed θ-Al2O3, α-Al2O3, CdAl2O4 and monteponite which dominate depending on the chemical composition.
    Arabian Journal of Chemistry 11/2014;
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    ABSTRACT: In the present study, sliver nanoparticles were synthesized using flower broth of Tagetes erecta as reductant by a simple and eco-friendly route. The aqueous silver ions when expose to flower broth were reduced and resulted in green synthesis of silver nanoparticles. The sliver nanoparticles were characterized by UV-visible spectroscopy, Zeta potential, Fourier transform infra-red spectroscopy (FTIR), X-Ray diffraction, Transmission electron microscopy (TEM) analysis, Energy dispersive X-Ray analysis (EDX) and Selected Area Electron Diffraction (SAED) pattern. UV-visible spectrum of synthesized silver nanoparticles showed maximum peak at 430 nm. TEM analysis revealed that the particles were spherical, hexagonal and irregular in shape and size rang from 10 to 90 nm and Energy dispersive X-ray (EDX) spectrum confirmed the presence of silver metal. Synergistic antimicrobial potential of silver nanoparticles was evaluated with various commercial antibiotics against Gram positive (S. aureus and B. cereus), Gram negative (E. coli and P. aeruginosa) bacteria and fungi (C. glabrata, C. albicans, C. neoformans). The antifungal activity of AgNPs with antibiotics was better than antibiotics alone against the tested fungal strains and Gram negative bacteria, thus signification of present study is in production of biomedical products.
    Arabian Journal of Chemistry 11/2014;