Transactions of the Royal Society of Tropical Medicine and Hygiene (T ROY SOC TROP MED H)

Publisher: Royal Society of Tropical Medicine and Hygiene, Oxford University Press (OUP)

Journal description

Transactions of the Royal Society of Tropical Medicine and Hygiene publishes original, peer-reviewed articles, and invited reviews across a broad range of topics relevant to the Society's goals, including: clinical tropical medicine and case reports, infectious diseases, parasitology and entomology, microbiology and virology, epidemiology, chemotherapy, immunology, public health, including social science. A key objective is to present the results of research that are broadly intelligible to workers from a range of disciplines. We welcome articles on translational research that may impact directly on clinical and public health practice in developing countries and those describing the application of new technologies in tropical medicine.

Current impact factor: 1.84

Impact Factor Rankings

2015 Impact Factor Available summer 2016
2014 Impact Factor 1.839
2013 Impact Factor 1.931
2012 Impact Factor 1.823
2011 Impact Factor 2.162
2010 Impact Factor 2.832
2009 Impact Factor 2.553
2008 Impact Factor 2.062
2007 Impact Factor 1.924
2006 Impact Factor 2.03
2005 Impact Factor 1.665
2004 Impact Factor 1.746
2003 Impact Factor 2.114
2002 Impact Factor 1.724
2001 Impact Factor 1.693
2000 Impact Factor 1.485
1999 Impact Factor 1.781
1998 Impact Factor 1.676
1997 Impact Factor 1.535

Impact factor over time

Impact factor

Additional details

5-year impact 2.10
Cited half-life >10.0
Immediacy index 0.41
Eigenfactor 0.01
Article influence 0.71
Website Transactions of the Royal Society of Tropical Medicine & Hygiene website
Other titles Transactions of the Royal Society of Tropical Medicine and Hygiene (Online), Trans R Soc Trop Med Hyg
ISSN 1878-3503
OCLC 53915292
Material type Document, Periodical, Internet resource
Document type Internet Resource, Computer File, Journal / Magazine / Newspaper

Publisher details

Oxford University Press (OUP)

  • Pre-print
    • Author can archive a pre-print version
  • Post-print
    • Author cannot archive a post-print version
  • Restrictions
    • 12 months embargo
  • Conditions
    • Pre-print can only be posted prior to acceptance
    • Pre-print must be accompanied by set statement (see link)
    • Pre-print must not be replaced with post-print, instead a link to published version with amended set statement should be made
    • Pre-print on author's personal website, employer website, free public server or pre-prints in subject area
    • Post-print in Institutional repositories or Central repositories
    • Publisher's version/PDF cannot be used
    • Published source must be acknowledged
    • Must link to publisher version
    • Set phrase to accompany archived copy (see policy)
    • Eligible authors may deposit in OpenDepot
    • The publisher will deposit in PubMed Central on behalf of NIH authors
    • Publisher last contacted on 19/02/2015
    • This policy is an exception to the default policies of 'Oxford University Press (OUP)'
  • Classification

Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: Background: We aimed to determine the virulence factor profile and phylogenetic grouping of uropathogenic Escherichia coli (UPEC) causing urinary tract infection (UTI) in patients with and without diabetes mellitus (DM). Methods: A total of 280 UPEC were collected from the urine samples of patients with DM (n=126) and patients suffering from non-DM UTIs (n=154). All isolates were subjected to phenotypic and genotypic virulence factor profile and phylogenetic grouping. Results: There was no significant difference in phenotypic virulence factors of UPEC causing UTI from patients with and without DM; alpha-haemolysin (DM=52, 41.2%; non-DM=69, 44.8%), mannose resistant haemagglutination (DM=6, 36.2%; non-DM=64, 41.5%), biofilm production (DM=33.3%; non-DM=25.9%), serum resistance (DM=27, 21.4%; non-DM=46, 29.8%), cell surface hydrophobicity (DM=22, 17.1%; non-DM=18, 11.6%) and mannose sensitive hemagglutnation (DM=18, 14.2%; non-DM=29, 18.8%). Among the genotypic virulence markers, papC gene was most prevalent in both patients with DM (n=65, 51.6%) and without DM (n=88, 57.1%), followed by hlyD gene (DM=36, 28.6%; non-DM=52, 33.8%). Only cnf-1 gene was observed to be significantly associated (p<0.05) with the non-DM status (n=35, 22.7%) than DM (n=15, 11.9%). Irrespective of the diabetic status, majority of the UPEC isolates (approximately 50%) belonged to phylogenetic group B2 predominantly harboring the virulence genes papC, hlyD and cnf-1. Conclusions: This study demonstrates that there may not be a differential selection of virulence properties of UPEC causing UTI in patients with DM and in the general population.
    Transactions of the Royal Society of Tropical Medicine and Hygiene 11/2015; DOI:10.1093/trstmh/trv086
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    ABSTRACT: Mathematical models of typhoid transmission were first developed nearly half a century ago. To facilitate a better understanding of the historical development of this field, we reviewed mathematical models of typhoid and summarized their structures and limitations. Eleven models, published in 1971 to 2014, were reviewed. While models of typhoid vaccination are well developed, we highlight the need to better incorporate water, sanitation and hygiene interventions into models of typhoid and other foodborne and waterborne diseases. Mathematical modeling is a powerful tool to test and compare different intervention strategies which is important in the world of limited resources. By working collaboratively, epidemiologists and mathematicians should build better mathematical models of typhoid transmission, including pharmaceutical and non-pharmaceutical interventions, which will be useful in epidemiological and public health practice.
    Transactions of the Royal Society of Tropical Medicine and Hygiene 09/2015; 109(11). DOI:10.1093/trstmh/trv075
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    ABSTRACT: Background: WHO recommends screening for TB and evaluation for isoniazid preventive therapy (IPT) based on evidence that they reduce TB-related morbidity and mortality among HIV-infected persons. In Vietnam, an IPT pilot was implemented in two provinces; TB screening, treatment and outcomes were evaluated to inform the adoption and scale-up of IPT. Methods: During April 2008 to March 2010, eligible HIV-infected persons aged >15 years, with no previous or current TB treatment, alcohol abuse or liver disease were screened for TB. If TB disease was ruled out based on symptoms, chest x-rays and sputum smears, isoniazid was administered for 9 months. Results: Among 1281 HIV-infected persons who received initial eligibility screening, 520 were referred to and evaluated at district TB clinics for TB disease or IPT eligibility. Active TB was diagnosed in 17 patients and all were started on treatment. Of 520 patients evaluated, 416 (80.0%) initiated IPT: 382 (91.8%) completed IPT, 17 (4.1%) stopped treatment, 8 (1.9%) died, 3 (0.7%) developed TB during IPT and 6 (1.4%) had unknown outcomes. No severe adverse events were reported. Conclusions: IPT treatment completion was high; no serious complications occurred. Improving and expanding intensified case-finding and IPT should be considered in Vietnam.
    Transactions of the Royal Society of Tropical Medicine and Hygiene 09/2015; 109(10):653-9. DOI:10.1093/trstmh/trv074
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    ABSTRACT: Background: There is a paucity of studies that compare efficacy of drugs obtained by different diagnostic methods. Methods: We compared the efficacy of a single oral dose albendazole (400 mg), measured as egg reduction rate, against soil-transmitted helminth infections in 210 school children (Jimma Town, Ethiopia) using both Kato-Katz thick smear and McMaster egg counting method. Results: Our results indicate that differences in sensitivity and faecal egg counts did not imply a significant difference in egg reduction rate estimates. Conclusion: The choice of a diagnostic method to assess drug efficacy should not be based on sensitivity and faecal egg counts only.
    Transactions of the Royal Society of Tropical Medicine and Hygiene 09/2015; 109(10):669-71. DOI:10.1093/trstmh/trv073
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    Transactions of the Royal Society of Tropical Medicine and Hygiene 09/2015; 109(9). DOI:10.1093/trstmh/trv064
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    ABSTRACT: Melioidosis is a tropical disease caused by infection with Burkholderia pseudomallei. Here, we report an 11 year (2002-2013) retrospective study of melioidosis cases in China. A total of 170 culture-confirmed melioidosis cases were included in our analysis, with culture-positive confirmation, biochemical identification and 16S DNA sequencing. A retrospective study design was employed and a correlational analysis of potential risk factors for mortality was carried out with logistic regression. We observed a year-over-year increasing trend in the incidence of melioidosis in Hainan, particularly after 2007 (annual peak of 64 cases in 2012). Farmers and fishers were the main group susceptible to melioidosis (75/170; 44.1%). Forty-six (27.1%) of the cases were fatal. Pneumonia (58/170; 34.1%) and septicaemia (44/170; 25.9%) were common presentations. Meanwhile, pre-existing diabetes (74/170; 43.5%) and being employed in a job that involves outdoor labour (148/170; 87.1%) emerged as common factors among affected patients. We did not observe a significant effect of seasonal variation on melioidosis mortality, but the greatest number of cases did occur in the rainiest season. This was the first clinical retrospective study of melioidosis in Hainan, China. The present data will be a useful resource to melioidosis researchers worldwide. © The Author 2015. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene. All rights reserved. For permissions, please e-mail:
    Transactions of the Royal Society of Tropical Medicine and Hygiene 08/2015; 109(10). DOI:10.1093/trstmh/trv065
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    ABSTRACT: Background: Although Clostridium difficile is a major cause of diarrhoea, its epidemiology in tropical settings is poorly understood. Strain characterisation requires work-up in specialised laboratories, often after prolonged storage without properly maintained cold chain. Methods: We screened 298 human faecal samples from Côte d'Ivoire using a rapid test for C. difficile glutamate dehydrogenase (GDH). GDH-positive samples were aerobically stored at disrupted cold chain conditions (mean duration: 11 days) before transfer to a reference laboratory for anaerobic culture, susceptibility testing, PCR assays and ribotyping. Results: Sixteen samples (5.4%) had a positive GDH screening test. C. difficile infection was confirmed in six specimens by culture and PCR, while no nucleic acids of C. difficile were detected in the culture-negative samples. Further analysis of stool samples harbouring toxigenic C. difficile strains confirmed that both GDH and toxins remained detectable for at least 28 days, regardless of storage conditions (aerobic storage at 4°C or 20°C). Conclusions: Storage conditions only minimally affect recovery of C. difficile and its toxins in stool culture. A rapid GDH screening test and subsequent transfer of GDH-positive stool samples to reference laboratories for in-depth characterisation may improve our understanding of the epidemiology of C. difficile in the tropics.
    Transactions of the Royal Society of Tropical Medicine and Hygiene 08/2015; 109(10). DOI:10.1093/trstmh/trv071
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    ABSTRACT: Smoking is an important risk factor of TB. However, no studies have been conducted to identify TB cases from smokers. We assessed the process and initial impact of active case finding among smokers at primary care facilities in a setting with high smoking rates and TB burden. A prospective quasi-experimental study was conducted in para-urban communities in Yunnan China between September 2013 and June 2014. Smokers attending primary care facilities in the intervention group were prescribed chest X-rays if they had diabetes or TB symptoms, or were elders or close contacts of TB patients. Those with X-rays suggestive of TB were referred to TB dispensaries for diagnosis. Passive case finding was practiced in the control group. In the intervention group, we screened 471 smokers with high risks of TB, of whom 73% took chest X-ray examinations. Eight TB cases were diagnosed, reflecting a 1.7% yield rate of all screened smokers. Smokers with diabetes (OR 6.003, 95% CI 1.057-34.075) were more likely to have TB compared with those without. In total, the intervention group reported significantly higher TB notification rate compared with the control group (38.6 vs 22.9 per 100 000, p=0.016). Active case finding among smokers with high risks of TB was feasible and contributed to improved notification rates. © The Author 2015. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene. All rights reserved. For permissions, please e-mail:
    Transactions of the Royal Society of Tropical Medicine and Hygiene 08/2015; 109(9). DOI:10.1093/trstmh/trv063