Medicinal chemistry (Shāriqah (United Arab Emirates)) Journal Impact Factor & Information

Publisher: Bentham Science Publishers

Journal description

Current impact factor: 1.39

Impact Factor Rankings

2015 Impact Factor Available summer 2015
2013 / 2014 Impact Factor 1.387
2012 Impact Factor 1.373
2011 Impact Factor 1.496
2010 Impact Factor 1.603
2009 Impact Factor 1.642

Impact factor over time

Impact factor
Year

Additional details

5-year impact 0.00
Cited half-life 3.20
Immediacy index 0.27
Eigenfactor 0.00
Article influence 0.00
ISSN 1875-6638

Publisher details

Bentham Science Publishers

  • Pre-print
    • Author can archive a pre-print version
  • Post-print
    • Author cannot archive a post-print version
  • Restrictions
    • 12 months embargo
  • Conditions
    • Author's pre-print on author's personal website, institutional repository and open access repository
    • Author's post-print on author's personal website, institutional repository, open access repository, PubMed Central and arXiv
    • Non-Commercial
    • Published source must be acknowledged
    • Must link to journal home page with DOI
    • Publisher's version/PDF cannot be used
  • Classification
    ​ yellow

Publications in this journal

  • Medicinal chemistry (Shāriqah (United Arab Emirates)) 07/2015;
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    ABSTRACT: A series of 3-benzyloxyhydantoin derivatives were designed and synthesized by introducing hydroxyurea pharmacophore into hydantoin rigid scaffold. The cytotoxic activities of the target compounds were evaluated in vitro against three cancer cell lines. Compounds 5b, 5c, 5e, 5g, 6c and 6g displayed high activity on all of the three cancer cell lines and the most promising compounds were 5g, 6g with IC50 values of 0.04 and 0.01μM. Binding of derivatives for the ribonucleotide reductase (RR) was investigated by use of molecular docking studies. Our findings show that modification at the C5 position of hydantoin with isopropyl or isobutyl was favorable to increasing binding affinity to the active site of the RR receptor and antiproliferative activity.
    Medicinal chemistry (Shāriqah (United Arab Emirates)) 07/2015;
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    ABSTRACT: Alzheimer’s disease (AD) is a type of neurodegenerative disorder which is responsible for many cognitive dysfunctions. According to a most accepted cholinergic hypothesis, cholinesterases (AChE and BChE) have a major role in AD symptoms. The use of small molecules as inhibitors is one of the most striking strategy to control AD. In the present work, a series of N-phenylthiazol-2-amine derivatives was screened against acetylcholinesterase (AChE) from Electrophorus electricus and butyrylcholinesterase (BChE) from horse serum by using Ellman’s method, taking neostigmine and donepezil as reference drugs. Some of the assayed compounds proved to be potent inhibitors for AChE and BChE activity. N-(2,3-dimethylphenyl)thiazol-2-amine 3j was found to be the most active inhibitor among the series with IC50 value of 0.009±0.002μM and 0.646±0.012 against AChE and BChE respectively. Molecular docking studies were carried out in order to better understand the ligand binding site interactions
    Medicinal chemistry (Shāriqah (United Arab Emirates)) 06/2015; 11(5). DOI:10.2174/1573406411666141230104536
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    ABSTRACT: Pyracantha fortuneana (Maxim.) Li (P. fortuneana), an Asian species of firethorn of family Rosaceae abundantly distributed in several regions in China, has been used as a traditional Chinese medicine. We have previously reported that polysaccharides extracted from P. fortuneana lowered the oxidative stress and inhibited the inflammatory responses in mice. Other studies recently reported that proanthocyanidins from P. fortuneana promoted cellular antioxidant activity of quercetin in HepG2 cell. Our present study aims to determine the hepatoprotective effects of Selenium enriched P. fortuneana polysaccharides (Se-PFPs) against carbon tetrachloride (CCl4)-induced liver injury in a mouse model. Mice were randomly grouped into five groups, 10 mice per group: (A) normal control group; (B) CCl4 group; (C) biphenyldicarboxylate pills (BP) + CCl4 group; (D) Se-PFP(I) + CCl4 group; and (E) Se-PFP(Ⅱ) + CCl4 group. Mice in A group were given olive oil (2 ml/kg body weight (b.w.)) by intraperitoneal injection (I.P.) twice a week for 5 weeks. Mice in groups B, C, D and E were given CCl4 (2 ml/kg b.w., 30% in olive oil) by I.P. injection twice a week for 5 weeks. Mice in C, D and E groups were also given supplements containing BP (200mg/kg), Se-PFP(I) (200mg/kg) and Se-PFP(II) (400mg/kg), respectively. After dosing for 5 weeks, serum and liver enzymes, lipid profile, and lipid peroxidation levels were measured. Real time (RT)-PCR and western blot were used to determine gene expression levels. CCl4 group displayed remarkable elevation in the levels of alanine transferase (ALT), aspartate transaminase (AST), H2O2, thiobarbituric acid reactive substances (TBAR), lactic dehydrogenase (LDH), lipid profile, malondialdehyde (MDA) and a remarkable decrease in glutathione peroxidase (GPx), glutathione (GSH), catalase (CAT), paraoxonase-1 (PON1), paraoxonase-3 (PON3), and superoxide dismutase (SOD). Similar to BP treatment, supplementation of mice with Se-PFPs resulted in reversal of biochemical indicators and expression levels of those genes caused by CCl4. Our study indicates that Se-PFP administration is effective in attenuating CCl4-induced liver injury. The mechanism underlying this effect may be attributed to the reduction of oxidative stress and inflammation in liver by Se-PFPs through up-regulation of the antioxidant system. Our study suggests that Se-PFP might be a potential dietary agent in the prevention of hepatic damage.
    Medicinal chemistry (Shāriqah (United Arab Emirates)) 06/2015; 11(999). DOI:10.2174/1573406411666150602153357
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    ABSTRACT: Metabolic syndrome is a disorder described by reduced insulin sensitivity, overweight, hyperlipidaemia, high blood pressure and myocardial disorders, mainly due to high fat diet and lack of physical activity. The peroxisome proliferator activated receptors (PPARs) are type II nuclear hormone receptors that regulate a number of processes in living systems, such as metabolism of carbohydrates and fatty acids, growth and differentiation of cell, and inflammatory reactions. Alpha, gamma and delta are the three distinct isoforms of PPAR. The stimulation of PPARδ alters body's energy fuel preference from glucose to fat. The PPARδ isoform is expressed ubiquitously in all tissues, especially in those tissues which involved in metabolism of lipids like adipose tissue, liver, kidney, and muscle. Currently, PPARδ is an emerging therapeutic target for the pharmacological therapy of disorders associated with metabolic syndrome. Several PPARδ selective agonists had been reported in last ten years, many of them had been advanced into the late phase of clinical trials such as Endurobol (GW501516). However, no PPARδ agonists are yet approved for human use. The present work had been planned to cover wide variety of PPARδ agonists reported till now along with their potential role to tackle various metabolic disorders. The present review has been planned to focus mainly the most popular PPARδ agonists.
    Medicinal chemistry (Shāriqah (United Arab Emirates)) 05/2015;
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    ABSTRACT: A new library of N,N,N',N'-tetradentate pyrazoly compounds containing a pyrazole moiety were synthesized by the condensation of (3,5-dimethyl-1H-pyrazol-1-yl)methanol 2a or (1H-pyrazol-1-yl)methanol 2b with a series of primary diamines in refluxed acetonitrile for 6h. The antifungal activity against the budding yeast Saccharomyces cerevisiae, as well as the antibacterial activity against Escherichia coli of these new tridentate ligands were studied. We found that that these tetradentate ligands act specifically as antifungal agents and lack antibacterial activity. Their biological activities depend on the nature of the structure of the compounds.
    Medicinal chemistry (Shāriqah (United Arab Emirates)) 05/2015;
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    ABSTRACT: A series of twenty molecules belonging to 2,5-disubstituted-1,3,4-oxadiazole derivatives of Diclofenac and Naproxen were designed, synthesized and their structures were confirmed by spectroscopy. The target compounds were evaluated for anti-inflammatory and analgesic activity. The result indicates that the compounds 12, 4, 6, 7 and 15 were found to have good analgesic and anti-inflammatory activities, while the compounds 12 and 14 were found to have good analgesic and the compound 22 were found to have good anti-inflammatory activities. HQSAR and Topomer QSAR studies were performed to get insights in the structures contributing for biological activity. The compounds bearing mono-substitution such as Cl, OCH3 and NO2 in the phenyl ring were found to have maximum analgesic and anti-inflammatory activities.
    Medicinal chemistry (Shāriqah (United Arab Emirates)) 05/2015;
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    ABSTRACT: Penetration of the blood brain barrier (BBB) by appropriate fluorescent probes remains a challenge in optical imaging and diagnostics. We designed, synthesized and observed the in vivo BBB penetration of a LASER syn-bimane probe. Results demonstrate that the Aib transporter unit in our probe may lead a fluorescent bimanyl moiety across the BBB.
    Medicinal chemistry (Shāriqah (United Arab Emirates)) 05/2015;
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    ABSTRACT: Daumone, a dauer-inducing pheromone and a series of lipid derivatives were synthesized from daumone to investigate structure-activity trends. Lipid derivatives demonstrated potent in vivo antiangiogenic activity on the chorioallantoic membrane, which exceeded that of fumagillin and thalidomide as reference agents. Among the 11 synthetic compounds tested, new derivatives 3, 11 and 13 showed the most potent antiangiogenic activity, which was twice that of fumagillin and thalidomide, replacing these as the most potent known antiangiogenic agents.
    Medicinal chemistry (Shāriqah (United Arab Emirates)) 05/2015;
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    ABSTRACT: We showed the di[3,5-diacetyl-1,2,4-triazolbis(4-cyclohexylthiosemicarbazonato) platinum(II)] complex, (W8), endowed with important antitumor properties. Here, we analysed whether W8 can affect human bone marrow-derived Mesenchymal Stem Cells, (hMSCs), involved in tissue repair, immunomodulatory properties and also capacity for homing to injure-tumor sites in ovarian cancer. Specifically, we analysed the effect of W8 on cell proliferation, response to scratch, and whether copper-derived cellular mechanism is used by this platinum(II) complex being studied. Results show, that W8 causes a significant inhibition of cell proliferation at µM concentration. This effect is directly related to the alteration of cytoskeletal proteins and inhibition of the response to scratch induced by the presence of foetal bovine serum. This strongly supports the notion of W8 triggers the energetic metabolism of hMSCs and adds an extra support by the results showing W8 relationship with the cellular copper ions. W8, acting in hMSCs, regulates in addition the inhibition of cell proliferation, the inhibition of tumor angiogenesis and metastasis.
    Medicinal chemistry (Shāriqah (United Arab Emirates)) 05/2015;
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    ABSTRACT: A series of 26 quaternary ammonium pyridoxine derivatives were synthesized and their cytotoxicity and antibacterial activity against clinically relevant bacterial strains were tested in vitro. The antibacterial activity of mono-ammonium salts increased with the rise of the lipophilicity and compound 3,3,5-trimethyl-8,8-dioctyl-1,7,8,9-tetrahydro-[1,3]dioxino[5,4-d]pyrrolo[3,4-b]pyridin-8-ium chloride (2d) reaches a maximum of that among them. Bis-ammonium salt of pyridoxine 4 with two dimethyloctylamine groups also demonstrated high antibacterial activity despite of lower lipophilicity. The results of MTT assay indicated that HEK 293 cells were more sensitive than HSF to quaternary ammonium pyridoxine derivatives. Compounds 2d and 4 did not induce the damage of the DNA and might be of interest in the development of new antimicrobials.
    Medicinal chemistry (Shāriqah (United Arab Emirates)) 05/2015;