Analytica chimica acta Journal Impact Factor & Information

Publisher: Elsevier Masson

Current impact factor: 4.51

Impact Factor Rankings

2015 Impact Factor Available summer 2016
2014 Impact Factor 4.513
2013 Impact Factor 4.517
2012 Impact Factor 4.387
2011 Impact Factor 4.555
2010 Impact Factor 4.31
2009 Impact Factor 3.757
2008 Impact Factor 3.146
2006 Impact Factor 2.894
2005 Impact Factor 2.76
2004 Impact Factor 2.588
2003 Impact Factor 2.21
2002 Impact Factor 2.114
2001 Impact Factor 2.073
2000 Impact Factor 1.849
1999 Impact Factor 1.894
1998 Impact Factor 1.692
1997 Impact Factor 1.778
1996 Impact Factor 1.874
1995 Impact Factor 1.887
1994 Impact Factor 1.696
1993 Impact Factor 1.734
1992 Impact Factor 2.033

Impact factor over time

Impact factor

Additional details

5-year impact 4.67
Cited half-life 7.60
Immediacy index 0.82
Eigenfactor 0.06
Article influence 1.07
ISSN 1873-4324

Publisher details

Elsevier Masson

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    • Author's post-print on open access repository after an embargo period of between 12 months and 48 months
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    • Author's post-print must be released with a Creative Commons Attribution Non-Commercial No Derivatives License
    • Publisher last reviewed on 01/05/2015
    • 'Elsevier Masson' is an imprint of 'Elsevier'
  • Classification

Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: In this research, the applicability of a new sorbent based on boronate affinity material is demonstrated. For this purpose, six strong polar nitrophenols were selected as models which are difficult to be extracted in neutral form (only based on hydrophobic interactions). The extracted nitrophenols were separated and determined by high-performance liquid chromatography with diode array detection. The sorbent was synthesized by in situ copolymerization of 3-acrylamidophenylboronic acid and divinylbenzene using dimethyl sulfoxide and azobisisobutyronitrile as porogen solvent and initiator, respectively. The effect of the preparation parameters in the polymerization mixture on extraction performance was investigated in detail. The size and morphology of the sorbent have been characterized via different techniques such as infrared spectroscopy, elemental analysis, scanning electron microscopy and mercury intrusion porosimetry. The important parameters influencing the extraction efficiency were studied and optimized thoroughly. Under the optimum extraction conditions, the limits of detection (S/N = 3) and limits of quantification (S/N = 10) for the target nitrophenols were 0.097-0.28 and 0.32-0.92 μg/L, respectively. The precision of the proposed method was evaluated in terms of intra- and inter-assay variability calculated as RSD, and it was found that the RSDs were all below 9%. Finally, the developed method was successfully applied for environmental water samples such as wastewater, tap, lake and river water. The recoveries varied within the range of 71.2-115% with RSD below 11% in all cases. The results well demonstrate that the new boronate affinity sorbent can extract nitrophenols effectively through multi-interactions including boron-nitrogen coordination, hydrogen-bond and hydrophobic interactions between sorbent and analytes.
    Analytica chimica acta 11/2015; 899:75-84. DOI:10.1016/j.aca.2015.10.004
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    ABSTRACT: Alpha-methylacyl-CoA racemase (AMACR) is over-expressed in many cancer types and can serve as a novel diagnostic biomarker. Development of convenient and sensitive detection methods of AMACR is of particular importance for cancer diagnosis. Aptamers are a type of recognition elements, which possess many advantages over antibody, making them suitable for applications in biosensing and biotechnology. In this work, we use the efficient surface modification of gold nanoparticles (AuNPs) to prepare the horseradish peroxidase (HRP) and aptamer dual-functionalized nanoprobe. The immobilization of HRP and thiol-terminated aptamer on the surface of AuNPs can be achieved through electrostatic interaction and the formation of Au-S bond, respectively. This nanoprobe, which is used as discriminating and catalytic probe, can be combined with enzyme immunoassay method to increase the detection sensitivity of AMACR. The detection limit can reach as low as 4.6 pg mL(-1) due to the dual signal amplification from enzymatic cycling and the high loading of enzymes on AuNPs. This sensitivity is about three orders of magnitude higher than that of AMACR aptamer based fluorescence method, which is also comparable to or one order of magnitude higher than that of ELISA. Furthermore, this method is more simple and effective, which not only avoids the conjugation between recognition element and the catalytic enzyme, but also achieves greater signal amplification. This assay could be used as a sensitive and selective platform for the detection of target protein.
    Analytica chimica acta 11/2015; 899:100-105. DOI:10.1016/j.aca.2015.10.007
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    ABSTRACT: A highly sensitive electrochemical immunoassay of chlorpyrifos (CPF) was developed by using a biocompatible quinone-rich polydopamine nanospheres modified glass carbon electrode as the sensor platform and multi-horseradish peroxidase-flake like Fe3O4 coated carbon nanotube nanocomposites as the signal label. Due to the quinone-rich polydopamine nanospheres, the platform exhibited excellent fixing capacity by simple coating of sticky polydopamine nanospheres and subsequent oxidization. By coprecipitation of Fe(3+) and Fe(2+) on polydopamine modified carbon nanotubes (CNTs) with the aid of ethylene glycol (EG), the flake-like Fe3O4 coated CNTs (CNTs@f-Fe3O4) were synthesized and chosen as the carrier of multi-enzyme label due to the high loading of secondary antibody (Ab2) and horseradish peroxidase (HRP) and also the peroxidase-mimic activity of Fe3O4. Under the optimum conditions, the immunosensor can detect CPF over a wide range with a detection limit of 6.3 pg/mL. Besides, the high specificity, reproducibility and stability of the proposed immunosensor were also proved. The preliminary application in real sample showed good recoveries, indicating it holds promise for fast analysis of CPF in aquatic environment.
    Analytica chimica acta 11/2015; 899:91-99. DOI:10.1016/j.aca.2015.09.057
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    ABSTRACT: A novel electrochemical sensor based on Cu-MOF-199 [Cu-MOF-199 = Cu3(BTC)2 (BTC = 1,3,5-benzenetricarboxylicacid)] and SWCNTs (single-walled carbon nanotubes) was fabricated for the simultaneous determination of hydroquinone (HQ) and catechol (CT). The modification procedure was carried out through casting SWCNTs on the bare glassy carbon electrode (GCE) and followed by the electrodeposition of Cu-MOF-199 on the SWCNTs modified electrode. Cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS) and scanning electron microscopy (SEM) were performed to characterize the electrochemical performance and surface characteristics of the as-prepared sensor. The composite electrode exhibited an excellent electrocatalytic activity with increased electrochemical signals towards the oxidation of HQ and CT, owing to the synergistic effect of SWCNTs and Cu-MOF-199. Under the optimized condition, the linear response range were from 0.1 to 1453 μmol L(-1) (RHQ = 0.9999) for HQ and 0.1-1150 μmol L(-1) (RCT = 0.9990) for CT. The detection limits for HQ and CT were as low as 0.08 and 0.1 μmol L(-1), respectively. Moreover, the modified electrode presented the good reproducibility and the excellent anti-interference performance. The analytical performance of the developed sensor for the simultaneous detection of HQ and CT had been evaluated in practical samples with satisfying results.
    Analytica chimica acta 11/2015; 899:57-65. DOI:10.1016/j.aca.2015.09.054
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    ABSTRACT: We fabricated a novel fluorescence biosensor for the selective detection of thrombin by using bovine serum albumin-capped CdS quantum dots (BSA-CdS QDs). Two kinds of designed DNA (DNA1 and DNA2) could bind to CdS QDs through the electrostatic interaction between DNA and Cd(2+) on the surface of CdS QDs. The obtained DNA/BSA-CdS QDs kept stable in the solution with the fluorescence intensity obviously enhanced. Hairpin structure of DNA1contained two domains, one is the aptamer sequence of thrombin and the other is the complementary sequence of DNA2. When thrombin was added, it would bind to DNA1 and induce the hairpin structure of DNA1 changed into G-quadplex structure. Meanwhile, DNA2 would transfer from the surface of CdS QDs to DNA1 via hybridization, which resulted in the removal of DNA1 and DNA2 from the surface of CdS QDs, and led to the fluorescence intensity of CdS QDs reduced. Thus, the determination of thrombin could be achieved by monitoring the change of the fluorescence intensity of CdS QDs. The present method is simple and fast, and exhibits good selectivity for thrombin over other proteins. We have successfully detected thrombin in human serum samples with satisfactory results.
    Analytica chimica acta 11/2015; 899:85-90. DOI:10.1016/j.aca.2015.09.051
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    ABSTRACT: Gold nanoparticle-enhanced target (AuNPET) was used for detailed investigation of various materials of biological origin - human fingerprint, onion bulb and chicken liver. Analysis of these objects was focused on toxic and harmful compounds - designer drug containing pentedrone, diphenylamine in onion and potentially cancerogenic metronidazole antibiotic in liver. Detection of large quantity of endogenous compounds from mentioned objects is also shown. Most of analyzed compounds were also localized with MS imaging and relationship between their function and location was discussed. Detected compounds belong to a very wide range of chemical compounds such as saccharides, ionic and non-ionic glycerides, amino acids, fatty acids, sulfides, sulfoxides, phenols etc. Fingerprint experiments demonstrate application of AuNPET for detection, structure confirmation and also co-localization of drug with ridge patterns proving person-drug contact.
    Analytica chimica acta 10/2015; 895:45-53. DOI:10.1016/j.aca.2015.09.003
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    ABSTRACT: Copper is a highly toxic environmental pollutant with bioaccumulative properties. Therefore, sensitive detection of Cu(2+) is very important to prevent over-ingestion, and visual detection is preferred for practical applications. In this work, we developed a simple and environmental friendly approach to synthesize hyperbranched polyethyleneimine-protected copper nanoclusters (hPEI-Cu NCs) with great stability against extreme pH, high ionic strength, thiols etching and light illumination, which were then conjugated to the surface of silica coated CdSe quantum dots (QDs) to design a ratiometric fluorescence probe. In the presence of different amounts of Cu(2+) ions, the fluorescence of Cu NCs can be drastically quenched, while the emission from QDs stayed constant to serve as a reference signal and the color of the probe changed from yellow-green to red, resulting in ratiometric and visualization detection of Cu(2+) ion with high accuracy. The detection limit for Cu(2+) was estimated to be 8.9 nM, much lower than the allowable level of Cu(2+) in drinking water (∼20 μM) set by U.S. Environmental Protection Agency. Additionally, this probe can be also applied for the determination of Cu(2+) ion in complex real water samples.
    Analytica chimica acta 10/2015; 895:95-103. DOI:10.1016/j.aca.2015.09.002
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    ABSTRACT: Celiac patients should feel confident in the safety of foods labelled or expected to be gluten-free. In this context, a targeted proteomic approach based on liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) technique was proposed to assess the presence of celiotoxic cereals, namely wheat, oats, barley and rye, in raw and processed food products. To this aim, unique marker peptides were properly selected in order to distinguish between the different cereal types. A revised cocktail solution based on reducing and denaturing agents was exploited for prolamin extraction from raw and processed food; in addition, defatting with hexane was carried out for sample clean-up, allowing to largely reduce problems related to matrix effect. Method validation on fortified rice flour showed good analytical performance in terms of sensitivity (limits of detection in the 2-18 mg kg(-1) range). However, poor trueness was calculated for self-made incurred bread (between 3 and 30% depending on the peptide), probably due to baking processes, which reduce gluten extractability. Thus, it is evident that in the case of processed foods further insights into sample treatment efficiency and reference materials for protein calibration are required to obtain accurate gluten determination. Finally, the developed method was applied for the analysis of market food products, offering the possibility to discriminate among cereals, with good agreement with labelled ingredients for gluten-containing foodstuffs.
    Analytica chimica acta 10/2015; 895:62-70. DOI:10.1016/j.aca.2015.09.008
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    ABSTRACT: A novel Ru(bpy)3(2+)-based electrochemiluminescence (ECL) sensing platform, using N-doped carbon nanodots (N-C dots) as co-reactant, was established for the sensitive and selective detection of bisphenol A (BPA). N-C dots not only could enhance the ECL signal, but also significantly improved the reproducibility and stability of Ru(bpy)3(2+) ECL system. The developed ECL sensing system was sensitive to detect BPA based on its efficient quenching effect on Ru(bpy)3(2+)/N-C dots. The N-C dots-enhanced ECL mechanism and BPA-quenched ECL mechanism were investigated. Under the optimum conditions, the inhibited ECL intensity was in good linear relationship versus the concentration of BPA in the range of 0.03-1.0 μM with the detection limit of 10 nM. The relative standard deviation (RSD) for 25 successive measurements with one sensor was 1.1% and for eight different sensors was 2.5%, respectively. The fabricated sensing platform was successfully applied for the detection of BPA in baby bottle and nipple, and relatively satisfactory recoveries were obtained.
    Analytica chimica acta 10/2015; 895:104-111. DOI:10.1016/j.aca.2015.08.055
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    ABSTRACT: An ultrasensitive and highly selective electrochemical sensor for the determination of p-nitrophenol (p-NP) was developed based on electrochemically treated nano polypyrrole/sodium dodecyl sulphate film (ENPPy/SDS film) modified glassy carbon electrode. The nano polypyrrole/sodium dodecyl sulphate film (NPPy/SDS film) was prepared and treated electrochemically in phosphate buffer solution. The surface morphology and elemental analysis of treated and untreated NPPy/SDS film were characterized by FESEM and EDX analysis, respectively. Wettability of polymer films were analysed by contact angle test. The hydrophilic nature of the polymer film decreased after electrochemical treatment. Effect of the pH of electrolyte and thickness of the ENPPy/SDS film on determination of p-NP was optimised by cyclic voltammetry. Under the optimised conditions, the p-NP was determined from the oxidation peak of p-hydroxyaminophenol which was formed from the reduction of p-NP in the reduction segment of cyclic voltammetry. A very good linear detection range (from 0.1 nM to 100 μM) and the best LOD (0.1 nM) were obtained for p-NP with very good selectivity. This detection limit is below to the allowed limit in drinking water, 0.43 μM, proposed by the U.S. Environmental Protection Agency (EPA) and earlier reports. Moreover, ENPPy/SDS film based sensor exhibits high sensitivity (4.4546 μA μM(-1)) to p-NP. Experimental results show that it is a fast and simple sensor for p-NP.
    Analytica chimica acta 10/2015; 899. DOI:10.1016/j.aca.2015.09.055
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    ABSTRACT: Exploration of new natural compounds is of vital significance for drug discovery and development. The conventional approaches by systematic phytochemical isolation are low-efficiency and consume masses of organic solvent. This study presents an integrated strategy that combines offline comprehensive two-dimensional liquid chromatography, hybrid linear ion-trap/Orbitrap mass spectrometry, and NMR analysis (2D LC/LTQ-Orbitrap-MS/NMR), aimed to establish a green protocol for the efficient discovery of new natural molecules. A comprehensive chemical analysis of the total ginsenosides of stems and leaves of Panax ginseng (SLP), a cardiovascular disease medicine, was performed following this strategy. An offline 2D LC system was constructed with an orthogonality of 0.79 and a practical peak capacity of 11,000. The much greener UHPLC separation and LTQ-Orbitrap-MS detection by data-dependent high-energy C-trap dissociation (HCD)/dynamic exclusion were employed for separation and characterization of ginsenosides from thirteen fractionated SLP samples. Consequently, a total of 646 ginsenosides were characterized, and 427 have not been isolated from the genus of Panax L. The ginsenosides identified from SLP exhibited distinct sapogenin diversity and molecular isomerism. NMR analysis was finally employed to verify and offer complementary structural information to MS-oriented characterization. The established 2D LC/LTQ-Orbitrap-MS/NMR approach outperforms the conventional approaches in respect of significantly improved efficiency, much less use of drug materials and organic solvent. The integrated strategy enables a deep investigation on the therapeutic basis of an herbal medicine, and facilitates new compounds discovery in an efficient and environmentally friendly manner as well.
    Analytica chimica acta 09/2015; 893:65-76. DOI:10.1016/j.aca.2015.08.048
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    ABSTRACT: In this work, a novel sandwich-type electrochemical immunosensor based on host-guest interaction was fabricated for the detection of alpha-fetoprotein (AFP). Due to the large specific surface area of multiwalled carbon nanotubes and the unique supramolecular recognition ability of β-cyclodextrins, ferrocenecarboxylic acid (Fc) was incorporated into this sensor platform by host-guest interaction to generate an electrochemical signal. And β-cyclodextrins functionalized silver supported adamantine-modified glucose oxidase (GOD-CD-Ag), was used as a label to improve the analytical performance of the immunosensor by the dual amplification strategy. The obtained GOD-CD-Ag conjugates could convert glucose into gluconic acid with the formation of hydrogen peroxide (H2O2). And then silver nanoparticles could in situ catalyze the reduction of the generated H2O2, dramatically improving the oxidation reaction of Fc. The developed immunosensor shows a wide linear calibration range from 0.001 to 5.0 ng/mL with a low detection limit (0.2 pg/mL) for the detection of AFP. The method, with ideal reproducibility and selectivity, has a wide application prospect in clinical research.
    Analytica chimica acta 09/2015; 893:49-56. DOI:10.1016/j.aca.2015.08.052
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    ABSTRACT: An electrochemical sensor was prepared using Au nanoparticles and reduced graphene successfully decorated on the glassy carbon electrode (Au/RGO/GCE) through an electrochemical method which was applied to detect Sunset Yellow (SY). The as-prepared electrode was characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), atomic force microscopy (AFM) and electrochemical measurements. The results of cyclic voltammetry (CV) proved that Au/RGO/GCE had the highest catalytic activity for the oxidation of SY as compared with GCE, Au/GCE, and RGO/GCE. Differential pulse voltammetry (DPV) showed that the linear calibration curves for SY on Au/RGO/GCE in the range of 0.002 μM-109.14 μM, and the detection limit was estimated to be 2 nM (S/N = 3). These results suggested that the obtained Au/RGO/GCE was applied to detect SY with high sensitivity, low detection limit and good stability, which provided a promising future for the development of portable sensor in food additives.
    Analytica chimica acta 09/2015; 893:41-48. DOI:10.1016/j.aca.2015.08.042