Analytica chimica acta Journal Impact Factor & Information

Publisher: Elsevier Masson

Journal description

Current impact factor: 4.52

Impact Factor Rankings

2015 Impact Factor Available summer 2015
2013 / 2014 Impact Factor 4.517
2012 Impact Factor 4.387
2011 Impact Factor 4.555
2010 Impact Factor 4.31
2009 Impact Factor 3.757
2008 Impact Factor 3.146
2006 Impact Factor 2.894
2005 Impact Factor 2.76
2004 Impact Factor 2.588
2003 Impact Factor 2.21
2002 Impact Factor 2.114
2001 Impact Factor 2.073
2000 Impact Factor 1.849
1999 Impact Factor 1.894
1998 Impact Factor 1.692
1997 Impact Factor 1.778
1996 Impact Factor 1.874
1995 Impact Factor 1.887
1994 Impact Factor 1.696
1993 Impact Factor 1.734
1992 Impact Factor 2.033

Impact factor over time

Impact factor

Additional details

5-year impact 3.52
Cited half-life 6.20
Immediacy index 0.66
Eigenfactor 0.08
Article influence 0.86
ISSN 1873-4324

Publisher details

Elsevier Masson

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    • Author can archive a pre-print version
  • Post-print
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    • On authors personal or authors institutions server
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    • Publisher's version/PDF cannot be used
    • Articles in some journals can be made Open Access on payment of additional charge
    • 'Elsevier Masson' is an imprint of 'Elsevier'
  • Classification
    ​ green

Publications in this journal

  • A M van Wijk, H A G Niederländer, M D van Ogten, G J de Jong
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    ABSTRACT: A CE-MS method has been developed to detect trace levels of potentially genotoxic alkyl halides. After derivatization of the target components with 4-dimethylaminopyridine (DMAP) or butyl 1-(pyridinyl-4yl) piperidine 4-carboxylate (BPPC), the natively positively charged derivatives are pre-concentrated by applying electrokinetic injection and separated by a highly efficient CZE method using a background electrolyte (BGE) consisting of 100mM of TRIS adjusted to pH 2.5 with phosphoric acid. Using a sheath liquid interface, subsequent MS detection allows highly specific and sensitive analysis of alkyl halides. Conditions for electrokinetic injection were optimized to allow selective and effective injection. Injection of samples with low water content at 10kV for 150s using a high concentration of buffer in the BGE resulted in optimum sample stacking during injection and a highly efficient CE separation. At the sample pH applied, neutral and negatively charged components are shown to be selectively discarded, resulting in injection of positively charged ions only. The sample matrix influences the efficiency of the injection, but when using an internal standard, reproducibilities better than 10% RSD are obtained. Relative recoveries of the derivatives spiked to different types of model API between 85 and 115% demonstrate that the method can be applied for quantitative analysis. Detection limits of lower than 1mgkg(-1) for the tested alkyl halides obtained in CE-MS at least equal the sensitivity obtained in LC-MS. The CE-MS method is a valuable alternative for the LC-MS method used for analysis of alkylation compounds. Copyright © 2015 Elsevier B.V. All rights reserved.
    Analytica chimica acta 05/2015; 874:75-83. DOI:10.1016/j.aca.2015.02.067
  • Maria A. Khalikova, Dalibor Šatínský, Petr Solich, Lucie Nováková
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    ABSTRACT: A novel simple, fast and efficient ultra-high performance supercritical fluid chromatography (UHPSFC) method was developed and validated for the separation and quantitative determination of eleven illegal dyes in chili-containing spices. The method involved a simple ultrasound-assisted liquid extraction of illegal compounds with tetrahydrofuran. The separation was performed using a supercritical fluid chromatography system and CSH Fluoro-Phenyl stationary phase at 70°C. The mobile phase was carbon dioxide and the mixture of methanol:acetonitrile (1:1, v/v) with 2.5% formic acid as an additive at the flow rate 2.0mLmin(-1). The UV-vis detection was accomplished at 500nm for seven compounds and at 420nm for Sudan Orange G, Butter Yellow, Fast Garnet GBC and Methyl Red due to their maximum of absorbance. All eleven compounds were separated in less than 5min. The method was successfully validated and applied using three commercial samples of chili-containing spices - Chili sauce (Indonesia), Feferony sauce (Slovakia) and Mojo sauce (Spain). The linearity range of proposed method was 0.50-9.09mgkg(-1) (r≥0.995). The detection limits were determined as signal to noise ratio of 3 and were ranged from 0.15mgkg(-1) to 0.60mgkg(-1) (1.80mgkg(-1) for Fast Garnet) for standard solution and from 0.25mgkg(-1) to 1.00mgkg(-1) (2.50mgkg(-1) for Fast Garnet, 1.50mgkg(-1) for Sudan Red 7B) for chili-containing samples. The recovery values were in the range of 73.5-107.2% and relative standard deviation ranging from 0.1% to 8.2% for within-day precision and from 0.5% to 8.8% for between-day precision. The method showed potential for being used to monitor forbidden dyes in food constituents. The developed UHPSFC method was compared to the UHPLC-UV method. The orthogonality of Sudan dyes separation by these two methods was demonstrated. Benefits and drawbacks were discussed showing the reliability of both methods for monitoring of studied illegal dyes in real food constituents. Copyright © 2015 Elsevier B.V. All rights reserved.
    Analytica chimica acta 05/2015; 874. DOI:10.1016/j.aca.2015.03.003
  • Ponnaboina Thirupathi, Lok Nath Neupane, Keun-Hyeung Lee
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    ABSTRACT: New fluorescent peptide-based sensors (1-3) for monitoring heparin in serum sample were synthesized using short peptides (1∼3mer) as a receptor. The peptide-based sensors (2 and 3) showed a sensitive ratiometric response to heparin both in aqueous buffered solution (10mM HEPES, pH 7.4) and in 2% human serum sample by increase of excimer emission of pyrene at 480nm and concomitant decrease of monomer emission of pyrene at 376nm, whereas the peptide-based sensor 1 showed a turn off response only by decrease of monomer emission at 376nm. 2 and 3 exhibited excellent selectivity toward heparin among various anions and competitors of heparin including chondroitin 4-sulfate (ChS) and hyaluronic acid (HA). Peptide-based sensor 3 showed a more sensitive response to heparin than 2. The detection limit of 3 was determined as 36pM (R(2)=0.998) for heparin in aqueous solution and 204pM (R(2)=0.999) for heparin in aqueous solutions containing 2% human serum. The peptide-based sensors, 2 and 3 provided a practical and potential tool for the detection and quantification of heparin in real biological samples. Copyright © 2015 Elsevier B.V. All rights reserved.
    Analytica chimica acta 05/2015; 873:88-98. DOI:10.1016/j.aca.2015.03.001
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    ABSTRACT: Immobilized antibodies with oriented and homogeneous patterns are crucial to solid-phase molecular recognition assay. Antibody binding protein-based immobilization can effectively present the desired antibodies. However, steadily installing the stromatoid protein with site-specific attachment manner onto a matrix surface remains to be elucidated. In this study, we present an optimal protocol to tightly attach an immunoglobulin G (IgG)-binding protein (Z-domain) through covalent incorporation of Cys-tag and maleimide group onto polystyrene surface to guarantee site-specific, oriented, and irreversible attachment, resulting in a highly efficient platform for three-dimensional IgG immobilization. The actual IgG-binding characteristic of immobilized Z-Cys was investigated by employing affinity chromatography and size exclusion chromatography. And the efficacy and potential of this platform was demonstrated by applying it to the analysis of interaction between rabbit anti-HRP IgG and its binding partner HRP. The proposed approach may be an attractive strategy to construct high performance antibody arrays and biosensors given that the antibody is compatible with the Z-domain. Copyright © 2015 Elsevier B.V. All rights reserved.
    Analytica chimica acta 05/2015; 872. DOI:10.1016/j.aca.2015.03.005
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    ABSTRACT: Two major issues need to be addressed in applying semiconductor biosensors to detecting proteins in immunoassays. First, the length of the antibody on the sensor surface surpasses the Debye lengths (approximately 1nm, in normal ionic strength solution), preventing certain specifically bound proteins from being tightly attached to the sensor surface. Therefore, these proteins do not contribute to the sensor's surface potential change. Second, these proteins carry a small charge and can be easily affected by the pH of the surrounding solution. This study proposes a magnetic bead-based immunoassay using a secondary antibody to label negatively charged DNA fragments for signal amplification. An externally imposed magnetic force attaches the analyte tightly to the sensor surface, thereby effectively solving the problem of the analyte protein's distance to the sensor surface surpassing the Debye lengths. In addition, a normal ion intensity buffer can be used without dilution for the proposed method. Experiments revealed that the sensitivity can be improved by using a longer DNA fragment for labeling and smaller magnetic beads as solid support for the antibody. By using a 90 base pair DNA label, the signal was 15 times greater than that without labeling. In addition, by using a 120nm magnetic bead, a minimum detection limit of 12.5ngmL(-1) apolipoprotein A1 can be measured. Furthermore, this study integrates a semiconductor sensor with a microfluidic chip. With the help of microvalves and micromixers in the chip, the length of the mixing step for each immunoassay has been reduced from 1h to 20min, and the sample volume has been reduced from 80μL to 10μL. In practice, a protein biomarker in a urinary bladder cancer patient's urine was successfully measured using this technique. This study provides a convenient and effective method to measure protein using a semiconductor sensor. Copyright © 2015 Elsevier B.V. All rights reserved.
    Analytica chimica acta 04/2015; 869. DOI:10.1016/j.aca.2015.03.002
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    ABSTRACT: Polythiophene (PT) was used as a surface modifier of graphene/Fe3O4 (G/Fe3O4) composite to increase merit of it, and also overcome some limitations and disadvantages of using G/Fe3O4 alone as solid phase extraction (SPE) sorbent. An in-situ chemical polymerization method was employed to prepare G/Fe3O4@PT nanocomposites. Application of this newly designed material in the magnetic SPE (MSPE) of polycyclic aromatic hydrocarbons (PAHs), as model analytes, in the environmental water samples was investigated. The characterization of the hybrid material was performed using transmission electron microscopy, scanning electron microscopy, energy-dispersive X-ray analysis, Fourier transform-infrared (FT-IR) spectroscopy and vibrating sample magnetometry. Seven important parameters, affecting the extraction efficiency of PAHs, including: amount of adsorbent, adsorption and desorption times, type and volume of the eluent solvent, initial sample volume and salt content of the sample were evaluated. The optimum extraction conditions were obtained as: 4min for extraction time, 20mg for sorbent amount, 100mL for initial sample volume, toluene as desorption solvent, 0.6mL for desorption solvent volume, 6min for desorption time and 30% (w/v) for NaCl concentration. Good performance data were obtained at the optimized conditions. Detection limits were in the range of 0.009-0.020μgL(-1) in the real matrix. The calibration curves were linear over the concentration ranges from 0.03 to 80μgL(-1) with correlation coefficients (R(2)) between 0.995 and 0.998 for all the analytes. Relative standard deviations were ranged from 4.3 to 6.3%. Appropriate recovery values, in the range of 83-107%, were also obtained for the real sample analysis. Copyright © 2014 Elsevier B.V. All rights reserved.
    Analytica chimica acta 04/2015; 868. DOI:10.1016/j.aca.2014.12.022
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    ABSTRACT: MicroRNAs (miRNAs) play an important regulatory role in cells and dysregulation of miRNA has been associated with a variety of diseases, making them a promising biomarker. In this work, a novel biosensing strategy has been developed for label-free detection of miRNA using surface plasmon resonance (SPR) coupled with DNA super-sandwich assemblies and biotin-strepavidin based amplification. The target miRNA is selectively captured by surface-bound DNA probes. After hybridization, streptavidin is employed for signal amplification via binding with biotin on the long DNA super-sandwich assemblies, resulting in a large increase of the SPR signal. The method shows very high sensitivity, capable of detecting miRNA at the concentration down to 9pM with a wide dynamic range of 6 orders of magnitude (from 1×10(-11)M to 1×10(-6)M) in 30min, and excellent specificity with discriminating a single base mismatched miRNA sequence. This biosensor exhibits good reproducibility and precision, and has been successfully applied to the detection of miRNA in total RNA samples extracted from human breast adenocarcinoma MCF-7 cells. It, therefore, offers a highly effective alternative approach for miRNA detection in biomedical research and clinical diagnosis. Copyright © 2015 Elsevier B.V. All rights reserved.
    Analytica chimica acta 04/2015; 874. DOI:10.1016/j.aca.2015.03.021
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    ABSTRACT: A new circular dichroism sensor for detecting Ni(2+) and Co(2+) was proposed for the first time using chiral chelating quantum dots. The detection principle was based on changing of circular dichroism signals of the chiral quantum dots when forming a chiral complex with Ni(2+) or Co(2+). l-Cysteine capped cadmium sulfide quantum dots (l-Cyst-CdS QDs) were proposed as a chiral probe. The CD spectrum of l-Cyst-CdS QDs was significantly changed in the presence of Ni(2+) and Co(2+). On the other hand, other studied cations did not alter the original CD spectrum. Moreover, when increasing the concentration of Ni(2+) or Co(2+), the intensity of the CD spectrum linearly increased as a function of concentration and could be useful for the quantitative analysis. The proposed CD sensor showed linear working concentration ranges of 10-60μM and 4-80μM with low detection limits of 7.33μМ and 1.13μM for the detection of Ni(2+) and Co(2+), respectively. Parameters possibly affected the detection sensitivity such as solution pH and incubation time were studied and optimized. The proposed sensor was applied to detect Ni(2+) and Co(2+) in real water samples, and the results agreed well with the analysis using the standard ICP-OES. Copyright © 2014 Elsevier B.V. All rights reserved.
    Analytica chimica acta 03/2015; 867. DOI:10.1016/j.aca.2014.12.004
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    ABSTRACT: A highly sensitive impedimetric immunosensor based on a gold nanoparticles/multiwall carbon nanotube-ionic liquid electrode (AuNPs/MW-CILE) was developed for the determination of human epidermal growth factor receptor 2 (HER2). Gold nanoparticles were used to enhance the extent of immobilization and to retain the immunoactivity of the antibody Herceptin on the electrode. Cyclic voltammetry and electrochemical impedance spectroscopy were employed for characterization of various layers coated onto the AuNPs/MW-CILE. The impedance measurements at different steps were based on the charge transfer kinetics of the [Fe(CN)6](3-/4-) redox pair. The immobilization of antibody and the corresponding antigen-antibody interaction at the electrode surface altered the interfacial electron transfer. The interactions of antibody with various concentrations of antigen were also monitored via the change of impedance response. The results showed that the charge transfer resistance increases linearly with increasing concentrations of HER2 antigen. The linear range and limit of detection were found as 10-110ngmL(-1) and 7.4ngmL(-1), respectively. The sensitivity and specificity of the immunosensor were validated. The results showed that the prepared immunosensor is a useful tool for screening of trace amounts of HER2 in serum samples of breast cancer patients. Copyright © 2015 Elsevier B.V. All rights reserved.
    Analytica chimica acta 03/2015; 874. DOI:10.1016/j.aca.2015.03.022
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    ABSTRACT: The purpose of this work was to study the feasibility of using a direct mercury analyzer (DMA) to simultaneously determine mercury (Hg) and organic matter content in sediment and soils. Organic carbon was estimated by re-weighing the sample boats post analysis to obtain loss-on-ignition (LOI) data. The DMA-LOI results were statistically similar (p<0.05) to the conventional muffle furnace approach. A regression equation was developed to convert DMA-LOI data to total organic carbon (TOC), which varied between 0.2% and 13.0%. Thus, mercury analyzers based on combustion can provide accurate estimates of organic carbon content in non-calcareous sediment and soils; however, weight gain from moisture (post-analysis), measurement uncertainty, and sample representativeness should all be taken into account. Sediment cores from seasonal wetland and open water areas from six oxbow lakes in the Mississippi River alluvial flood plain were analyzed. Wetland sediments generally had higher levels of Hg than open water areas owing to a greater fraction of fine particles and higher levels of organic matter. Annual loading of Hg in open water areas was estimated at 4.3, 13.4, 19.2, 20.7, 129, and 135ngcm(-2)yr(-1) for Beasley, Roundaway, Hampton, Washington, Wolf and Sky Lakes, respectively. Generally, the interval with the highest Hg flux was dated to the 1960s and 1970s. Copyright © 2015 Elsevier B.V. All rights reserved.
    Analytica chimica acta 03/2015; 871. DOI:10.1016/j.aca.2015.03.011
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    ABSTRACT: This paper describes a new, efficient and versatile method for the sampling and preconcentration of PAH in environmental water matrices using special hybrid magnetic carbon nanotubes. These N-doped amphiphilic CNT can be easily dispersed in any aqueous matrix due to the N containing hydrophilic part and at the same time show high efficiency for the adsorption of different PAH contaminants due to the very hydrophobic surface. After adsorption, the CNT can be easily removed from the medium by a simple magnetic separation. GC/MS analyses showed that the CNT method is more efficient than the use of polydimethylsiloxane (PDMS) with much lower solvent consumption, technical simplicity and time, showing good linearity (range 0.18-80.00μgL(-1)) and determination coefficient (R(2)>0.9810). The limit of detection ranged from 0.05 to 0.42μgL(-1) with limit of quantification from 0.18 to 1.40μgL(-1). Recovery (n=9) ranged from 80.50±10 to 105.40±12%. Intraday precision (RSD, n=9) ranged from 1.91 to 9.01%, whereas inter day precision (RSD, n=9) ranged from 7.02 to 17.94%. The method was applied to the analyses of PAH in four lake water samples collected in Belo Horizonte City, Brazil. Copyright © 2015 Elsevier B.V. All rights reserved.
    Analytica chimica acta 03/2015; 873. DOI:10.1016/j.aca.2015.02.063
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    ABSTRACT: In the present manuscript, an electrochemical sensor for the sensitive detection of Tl(+), Pb(2+) and Hg(2+) is described. A new composite electrode has been fabricated using graphene, 1-n-octylpyridinum hexafluorophosphate (OPFP), and [2,4-Cl2C6H3C(O)CHPPh3] (L), as a new synthetic phosphorus ylide. The physicochemical and electrochemical characterizations of fabricated sensor were investigated in details. The advantages of the proposed composite electrode are its ability in simultaneous electrochemical detection of Tl(+), Pb(2+) and Hg(2+) with good selectivity, stability and no need for separating of the three species from complex mixtures prior to electrochemical measurements. The analytical performance of the proposed electrode was examined using square wave voltammetry. Tl(+), Pb(2+) and Hg(2+) can be determined in linear ranges from 1.25×10(-9) to 2.00×10(-7)molL(-1). Low detection limits of 3.57×10(-10)molL(-1) for Tl(+), 4.50×10(-10)molL(-1) for Pb(2+) and 3.86×10(-10)molL(-1) for Hg(2+) were achieved. Finally, the proposed electrochemical sensor was applied to detect trace analyte ions in various water and soil samples with satisfactory results. Copyright © 2015 Elsevier B.V. All rights reserved.
    Analytica chimica acta 03/2015; 870. DOI:10.1016/j.aca.2015.03.004
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    ABSTRACT: A coumarine-imino-C2-glucosyl conjugate (L) was synthesized and characterized. The conjugate L is found to recognize Cu(2+) in aqueous HEPES buffer by exhibiting a 95% fluorescence quenching in pH range 7-10 even in the presence of several biologically and ecologically relevant metal ions. Fluorescence on-off behavior has been clearly demonstrated on the basis of the binding variability of Cu(2+) to L. The binding has been elicited through the changes observed in fluorescence, absorption, ESI-MS and (1)H NMR titrations. All the other thirteen metal ions studied did not show any change in the fluorescence emission. These ions do not interfere with the recognition of Cu(2+) by L. The structural features of [CuL]2 complex in both the isomeric forms were established by DFT computational calculations. The utility of L has been demonstrated by showing its sensitivity toward Cu(2+) on a thin layer of silica gel. The L gives sensitive fluorescence signals for Cu(2+) even in blood serum and exhibits appropriate fluorescence responses in living cells. Copyright © 2015 Elsevier B.V. All rights reserved.
    Analytica chimica acta 02/2015; 873. DOI:10.1016/j.aca.2015.02.065
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    ABSTRACT: In this study, a convenient and extensible automated ionic liquid-based in situ dispersive liquid-liquid microextraction (automated IL-based in situ DLLME) was developed. 1-Octyl-3-methylimidazolium bis[(trifluoromethane)sulfonyl]imide ([C8MIM]NTf2) is formed through the reaction between [C8MIM]Cl and lithium bis[(trifluoromethane)sulfonyl]imide (LiNTf2) to extract the analytes. Using a fully automatic SPE workstation, special SPE columns packed with nonwoven polypropylene (NWPP) fiber, and a modified operation program, the procedures of the IL-based in situ DLLME, including the collection of a water sample, injection of an ion exchange solvent, phase separation of the emulsified solution, elution of the retained extraction phase, and collection of the eluent into vials, can be performed automatically. The developed approach, coupled with high-performance liquid chromatography-diode array detection (HPLC-DAD), was successfully applied to the detection and concentration determination of benzoylurea (BU) insecticides in water samples. Parameters affecting the extraction performance were investigated and optimized. Under the optimized conditions, the proposed method achieved extraction recoveries of 80% to 89% for water samples. The limits of detection (LODs) of the method were in the range of 0.16-0.45ngmL(-1). The intra-column and inter-column relative standard deviations (RSDs) were <8.6%. Good linearity (r>0.9986) was obtained over the calibration range from 2 to 500ngmL(-1). The proposed method opens a new avenue for automated DLLME that not only greatly expands the range of viable extractants, especially functional ILs but also enhances its application for various detection methods. Furthermore, multiple samples can be processed simultaneously, which accelerates the sample preparation and allows the examination of a large number of samples. Copyright © 2015 Elsevier B.V. All rights reserved.
    Analytica chimica acta 02/2015; 872. DOI:10.1016/j.aca.2015.02.061
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    ABSTRACT: This paper reports a facile and general method for preparing an imprinted polymer thin shell with Mn-doped ZnS quantum dots (QDs) at the surface of silica nanoparticles by stepwise precipitation polymerization to form the highly-controllable core-shell nanoparticles (MIPs@SiO2-ZnS:Mn QDs) and sensitively recognize the target 2,4-dichlorophenol (2,4-DCP). Acrylamide (AM) and ethyl glycol dimethacrylate (EGDMA) were used as the functional monomer and the cross-linker, respectively. The MIPs@SiO2-ZnS:Mn QDs had a controllable shell thickness and a high density of effective recognition sites, and the thickness of uniform core-shell 2,4-DCP-imprinted nanoparticles was controlled by the total amounts of monomers. The MIPs@SiO2-ZnS:Mn QDs with a shell thickness of 45nm exhibited the largest quenching efficiency to 2,4-DCP by using the spectrofluorometer. After the experimental conditions were optimized, a linear relationship was obtained covering the linear range of 1.0-84μmolL(-1) with a correlation coefficient of 0.9981 and the detection limit (3σ/k) was 0.15μmolL(-1). The feasibility of the developed method was successfully evaluated through the determination of 2,4-DCP in real samples. This study provides a general strategy to fabricate highly-controllable core-shell imprinted polymer-contained QDs with highly selective recognition ability. Copyright © 2015 Elsevier B.V. All rights reserved.
    Analytica chimica acta 02/2015; 870. DOI:10.1016/j.aca.2015.02.025