Carbohydrate research Journal Impact Factor & Information

Publisher: ScienceDirect (Online service), Elsevier

Journal description

Current impact factor: 1.97

Impact Factor Rankings

2015 Impact Factor Available summer 2015
2013 / 2014 Impact Factor 1.966
2012 Impact Factor 2.044
2011 Impact Factor 2.332
2010 Impact Factor 1.898
2009 Impact Factor 2.025
2008 Impact Factor 1.96
2007 Impact Factor 1.723
2006 Impact Factor 1.703
2005 Impact Factor 1.669
2004 Impact Factor 1.451
2003 Impact Factor 1.533
2002 Impact Factor 1.631
2001 Impact Factor 1.349
2000 Impact Factor 1.606
1999 Impact Factor 1.252
1998 Impact Factor 1.354
1997 Impact Factor 1.437
1996 Impact Factor 1.417
1995 Impact Factor 1.506
1994 Impact Factor 1.569
1993 Impact Factor 1.363
1992 Impact Factor 1.506

Impact factor over time

Impact factor

Additional details

5-year impact 2.17
Cited half-life 0.00
Immediacy index 0.45
Eigenfactor 0.02
Article influence 0.53
Other titles Carbon (En ligne)
ISSN 1873-426X
OCLC 300759987
Material type Periodical, Internet resource
Document type Internet Resource, Journal / Magazine / Newspaper

Publisher details


  • Pre-print
    • Author can archive a pre-print version
  • Post-print
    • Author can archive a post-print version
  • Conditions
    • Pre-print allowed on any website or open access repository
    • Voluntary deposit by author of authors post-print allowed on authors' personal website, or institutions open scholarly website including Institutional Repository, without embargo, where there is not a policy or mandate
    • Deposit due to Funding Body, Institutional and Governmental policy or mandate only allowed where separate agreement between repository and the publisher exists.
    • Permitted deposit due to Funding Body, Institutional and Governmental policy or mandate, may be required to comply with embargo periods of 12 months to 48 months .
    • Set statement to accompany deposit
    • Published source must be acknowledged
    • Must link to journal home page or articles' DOI
    • Publisher's version/PDF cannot be used
    • Articles in some journals can be made Open Access on payment of additional charge
    • NIH Authors articles will be submitted to PubMed Central after 12 months
    • Publisher last contacted on 18/10/2013
  • Classification
    ​ green

Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: Lactobacilli are valuable strains for commercial (functional) food fermentations. Their cell surface-associated polysaccharides (sPSs) possess important functional properties, such as acting as receptors for bacteriophages (bacterial viruses), influencing autolytic characteristics and providing protection against antimicrobial peptides. The current report provides an elaborate molecular description of several surface carbohydrates of Lactobacillus delbrueckii subsp. bulgaricus strain 17. The cell surface of this strain was shown to contain short chain poly(glycerophosphate) teichoic acids and at least two different sPSs, designated here as sPS1 and sPS2, whose chemical structures were examined by 2D nuclear magnetic resonance spectroscopy and methylation analysis. Neutral branched sPS1, extracted with n-butanol, was shown to be composed of hexasaccharide repeating units (-[α-d-Glcp-(1-3)-]-4-β-l-Rhap2OAc-4-β-d-Glcp-[α-d-Galp-(1-3)]-4-α-Rhap-3-α-d-Galp-), while the major component of the TCA-extracted sPS2 was demonstrated to be a linear d-galactan with the repeating unit structure being (-[Gro-3P-(1-6)-]-3-β-Galf-3-α-Galp-2-β-Galf-6-β-Galf-3-β-Galp-). Copyright © 2015 Elsevier Ltd. All rights reserved.
    Carbohydrate research 06/2015; 413. DOI:10.1016/j.carres.2015.06.001
  • [Show abstract] [Hide abstract]
    ABSTRACT: Eight new oleanane-type triterpenoid saponins, schisusaponins A-H, along with eight known triterpenoid saponins, were isolated from the root bark of Schima superb (Theaceae). Their structures were elucidated on the basis of extensive spectroscopic analyses and chemical methods. The cytotoxicity of the new compounds against B16 melanoma cells was assessed. Among the isolated new saponins, schisusaponins C and E showed more potent effects (with IC50 values of 10.08 and 10.89 μM) than vinblastine (with an IC50 value of 19.48 μM). Copyright © 2015 Elsevier Ltd. All rights reserved.
    Carbohydrate research 06/2015; 413. DOI:10.1016/j.carres.2015.05.014
  • [Show abstract] [Hide abstract]
    ABSTRACT: Radical-mediated addition reactions of thiols to O-peracetylated exo-galactal and exo-xylal with 2,2-dimethoxy-2-phenylacetophenone as the photoinitiator resulted in high yielding formation of the corresponding β-d-glycopyranosylmethyl-sulfide derivatives (2,6-anhydro-1-deoxy-1-S-substituted-1-thio-alditols) with exclusive regio- and very high stereoselectivity, including disaccharide mimicks with Gly-CH2-S-Gly scaffolds. Copyright © 2015. Published by Elsevier Ltd.
    Carbohydrate research 06/2015; 413. DOI:10.1016/j.carres.2015.05.008
  • [Show abstract] [Hide abstract]
    ABSTRACT: Thioglycoside-containing trimannose analogs were designed and prepared to mimic the natural N-glycan core trisaccharide α-d-Man-(1→3)-[α-d-Man-(1→6)]-d-Man. (1→6)-S-Linked trimannoside 1 and its trivalent cluster 2 were synthesized in 11 and 15 steps, respectively, taking advantages of the armed mannopyranosyl trichloroacetimidate as glycosyl donor. Hemagglutination inhibition of the two new thiomannotriose analogs was preliminarily examined. Comparing to the parent trimannoside α-d-Man-(1→3)-[α-d-Man-(1→6)]-d-Man-OMe, the cluster mannotrioside 2 presented a comparable binding affinity to Con A, while the monomer 6-S-trimannoside 1 exhibited a slightly lower inhibition ability. Copyright © 2015 Elsevier Ltd. All rights reserved.
    Carbohydrate research 05/2015; 412:56-65. DOI:10.1016/j.carres.2015.05.001
  • [Show abstract] [Hide abstract]
    ABSTRACT: Biofilm formation and chronic infections with Pseudomonas aeruginosa depend on lectins produced by the bacterium. The bacterial C-type lectin LecB binds to the two monosaccharides l-fucose and d-mannose and conjugates thereof. Previously, d-mannose derivatives with amide and sulfonamide substituents at C6 were reported as potent inhibitors of the bacterial lectin LecB and LecB-mediated bacterial surface adhesion. Because d-mannose establishes a hydrogen bond via its 6-OH group with Ser23 of LecB in the crystal structure and may be beneficial for binding affinity, we extended d-mannose and synthesized mannoheptoses bearing the free 6-OH group as well as amido and sulfonamido-substituents at C7. Two series of diastereomeric mannoheptoses were synthesized and the stereochemistry was determined by X-ray crystallography. The potency of the mannoheptoses as LecB inhibitors was assessed in a competitive binding assay. The data reveal a diastereoselectivity of LecB for (6S)-mannoheptose derivatives with increased activity over methyl α-d-mannoside. Copyright © 2015 Elsevier Ltd. All rights reserved.
    Carbohydrate research 05/2015; 412. DOI:10.1016/j.carres.2015.04.010
  • [Show abstract] [Hide abstract]
    ABSTRACT: A series of surfactants combining carbohydrate and imidazolium head groups were prepared and investigated on their assembly behavior. The presence of the imidazolium group dominated the interactions of the surfactants, leading to high CMCs and large molecular surface areas, reflected in curved rather than lamellar surfactant assemblies. The carbohydrate, on the other hand, stabilized molecular assemblies slightly and reduced the surface tension of surfactant solutions considerably. A comparative emulsion study discourages the use of pure alkyl imidazolium glycosides owing to reduced assembly stabilities compared with APGs. However, the surfactants are believed to have potential as component in carbohydrate based surfactant mixtures. Copyright © 2015 Elsevier Ltd. All rights reserved.
    Carbohydrate research 05/2015; 412. DOI:10.1016/j.carres.2015.04.022
  • [Show abstract] [Hide abstract]
    ABSTRACT: A series of novel artesunate-polyrotaxanes (ATS-PRs) with folic acid capped, in which artesunate (ATS) was covalently bound to a cyclodextrin (CD) of the polyrotaxane (PR), were synthesized and were characterized by NMR, XRD, TG and DSC. The cytotoxicities of ATS-PRs on human colon cancer cell lines HT-29, SW480, HTC116 and DLD-1 showed that their antitumor activities were better than that of artesunate (ATS) and dihydroartemisinin (DHA). These ATS-PRs may provide a useful approach to the development of a highly effective drug candidate for the chemotherapy of human colon cancer. Copyright © 2015 Elsevier Ltd. All rights reserved.
    Carbohydrate research 05/2015; 412. DOI:10.1016/j.carres.2015.04.021
  • [Show abstract] [Hide abstract]
    ABSTRACT: Molecular labeling and detection techniques are essential to research in life science. Here, a method for glycoprotein labeling/carbohydrate detection through glycan replacement, termed glycoprotein labeling with click chemistry (GLCC), is described. In this method, a glycoprotein is first treated with specific glycosidases to remove certain sugar residues, a procedure that creates acceptor sites for a specific glycosyltransferase. A 'clickable' monosaccharide is then installed onto these sites by the glycosyltransferase. This modified glycoprotein is then conjugated to a reporter molecule using a click chemistry reaction. For glycoproteins that already contain vacant glycosylation sites, deglycosylation is not needed before the labeling step. As a demonstration, labeling on fetal bovine fetuin, mouse immunoglobulin IgG and bacterial expressed human TNFα and TNFβ are shown. Compared to traditional ways of protein labeling, labeling at glycosylation sites with GLCC is considerably more specific and less likely to have adverse effects, and, when utilized as a method for carbohydrate detection, this method is also highly specific and sensitive. Copyright © 2015 Elsevier Ltd. All rights reserved.
    Carbohydrate research 05/2015; 412. DOI:10.1016/j.carres.2015.04.018
  • [Show abstract] [Hide abstract]
    ABSTRACT: The following structure of the O-polysaccharide of Escherichia coli HS1/2 serving as a primary receptor for bacteriophage DT57-12 was elucidated by sugar analysis along with 1D and 2D (1)H and (13)C NMR spectroscopy: This structure is shared by E. coli O87 type strain. Putatively assigned functions of genes in the O-antigen gene cluster of E. coli O87 are consistent with the O-polysaccharide structure established. Copyright © 2015 Elsevier Ltd. All rights reserved.
    Carbohydrate research 05/2015; 412. DOI:10.1016/j.carres.2015.04.014
  • [Show abstract] [Hide abstract]
    ABSTRACT: For decades, the enzymatic conversion of recalcitrant polysaccharides such as cellulose and chitin was thought to solely rely on the synergistic action of hydrolytic enzymes, but recent work has shown that lytic polysaccharide monooxygenases (LPMOs) are important contributors to this process. Here, we have examined the initial rate enhancement an LPMO (CBP21) has on the hydrolytic enzymes (ChiA, ChiB, and ChiC) of the chitinolytic machinery of Serratia marcescens through determinations of apparent kcat (kcat(app)) values on a β-chitin substrate. kcat(app) values were determined to be 1.7±0.1 s(-1) and 1.7±0.1 s(-1) for the exo-active ChiA and ChiB, respectively and 1.2±0.1 s(-1) for the endo-active ChiC. The addition of CBP21 boosted the kcat(app) values of ChiA and ChiB giving values of 11.1±1.5 s(-1) and 13.9±1.4 s(-1), while there was no effect on ChiC (0.9±0.1 s(-1)). Copyright © 2015 Elsevier Ltd. All rights reserved.
    Carbohydrate research 04/2015; 407. DOI:10.1016/j.carres.2015.02.010
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    ABSTRACT: Chemotaxis is one of the most essential cell physiological responses, which was developed in parallel the molecular evolution of signal molecules. Previously good correlations were found between chemotactic moieties and physicochemical properties (SEA, solubility, pKa) of peptide type ligands in Tetrahymena model. However, references are rather weak in eukaryotic chemotaxis about significance of simple carbohydrates. In the present work our goal is (i) to investigate the chemotactic effect of 10 mono- and disaccharides in the eukaryotic Tetrahymena pyriformis; (ii) to describe effective ligands with physicochemical parameters; (iii) to test whether sugars are acting via induction of metabolic pathways. Our results are: (i) the tested sugars can trigger both significant attractant (d-glucose, d-mannose) and significant repellent (d-glucosamine, d-fructose, N-acetyl-d-galactosamine, d-arabinose) effects, while some of the sugars (maltose, lactose, sucrose, d-galactose) had no effect. (ii) Correlations were described between the chemotactic effectiveness of the ligands and their physicochemical characters (TPSA, XLogP), which are supposed to influence the internalization of the sugars. (iii) All ligands proved to have low selection potential, which refers to a 'short-term' receptor moiety or influencing specific metabolic pathways. (iv) Starvation elicited modified, strong chemoattractive responsiveness towards glucose; however, it was independent of concentration while 1 h insulin treatment resulted in an increased and concentration dependent chemotaxis induced by glucose. Copyright © 2015 Elsevier Ltd. All rights reserved.
    Carbohydrate research 04/2015; 407. DOI:10.1016/j.carres.2015.02.009
  • [Show abstract] [Hide abstract]
    ABSTRACT: Uridine 5'-diphosphate-glucuronic acid (UDP-GlcA) and UDP-galacturonic acid (UDP-GalA), the unique carboxylic acid-formed sugar nucleotides, are key precursors involved in the biosynthesis of numerous cell components. Limited availability of those components has been hindering the development of efficient ways towards facile synthesis of bioactive glycans such as glycosaminoglycans. In current study, we biochemically characterized two UDP-sugar pyrophosphorylases from Arabidopsis thaliana (AtUSP) and Bifidobacterium infantis ATCC15697 (BiUSP), and compared their activities towards a panel of sugar-1-phosphates and derivatives. Both enzymes showed significant pyrophosphorylation activities towards GlcA-1-phosphate, and AtUSP also exhibited comparable activity towards GalA-1-phosphate. By combining with monosaccharide-1-phosphate kinases, we have developed an efficient and facile one-pot three-enzyme approach to quickly obtain hundreds milligrams of UDP-GlcA and UDP-GalA. Copyright © 2015 Elsevier Ltd. All rights reserved.
    Carbohydrate research 04/2015; 411. DOI:10.1016/j.carres.2015.04.001
  • [Show abstract] [Hide abstract]
    ABSTRACT: An efficient O3-monodesilylation method has been developed for the derivatization of per-3-O-silylated cyclodextrin (CD) derivatives. Using hydrochloric acid as a reagent, the O3-monodesilylation was found to be regioselective, mild, practical and general as it can be applied to all α-, β- and γ-CDs. The advantage of the methodology is that the acid-catalyzed O3-desilylation can be carried out in a stepwise manner so that different types of functional groups can be introduced to a CD molecule at different stage of the O3-desilylations. This makes the current methodology flexible and versatile. This current methodology constitutes one of the few methodologies available for the regioselective modification of CDs at the secondary face. Copyright © 2015 Elsevier Ltd. All rights reserved.
    Carbohydrate research 04/2015; 410. DOI:10.1016/j.carres.2015.04.003
  • [Show abstract] [Hide abstract]
    ABSTRACT: A new series of 1,2,3-triazole eugenol glucosides were synthesized. The new compound structures were confirmed by MS, (1)H NMR and (13)C NMR. All of the synthesized compounds were screened for antimicrobial and cytotoxic activity. Five compounds exerted significant activity against the Gram-negative bacteria Salmonella typhimurium with low IC50 values (49.73-68.53 μΜ), and seven compounds were active against the Gram-positive bacteria Micrococcus luteus (42.89-210.94 μM). In vitro cytotoxicity on mouse spleen cells was also evaluated. One compound bearing a phenyl substituent at the triazole ring showed good activity against Salmonella typhimurium (49.73 μM) and low toxicity to normal cells (CC50=157.83 μM). Thus, the compounds herein can be considered for further modification for improving their antibacterial activity or obtaining novel antibacterial drug candidates. Copyright © 2015 Elsevier Ltd. All rights reserved.
    Carbohydrate research 04/2015; 410. DOI:10.1016/j.carres.2015.04.002
  • [Show abstract] [Hide abstract]
    ABSTRACT: Structure of the O-specific polysaccharide from Pseudomonas chlororaphis subsp. aureofaciens UCM B-306 was elucidated by sugar analysis along with 1D and 2D (1)H and (13)C NMR spectroscopy. The polysaccharide is built up of trisaccharide repeats containing d-rhamnose, 2,4-diacetamido-2,4,6-trideoxy-d-glucose (d-QuiNAc4NAc), and 2-acetamido-2-deoxy-d-galacturonic acid (d-GalNAcA), which is amidated in ∼40% repeats. It was suggested that the O-polysaccharide has a blockwise structure, which can be presented as follows: -[→3)-α-d-Rhap-(1→4)-α-d-GalpNAcA-(1→3)-α-d-QuipNAc4NAc-(1-]n→ and -[→3)-α-d-Rhap-(1→4)-α-d-GalpNAcAN-(1→3)-α-d-QuipNAc4NAc-(1-]m→, where GalNAcAN indicates 2-acetamido-2-deoxy-d-galacturonamide, n:m=∼3:2. Copyright © 2015 Elsevier Ltd. All rights reserved.
    Carbohydrate research 04/2015; 410. DOI:10.1016/j.carres.2015.03.019