Carbohydrate research Journal Impact Factor & Information

Publisher: ScienceDirect (Online service), Elsevier

Journal description

Current impact factor: 1.92

Impact Factor Rankings

2015 Impact Factor Available summer 2015
2013 / 2014 Impact Factor 1.966
2012 Impact Factor 2.044
2011 Impact Factor 2.332
2010 Impact Factor 1.898
2009 Impact Factor 2.025
2008 Impact Factor 1.96
2007 Impact Factor 1.723
2006 Impact Factor 1.703
2005 Impact Factor 1.669
2004 Impact Factor 1.451
2003 Impact Factor 1.533
2002 Impact Factor 1.631
2001 Impact Factor 1.349
2000 Impact Factor 1.606
1999 Impact Factor 1.252
1998 Impact Factor 1.354
1997 Impact Factor 1.437
1996 Impact Factor 1.417
1995 Impact Factor 1.506
1994 Impact Factor 1.569
1993 Impact Factor 1.363
1992 Impact Factor 1.506

Impact factor over time

Impact factor

Additional details

5-year impact 2.17
Cited half-life 0.00
Immediacy index 0.45
Eigenfactor 0.02
Article influence 0.53
Other titles Carbon (En ligne)
ISSN 1873-426X
OCLC 300759987
Material type Periodical, Internet resource
Document type Internet Resource, Journal / Magazine / Newspaper

Publisher details


  • Pre-print
    • Author can archive a pre-print version
  • Post-print
    • Author can archive a post-print version
  • Conditions
    • Authors pre-print on any website, including arXiv and RePEC
    • Author's post-print on author's personal website immediately
    • Author's post-print on open access repository after an embargo period of between 12 months and 48 months
    • Permitted deposit due to Funding Body, Institutional and Governmental policy or mandate, may be required to comply with embargo periods of 12 months to 48 months
    • Author's post-print may be used to update arXiv and RepEC
    • Publisher's version/PDF cannot be used
    • Must link to publisher version with DOI
    • Author's post-print must be released with a Creative Commons Attribution Non-Commercial No Derivatives License
    • Publisher last reviewed on 03/06/2015
  • Classification
    ​ green

Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: The conformation of the carbohydrate molecules is a subject of many theoretical and experimental studies. The different timescales associated with the particular degrees of freedom hinder the progress in both those fields. The present paper reports the results of computational studies aimed at elucidating and characterizing the potential correlations between the two main structural determinants of the carbohydrate structure, i.e. the ring conformation and the orientation of the glycosidic bonds (expressed in terms of the ϕ and ψ glycosidic dihedral angles). The free energy landscapes computed for 16 different oligomers composed of unsubstituted, 1,4-linked hexopyranose residues allowed for a detailed insight into how the ring geometry affects the glycosidic linkage conformation. The factor of main importance appeared to be the local changes of the chain length induced by the ring conformational rearrangements. This effect is important mainly for the carbohydrate chains exploiting the glycosidic bonds of uniform orientation with respect to the ring (i.e. either exclusively axially or exclusively equatorially oriented). The shape of the ring may affect the (ϕ,ψ) free energy maps but only if the population of the alternative ring conformers is relatively high and (at the same time) the presence of such conformers is associated with the significant shifts of the favorable ϕ and ψ values. Copyright © 2015 Elsevier Ltd. All rights reserved.
    Carbohydrate research 08/2015; 415:17-27. DOI:10.1016/j.carres.2015.07.018
  • [Show abstract] [Hide abstract]
    ABSTRACT: Haliotis discus hannai Ino (Haliotis) is a highly valued marine shellfish, and it is sometimes replaced by another cheaper Gastropoda mollusk, Volutharpa ampullacea perryi (Volutharpa). Polysaccharides from pleopods, viscera and gonads of these two gastropods were compared by analyzing the mono- and di-saccharides in their acid hydrolysates using high performance liquid chromatography-mass spectrometry (HPLC-MS(n)) after 1-phenyl-3-methyl-5-pyrazolone (PMP) derivatization. Disaccharide analysis revealed the distribution of uronic acid-containing polysaccharides (UACPs) in the biological samples. GlcA-(1→2)-Man, GlcA-(1→3)-GalN, and another disaccharide consisting of a hexuronic acid linked to a hexose were found in the hydrolysates, which indicated the existence of AGSP (abalone gonad sulfated polysaccharide) with the backbone composed of →2)-α-Man(1→4)-β-GlcA(1→ repeating unit, AAP (abalone glycosaminoglycan-like polysaccharide) with the backbone of →3)-GalNAc-(1→2)-GlcA-(1→3)-GalNAc-(1→4)-GlcA-(1→ repeating unit, and unidentified DS1P containing a hexuronic acid linked to a hexose unit, respectively. As shown by extracted ion chromatograms (XICs), AAP was the only UACP found in pleopods of the two gastropods; gonads and viscera of Haliotis contained DS1P and AGSP, while those of Volutharpa contained DS1P, AGSP as well as AAP. Monosaccharides in the acid hydrolysates were demonstrated in XICs by extracting their corresponding PMP derivative quasi-molecular ions one by one, and the results indicated the similar conclusion to the disaccharide analysis. Therefore, it could be concluded that polysaccharides from pleopods of the two gastropods are very similar, while those from their viscera and gonads differ greatly. Copyright © 2015 Elsevier Ltd. All rights reserved.
    Carbohydrate research 07/2015; 415:48-53. DOI:10.1016/j.carres.2015.07.009
  • [Show abstract] [Hide abstract]
    ABSTRACT: The parasitic life cycle of Leishmania includes an extracellular promastigote stage that occurs in the gut of the insect vector. During that period, the sucrose metabolism and more specifically the first glycosidase of this pathway are essential for growth and survival of the parasite. We investigated the expression of the invertase BfrA in the promastigote and amastigote stages of three parasite species representative of the three various clinical forms and of various geographical areas, namely Leishmania major, L. donovani and L. braziliensis. Thereafter, we cloned, overexpressed and biochemically characterized this invertase BfrA from L. major, heterologously expressed in both Escherichia coli and L. tarentolae. For all species, expression levels of BfrA mRNA were correlated to the time of the culture and the parasitic stage (promastigotes > amastigotes). BfrA exhibited no activity when expressed as a glycoprotein in L. tarentolae but proved to be an invertase when not glycosylated, yet owing low sequence homology with other invertases from the same family. Our data suggest that BfrA is an original invertase that is located inside the parasite. It is expressed in both parasitic stages, though to a higher extent in promastigotes. This work provides new insight into the parasite sucrose metabolism. Copyright © 2015 Elsevier Ltd. All rights reserved.
    Carbohydrate research 07/2015; 415:31-38. DOI:10.1016/j.carres.2015.07.001
  • [Show abstract] [Hide abstract]
    ABSTRACT: Routes for efficient synthesis of four (4″-, 2″-, 2'-, and 6-) monodeoxy analogs of the trisaccharide α-d-Glcp-(1→3)-α-d-Manp-(1→2)-α-d-ManpOMe have been developed. For the introduction of the 2'- and 2″-deoxy motifs the most efficient way was to use a 1,2-di-bromo-mannosyl donor in silver triflate-promoted couplings to construct the α-glycosidic linkage followed by reduction of the 2-bromo-function to a 2-deoxy motif at the di- or trisaccharide level. In contrast, the 4″- and 6-deoxy functions were introduced already at the monosaccharide stage. The most challenging part of the syntheses was the stereoselective formation of the non-reducing end cis-α-d-glucosidic linkages. The established α-directing effect of a 3-O-acetyl group in glucosyl donors was explored but the magnitude of the effect was variable and dependent on donor/acceptor structure and nature of promoter and an optimization had to be made for each individual glycosylation. Copyright © 2015 Elsevier Ltd. All rights reserved.
    Carbohydrate research 07/2015; 414:65-71. DOI:10.1016/j.carres.2015.07.006
  • [Show abstract] [Hide abstract]
    ABSTRACT: New cryptands including bis-azacrown and saccharidic moieties in their structure were prepared in several steps by applying Staudinger-aza-Wittig reaction (SAW). Syntheses have been started from cheap, easily available commercial compounds such as D-glucose, D-cellobiose and D-lactose subsequently transformed into their derivatives in fairly good yields (60-65%) and suitable to give desired final cryptands by direct SAW coupling reactions. Copyright © 2015 Elsevier Ltd. All rights reserved.
    Carbohydrate research 07/2015; 414:51-59. DOI:10.1016/j.carres.2015.07.007
  • [Show abstract] [Hide abstract]
    ABSTRACT: The [4-thio]-S-ribosylhomocysteine (SRH) analogs containing substitution of a sulfur atom for the endocyclic oxygen were synthesized by coupling of the 4-thioribose substrates with a thiolate generated from the protected homocysteine. Coupling of the protected 1-deoxy-5-O-mesyl-S-oxo-4-thio-D-ribofuranose with homocysteinate salt gave the C4 epimers of [4-thio]-SRH at the sulfoxide oxidation level lacking a hydroxyl group at anomeric carbon. Treatment of these sulfoxides with BF3⋅Et2O/NaI affected simultaneous reduction to sulfide and global deprotection affording 1-deoxy-4-thio-SRH analog. Treatment of the protected 1-deoxy-S-oxo-4-thio-D-ribofuranose sulfoxide with DAST/SbCl3 resulted in the fluoro-Pummerer rearrangement to give 4-thio-β-D-ribofuranosyl fluoride. Mesylation of the latter at 5-hydroxyl position followed by coupling with homocysteinate salt and subsequent global deprotection with trifluoroacetic acid afforded [4-thio]-SRH thiohemiacetal. Copyright © 2015 Elsevier Ltd. All rights reserved.
    Carbohydrate research 07/2015; 415:39-47. DOI:10.1016/j.carres.2015.07.005
  • [Show abstract] [Hide abstract]
    ABSTRACT: The carbohydrate moieties of arabinogalactan-proteins (AGPs) have β-(1→3)-galactan backbones to which side chains of (1→6)-linked β-Gal residues are attached through O-6. Some of these side chains are further substituted with other sugars. We investigated the structure of l-Fuc-containing oligosaccharides released from the carbohydrate moieties of a radish leaf AGP by digestion with α-l-arabinofuranosidase, followed by exo-β-(1→3)-galactanase. We detected a series of neutral β-(1→6)-galactooligosaccharides branching variously at O-3 of the Gal residues, together with corresponding acidic derivatives terminating in 4-O-methyl-GlcA (4-Me-GlcA) or GlcA at the non-reducing terminals. In neutral oligosaccharides with degree of polymerization (dp) mainly higher than 10, l-Fuc groups were attached through l-Ara residues as the sequence, α-l-Fucp-(1→2)-α-l-Araf-(1→. This sequence was verified by isolation of the pentasaccharide α-l-Fuc-(1→2)-α-l-Araf-(1→3)-β-Gal-(1→6)-β-Gal-(1→6)-Gal upon digestion of the higher oligosaccharides with endo-β-(1→6)-galactanase. By contrast, in lower polymerized (predominantly dp 4) acidic oligosaccharides, l-Fuc groups were attached directly at the non-reducing terminals through α-(1→2)-linkages, resulting in the release of the tetrasaccharides, α-l-Fucp-(1→2)-β-GlcA-(1→6)-β-Gal-(1→6)-Gal and α-l-Fucp-(1→2)-β-4-Me-GlcA-(1→6)-β-Gal-(1→6)-Gal. In long acidic oligosaccharides with dp mainly higher than 13, l-Fuc groups localized on branches were attached to the uronic acids directly and/or l-Ara residues as in the neutral oligosaccharides. Copyright © 2015 Elsevier Ltd. All rights reserved.
    Carbohydrate research 07/2015; 415:1-11. DOI:10.1016/j.carres.2015.07.002
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    ABSTRACT: Protein-carbohydrate interactions (PCIs) involve a variety of essential biological processes such as cell recognition and migration, metabolism processes and immunological reactions, which are important for securing functions of living organisms. Due to the polysaccharide structural diversity and dynamics flexibility, PCIs can be very difficult for experimental measurement and computer prediction. Here we report a simple method for docking polysaccharide to proteins whose binding pockets have a Tryptophan box. The method samples polysaccharide conformations using constraint conditions imposed by the box, evaluate the conformation energies based on a knowledge-based potential function, and finds the best docking structures using the conventional Monte Carlo simulated annealing technique. We applied the method to dock polysaccharides with 2 to 4 monomers to three carbohydrate-binding proteins, whose pockets have clear aromatic residue-defined binding channels. The predictions found correct carbohydrate binding conformations with atomic RMSD of 1.1-1.6 Å from X-ray crystal structures. The calculation can be performed in ordinary PC and only cost a couple of minutes for a single docking. Our method, when combined with other docking programs, provides a reliable start conformation for further accurate simulation of PCIs. Copyright © 2015 Elsevier Ltd. All rights reserved.
    Carbohydrate research 07/2015; 414:78-84. DOI:10.1016/j.carres.2015.07.013
  • [Show abstract] [Hide abstract]
    ABSTRACT: Novel bis-triazole glycoconjugates were designed and prepared successfully via 5 steps from propargyl per-O-acetyl-β-d-glucoside or xyloside (total yield of 48-53%), after utilizing a three-component condensation of propargyl per-O-acetyl-β-d-glycoside, formaldehyde, and sodium azide as a key step to synthesize 2-hydroxymethyl-2H-1,2,3-triazole glycoconjugates. The developed bis-triazole glycoconjugates would be crucial in antivirus pharmacology and chemical biology. Copyright © 2015 Elsevier Ltd. All rights reserved.
    Carbohydrate research 07/2015; 414:72-77. DOI:10.1016/j.carres.2015.07.004
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    ABSTRACT: Eight new nonsulfated triterpene glycosides, cladolosides C3 (1), E1 (2), E2 (3), F1 (4), F2 (5), G (6), H1 (7) and H2 (8) have been isolated from the tropical Indo-West Pacific sea cucumber Cladolabes schmeltzii (Cladolabinae, Sclerodactylidae, Dendrochirotida) collected in the Vietnamese shallow waters. The structures of the glycosides were elucidated by 2D NMR spectroscopy and mass-spectrometry. Glycosides 2, 3, 4, and 5 have pentasaccharide branched carbohydrate moieties and differ from each other by monosaccharide compositions and aglycone structures. At that, glycosides 2 and 3 contain three xylose, one 3-O-methyl-glucose and one quinovose residues, while glycosides 4 and 5 have two quinovose, two xylose and one 3-O-methyl-glucose residues. Compounds 1 and 6-8 are hexaosides differing from each other by aglycone structures and by the fifth monosaccharide residue, which proved to be glucose in cladoloside C3 (1), xylose in cladoloside G (6) and quinovose in cladolosides H1 (7) and H2 (8). The presence of quinovose residue in the fifth position, as in 4, 5, 7 and 8 has never been earlier found in carbohydrate chains of triterpene glycosides from sea cucumbers. The carbohydrate chains with xylose in the fifth position of pentaosides and hexaosides are also very unusual for holothurious glycosides. All the substances demonstrate strong or moderate cytotoxic and hemolytic effects with hexaosides being more active than the corresponding pentaosides. Peculiarities of the biosynthesis and biochemical evolution of glycosides of this type are discussed. Copyright © 2015 Elsevier Ltd. All rights reserved.
    Carbohydrate research 06/2015; 414. DOI:10.1016/j.carres.2015.06.005
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    ABSTRACT: The O-polysaccharide (O-antigen) of Escherichia coli O169 was studied by sugar analysis along with 1D and 2D (1)H and (13)C NMR spectroscopy. The following structure of the branched hexasaccharide repeating unit was established: The O-polysaccharide of E. coli O169 differs from that of Shigella boydii type 6 only in the presence of a side-chain glucose residue. A comparison of the O-antigen biosynthesis gene clusters between the galF to gnd genes in the genomes of the two bacteria revealed their close relationship. The glycosyltransferase gene responsible for the formation of the β-d-Glcp-(1→6)-α-d-Galp linkage in the O-antigen was identified in the gene cluster. Copyright © 2015 Elsevier Ltd. All rights reserved.
    Carbohydrate research 06/2015; 414. DOI:10.1016/j.carres.2015.05.016
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    ABSTRACT: β-N-Acetyl-d-hexosaminidases are responsible for the metabolism of glycoconjugates in diverse physiological processes that are important targets for medicine and pesticide development. Fourteen new NAG-thiazoline derivatives were synthesized by cyclization and click reaction using d-glucosamine hydrochloride as the starting material. All the compounds created were characterized by NMR and HRMS spectra. A preliminary bioassay, using four enzymes from two β-N-acetyl-d-hexosaminidase families, showed that most of the compounds synthesized exhibit selective inhibition of GH84 β-N-acetyl-d-hexosaminidase. Among the compounds tested, compounds 5a (IC50=12.6 μM, hOGA) and 5e (IC50=12.5 μM, OfOGA) proved to be a highly selective and potent inhibitor. Copyright © 2015 Elsevier Ltd. All rights reserved.
    Carbohydrate research 06/2015; 413. DOI:10.1016/j.carres.2015.06.004
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    ABSTRACT: A flavinium catalyst, in conjunction with hydrogen peroxide as stoichiometric oxidant, allowed the aqueous conversion of non-protected thioglycosides into the corresponding glycosyl sulfoxides. These glycosyl sulfoxides displayed only very weak inhibitory activity against corresponding glycosidases. Copyright © 2015 Elsevier Ltd. All rights reserved.
    Carbohydrate research 06/2015; 413. DOI:10.1016/j.carres.2015.06.003