Archives of gerontology and geriatrics

Publisher: Elsevier

Current impact factor: 1.85

Impact Factor Rankings

2015 Impact Factor Available summer 2016
2014 Impact Factor 1.853
2013 Impact Factor 1.525
2012 Impact Factor 1.704
2011 Impact Factor 1.452
2010 Impact Factor 1.438
2009 Impact Factor 1.36
2008 Impact Factor 1.27
2007 Impact Factor 1.289
2006 Impact Factor 1.136
2005 Impact Factor 0.76
2004 Impact Factor 0.556
2003 Impact Factor 0.5
2002 Impact Factor 0.681
2001 Impact Factor 0.457
2000 Impact Factor 0.269
1999 Impact Factor 0.311
1998 Impact Factor 0.333
1997 Impact Factor 0.233
1996 Impact Factor 0.347
1995 Impact Factor 0.472
1994 Impact Factor 0.779
1993 Impact Factor 0.298
1992 Impact Factor 0.55

Impact factor over time

Impact factor

Additional details

5-year impact 1.86
Cited half-life 5.00
Immediacy index 0.30
Eigenfactor 0.01
Article influence 0.53
ISSN 1872-6976

Publisher details


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    • Publisher last reviewed on 03/06/2015
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Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: Background: Sensory impairment affects an increasing number of elderly adults, with a negative psychological impact. Our objective was to examine the associations of visual and hearing impairment with subjective well-being (SWB), an important psychological concept defined by life satisfaction [LS], positive affect [PA], negative affect [NA], and affect balance [AB] among long-lived individuals (LLIs) over 95 years of age. Methods: Data on 442 LLIs from the Rugao longevity cohort, a population-based study in Rugao, China, were analyzed. Graded classifications of visual and hearing impairment (none, mild, moderate, and severe) were constructed from self-reported items. Bivariate correlation and multiple regression analysis were performed to test the associations. Results: Approximately 66.1% and 87.3% of the subjects reported varying degrees of visual and hearing impairment. Following the degree of vision impairment, LS, PA, and AB decreased linearly, whereas NA increased linearly (all p for trend<0.05). Vision was significantly related to LS (r=0.238, p<0.001), PA (r=0.142, p<0.01), NA (r=-0.157, p<0.001), and AB (r=0.206, p<0.001). After adjustment for multiple variables including functional ability, an important factor of SWB, the associations of vision impairment with LS, NA, and AB, while diminished, still existed. Conclusions: Visual impairment, but not hearing impairment, was independently associated with low SWB among LLIs, and functional ability may play a mediating role in the observed relationship. The findings indicate that rehabilitation targeted for those with reduced vision and functioning in long-lived populations may be important for promoting well-being and quality of life.
    Archives of gerontology and geriatrics 11/2015; DOI:10.1016/j.archger.2015.10.011
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    ABSTRACT: Introduction: This study was performed to examine the characteristics of indoor and outdoor falls in older patients and the factors related to severe injury in the emergency department (ED). Methods: In total, 26,515 patients fell indoors and 19,581 outdoors. The general and clinical characteristics were compared between the two groups and factors associated with severe injury following the falls were evaluated. Results: Younger males fell more frequently outdoors than indoors. The common activities during outdoor falls were sports and leisure activities. Environmental hazards lead to more outdoor falls than indoor falls. Factors associated with severe injury after indoor falls were transport to the ED by public ambulance or from another medical facility rather than individual transportation, fall from stairs rather than fell over, and a head and neck injury rather than a lower extremity injury. Factors related to severe injury after outdoor falls were male sex, transport to the ED by public ambulance or from another medical facility or by another method rather than individual transportation, state employed, fall from stairs rather than fell over, head and neck or thorax or abdomen injury rather than a lower extremity injury. Conclusion: Transport to the ED by public ambulance or from another medical facility, and head and neck injury were risks for severe injury following indoor and outdoor falls in elderly subjects. Efforts to identify the risk factors for severe injury and for falling itself are important to prevent and reduce fall injuries in elderly subjects.
    Archives of gerontology and geriatrics 11/2015; DOI:10.1016/j.archger.2015.10.003
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    ABSTRACT: Background: For older individuals with multimorbidity the appropriateness of prescribing preventive medicines remains a challenge. Objective: Investigate the prevalence and temporal trends in utilisation of preventive medicines in older New Zealanders from 2005 to 2013 stratified according to age, sex, ethnicity and district health board domicile. Methods: A repeated cross-sectional analysis was conducted on pharmaceutical dispensing data for all individuals' ≥65 years. Variable medication possession ratio (VMPR) was used to measure adherence. Prescribing of low-dose aspirin, clopidogrel, dipyridamole, warfarin, dabigatran, statins and bisphosphonates with a VMPR≥0.8 were examined. Results: Aspirin utilisation increased by 19.55% (95% CI: 19.39-19.70), clopidogrel by 2.93% (95% CI: 2.88-2.97) and dipyridamole decreased by 0.65% (95% CI: -0.70 to -0.59). Utilisation of aspirin with clopidogrel increased by 1.78% (95% CI: 1.74-1.81) and aspirin with dipyridamole increased by 0.54% (95% CI: 0.50-0.58%).Warfarin decreased by 0.87% (95% CI: -0.96 to -0.78) and dabigatran increased by 0.65% (95% CI: 0.60-0.70). Statins increased by 7.0% (95% CI: 6.82-7.18) and bisphosphonates decreased by 2.37% (95% CI: -2.44 to -2.30). Aspirin, clopidogrel, dabigatran and statins utilisation showed a greater increase in males. Interestingly, clopidogrel, warfarin and statins use increased in older adults aged 85+ compared to the younger age groups (65-84 years). Conclusion: To our knowledge, this is the first study investigating the prevalence and trends of preventive medicines use in older people in New Zealand. This study may facilitate further research to examine the appropriateness of prescribing these medicines in older people with multimorbidity.
    Archives of gerontology and geriatrics 11/2015; DOI:10.1016/j.archger.2015.10.007
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    ABSTRACT: Purpose: To investigate whether mitochondrial DNA (mtDNA) damage, specifically deletion, contributes to the development of atherosclerosis or is simply a secondary effect of the primary factors causing atherosclerosis. Materials and methods: mtDNA deletion was detected by PCR in the aortic root of atherosclerosis-prone C57BL/6J apolipoprotein (Apo) E gene deficient (-/-) mice and control C57BL/6J mice at different ages. Atherosclerotic plaques in the Apo E-/- mice were assessed using frozen sections of the aortic root. The protein levels of COX III and 8-oxoguanine glycosylase (OGG1) were determined. Results: while mtDNA deletions accumulated significantly in mice as young as 2- month-old, atherosclerotic plaques were not detected until mice were 6 months old or older, suggesting that mtDNA deletion occurs prior to the formation of atherosclerotic plaques in the aortic root of these mice. Moreover, the expression levels of mtDNA-encoded COX III protein in both 2-month-old and 16-month-old C57BL/6J ApoE-/- mice were significantly lower than those in C57BL/6J mice (p<0.05). Additionally, the protein level of 8-oxoguanine glycosylase (OGG1), a mitochondrial enzyme that functions in DNA excision repair, decreased with age in these mice, indicating that age-related down-regulation of mtDNA excision repair also contributes to atherosclerosis in C57BL/6J ApoE-/- mice. Conclusion: These results reveal that mtDNA deletions occur during the early "initiation" stage of atherosclerosis in C57BL/6J ApoE-/- mice and have the potential to promote atherosclerosis.
    Archives of gerontology and geriatrics 11/2015; DOI:10.1016/j.archger.2015.11.004
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    ABSTRACT: Objective: This study aimed to evaluate the association between reproductive variables and metabolic syndrome (MetS) among Chinese community elderly women. Methods: We conducted a cross-sectional study in a Beijing urban district. A two-stage stratified clustering sampling method was used and 1251 elderly women were included. Results: The prevalence of MetS was 65.1% in this population. Women with MetS had younger menarche age, a greater number of years after menopause, higher gravidity and parity. The prevalence of MetS showed an increasing trend for tertiles of years after menopause (p=0.002) and number of children (p<0.001), while decreasing trend for menarche age (p=0.021). Logistic regression showed ORs of age at menarche, years after menopause and number of children for MetS were 0.94, 1.40, and 1.36 for second and 0.63, 1.58, and 1.75 for last tertiles. Conclusion: There is strong association between reproductive variables and higher risk of MetS. Simple information on timing of menarche and menopause could help identify women who may have higher risk of getting MetS and take early action to prevent related chronic diseases.
    Archives of gerontology and geriatrics 11/2015; DOI:10.1016/j.archger.2015.11.003
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    ABSTRACT: Background: Changes in the default mode network (DMN) activity are early features of Alzheimer's disease (AD) and may be linked to AD-specific Aβ pathology. Methods: Cognitive profiles; DMN connectivity alterations; and cerebrospinal fluid (CSF) amyloid beta (Aβ)1-42, total tau, phosphorylated tau 181, and α-synuclein levels were studied in 21 patients with AD and 10 controls. Results: DMN activity is altered in AD. Posterior cingulate cortex (PCC) functional connectivity with other parts of DMN was related to cognitive function scores. The reduction of connectivity of the dorsal PCC with the retrosplenial cortex on the right side was closely related to decreased CSF Aβ1-42 levels in patients with AD. Conclusions: The dorsal PCC and retrosplenial cortex may have special importance in the pathogenesis and cognitive findings of AD.
    Archives of gerontology and geriatrics 10/2015; DOI:10.1016/j.archger.2015.09.010
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    ABSTRACT: Objective: The purpose of this study was to compare the effect of two different approaches of dual-task training and executive training on pattern of gait in older adults with balance impairment. Methods: Thirty older adults with the mean age of 73.8 participated in the study. They scored 52 or less on the Berg Balance Scale (BBS), and walked with a self-selected gait speed of 1.1m/s or less. Participants were randomly assigned to one of the three groups: experimental group one (cognitive dual-task (CDT) training) that focused on gait performance under dual task condition; experimental group two (executive function (EF) training) who underwent 3 types of training on working memory, inhibition, speed of processing; and a control group. Subjects walked 10m, under single-task and dual-task (DT) conditions where kinematics parameters were recorded. Participants in experimental groups received 45-min training sessions, 3 times a week for 8 weeks. The data obtained was analyzed using repeated measure at a criterion p-value of 0.05. Results: The results showed that after training, changes of walking speed, length of stride and step, times of stride, step, single support, and double support, were significant at p<0.05. Asymmetry index in walking with dual task condition increased significantly, but after training asymmetry in DT condition decreased significantly in EF group. Conclusions: Both training groups showed improvements in gait parameters in the post test compared with that in the control group; however, in EF training group, symmetry of limbs and inter-coordination, improved more than that in CDT group.
    Archives of gerontology and geriatrics 10/2015; DOI:10.1016/j.archger.2015.10.001
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    ABSTRACT: Objective: The issue of non-response in dementia epidemiological studies, which may result in the underestimation of the prevalence of dementia, has attracted little attention. We aimed to explore the causes and related factors of non-response in a dementia survey among Chinese veterans. Methods: A two-phase, cross-sectional study investigated the prevalence of dementia and mild cognitive impairment in Chinese veterans aged ≥60 years. We collected the socio-demographic data and prior medical history, evaluated the health status of veterans and their caregivers, assessed the cognitive status of veterans, and evaluated the care burden of caregivers by Caregiver Burden Inventory (CBI). Results: Of 9676 eligible participants, 525 (5.4%) veterans in phase 1 and 1706 (35.0%) veterans among 4875 veterans in phase 2 did not respond. Illness, hospitalization and death accounted for 63.0% and 75.5% non-response in phases 1 and 2, respectively. Non-participation in social activities, self-perceived poor health status, worsened health changes, self-reported need for life care, and history of hearing loss or glaucoma independently predicted non-response in phase 1 or 2. The heavy care burden, suggested by the higher CBI scores and self-reported health deterioration of the primary caregivers, predicted non-response in phase 1 or 2. Conclusions: The negative factors from both the participants and their caregivers independently predicted the non-response in the dementia study in an older population. Preventative strategies from the perspectives of the participants and caregivers should be developed to improve the response rates in both phases in a cross-sectional study.
    Archives of gerontology and geriatrics 10/2015; DOI:10.1016/j.archger.2015.08.018
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    ABSTRACT: Objective: This analysis assessed the extent to which: (1) wrist accelerometer measures were associated with difficulty performing specific activities of daily living and instrumental activities of daily living and (2) these measures contributed important information about disability beyond a typical self-reported vigorous activity frequency question. Methods: We used data from the National Social Life, Health and Aging Project (NSHAP) accelerometry sub-study (n=738). Activity was assessed using two wrist-accelerometer measures assessed over 3 days (routine activity expressed as mean count/15s epoch during wake time, and immobile time expressed as the proportion of wake time spent immobile), and self-reported average vigorous activity frequency. The association between routine activity, immobile time and difficulty performing fourteen activities of daily living (ADLs) and instrumental activities of daily living (IADLs) plus two summary measures (any ADL or IADL difficulty), was assessed using logistic regression models, with and without controlling for self-reported vigorous activity. Results: Self-reported activity was mildly correlated with routine activity (r=0.27) and immobile time (r=-0.21). Routine activity, immobile time, and self-reported vigorous activity were significantly associated with twelve, ten, and fourteen disability measures, respectively. After controlling for self-reported activity, significant associations remained between routine activity and eight disabilities, and immobile time and six disabilities. Conclusion: Wrist accelerometry measures were associated with many ADL and IADL disabilities among older adults. Wrist acclerometry in older adults may be useful to help assess disability risks and set individualized physical activity targets.
    Archives of gerontology and geriatrics 10/2015; DOI:10.1016/j.archger.2015.09.004
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    ABSTRACT: Background: Age and gender effects on muscle tone and mechanical properties have not been studied using hand-held myometric technology. Monitoring changes in muscle properties with ageing in community settings may provide a valuable assessment tool for detecting those at risk of premature decline and sarcopenia. Objective: This study aimed to provide objective data on the effects of ageing and gender on muscle tone and mechanical properties of quadriceps (rectus femoris) and biceps brachii muscles. Methods: In a comparative study of 123 healthy males and females (aged 18-90 years; n=61 aged 18-35; n=62 aged 65-90) muscle tone, elasticity and stiffness were measured using the MyotonPRO device. Results: Stiffness was greater and elasticity lower in older adults for BB and RF (p<0.001). Tone was significantly greater in older adults for BB but not for RF when data for males and females were combined (p=0.28). There were no gender differences for BB in either age group. In RF, males had greater stiffness (young males 292 vs females 233N/m; older males 328 vs females 311N/m) and tone (young 16.4 vs 13.6Hz; older 16.7 vs 14.9Hz). Elasticity in RF was lower in young males than females but did not differ between the older groups (both males and females log decrement 1.6). Conclusions: Stiffness and tone increased with ageing and elasticity decreased. These findings have implications for detecting frailty using a novel biomarker. Age and gender differences are important to consider when assessing effects of pathological conditions on muscle properties in older people.
    Archives of gerontology and geriatrics 10/2015; DOI:10.1016/j.archger.2015.09.011
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    ABSTRACT: Background: There are few data on mortality rates in the general elderly living in sub-Saharan Africa. We aimed to detail three-year mortality rates in a population of rural community-dwelling older adults in northern Tanzania. Methods: We performed a community-based study of 2232 people aged 70 years and over living in Hai district, Tanzania. At baseline, participants underwent clinical assessment for disability, neurological disorders, hypertension, atrial fibrillation and memory problems. At three-year follow-up mortality data were collected. Mortality rates were compared to UK estimates. Results: At follow-up, data were available for 1873 subjects (83.9%). Of those, 208 (11.1%, 95% CI 9.7-12.5) had died. The age-standardised mortality rate was 10.2% (95% CI 8.8-11.6). Age-standardised mortality rates were lower than estimated for the UK (13.9%). In Cox regression analysis, greater age, higher levels of functional disability, use of a walking aid, subjective report of memory problems, being severely underweight and being normotensive were significant predictors of mortality. Conclusions: Those who survive to old age in Tanzania appear to have relatively low mortality rates. Physical and cognitive disabilities were strongly associated with mortality risk in this elderly community-dwelling population. The association between blood pressure and mortality merits further study.
    Archives of gerontology and geriatrics 10/2015; DOI:10.1016/j.archger.2015.10.008
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    ABSTRACT: Objective: To clarify the cross-sectional and longitudinal relationships between white matter hyperintensities (WMH) and dementia in Parkinson's disease (PD) patients. Methods: One hundred thirty-two PD patients were included. Using medical records, the patient data including Hoehn and Yahr stage, postural instability, neuropsychological tests and magnetic resonance imaging were analyzed. The degree of WMH was rated according to a modified Fazekas scale. The relationship between the variables and dementia was analyzed using the independent t-test, the chi-square test, logistic regression analysis and the Cox proportional hazard model. Results: The mean age of the study patients (35 males and 97 females) was 71.6 years (range, 45-93 years). The baseline WMH was associated not only cross-sectionally with the contemporary prevalence of dementia but also longitudinally with subsequent occurrence of dementia in the univariate analysis. These relationships became attenuated and statistically insignificant in the multivariate analysis after adjusting for confounders. It was postural instability that consistently predicted dementia in both the cross-sectional and the longitudinal data. Conclusions: Our study showed that baseline WMH was not independently associated with dementia, and instead postural instability revealed at first examination can be a more reliable predictor of dementia in PD patients.
    Archives of gerontology and geriatrics 10/2015; DOI:10.1016/j.archger.2015.10.006
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    ABSTRACT: Objective: To investigate the impact of multicomponent, nonpharmacologic interventions (MNI) on perioperative cortisol and melatonin levels, as well as postoperative delirium (PD), in elderly oral cancer patients. Methods: A total of 160 elderly oral cancer patients who underwent tumor resection surgery and completed our investigation were included in this study. The cancer patients were randomly divided into 2 groups: Group U or Group I. During the perioperative period, Group U received usual care, while Group I received MNI, which is based on usual care and aims to decrease the risk of PD. MNI focused on general geriatric approaches and supportive nursing care. On the day before surgery and the first three postoperative days, nocturnal (20:00-8:00) urine samples were collected. The melatonin sulfate and cortisol levels in the urine samples were determined. Moreover, the RASS (Richmond Agitation Sedation Scale), CAM-ICU (Confusion Assessment Method for the Intensive Care Unit) and QoR40 (40-item quality of recovery score) scores were dynamically monitored. Results: There were no significant differences in the general characteristics between the 2 groups. After surgery, the melatonin sulfate levels in the nocturnal urine of Group I were higher than those in Group U. The cortisol concentrations were lower in Group I compared to those in Group U. Group I achieved better postoperative RASS and QoR40 scores than Group U. Compared to Group U, Group I also experienced less PD (incidence and duration). Conclusions: MNI ameliorated some postoperative disturbances regarding sleep and stress, decreased the incidence of PD and improved recovery quality.
    Archives of gerontology and geriatrics 10/2015; DOI:10.1016/j.archger.2015.10.009
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    ABSTRACT: Background: Vascular dementia is related to intracranial arteriosclerosis associated with deep white matter lesions (DWMLs). DWMLs have been linked to thrombogenesis due to sustained platelet activation; therefore, an accurate hematological marker is needed. This study was done to evaluate the usefulness of a new method to examine the function of activated platelets in order to assess DWMLs associated with cognitive decline. Methods: A total of 143 individuals (70.4±6.1 years old) who underwent hospital-based health screening using head MRI were evaluated. DWLs were evaluated on T2-weighted and FLAIR images by semi-quantitatively grading them from Grade 0 (none) to Grade 3 (severe) using the Fazekas classification. Cognitive function was evaluated using the MMSE and the word fluency test. Platelet activation was assessed using fluorescence-labeled anti-human platelet monoclonal antibodies and semi-quantitatively determining PAC-1- and CD62P-positive rates by flow cytometry. Results: Significant increases in hypertension and CD62P levels were observed with increasing DWML grade (2.6% in Group 0, 3.1% in Group 1, 4.1% in Group 2, and 5.0% in Group 3). CD62P levels were defined as elevated when they were above the mean+2SD of the Grade 0 group, and the odds ratio of the Grade 2+3 group was 3.03. A significant negative correlation was observed between CD62P levels and word fluency tests or the MMSE score. Conclusion: Elevations in CD62P levels, which reflect platelet function activation, were associated with white matter lesions accompanied by a decline in cognitive function. CD62P levels may be useful as a sensitive clinical marker for the early detection of DWMLs with cognitive decline.
    Archives of gerontology and geriatrics 09/2015; DOI:10.1016/j.archger.2015.09.001
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    ABSTRACT: Background: In absence of curative treatments for dementia with type 2 diabetes mellitus (T2DM), mild cognitive impairment (MCI) in T2DM, the preclinical transitional states of dementia with T2DM has attracted dramatic attention. Our study was to estimate the prevalence and distribution of MCI in T2DM subjects from China, and identify influencing factors of subjects in MCI with T2DM. Methods: In the present study, we performed cluster random sampling of 8213 people aged 65 years and older in Tianjin, a metropolitan city, located in northern China. All participants were interviewed and screened for T2DM. 1109 subjects with T2DM were initially screened with American Diabetes Association criteria for diagnosis of diabetes mellitus and were diagnosed with MCI and dementia according to the criteria of DSM-IIIR. The prevalence of MCI and dementia in subjects with T2DM were compared with that in ordinary subjects. Logistic regression analyses were performed to evaluate risk of MCI with T2DM. Results: Among all 8213 subjects, overall MCI and dementia with T2DM prevalence were 13.5% and 2.34%, respectively. Compared with ordinary subjects, the prevalence of MCI in the present study was more frequent than the prevalence of MCI for the general population in almost each age group. In the univariate analyses, among all diabetic subjects, compared with cognitive intactly subjects, MCI subjects had significantly higher levels of age, current smoking, mean waist circumference, duration from onset of diabetes, insulin intake, systolic BP, fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c) and immunoreactive insulin (IRI). In multivariate logistic regression analyses, variables including current smoking, duration from onset of diabetes, FPG, HbA1c and IRI were significantly associated with increased risk for MCI with T2DM, the ORs were 1.36,1.33,1.17,1.25 and 1.33, respectively (all P<0.05). Conclusions: The present study confirms the high prevalence of MCI with T2DM among the elderly population of China. T2DM is related to a higher risk of MCI in a population with a high prevalence of this disorder and may aggravate the clinical picture as a concomitant factor.
    Archives of gerontology and geriatrics 09/2015; DOI:10.1016/j.archger.2015.09.003