Recent Patents on Drug Delivery & Formulation

Publications in this journal

• Article: Recent Advances and Patents in Solid Dispersion Technology

  Babar Iqbal, Asgar Ali, Javed Ali, Sanjula Baboota, Sonal Gupta, Shweta Dang, Shadab Muhammad, Jasjeet K. Sahni
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  ABSTRACT: High lipophilicity and high lattice energy of drugs, which result in poor solubility are major real challenges in the pharmaceutical industry for the successful development and commercialization of suitable dosage forms. Therefore various formulation strategies like complexation, lipid based systems, micronization, nanonization, co-crystals, solid dispersions, solubilization etc. have been investigated to resolve the problems associated with solubility related oral bioavailability of poorly water soluble drugs. This article focuses on solid dispersions which is used as one of the formulation strategies to improve the solubility and bioavailability of BCS class II drugs. The present review discusses the fundamentals of solid dispersions, their formulation techniques including various carriers used, their applications, limitations as well as provide an insight into the various alternative approaches to overcome problems associated with solid dispersions. This review also discusses some important aspects of solid dispersion like phase transition, importance of Tg for solid dispersion, controlled release formulations, IVIVC, and the prospect of innovative solid dispersions. Furthermore, the different patents highlighting the applications of solid dispersions have also been comprehensively discussed in the present review.
  Recent Patents on Drug Delivery & Formulation 08/2011; 5(3):244-264.
• Article: Patented Herbal Formulations and their Therapeutic Applications

  Mohamed Musthaba, Sanjulae Baboota, Tanwir M.D. Athar, Kamal Y. Thajudeen, Sayeed Ahmed, Javed Ali
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  ABSTRACT: Recently, there is a greater global interest in non synthetic, natural medicines derived from plant sources due to better tolerance and minimum adverse drug reactions as compared to synthetic medicines. Herbal products are also commonly used by the patients with certain chronic medical conditions, including breast cancer, liver disease, human immunodeficiency, asthma and rheumatological disorders. WHO estimates that about three-quarters of the world's population currently uses herbs and other forms of traditional medicines for the treatment of various diseases. The herbs are formulated in different modern dosage forms, such as Tablets, Capsules, Topical cream, Gel, Ointment and even some novel drug delivery forms, like extended release, sustained release, and microencapsules dosage forms. Patenting of herbal formulations has increased over the past few years and scientific evidence of therapeutic activity has been reported by performing various in vitro and in vivo experiments. This manuscript deals with various patented herbal formulations with their therapeutic application against various disases.
  Recent Patents on Drug Delivery & Formulation 10/2010; 4(3):231-244.
• Article: Chronotherapeutics: a Promising drug delivery findings of the Last two decades

  Javed Ali, nitin sehgal, mohd Javed Qureshi, Alka Ahuja, Sanjula Baboota
  Recent Patents on Drug Delivery & Formulation 01/2010; 4(2):1-16.
• Article: Recent Advances in Developing Ophthalmic Formulations: A Patent Review

  Guang W. Lu
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  ABSTRACT: In an effort to improve the drug solubility, stability and/or ocular bioavailability of ophthalmic formulations, various approaches have been explored in the recent past. Additionally, different formulations have been investigated in order to seek those preservative systems that are more tolerable to the ocular tissue. Over the past ten years, inventions in ophthalmic formulations directed toward front-of-eye instillations have concentrated in the areas of new excipients' applications, novel and combined use of conventional excipients, and developments of novel dosage forms. Among these areas, applications of polymeric excipients, cyclodextrins and stabilized chloride dioxide (SCD) have been the most actively studied fields. In addition, oil-in-water (O/W) emulsions have been becoming more popular as an ophthalmic dosage form due to the potentials in increasing drug solubility, stabilizing active pharmaceutical ingredients (APIs), improving ocular tolerance, and providing palliative effects. Some of these innovations from the past decade have the capability of leading to new commercial products. This patent review has a useful knowledge in the advancement for treating various ophthalmic diseases.
  Recent Patents on Drug Delivery & Formulation 12/2009; 4(1):49-57.
• Source

  Available from: benthamscience.com

  Article: Mucoadhesive Vaginal Drug Delivery Systems

  Fusun Acarturk
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  ABSTRACT: Vaginal delivery is an important route of drug administration for both local and systemic diseases. The vaginal route has some advantages due to its large surface area, rich blood supply, avoidance of the first-pass effect, relatively high permeability to many drugs and self-insertion. The traditional commercial preparations, such as creams, foams, gels, irrigations and tablets, are known to reside in the vaginal cavity for a relatively short period of time owing to the selfcleaning action of the vaginal tract, and often require multiple daily doses to ensure the desired therapeutic effect. The vaginal route appears to be highly appropriate for bioadhesive drug delivery systems in order to retain drugs for treating largely local conditions, or for use in contraception. In particular, protection against sexually-transmitted diseases is critical. To prolong the residence time in the vaginal cavity, bioadhesive therapeutic systems have been developed in the form of semi-solid and solid dosage forms. The most commonly used mucoadhesive polymers that are capable of forming hydrogels are synthetic polyacrylates, polycarbophil, chitosan, cellulose derivatives (hydroxyethycellulose, hydroxypropylcellulose and hydroxypropylmethylcellulose), hyaluronic acid derivatives, pectin, tragacanth, carrageenan and sodium alginate. The present article is a comprehensive review of the patents related to mucoadhesive vaginal drug delivery systems.
  Recent Patents on Drug Delivery & Formulation 10/2009; 3(3):193-205.
• Article: Impact of Magnetic Nanoparticles in Biomedical Applications

  Saba Naqvi, Mohd Samim, Zeenat Iqbal, Sushma Telagoanker, Farhan Jalees Ahmed, Amaranth Maitra
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  ABSTRACT: In the recent years, there has been a growing interest in the development of nanoparticles based targeting agents for the tumor diagnostics and therapeutics. This is because of their potential to detect the tumor and treat the diseased tissue at the cellular and molecular level. In this respect nanoscale magnetic materials have shown a very promising therapeutic concept and offer a new perspective for the diagnostic and target drug delivery approach. The magnetic nanocarriers have the ability to accumulate at any desired pharmacological site just by the guidance of external magnetic field. But, the interactions of these magnetic nanocarriers with the biological environment are rare and depend largely upon their surface chemistry and size. To increase the interactions and achieve the desired pharmaceutically acceptable delivery system, the surface of magnetic nanocarriers is modified in various ways by coating with organic polymers and inorganic metals or oxides. On the basis of surface characteristics, a number of effective magnetically driven therapies have been proposed by many researchers and protected through patents time to time.
  Recent Patents on Drug Delivery & Formulation 03/2009;
• Article: Patented herbal formulations and their therapeutic applications.

  Mohamed Musthaba, Sanjula Baboota, Tanwir M D Athar, Kamal Y Thajudeen, Sayeed Ahmed, Javed Ali
  Recent Patents on Drug Delivery & Formulation 01/2009;
• Article: Recent Developments and Patenting of Lipoprotein Based Formulations

  Andras G. Lacko, Donald R. Stewart, Robert McClain, Laszlo Prokai, Walter J. McConathy
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  ABSTRACT: Rapid advances in drug discovery and development have spawned numerous innovative drug delivery approaches [1]. Although these efforts have primarily focused on optimizing the performance of drugs targeted for the current market, enhanced delivery of drugs may also result in the revitalization of marginally effective or failed formulations due to their original poor solubility. Plasma lipoproteins have long been considered as appropriate models for drug delivery vehicles, particularly because of their potential for transporting chemicals with low water solubility [2]. Additional features that render lipoproteins particularly suitable for drug delivery are their natural, bio-compatible components, their small size, the ability to deliver the drug itself rather than a prodrug or conjugate and their receptor mediated their uptake [3] or the uptake of their payload [4,5], particularly by cancer cells [6,7]. There has been increased activity in the patenting of lipoprotein type formulations in the last several years, primarily with the aim of developing enhanced drug delivery vehicles. This communication attempts to review the patenting activity in this area with particular focus on drug delivery and cancer chemotherapy.
  Recent Patents on Drug Delivery & Formulation 05/2007; 1(2):143-145.