Minerva anestesiologica Journal Impact Factor & Information

Journal description

The journal Minerva Anestesiologica publishes scientific papers on anesthesiology, resuscitation, analgesia and intensive care. Frequency: Monthly. Official Journal of the Italian Society of Anesthesiology, Analgesia, Resuscitation, and Intensive Care.

Current impact factor: 2.27

Impact Factor Rankings

2015 Impact Factor Available summer 2015
2013 / 2014 Impact Factor 2.272
2012 Impact Factor 2.818
2011 Impact Factor 2.656
2010 Impact Factor 2.581
2009 Impact Factor 1.614
2008 Impact Factor 1.627

Impact factor over time

Impact factor
Year

Additional details

5-year impact 2.12
Cited half-life 3.00
Immediacy index 0.61
Eigenfactor 0.00
Article influence 0.41
Website Minerva Anestesiologica website
ISSN 1827-1596

Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: Post-dural puncture headache (PDPH) is one of the most frequent complications of neuraxial anesthesia and analgesia. The objective is to determine risk factors of PDPH receiving a blood-patch in the obstetric population. Between November 2009 and January 2013, 10914 women delivered in Port Royal maternity unit (Paris, France). The incidence of PDPH receiving a blood- patch was calculated among those who received neuraxial analgesia or anesthesia for delivery. Then we performed a case-control study to identify risk factors for PDPH receiving a blood-patch by comparing women who experienced PDPH receiving a blood-patch with some women randomly selected by computer among those who delivered during the study period (4 controls for 1 case, univariate and multivariate analysis). Among the 10685 women who had neuraxial analgesia or anesthesia, 0.4% had a PDPH receiving a blood-patch. In the univariate analysis, cervix dilatation ≥7 cm, lateral decubitus position during the neuraxial procedure and multiple punctures were significantly associated with PDPH receiving a blood-patch, whereas maternal body mass index, age, mode of delivery, performance at night and level of needle insertion were not. In the multivariate analysis, cervix dilatation ≥7 cm and multiple punctures significantly increased the risk of PDPH receiving a blood-patch (odd ratios 6.5 (IC95% [1.5-29.3]) and 5.6 (IC95% [2.2-14.0]) respectively). Experience of the anesthesiologist was not associated with PDPH in both univariate and multivariate analysis. In the obstetric population, a cervix dilation ≥7 cm during labor and multiple punctures are independent risk factors for PDPH receiving a blood-patch.
    Minerva anestesiologica 07/2015;
  • Minerva anestesiologica 07/2015;
  • Minerva anestesiologica 07/2015;
  • Minerva anestesiologica 07/2015;
  • Minerva anestesiologica 07/2015;
  • Minerva anestesiologica 07/2015;
  • [Show abstract] [Hide abstract]
    ABSTRACT: The pharmacokinetics for sevoflurane and desflurane makes them suitable for low flow anaesthesia. The aim of the present study was to assess the use of desflurane and sevoflurane at constant vaporizer settings and fixed low fresh gas flows. One hundred ASA 1-2 patients undergoing elective laparoscopic surgery were randomized into 4 groups (25 patients each): a fixed fresh gas flow 1.0 or 0.5 L/min with desflurane (D1.0 and D0.5) or sevoflurane (S1.0 and S0.5) throughout anaesthesia. A fixed vaporizer setting, sevoflurane 6% and desflurane 18% was used during wash-in. Time to reach 1 and 1.5 MAC, emergence and gas consumption from start to end of surgery was studied. Time to reach 1 MAC age adjusted desflurane or sevoflurane was D0.5 8.5 ± 1.7, D1.0 3.7 ± 0.7, S0.5 15.2 ± 2.4 and S1.0 6.2 ± 1.3 minutes, respectively (P< 0.001), and times to increase from 1 to 1.5 MAC differed also significantly. Desflurane anaesthesia was associated to significantly shorter time to extubation 6.7 ± 2.3 vs. 10 ± 2.3 minutes for sevoflurane (p <0.001). The amount of agent consumed g/min. was significantly reduced for both 0.5 L/min groups: 30% less for desflurane and 19% for sevoflurane. We found an almost twice as rapid wash-in with desflurane and expectedly faster emergence. Gas consumption was lower at 0.5 L/min than it was at 1 L/min for both gases studied however most pronounced for desflurane. Desflurane has clear advantages for minimal fresh gas flow anaesthesia.
    Minerva anestesiologica 07/2015;
  • Minerva anestesiologica 07/2015;
  • [Show abstract] [Hide abstract]
    ABSTRACT: Having a dynamic view of postoperative pain resolution allows a better understanding of the transition towards chronic pain. Sleep and quality of life are important determinants of satisfaction after TKA, besides functional recovery and pain. For 114 patients undergoing TKA we recorded the presence of pain at rest, pain evoked at movement and pain located at the incision site in the acute (postoperative day 1, 2, 3, 8), subacute (30 days, 3 months) and chronic (6 months and 1 year) period. Analgesics consumption and need of medical assistance for pain were questioned. Quality of life measured by the impact on enjoyment of life, sleep and mood were monitored. Average incidence for subacute pain was 54% at rest, 66% at mobilization. For chronic pain, the incidence was 14% at rest, 22% during mobilization. Pain at rest peaked at day 30 while pain during mobilization displayed a plateau between day 8 and 3 months. Three per cent of the patients complained at 1 year of pain at the incision site. 11% of patients still took analgesics one year after the surgery. More than 40% of patients reported moderate to severe alterations of sleep and quality of life in the acute period, decreasing to less than a half at one year. The trajectories of the different types of pain after TKA show their nonlinear evolution, highlighting the need of a better pain control at precise moments. Sleep disturbances and alterations of quality of life are still present one year after the surgery.
    Minerva anestesiologica 07/2015;
  • [Show abstract] [Hide abstract]
    ABSTRACT: The aim of this study was to evaluate the effects of vancomycin pharmacokinetics (PKs) on effectiveness and safety in the treatment of Gram-positive infections due to pathogens other than methicillin-resistant Staphylococcus aureus (MRSA). Prospective study including septic patients received either continuous (n=21) or intermittent (n=21) infusions of vancomycin; the target drug concentration was 15-20 mg/L and target area under the curve of vancomycin concentrations over the minimum inhibitory concentration of the pathogen on day 1 (AUC24/MIC) >400. Clinical and microbiological responses, the development of acute kidney injury (AKI) and therapy costs were recorded. The median AUC24/MIC was 195(133-343) vs. 189(136-328) mg/L*h in the continuous and intermittent infusion groups. Target drug concentrations were achieved in 15/21 vs. 9/21 (p=0.12) patients and AUC24/MIC >400 in only 5/21 vs. 3/21 (p=0.35) patients of continuous and intermittent groups, respectively. High clinical cure (17/21 for continuous vs. 17/21 for intermittent, p=1.00) and microbiological eradication (17/21 vs. 15/21, p=0.47) were observed in both groups and not associated with drug concentrations or with AUC24/MIC. AKI was diagnosed during therapy in 5/21 patients in the continuous group and 8/21 in the intermittent group (p=0.32). The median total therapy costs were lower in the continuous than in the intermittent group (377 [304-485] vs. 552 [371-644] €, p=0.04). Vancomycin resulted in high clinical response during non-MRSA Gram- positive infections treatment even at drug concentrations lower than those for MRSA. A continuous infusion of vancomycin was associated with a significant reduction in therapy costs compared to intermittent infusions.
    Minerva anestesiologica 07/2015;
  • Minerva anestesiologica 07/2015;
  • [Show abstract] [Hide abstract]
    ABSTRACT: Opioid analgesics are important therapeutic options for chronic non-cancer pain (CNCP), recognized as a major public health issue with high social and economic burden. The increasing therapeutic opioid use for CNCP, misuse and abuse of prescription opioids have become matters of severe concern in USA. The recent position paper of the American Academy of Neurology (AAN) about the use of opioids in USA expresses growing alarms about opioid misuse/abuse, and has alerted physicians worldwide to rethink about their prescription practice. Current US practice in opioid prescription has been associated with morbidity and mortality of epidemic proportions: over 100,000 people directly or indirectly died from prescribed opioids in USA in the last twenty years, reaching 16,651 deaths in 2010. The actually alarming data from US have initiated pain physicians and researchers to re-evaluate their prescribing policies and attitudes for long-term treatment of non-cancer patients with opioids. In this position paper it is explained that any change in clinical behaviour should not be based on an uncritical generalization of the US data that do not reflect the European situation. The primary objective of pain physicians remains to adequately treat chronic pain. Opioids are and will continue to remain an essential part of the "armamentarium against pain"; physicians should use them in the best way, i.e. after thorough diagnosis, assessment of alternative therapeutic options in the context of a multimodal treatment concept, and with repeated careful reevaluations of the proper indication by a close long-term follow up of any chronic opioid patient.
    Minerva anestesiologica 07/2015;
  • [Show abstract] [Hide abstract]
    ABSTRACT: Systemic response to cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) causes the activation of endocrine, metabolic, hemodynamic and inflammatory processes. The aim of this work is to describe and analyze the time course of the inflammatory markers concentration during CRS+HIPEC in plasma and peritoneal fluids and the association with hemodynamic and metabolic parameters. Pre-, Intra- and Post-operative data were collected. Tumor necrosis factor (TNF), interleukine 6, procalcitonine (PCT), cancer antigen 125 (CA-125) in blood and in peritoneal fluids were evaluated. Thirty-eight patients included, 29 (76.3%) female. Mean/median PCI: 9.2/5. Primary malignancy: 5 colo-rectal (13.2%), 5 gastric (13.2%), 23 ovarian (60.5%) and 5 others (13.2%). CCR 0-1 reached in all patients. Cardiac Index, Heart rate and Central Venous Pressure, increased during the procedure while Stroke Volume Variation showed a decrease. Mean Arterial Pressure and Superior Vena Cava Oxygenation were stable through the whole procedure. TNF and CA-125 were steady during the whole procedure; IL-6 had a relevant increase from baseline to start of perfusion (p<0.01); PCT had a steady increase at every time point. Peritoneal sampling showed a statistically significant increase (p<0.01) between start and end of the perfusion phase for all markers but TNF. Serum and peritoneal marker concentration were similar for TNF, PCT and CA-125. IL-6 showed a sharp difference. The most significant variations are those of IL-6 and PCT. The cytokines level parallel the hemodynamic derangements. Treatment during HIPEC should mimic the established treatment during sepsis and septic shock.
    Minerva anestesiologica 07/2015;
  • [Show abstract] [Hide abstract]
    ABSTRACT: Deflation of the cuff of the endotracheal tube (ETT) before tracheal extubation is considered mandatory and safe practice. However, there are potential shortcomings associated with this practice (e.g., aspiration around the uncuffed ETT, loss of positive airway pressure, difficulty in generating an effective cough at the time of extubation). By contrast, keeping the cuff inflated during extubation will minimize the risk of tracheal aspiration around the ETT, and it will reliably allow maintenance of positive airway pressure until extubation, effective lung recruitment before extubation, and generation of an effective cough during extubation. All of these factors might reduce the overall risk of immediate post-extubation and postoperative respiratory and pulmonary complications. Mandatory monitoring of cuff pressure ensures a remaining rather small, highly compressible cuff volume around the ETT which is unlikely to carry per se the risk of producing laryngeal trauma. In my view, as the overall advantages of not deflating the cuff before extubation outweigh the disadvantages, anesthetists should not have to deflate the cuff of the ETT before extubation. Ultimately, only a randomized controlled trial will be able to assess the effect of such practice on patient outcome.
    Minerva anestesiologica 07/2015;
  • [Show abstract] [Hide abstract]
    ABSTRACT: Two large phase-III prospective, multicenter, controlled, double-blind, randomized clinical trials (the PROTECT III study; the SYNAPSE study) evaluated the effectiveness of an early administration of progesterone in patients with moderate to severe traumatic brain injury (TBI). In the PROTECT III trial, patients were included if the admission Glasgow Coma Scale (GCS) was within 4-12, whereas the SYNAPSE trial only included patients with GCS 4-8. The total dose of progesterone was nearly similar in both studies and drug administration was initiated early after injury (within 4 hours for a total of 96 hours in PROTECT; within 8 hours for 120 hours in SYNAPSE). In the PROTECT trial, primary outcome was 6-month favorable neurological outcome (defined using the Glasgow Outcome Scale), while in the SYNAPSE trial it was the 6-month Glasgow Outcome Scale (GOS). Secondary outcomes, in both studies, included 6-month mortality. The PROTECT trial was interrupted for futility after the second interim analysis (882 patients randomized out of the 1140 initially planned); the SYNAPSE trial included 1195 patients. In PROTECT, the proportion of patients with favorable outcome was similar between groups (51% for progesterone vs. 56% for placebo; RR 3.03 [95% CI 1.96-4.66]); in SYNAPSE, no difference in GOS between the progesterone and placebo group was found (OR 0.96 [95% CI 0.77-1.18]). There was no difference in 6-month mortality or any of the other secondary outcomes between groups in the two trials. These studies demonstrated that early progesterone administration did not provide any benefit on the neurological recovery of TBI patients.
    Minerva anestesiologica 07/2015;