Journal of Innovative Optical Health Sciences

Publisher: World Scientific (Firm)

Description

  • Impact factor
    0.63
  • 5-year impact
    0.63
  • Cited half-life
    0.00
  • Immediacy index
    0.00
  • Eigenfactor
    0.00
  • Article influence
    0.19
  • Other titles
    Innovative optical health sciences, JIOHS
  • ISSN
    1793-5458
  • OCLC
    318613357
  • Material type
    Periodical
  • Document type
    Journal / Magazine / Newspaper

Publications in this journal

  • Journal of Innovative Optical Health Sciences 01/2015; 8(5):1550019.
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Au–Ft, as a green synthesized nanoparticle, is composed of a ferritin nanocage enclosing a pair of Au nanoclusters inside. Our previous study has demonstrated that Au–Ft can be an excellent fluorescent probe for whole body imaging of mice with kidney specific targeting. But, the accurate localization of Au–Ft in kidney is still absent. In the current study, we detected and assessed the cellular and subcellular localization of Au–Ft in renal cortex and medulla of nu/nu mice after tail vein injection by using Nuance optical system (CRi, Woburn, USA) and inForm intelligent image analysis software based on single cell segmentation. We obtained the fluorescence intensity and cellular location of kidney-targeting Au–Ft probe in particular cell of renal glomerulus or renal tubules, which provided valuable proofs to clarify the mechanism of Au–Ft selective enrichment in kidney and the associated metabolic processes.
    Journal of Innovative Optical Health Sciences 05/2014; 07(03).
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Microglial activation plays an important role in neurodegenerative diseases. Once activated, they have macrophage-like capabilities, which can be beneficial by phagocytosis and harmful by secretion of neurotoxins. However, the resident microglia always fail to trigger an effective phagocytic response to clear dead cells or Aβ deposits during the progression of neurodegeneration. Therefore, the regulation of microglial phagocytosis is considered a useful strategy in searching for neuroprotective treatments. In this study, our results showed that low-power laser irradiation (LPLI) (20 J/cm2) could enhance microglial phagocytic function in LPS-activated microglia. We found that LPLI-mediated microglial phagocytosis is a Rac-1-dependent actin-based process, that a constitutively activated form of Rac1 (Rac1Q61L) induced a higher level of actin polymerization than cells transfected with wild-type Rac1, whereas a dominant negative form of Rac1 (Rac1T17N) markedly suppressed actin polymerization. In addition, the involvement of Rac1 activation after LPLI treatment was also observed by using a Raichu fluorescence resonance energy transfer (FRET)-based biosensor. We also found that PI3K/Akt pathway was required in the LPLI-induced Rac1 activation. Our research may provide a feasible therapeutic approach to control the progression of neurodegenerative diseases.
    Journal of Innovative Optical Health Sciences 05/2014; 07(03).
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: A multi-GPU system designed for high-speed, real-time signal processing of optical coherence tomography (OCT) is described herein. For the OCT data sampled in linear wave numbers, the maximum processing rates reached 2.95 MHz for 1024-OCT and 1.96 MHz for 2048-OCT. Data sampled using linear wavelengths were re-sampled using a time-domain interpolation method and zero-padding interpolation method to improve image quality. The maximum processing rates for 1024-OCT reached 2.16 MHz for the time-domain method and 1.26 MHz for the zero-padding method. The maximum processing rates for 2048-OCT reached 1.58 MHz, and 0.68 MHz, respectively. This method is capable of high-speed, real-time processing for OCT systems.
    Journal of Innovative Optical Health Sciences 05/2014; 07(03).
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: This work presents the use of extended Modified Lambert Beer (MLB) model for accurate and continuous monitoring of percent blood carboxyhemoglobin (COHb) (SCO) and oxyhemoglobin (OxyHb) saturation (SO2) via a fitting procedure. This quantification technique is based on the absorption characteristics of hemoglobin derivatives in the wavelength range of 520–600 nm to give the best estimates of the required parameters. A comparison of the performance of the developed model and MLB law is made using attenuation data from Monte Carlo simulations for a two-layered skin model. The results revealed a lower mean absolute error of 0.4% in the values estimated by the developed model as compared to 10% that is given by the MLB law. This study showed that the discussed approach is able to provide consistent and accurate measurement of blood SO2 and SCO across different skin pigmentations suggesting that it may potentially be used as an alternative means for clinical diagnosis of carbon monoxide (CO) poisoning.
    Journal of Innovative Optical Health Sciences 05/2014; 07(03).
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Near infrared (NIR) emitting quantum dots (QDs) is a promising candidate for biomedical imaging in living tissues. However, the biomedical application of NIR QDs was not satisfactory due to their toxicity. Ag2S QDs was reported to have negligible toxicity in organisms. Therefore, the appropriate narrow bandgap and low toxicity of Ag2S QDs facilitated them to be a promising contrast agent for fluorescence imaging. Here, a low toxicity, stable and highly luminescent NIR Ag2S QDs were prepared by one-step aqueous method using 2-mercaptopropionic acid (MPA) as the coating layers. Emission wavelength of Ag2S QDs could be tuned between 780 and 950 nm. MTT assay results indicated that there was no significant biotoxicty for Ag2S QDs. These NIR QDs exhibited excellent biocompatibility in tumor cells. The cellular uptake and localization of Ag2S QDs was studied using laser confocal scanning microscopy. Ag2S QDs were effectively internalized by the cells. Therefore, Ag2S QDs, acting as a novel fluorescence probe, has promising potential in biolabeling, deep tissue imaging, diagnostics and photodynamic therapy.
    Journal of Innovative Optical Health Sciences 05/2014; 07(03).
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Treatment of malignant brain tumors continues to challenge scientists and clinicians alike. Location of these tumors within the central nervous system (CNS), which is considered a "privileged" organ, can prevent the penetration of chemotherapeutic agents through the blood–brain barrier (BBB). To overcome this limitation, nanoparticles are taken up and transported by macrophage and then delivered directly into the CNS. In this study, we used macrophage to uptake the folate-targeted bifunctional micelles loaded with near-infrared (NIR) dye ICG-Der-01 and investigate the dynamic bio-distributions of macrophage after intravenous injection into tumor-bearing mice. In vitro cellular experiments by confocal microscopy indicated that the uptake of micelles in macrophage was greatly enhanced due to the folate receptor overexpression. Dynamic bio-distributions of macrophage showed a rapid clearing rate through the liver intestine pathway. In conclusion, macrophage could potentially be used as nanoparticle drug carriers and require further investigation.
    Journal of Innovative Optical Health Sciences 05/2014; 07(03).