IET Nanobiotechnology (IET NANOBIOTECHNOL)

Publisher: Institution of Engineering and Technology, Institution of Engineering and Technology

Journal description

IET Nanobiotechnology covers all aspects of research and emerging technologies including, but not limited to: Fundamental theories and concepts applied to biomedical-related devices and methods at the micro- and nano-scale (including methods that employ electrokinetic, electrohydrodynamic, and optical trapping techniques); Micromachining and Microfabrication tools and techniques applied to the top-down approach to Nanobiotechnology; Nanomachining and Nanofabrication tools and techniques directed towards biomedical and biotechnological applications (e.g. applications of Atomic Force Microscopy, Scanning Probe Microscopy and related tools); Colloid chemistry applied to Nanobiotechnology (e.g. cosmetics, suntan lotions, bio-active nanoparticles); Microtechnologies such as Lab-on-Chip applied to pharmaceutical, biomedical and biotechnological applications; Techniques for probing cell physiology, cell adhesion sites and cell-cell communication; Molecular self-assembly, including concepts of supramolecular chemistry, molecular recognition, and DNA Nanotechnology; Societal issues such as health and the environment.

Current impact factor: 1.72

Impact Factor Rankings

2015 Impact Factor Available summer 2015
2013 / 2014 Impact Factor 1.723
2012 Impact Factor 1
2011 Impact Factor 1.833
2010 Impact Factor 1.857
2009 Impact Factor 2.077
2008 Impact Factor 1.562
2007 Impact Factor

Impact factor over time

Impact factor

Additional details

5-year impact 1.53
Cited half-life 4.10
Immediacy index 0.25
Eigenfactor 0.00
Article influence 0.39
Website IET Nanobiotechnology website
Other titles IET NBT, Nanobiotechnology
ISSN 1751-8741
OCLC 86085276
Material type Periodical, Internet resource
Document type Journal / Magazine / Newspaper, Internet Resource

Publisher details

Institution of Engineering and Technology

  • Pre-print
    • Author can archive a pre-print version
  • Post-print
    • Author can archive a post-print version
  • Conditions
    • Pre-print to be removed on archiving of authors post-print
    • On a non-profit server
    • Set phrase to accompany pre-print (see link below)
    • On institutional server or institutional repository
    • Publisher copyright and source must be acknowledged
    • Must link to publisher version
    • Publisher's version/PDF cannot be used
    • If funding rules apply authors may post author version in designated repository
  • Classification
    ​ green

Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: Hierarchical porous fibre scaffolds with mesoporous bioglasses (MBGs) and polylactic acid (PLA) were successfully fabricated by the electrospinning method. These compound scaffolds possess macropores with sizes of about 100 nm because of the solvent evaporation from the fibre and the mesoporous structure ( ∼4.0 nm) originated from MBGs. The biomineralisation ability was investigated in simulated body fluid. The fibre structure is beneficial for inducing the growth of hydroxyapatite. In addition, compared with pure MBGs, the materials (MP-1 and MP-2) exhibit a long-acting drug release process up to 140 h and the drug release process corresponds with the Fickian diffusion mechanism. With the special fibre morphology and the hierarchical porous structure, the MBGs/PLA fibre scaffolds are expected to have potential application for bone tissue repair and regeneration.
    IET Nanobiotechnology 04/2015; 9(2):58-65. DOI:10.1049/iet-nbt.2013.0011
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    ABSTRACT: Spherical macroporous poly(lactic-co-glycolic acid) (PLGA) has been synthesised using an emulsion method. Polyvinyl alcohol and Pluronic F127 have been used as dispersing and porogen agent, respectively. The diameter of the spherical PLGA is about 20 μm and the pore size of the PLGA macroporous is about 2-2.5 μm observed by scanning electron microscopy. After immersing in simulated body fluid, the PLGA materials can induce the formation of hydroxyapatite (HAP) on their surface. The HAP-PLGA has been obtained and used as the host for drug release. Furthermore, the drug-loaded samples possess the various drug release performance by adjusting the thickness of the HAP layer. This highly satisfied composite material is expected to be promising in the applications in tissue regeneration engineering.
    IET Nanobiotechnology 02/2015; 9(1):1-4. DOI:10.1049/iet-nbt.2013.0066
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    ABSTRACT: The fluorescence labelling of plant hormone binding sites is an important analytical technique in research on the molecular mechanisms of plant hormone activities. The authors synthesised a jasmonic acid (JA)-conjugated ZnS:Mn quantum dot (QD) probe, with a cubic structure and average hydrodynamic sizes of about 17.0 nm. The maximum fluorescence emission of the probe was recorded at about 585 nm. The probe was used for fluorescence labelling of JA binding sites in mung bean seedling tissues. Analysis revealed that the probe exhibited high selectivity to JA binding sites and good performance in eliminating interference from background fluorescence in plant tissues. In addition, the probe did not exhibit any apparent biotoxicity, and is much more suitable than probes constructed from CdTe QDs for the analysis of biological samples.
    IET Nanobiotechnology 02/2015; 9(1):35-42. DOI:10.1049/iet-nbt.2014.0002
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    ABSTRACT: The aim of this study was to evaluate four immunoassays, based on amine-modified bovine serum albumin nanoparticles (AMBSANPs). First, the capability of nitrate absorption by AMBSANPs under different conditions was evaluated. Then, serial concentrations of pure βHCG were added to wells coated with βHCG antibody for immunoassays 1 and 2, and wells coated with βHCG aptamer for immunoassays 3 and 4. Next, AMBSANPs conjugated with βHCG antibody was added for immunoassays 1 and 3, and AMBSANPs conjugated with βHCG aptamer were added for immunoassays 2 and 4. Finally, the optical density (OD) of each well was read at 340 nm, and compared with controls. Moreover, the concentration of βHCG in the clinical samples was quantified by immunoassays 1, 2, 3, 4 and ELISA, and then compared. The effect of some serum interferences on these immunoassay methods was evaluated. The authors observed that the amount of nitrate absorption by AMBSANPs increased with an increase in H + ion concentration and temperature, and decreased with an increase in ion strength. The correlation (R(2)) between ELISA and immunoassays 1, 2, 3 and 4 were 0.97, 0.97, 0.98, 0.99, respectively. It was found that the increase in the serum interferences led to a decrease in the measured βHCG concentration.
    IET Nanobiotechnology 02/2015; 9(1):43-51. DOI:10.1049/iet-nbt.2014.0003
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    ABSTRACT: Effects were studied of vapour chamber on specific gas permeability of nanosilane (NS)-treated medium-density fibreboards (MDFs). Size range of nanoparticles was 20-80 nm. NS was used at four consumption levels of 0, 50, 100 and 150 g/kg dry wood fibres. Density of all treatments was kept constant at 0.67 g/cm(3). Specimens were kept for 18 weeks in vapourised chamber; their specific gas permeability was measured every two weeks. Results showed that extreme moisture uptake because of the biological structure of wood fibres, as well as mold and fungi growth on the specimens from the tenth week, resulted in the breaking down of the urea-formaldehyde resin; they also weakened the water-repellant effect of NS; consequently, the permeability increased significantly. It can be concluded that NS makes MDF susceptible to molds and therefore NS-treated MDF panels are not recommended for moist climates in which boards are exposed to water vapours in the air for a long time, although NS-panels primarily showed higher impermeability to water.
    IET Nanobiotechnology 02/2015; 9(1):11-8. DOI:10.1049/iet-nbt.2013.0064
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    ABSTRACT: Currently, nanometal oxides find their role in different biological applications such as tissue engineering, implant and bone replacement materials. Owing to the increased use of nanoparticles, it is necessary to understand their release and toxicity in the biological system. In this regard, three independent studies such as in vitro cytotoxicity, antioxidant activity and biocompatibility of nano- and micrometal oxide particles such as alumina (Al2O3) and silica (SiO2) are evaluated. It is evident from cell viability study that nanoAl2O3 and SiO2 particles are less toxic when compared with microAl2O3 and SiO2 to NIH 3T3 cell lines up to 200 µg/ml. Antioxidant properties of micro- and nanoAl2O3 in terms of radical scavenging percentage for micro- and nanoAl2O3 are 59.1% and 72.1%, respectively, at 100 mg. Similarly, the radical scavenging percentage of nano- and bulk SiO2 are 81.0% and 67.2%, respectively. The present study reveals that the cellular behaviour, interaction and biocompatibility of metal oxides differ with dose, particle size, contact angle and zeta potential. The present study opens up a new strategy to analyse in vitro nanotoxicity.
    IET Nanobiotechnology 02/2015; 9(1):27-34. DOI:10.1049/iet-nbt.2013.0067
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    ABSTRACT: Extracellular and intracellular biosynthesis of silver nanoparticles (AgNPs) by Euglena gracilis (EG) strain and Euglena intermedia (EI) strain are reported in this study. The obtained nanoparticles showed an absorption peak approximates 420 nm in the UV-visible spectrum, corresponding to the plasmon resonance of AgNPs. According to the result of inductively coupled plasma-atomic emission spectrometer, the intakes of silver ions by EI and EG are roughly equal. The transmission electron microscope (TEM) analysis of the successful in vivo and in vitro synthesised AgNPs indicated the sizes, ranging from 6 to 24 nm and 15 to 60 nm in diameter, respectively, and a spherical-shaped polydispersal of the particles. The successful formation of AgNPs has been confirmed by energy dispersive X-ray analysis connected to the TEM. The Fourier transform infrared spectroscopy measurements reveal the presence of bioactive functional groups such as amines are found to be the capping and stabilising agents of nanoparticles. To our knowledge, this is the first report where two kinds of Euglena microalga were used as the potential source for in vivo and in vitro biosynthesis of AgNPs.
    IET Nanobiotechnology 02/2015; 9(1):19-26. DOI:10.1049/iet-nbt.2013.0062
  • IET Nanobiotechnology 01/2015; DOI:10.1049/iet-nbt.2014.0012
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    ABSTRACT: In this study, silver (Ag) was used to render antibacterial properties to a new class of BG materials. This was achieved by synthesis of a sol-gel derived BG in the system of SiO2–CaO–P2O5–Ag2O BG with three different molar ratios of silveroxide. The antibacterial effect of different masses of Ag-BGs on three strains of bacteria; Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus, was compared with that of Ag-free BG sample, by the viable colony count and the disc diffusion methods in vitro. The human osteoblast cells viability and cytotoxicity were evaluated by MTT and LDH specific activity assays, respectively, after culturing the cells in contact with different masses of the bio active glasses. The results showed that the Ag-BG samples had a broad spectrum antibacterial efficacy in aAg concentration-dependent manner. The 2% Ag-BG had the highest effect during the first 10 minutes to 72 hours. The minimum inhibitory concentration (MIC) of 2% Ag-BG was estimated to be 2 mg/ml for E. coli and P. aeruginosa and 2.66 mg/ml for S. aureus. 0.5% Ag-BG repressed growth of E.coli after 1 hour, but did not have any detectable antibacterial effect for longer periods. Evaluation of effects of prepared Ag-BG on Human osteoblast cells viability showed that 1% and 2% samples changed the cell proliferation rate in masses of more than 3.33 mg/ml and 2 mg/ml, respectively. In addition, LDH activity assay confirmed the data obtained from MTT test. It was concluded that the susceptibility of the gram positive bacterium (S. aureus) to the Ag-BG samples was less than the gram negative bacteria (E. coli and P. aeruginosa). Moreover, in a typical manner, the release of Ag ions from the glass structure started immediately, continued steadily and affected bacterial growth when reached its critical concentration in the medium. This systematic study can illustrate the optimum antibacterial property of the Ag-BG samples in masses of 3.33 mg/ml and 2 mg/ml for 1% and 2% Ag, respectively, for prevention of post-transplant infections.
    IET Nanobiotechnology 01/2015;
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    ABSTRACT: The catalytic reduction of methylene blue was studied using biosynthesised gold–silver (Au–Ag) alloy nanoparticles (NPs). The fungal biomass of Trichoderma harzianum was used as reducing and stabilising agent in the synthesis of Au–Ag alloy NPs. The synthesised NPs were well characterised by UV–vis spectroscopy, dynamic light scattering, X-ray diffraction, transmission electron microscopy, energy dispersive X-ray spectroscopy and Fourier transform infrared spectroscopy. The plausible synthesis mechanism involved in the formation of Au–Ag alloy NPs was also discussed with diagrammatic representation. A series of experiments were performed to investigate the catalytic activity of the as-prepared Au–Ag alloy NPs and found that the alloy NPs show excellent catalytic activity.
    IET Nanobiotechnology 12/2014; DOI:10.1049/iet-nbt.2014.0043
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    ABSTRACT: Specific primers play an important role in polymerase chain reaction (PCR) experiments, and therefore it is essential to find specific primers of outstanding quality. Unfortunately, many PCR constraints must be simultaneously inspected which makes specific primer selection difficult and time-consuming. This paper introduces a novel computational intelligence-based method, Teaching-Learning-Based Optimisation, to select the specific and feasible primers. The specified PCR product lengths of 150-300 bp and 500-800 bp with three melting temperature formulae of Wallace's formula, Bolton and McCarthy's formula and SantaLucia's formula were performed. The authors calculate optimal frequency to estimate the quality of primer selection based on a total of 500 runs for 50 random nucleotide sequences of 'Homo species' retrieved from the National Center for Biotechnology Information. The method was then fairly compared with the genetic algorithm (GA) and memetic algorithm (MA) for primer selection in the literature. The results show that the method easily found suitable primers corresponding with the setting primer constraints and had preferable performance than the GA and the MA. Furthermore, the method was also compared with the common method Primer3 according to their method type, primers presentation, parameters setting, speed and memory usage. In conclusion, it is an interesting primer selection method and a valuable tool for automatic high-throughput analysis. In the future, the usage of the primers in the wet lab needs to be validated carefully to increase the reliability of the method.
    IET Nanobiotechnology 12/2014; 8(4):238-46. DOI:10.1049/iet-nbt.2013.0055
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    ABSTRACT: In this study, we prepared amorphous and crystalline silica nanoparticles from rice hulls biomass using pyrolysis technique at different processing temperatures such as 923, 973, 1023, 1073, 1123 and 1173 K. X-ray fluorescence studies show that the purity of all the synthesised silica nanoparticles is in the range of 98-99.7%. X-ray diffraction studies reveal that amorphous silica nanoparticles are formed at 923-1023 K, whereas crystalline particles at 1073-1173 K. Morphology and microstructure of silica nanoparticles are studied by scanning electron and transmission electron microscopes. Silica nanoparticles obtained at different processing temperatures yield particle size in the range of 6-100 nm. Chemical composition and surface functionalities of the particles are examined by energy-dispersive X-ray diffraction and Fourier transform infrared spectroscopic studies. The developed method effectively uses rice hulls biomass as a green natural source in the synthesis of amorphous and crystalline silica nanoparticles with high-specific surface area. The optimised processing temperature (1023 K) enables amorphous silica nanoparticles to have high-specific surface area of 538 m(2)g(-1).
    IET Nanobiotechnology 12/2014; 8(4):290-4. DOI:10.1049/iet-nbt.2013.0057
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    ABSTRACT: Brosimum gaudichaudii Tréc. (Moraceae) is a common Brazilian Cerrado plant known by its pharmaceutical industry relevance. The authors investigated the latex protein components and potential biotechnological applications. Some protein fragments had their sequences elucidated, presenting similarities to jacalin and Kunitz-type trypsin inhibitors. Amino acid residue modifications were found, such as glutamine N-terminal residue cyclisation into pyroglutamic acid residue, and mass differences corresponding to hexoses and N-acetylhexosamine presence. The latex was used to produce a nanoscale structured film, which presented an increased attraction and reduced adhesion behaviours. The film presented high homogeneity, as observed by low nanoroughness values, probably because of its intrinsic components, such as the jacalin-like protein that has known agglutination properties. The immobilised Kunitz-type trypsin inhibitor presence in the latex film allow us to point out to applications related to this inhibition, as in active food packaging, since these peptidase inhibitors are able to inhibit pests and microorganism proliferation.
    IET Nanobiotechnology 12/2014; 8(4):222-9. DOI:10.1049/iet-nbt.2013.0042
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    ABSTRACT: A novel pH-sensitive drug release system has been synthesised by functional mesoporous silica materials. SBA-15, calcium modified SBA-15 (Ca-SBA-15) and phosphate modified SBA-15 (PO4-SBA-15) were synthesised using solvent evaporation method. It is a simple and feasible way to prepare the doping mesoporous silica materials. They show the large surface are, high pore volume and uniform pore size. Metformin hydrochloride was used as the model drug, and the control release behaviour was investigated. The functional mesoporous silica materials show the pH sensitive drug release behaviour because of the adjustable interaction between the drug molecule and the host.
    IET Nanobiotechnology 12/2014; 8(4):179-83. DOI:10.1049/iet-nbt.2013.0019